Brant E. Isakson

Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine

Affiliated withUniversity of Virginia School of Medicine

Research Area

Biography

Brant E. Isakson has not added Biography.
If you are Brant E. Isakson and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2017

Other Publications

Article	Year
Culturing alveolar type I, alveolar type II, and mixed cell populations by altering the extracellular matrix promotes changes in intercellular signaling mechanisms. Chest\| PubMed ID: 11893676	2002
Heterocellular cultures of pulmonary alveolar epithelial cells grown on laminin-5 supplemented matrix. In vitro cellular & developmental biology. Animal\| PubMed ID: 12605538	2002
Cell-cell communication in heterocellular cultures of alveolar epithelial cells. American journal of respiratory cell and molecular biology\| PubMed ID: 12748060	2003
Connexins: gaps in our knowledge of vascular function. Physiology (Bethesda, Md.)\| PubMed ID: 15381756	2004
Heterocellular contact at the myoendothelial junction influences gap junction organization. Circulation research\| PubMed ID: 15961721	2005
Extracellular matrix-driven alveolar epithelial cell differentiation in vitro. Experimental lung research\| PubMed ID: 16047415	2005
Connexin40 and connexin43 in mouse aortic endothelium: evidence for coordinated regulation. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 16284228	2006
Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communication. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 16857951	2006
Laminin-332 alters connexin profile, dye coupling and intercellular Ca2+ waves in ciliated tracheal epithelial cells. Respiratory research\| PubMed ID: 16884540	2006
Vascular gap junctions in hypertension. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 17015783	2006
Ca2+ and inositol 1,4,5-trisphosphate-mediated signaling across the myoendothelial junction. Circulation research\| PubMed ID: 17218602	2007
Incidence of protein on actin bridges between endothelium and smooth muscle in arterioles demonstrates heterogeneous connexin expression and phosphorylation. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 18408134	2008
Connexins in vascular physiology and pathology. Antioxidants & redox signaling\| PubMed ID: 18834327	2009
Localized expression of an Ins(1,4,5)P3 receptor at the myoendothelial junction selectively regulates heterocellular Ca2+ communication. Journal of cell science\| PubMed ID: 18946029	2008
The myoendothelial junction: breaking through the matrix? Microcirculation (New York, N.Y. : 1994)\| PubMed ID: 19330678	2009
Oxidized phospholipid species promote in vivo differential cx43 phosphorylation and vascular smooth muscle cell proliferation. The American journal of pathology\| PubMed ID: 19608875	2009
The importance of serine 161 in the sodium channel beta3 subunit for modulation of Na(V)1.2 gating. Pflugers Archiv : European journal of physiology\| PubMed ID: 19806359	2010
Site-specific connexin phosphorylation is associated with reduced heterocellular communication between smooth muscle and endothelium. Journal of vascular research\| PubMed ID: 20016202	2010
Plasminogen activator inhibitor-1 regulates myoendothelial junction formation. Circulation research\| PubMed ID: 20133900	2010
Enhanced connexin 43 expression delays intra-mitotic duration and cell cycle traverse independently of gap junction channel function. Journal of cellular biochemistry\| PubMed ID: 20512937	2010
Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circulation research\| PubMed ID: 20651288	2010
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature\| PubMed ID: 20944749	2010
Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21071693	2011
A new method for in vivo visualization of vessel remodeling using a near-infrared dye. Microcirculation (New York, N.Y. : 1994)\| PubMed ID: 21418375	2011
Pannexin1 regulates Î±1-adrenergic receptor- mediated vasoconstriction. Circulation research\| PubMed ID: 21546608	2011
Spontaneous lung dysfunction and fibrosis in mice lacking connexin 40 and endothelial cell connexin 43. The American journal of pathology\| PubMed ID: 21641379	2011
Characterization of the thoracodorsal artery: morphology and reactivity. Microcirculation (New York, N.Y. : 1994)\| PubMed ID: 22335567	2012
A novel mRNA binding protein complex promotes localized plasminogen activator inhibitor-1 accumulation at the myoendothelial junction. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 22383705	2012
Loss of compliance in small arteries, but not in conduit arteries, after 6 weeks exposure to high fat diet. Journal of cardiovascular translational research\| PubMed ID: 22467359	2012
Smooth muscle specific deletion of Ndst1 leads to decreased vessel luminal area and no change in blood pressure in conscious mice. Journal of cardiovascular translational research\| PubMed ID: 22555965	2012
MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation. Circulation research\| PubMed ID: 22652908	2012
Mechanisms of ATP release and signalling in the blood vessel wall. Cardiovascular research\| PubMed ID: 22678409	2012
Expression of pannexin isoforms in the systemic murine arterial network. Journal of vascular research\| PubMed ID: 22739252	2012
Posttranslational modifications in connexins and pannexins. The Journal of membrane biology\| PubMed ID: 22739962	2012
Pannexin 1 in the regulation of vascular tone. Trends in cardiovascular medicine\| PubMed ID: 22841835	2012
S-nitrosylation inhibits pannexin 1 channel function. The Journal of biological chemistry\| PubMed ID: 23033481	2012
Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction. The Journal of clinical investigation\| PubMed ID: 23093775	2012
Endothelial cell expression of haemoglobin α regulates nitric oxide signalling. Nature\| PubMed ID: 23123858	2012
Loss of collectrin, an angiotensin-converting enzyme 2 homolog, uncouples endothelial nitric oxide synthase and causes hypertension and vascular dysfunction. Circulation\| PubMed ID: 24048198	2013
Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1. Molecular and cellular biochemistry\| PubMed ID: 24101444	2014
Diverse post-translational modifications of the pannexin family of channel-forming proteins. Channels (Austin, Tex.)\| PubMed ID: 24418849	2014
Secreting von Willebrand factor in a Gα-SNAP. Blood\| PubMed ID: 24434997	2014
Differentiating connexin hemichannels and pannexin channels in cellular ATP release. FEBS letters\| PubMed ID: 24548565	2014
Pannexin-1 as a potentiator of ligand-gated receptor signaling. Channels (Austin, Tex.)\| PubMed ID: 24576994	2014
Connexins, pannexins and innexins: protein cousins with overlapping functions. FEBS letters\| PubMed ID: 24613922	2014
Regulation of cellular communication by signaling microdomains in the blood vessel wall. Pharmacological reviews\| PubMed ID: 24671377	2014
Hemoglobin α in the blood vessel wall. Free radical biology & medicine\| PubMed ID: 24832680	2014
The myoendothelial junction: connections that deliver the message. Physiology (Bethesda, Md.)\| PubMed ID: 24985328	2014
Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25278292	2014
A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells. Science signaling\| PubMed ID: 25690012	2015
Emerging concepts regarding pannexin 1 in the vasculature. Biochemical Society transactions\| PubMed ID: 26009197	2015
Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation. Nature communications\| PubMed ID: 26242575	2015
The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration. American journal of physiology. Cell physiology\| PubMed ID: 26289751	2015
Endothelial nitric oxide synthase in the microcirculation. Cellular and molecular life sciences : CMLS\| PubMed ID: 26390975	2015
Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes. Molecular metabolism\| PubMed ID: 26413467	2015
CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability. The Journal of clinical investigation\| PubMed ID: 26999610	2016
Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition. Biochimica et biophysica acta\| PubMed ID: 27106139	2016
Small Interfering RNA-Mediated Connexin Gene Knockdown in Vascular Endothelial and Smooth Muscle Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 27207287	2016
Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 27255725	2016
Cardiovascular magnetic resonance detects the progression of impaired myocardial perfusion reserve and increased left-ventricular mass in mice fed a high-fat diet. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance\| PubMed ID: 27609091	2016
AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus. Circulation research\| PubMed ID: 27650556	2016
Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX). Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 27802421	2016
Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia. Antioxidants & redox signaling\| PubMed ID: 27889956	2017
Pannexin channel and connexin hemichannel expression in vascular function and inflammation. BMC cell biology\| PubMed ID: 28124621	2017
Signaling Pathways Linked to Serotonin-Induced Superoxide Anion Production: A Physiological Role for Mitochondria in Pulmonary Arteries. Frontiers in physiology\| PubMed ID: 28232807	2017
Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 28283548	2017
The Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature. Antioxidants & redox signaling\| PubMed ID: 28288516	2017
ZP1609/danegaptide and mitochondrial connexin hemichannels: a harbinger for peptide drug design. British journal of pharmacology\| PubMed ID: 28567717	2017