Ronald L. Klein

Department of Pharmacology, louisiana state university health sciences center

Affiliated withlouisiana state university health sciences center

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2017

Other Publications

Article	Year
Neuropathological and behavioral consequences of adeno-associated viral vector-mediated continuous intrastriatal neurotrophin delivery in a focal ischemia model in rats. Neurobiology of disease\| PubMed ID: 11895371	2002
Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra. Human gene therapy\| PubMed ID: 11916484	2002
Dose and promoter effects of adeno-associated viral vector for green fluorescent protein expression in the rat brain. Experimental neurology\| PubMed ID: 12093083	2002
Pre- and post-synaptic modification by neurotrophins. Neuroscience research\| PubMed ID: 12103437	2002
Gene delivery to the eye using adeno-associated viral vectors. Methods (San Diego, Calif.)\| PubMed ID: 12413426	2002
Measurements of vector-derived neurotrophic factor and green fluorescent protein levels in the brain. Methods (San Diego, Calif.)\| PubMed ID: 12413428	2002
Particle detection, number estimation, and feature measurement in gene transfer studies: optical fractionator stereology integrated with digital image processing and analysis. Methods (San Diego, Calif.)\| PubMed ID: 12413429	2002
Suppression of insult-induced neurogenesis in adult rat brain by brain-derived neurotrophic factor. Experimental neurology\| PubMed ID: 12429205	2002
Adeno-associated virus vector expressing nerve growth factor enhances cholinergic axonal sprouting after cortical injury in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12684466	2003
Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model. Investigative ophthalmology & visual science\| PubMed ID: 14507880	2003
Long-term neuronal effects and disposition of ectopic preproNGF gene transfer into the rat septum. Human gene therapy\| PubMed ID: 14577926	2003
Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau. The American journal of pathology\| PubMed ID: 14695347	2004
Recombinant adeno-associated virus serotype 2 effectively transduces primary rat brain astrocytes and microglia. Brain research. Brain research protocols\| PubMed ID: 15519948	2004
Adeno-associated viruses containing bFGF or BDNF are neuroprotective against excitotoxicity. Current eye research\| PubMed ID: 15764082	2004
Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat. Neurobiology of disease\| PubMed ID: 16137567	2005
Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16325474	2006
Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model. Neuroscience letters\| PubMed ID: 16554120	2006
Memory-related deficits following selective hippocampal expression of Swedish mutation amyloid precursor protein in the rat. Experimental neurology\| PubMed ID: 16780838	2006
AAV8, 9, Rh10, Rh43 vector gene transfer in the rat brain: effects of serotype, promoter and purification method. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17955025	2008
Tau expression levels from various adeno-associated virus vector serotypes produce graded neurodegenerative disease states. The European journal of neuroscience\| PubMed ID: 18380664	2008
Effect of CNTF on retinal ganglion cell survival in experimental glaucoma. Investigative ophthalmology & visual science\| PubMed ID: 19060281	2009
Pronounced microgliosis and neurodegeneration in aged rats after tau gene transfer. Neurobiology of aging\| PubMed ID: 19155101	2010
Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19223871	2009
PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models. Brain research\| PubMed ID: 19368808	2009
Bilateral effects of unilateral GDNF administration on dopamine- and GABA-regulating proteins in the rat nigrostriatal system. Experimental neurology\| PubMed ID: 19460370	2009
Versatile somatic gene transfer for modeling neurodegenerative diseases. Neurotoxicity research\| PubMed ID: 19669852	2009
Transcriptome analysis of a tau overexpression model in rats implicates an early pro-inflammatory response. Experimental neurology\| PubMed ID: 20346943	2010
Circulating neprilysin clears brain amyloid. Molecular and cellular neurosciences\| PubMed ID: 20558294	2010
Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory. Behavioural brain research\| PubMed ID: 20727915	2011
Expansive gene transfer in the rat CNS rapidly produces amyotrophic lateral sclerosis relevant sequelae when TDP-43 is overexpressed. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20877346	2010
Genetic strategies to study TDP-43 in rodents and to develop preclinical therapeutics for amyotrophic lateral sclerosis. The European journal of neuroscience\| PubMed ID: 21777407	2011
Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus. Experimental neurology\| PubMed ID: 22177996	2012
The advent of AAV9 expands applications for brain and spinal cord gene delivery. Expert opinion on biological therapy\| PubMed ID: 22519910	2012
Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase. Cancer science\| PubMed ID: 22533343	2012
Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats. Behavioural brain research\| PubMed ID: 22561128	2012
A spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson's disease. PloS one\| PubMed ID: 23028885	2012
Imaging the response of the retina to electrical stimulation with genetically encoded calcium indicators. Journal of neurophysiology\| PubMed ID: 23343890	2013
Recombinant AAV9-TLK1B administration ameliorates fractionated radiation-induced xerostomia. Human gene therapy\| PubMed ID: 23614651	2013
Pre-immunization with an Intramuscular Injection of AAV9-Human Erythropoietin Vectors Reduces the Vector-Mediated Transduction following Re-Administration in Rat Brain. PloS one\| PubMed ID: 23667683	2013
Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23689600	2013
Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates. Journal of medical primatology\| PubMed ID: 25639184	2015
AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats. Molecular therapy. Methods & clinical development\| PubMed ID: 26445725	2015
Sequential Adeno-Associated Viral Vector Serotype 9-Green Fluorescent Protein Gene Transfer Causes Massive Inflammation and Intense Immune Response in Rat Striatum. Human gene therapy\| PubMed ID: 26847924	2016
Gene vector 'magic bullet': targeted expression in the central nervous system after peripheral delivery using the synapsin promoter. Expert opinion on therapeutic targets\| PubMed ID: 27424738	2016
Severe respiratory changes at end stage in a FUS-induced disease state in adult rats. BMC neuroscience\| PubMed ID: 27793099	2016
Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B. Frontiers in molecular neuroscience\| PubMed ID: 27867348	2016
Corrigendum: Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B. Frontiers in molecular neuroscience\| PubMed ID: 28008310	2016
p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration. PloS one\| PubMed ID: 28076378	2017
Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 kDa C-terminal Fragment to Mimic Amyotrophic Lateral Sclerosis. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 28160795	2013
Entorhinal tau pathology disrupts hippocampal-prefrontal oscillatory coupling during associative learning. Neurobiology of aging\| PubMed ID: 28735144	2017