Christopher Chen

Memory Aging and Cognition Centre, National University Health System

Affiliated withNational University Health System National University of Singapore

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 19	2017

Other Publications

Article	Year
Apolipoprotein ɛ4 is Associated with Dementia and Cognitive Impairment Predominantly Due to Alzheimer's Disease and Not with Vascular Cognitive Impairment: A Singapore-Based Cohort. Journal of Alzheimer's disease : JAD\| PubMed ID: 26923016	2016
Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease. Psychopharmacology\| PubMed ID: 20625884	2011
The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke. Journal of the neurological sciences\| PubMed ID: 20889166	2010
Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia. Neuroreport\| PubMed ID: 20890229	2010
Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex. Neurochemistry international\| PubMed ID: 21034788	2010
Cortisol response to individualised graded insulin infusions: a reproducible biomarker for CNS compounds inhibiting HPA activation. British journal of clinical pharmacology\| PubMed ID: 21175444	2010
Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease. Neurochemistry international\| PubMed ID: 21419184	2011
Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias. Journal of the neurological sciences\| PubMed ID: 22129936	2012
Brief screening tests during acute admission in patients with mild stroke are predictive of vascular cognitive impairment 3-6 months after stroke. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 22496580	2012
The Montreal Cognitive Assessment is superior to the Mini-Mental State Examination in detecting patients at higher risk of dementia. International psychogeriatrics\| PubMed ID: 22687278	2012
Changes in cerebral hemodynamic and cognitive parameters after external carotid-internal carotid bypass surgery in patients with severe steno-occlusive disease: a pilot study. Journal of the neurological sciences\| PubMed ID: 22846792	2012
The informant AD8 is superior to participant AD8 in detecting cognitive impairment in a memory clinic setting. Journal of Alzheimer's disease : JAD\| PubMed ID: 23380993	2013
The NeuroAiD II (MLC901) in Vascular Cognitive Impairment Study (NEURITES). Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 23548916	2013
Patterns of neuropsychological impairment in Alzheimer's disease and mixed dementia. Journal of the neurological sciences\| PubMed ID: 23978422	2013
Cognitive screening improves the predictive value of stroke severity scores for functional outcome 3-6 months after mild stroke and transient ischaemic attack: an observational study. BMJ open\| PubMed ID: 24002980	2013
Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden. Neurochemistry international\| PubMed ID: 24200817	2014
Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study. Alzheimer disease and associated disorders\| PubMed ID: 24322485	2014
Improving screening for vascular cognitive impairment at three to six months after mild ischemic stroke and transient ischemic attack. International psychogeriatrics\| PubMed ID: 24423626	2014
Microvascular network alterations in the retina of patients with Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 24439169	2014
Novel pathophysiological markers are revealed by iTRAQ-based quantitative clinical proteomics approach in vascular dementia. Journal of proteomics\| PubMed ID: 24448401	2014
Diagnostic Criteria for Vascular Cognitive Disorders: A VASCOG Statement. Alzheimer disease and associated disorders\| PubMed ID: 24632990	2014
Brain lipidomes of subcortical ischemic vascular dementia and mixed dementia. Neurobiology of aging\| PubMed ID: 24684787	2014
Intracranial stenosis, cerebrovascular diseases, and cognitive impairment in chinese. Alzheimer disease and associated disorders\| PubMed ID: 24731981	2015
Discovery of prognostic biomarker candidates of lacunar infarction by quantitative proteomics of microvesicles enriched plasma. PloS one\| PubMed ID: 24752076	2014
Computer tomography for prediction of cognitive outcomes after ischemic cerebrovascular events. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association\| PubMed ID: 24794946	2014
A pilot study to examine the correlation between cognition and blood biomarkers in a Singapore Chinese male cohort with type 2 diabetes mellitus. PloS one\| PubMed ID: 24816647	2014
Microvascular network alterations in retina of subjects with cerebral small vessel disease. Neuroscience letters\| PubMed ID: 24937268	2014
Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 25261450	2015
Retinal vascular fractals and cognitive impairment. Dementia and geriatric cognitive disorders extra\| PubMed ID: 25298774	2014
Retinal microvasculature in Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 25351108	2014
Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 25428254	2015
Retinal neurodegeneration on optical coherence tomography and cerebral atrophy. Neuroscience letters\| PubMed ID: 25451722	2015
Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia. Neurochemistry international\| PubMed ID: 25497727	2015
Feasibility and acceptability of the informant AD8 for cognitive screening in primary healthcare: a pilot study. TheScientificWorldJournal\| PubMed ID: 25548780	2014
Markers of cardiac dysfunction in cognitive impairment and dementia. Medicine\| PubMed ID: 25569645	2015
Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 25956990	2015
Risk Factors and Consequences of Cortical Thickness in an Asian Population. Medicine\| PubMed ID: 26061305	2015
Association of neuropsychiatric symptoms and sub-syndromes with cognitive impairment in community-dwelling Asian elderly. International psychogeriatrics\| PubMed ID: 26201550	2015
Prevalence and Risk Factors of Acute Incidental Infarcts. Stroke\| PubMed ID: 26294677	2015
Association of Magnetic Resonance Imaging Markers of Cerebrovascular Disease Burden and Cognition. Stroke\| PubMed ID: 26330446	2015
Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice. Scientific reports\| PubMed ID: 26346625	2015
Subcortical Atrophy in Cognitive Impairment and Dementia. Journal of Alzheimer's disease : JAD\| PubMed ID: 26402115	2015
Extracellular vesicles are rapidly purified from human plasma by PRotein Organic Solvent PRecipitation (PROSPR). Scientific reports\| PubMed ID: 26419333	2015
Prevalence of Cognitive Impairment and Dementia in Malays - Epidemiology of Dementia in Singapore Study. Current Alzheimer research\| PubMed ID: 26428410	2017
Ocular Fundus Photography as a Tool to Study Stroke and Dementia. Seminars in neurology\| PubMed ID: 26444393	2015
Clinical utility of the informant AD8 as a dementia case finding instrument in primary healthcare. Journal of Alzheimer's disease : JAD\| PubMed ID: 26444776	2016
Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP. Frontiers in behavioral neuroscience\| PubMed ID: 26648852	2015
Rapid Screening for Cognitive Impairment in Parkinson's Disease: A Pilot Study. Parkinson's disease\| PubMed ID: 26713170	2015
Risk Factors of Cognitive Impairment and Brief Cognitive Tests to Predict Cognitive Performance Determined by a Formal Neuropsychological Evaluation of Primary Health Care Patients. Journal of the American Medical Directors Association\| PubMed ID: 26785695	2016
Beyond Screening: Can the Mini-Mental State Examination be Used as an Exclusion Tool in a Memory Clinic? Diagnostics (Basel, Switzerland)\| PubMed ID: 26854165	2015
The Combined Utility of a Brief Functional Measure and Performance-Based Screening Test for Case Finding of Cognitive Impairment in Primary Healthcare. Journal of the American Medical Directors Association\| PubMed ID: 26857297	2016
Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer's disease with cerebrovascular disease. Molecular brain\| PubMed ID: 26983404	2016
The Montreal Cognitive Assessment is superior to National Institute of Neurological Disease and Stroke-Canadian Stroke Network 5-minute protocol in predicting vascular cognitive impairment a... BMC neurology\| PubMed ID: 27067253	2016
Validation of the Total Cerebrovascular Disease Burden Scale in a Community Sample. Journal of Alzheimer's disease : JAD\| PubMed ID: 27079726	2016
ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Scientific reports\| PubMed ID: 27189808	2016
A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium. Alzheimer's & dementia (Amsterdam, Netherlands)\| PubMed ID: 27239529	2015
Cerebral microbleeds and neuropsychiatric symptoms in an elderly Asian cohort. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 27261503	2017
Changing Patterns of Patient Characteristics in a Memory Clinic in Singapore. Journal of the American Medical Directors Association\| PubMed ID: 27449635	2016
Intracranial stenosis in cognitive impairment and dementia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 27488908	2017
The Diagnostic Utility of the NINDS-CSN Neuropsychological Battery in Memory Clinics. Dementia and geriatric cognitive disorders extra\| PubMed ID: 27504116	2016
Growth differentiation factor-15 and white matter hyperintensities in cognitive impairment and dementia. Medicine\| PubMed ID: 27537582	2016
The Association Between Retinal Neuronal Layer and Brain Structure is Disrupted in Patients with Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 27567815	2016
Inter-hemispheric functional dysconnectivity mediates the association of corpus callosum degeneration with memory impairment in AD and amnestic MCI. Scientific reports\| PubMed ID: 27581062	2016
Cortical cerebral microinfarcts on 3T MRI: A novel marker of cerebrovascular disease. Neurology\| PubMed ID: 27590296	2016
Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias. Molecular brain\| PubMed ID: 27609071	2016
Poststroke Cognitive Decline is Independent of Longitudinal Changes in Cerebral Hemodynamics Parameters. Journal of neuroimaging : official journal of the American Society of Neuroimaging\| PubMed ID: 27623192	2017
Muscarinic M1 Receptor Coupling to G-protein is Intact in Parkinson's Disease Dementia. Journal of Parkinson's disease\| PubMed ID: 27662332	2016
Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature neuroscience\| PubMed ID: 27694991	2016
Evaluation of an fMRI USPIO-based assay in healthy human volunteers. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 27775841	2017
Impact of Strategically Located White Matter Hyperintensities on Cognition in Memory Clinic Patients with Small Vessel Disease. PloS one\| PubMed ID: 27824925	2016
Prognostic Factors and Pattern of Long-Term Recovery with MLC601 (NeuroAiD™) in the Chinese Medicine NeuroAiD Efficacy on Stroke Recovery - Extension Study. Cerebrovascular diseases (Basel, Switzerland)\| PubMed ID: 27846631	2017
Imaging retina to study dementia and stroke. Progress in retinal and eye research\| PubMed ID: 28057562	2017
Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke. Molecular neurobiology\| PubMed ID: 28092085	2017
Association Between Subclinical Cardiac Biomarkers and Clinically Manifest Cardiac Diseases With Cortical Cerebral Microinfarcts. JAMA neurology\| PubMed ID: 28166312	2017
Serum IL-8 is a marker of white-matter hyperintensities in patients with Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands)\| PubMed ID: 28239640	2017
Decline in changing Montreal Cognitive Assessment (MoCA) scores is associated with post-stroke cognitive decline determined by a formal neuropsychological evaluation. PloS one\| PubMed ID: 28346532	2017
Prevalence, risk factors and consequences of cerebral small vessel diseases: data from three Asian countries. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 28600443	2017
Ankle brachial index, MRI markers and cognition: The Epidemiology of Dementia in Singapore study. Atherosclerosis\| PubMed ID: 28709046	2017
Detection, risk factors, and functional consequences of cerebral microinfarcts. The Lancet. Neurology\| PubMed ID: 28716371	2017
Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer's disease with and without cerebrovascular disease. Alzheimer's research & therapy\| PubMed ID: 28818116	2017
Repeatability and Reproducibility of Retinal Neuronal and Axonal Measures on Spectral-Domain Optical Coherence Tomography in Patients with Cognitive Impairment. Frontiers in neurology\| PubMed ID: 28861029	2017
Influence of cerebrovascular disease on brain networks in prodromal and clinical Alzheimer's disease. Brain : a journal of neurology\| PubMed ID: 29053778	2017