Tien Y. Wong

Singapore Eye Research Institute, Singapore National Eye Centre

Affiliated withSingapore National Eye Centre National University of Singapore

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 19	2017

Other Publications

Article	Year
Diabetes, hyperglycemia, and central corneal thickness: the Singapore Malay Eye Study. Ophthalmology\| PubMed ID: 17964654	2008
The prevalence and types of glaucoma in malay people: the Singapore Malay eye study. Investigative ophthalmology & visual science\| PubMed ID: 18441307	2008
Determinants of the optic cup to disc ratio in an Asian population: the Singapore Malay Eye Study (SiMES). Archives of ophthalmology (Chicago, Ill. : 1960)\| PubMed ID: 18695105	2008
Central corneal thickness and its associations with ocular and systemic factors: the Singapore Malay Eye Study. American journal of ophthalmology\| PubMed ID: 19152872	2009
The relationship of intraocular pressure with age, systolic blood pressure, and central corneal thickness in an asian population. Investigative ophthalmology & visual science\| PubMed ID: 19458324	2009
Relationship of retinal vascular caliber with optic disc and macular structure. American journal of ophthalmology\| PubMed ID: 19481730	2009
Age-related macular degeneration and risk of coronary heart disease and stroke: the Cardiovascular Health Study. Ophthalmology\| PubMed ID: 19592102	2009
Diabetes, metabolic abnormalities, and glaucoma. Archives of ophthalmology (Chicago, Ill. : 1960)\| PubMed ID: 19822853	2009
Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases in Asians. Ophthalmic epidemiology\| PubMed ID: 19995197	2009
Admixture mapping scans identify a locus affecting retinal vascular caliber in hypertensive African Americans: the Atherosclerosis Risk in Communities (ARIC) study. PLoS genetics\| PubMed ID: 20419148	2010
Refractive error, axial dimensions, and primary open-angle glaucoma: the Singapore Malay Eye Study. Archives of ophthalmology (Chicago, Ill. : 1960)\| PubMed ID: 20625053	2010
Hyperopic refractive error and shorter axial length are associated with age-related macular degeneration: the Singapore Malay Eye Study. Investigative ophthalmology & visual science\| PubMed ID: 20671287	2010
Is the pediatric quality of life inventory valid for use in preschool children with refractive errors? Optometry and vision science : official publication of the American Academy of Optometry\| PubMed ID: 20852452	2010
The heritability and sibling risk of angle closure in Asians. Ophthalmology\| PubMed ID: 21035870	2011
Clinical practice. Retinal-vein occlusion. The New England journal of medicine\| PubMed ID: 21105795	2010
Novel anterior-chamber angle measurements by high-definition optical coherence tomography using the Schwalbe line as the landmark. The British journal of ophthalmology\| PubMed ID: 21183513	2011
Determinants of image quality of Heidelberg Retina Tomography II and its association with optic disc parameters in a population-based setting. American journal of ophthalmology\| PubMed ID: 21257147	2011
Determinants of corneal biomechanical properties in an adult Chinese population. Ophthalmology\| PubMed ID: 21333357	2011
Diabetic retinopathy in 2011: further insights from new epidemiological studies and clinical trials. Diabetes care\| PubMed ID: 21447672	2011
Comparison of ocular response analyzer parameters in chinese subjects with primary angle-closure and primary open-angle glaucoma. Archives of ophthalmology (Chicago, Ill. : 1960)\| PubMed ID: 21482869	2011
Prevalence and causes of visual impairment and blindness in an urban Indian population: the Singapore Indian Eye Study. Ophthalmology\| PubMed ID: 21621261	2011
Cataract prevalence varies substantially with assessment systems: comparison of clinical and photographic grading in a population-based study. Ophthalmic epidemiology\| PubMed ID: 21780875	2011
The microvasculature in chronic kidney disease. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 21784828	2011
Emerging evidence concerning systemic safety of anti-VEGF agents--should ophthalmologists be concerned? American journal of ophthalmology\| PubMed ID: 21855670	2011
Racial differences in the prevalence of diabetes but not diabetic retinopathy in a multi-ethnic Asian population. Investigative ophthalmology & visual science\| PubMed ID: 21862647	2011
Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe). Investigative ophthalmology & visual science\| PubMed ID: 21873659	2011
Independent impact of area-level socioeconomic measures on visual impairment. Investigative ophthalmology & visual science\| PubMed ID: 21969296	2011
Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations. Human molecular genetics\| PubMed ID: 21984434	2012
Determinants of quantitative optic nerve measurements using spectral domain optical coherence tomography in a population-based sample of non-glaucomatous subjects. Investigative ophthalmology & visual science\| PubMed ID: 22039236	2011
The prevalence and risk factors of ocular trauma: the Singapore Indian eye study. Ophthalmic epidemiology\| PubMed ID: 22053838	2011
Retinal microvascular calibre and risk of incident diabetes: the multi-ethnic study of atherosclerosis. Diabetes research and clinical practice\| PubMed ID: 22088792	2012
Lipids and diabetic retinopathy. Expert opinion on biological therapy\| PubMed ID: 22122357	2012
Impact of Bilateral Open and Closed-angle Glaucoma on Glaucoma-specific Functioning in Asians. Journal of glaucoma\| PubMed ID: 22157514	2011
Prevalence of and risk factors for age-related macular degeneration in a multiethnic Asian cohort. Archives of ophthalmology (Chicago, Ill. : 1960)\| PubMed ID: 22159171	2012
Prevalence and risk factors of epiretinal membrane in Asian Indians. Investigative ophthalmology & visual science\| PubMed ID: 22247478	2012
Asian age-related macular degeneration phenotyping study: rationale, design and protocol of a prospective cohort study. Clinical & experimental ophthalmology\| PubMed ID: 22299650	2012
Global prevalence and major risk factors of diabetic retinopathy. Diabetes care\| PubMed ID: 22301125	2012
Comparison of scanning laser ophthalmoscopy and high-definition optical coherence tomography measurements of optic disc parameters. The British journal of ophthalmology\| PubMed ID: 22322203	2012
Impact of migration and acculturation on prevalence of type 2 diabetes and related eye complications in Indians living in a newly urbanised society. PloS one\| PubMed ID: 22506053	2012
Age-related macular degeneration and long-term risk of stroke subtypes. Stroke\| PubMed ID: 22535267	2012
Age-related macular degeneration. Lancet (London, England)\| PubMed ID: 22559899	2012
Prevalence and risk factors of diabetic retinopathy in migrant Indians in an urbanized society in Asia: the Singapore Indian eye study. Ophthalmology\| PubMed ID: 22709419	2012
Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals. Disease models & mechanisms\| PubMed ID: 22730475	2012
Pentosidine levels in nonproteinuric diabetes associated with both low estimated glomerular filtration rate and cataract. Diabetes, metabolic syndrome and obesity : targets and therapy\| PubMed ID: 22807634	2012
Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography. Investigative ophthalmology & visual science\| PubMed ID: 22836772	2012
Language barrier and its relationship to diabetes and diabetic retinopathy. BMC public health\| PubMed ID: 22974298	2012
Retinal microvascular signs and risk of stroke: the Multi-Ethnic Study of Atherosclerosis (MESA). Stroke\| PubMed ID: 23111439	2012
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Nature genetics\| PubMed ID: 23291589	2013
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. PloS one\| PubMed ID: 23326517	2013
Lack of awareness of common eye conditions in the community. Ophthalmic epidemiology\| PubMed ID: 23350556	2013
Genome-wide association study of retinopathy in individuals without diabetes. PloS one\| PubMed ID: 23393555	2013
How much eye care services do Asian populations need? Projection from the Singapore Epidemiology of Eye Disease (SEED) study. Investigative ophthalmology & visual science\| PubMed ID: 23439593	2013
Racial variations in the prevalence of refractive errors in the United States: the multi-ethnic study of atherosclerosis. American journal of ophthalmology\| PubMed ID: 23453694	2013
Associations of iris structural measurements in a Chinese population: the Singapore Chinese Eye Study. Investigative ophthalmology & visual science\| PubMed ID: 23538059	2013
Validity of a new optic disc grading software for use in clinical and epidemiological research. Clinical & experimental ophthalmology\| PubMed ID: 23566165	2013
Marital status and its relationship with the risk and pattern of visual impairment in a multi-ethnic Asian population. Journal of public health (Oxford, England)\| PubMed ID: 23658389	2014
Genetic loci for retinal arteriolar microcirculation. PloS one\| PubMed ID: 23776548	2013
Retinal vascular fractal and blood pressure in a multiethnic population. Journal of hypertension\| PubMed ID: 23787404	2013
Treatment of age-related macular degeneration. Lancet (London, England)\| PubMed ID: 23870812	2013
Cardio-metabolic risk factors and prehypertension in persons without diabetes, hypertension, and cardiovascular disease. BMC public health\| PubMed ID: 23919264	2013
Myopia and age-related cataract: a systematic review and meta-analysis. American journal of ophthalmology\| PubMed ID: 23938120	2013
Epidemiology and disease burden of pathologic myopia and myopic choroidal neovascularization: an evidence-based systematic review. American journal of ophthalmology\| PubMed ID: 24099276	2014
Relationship between ganglion cell-inner plexiform layer and optic disc/retinal nerve fibre layer parameters in non-glaucomatous eyes. The British journal of ophthalmology\| PubMed ID: 24123901	2013
The economic cost of myopia in adults aged over 40 years in Singapore. Investigative ophthalmology & visual science\| PubMed ID: 24159089	2013
Challenges in elucidating the genetics of diabetic retinopathy. JAMA ophthalmology\| PubMed ID: 24201651	2014
Retinal vascular caliber and the development of hypertension: a meta-analysis of individual participant data. Journal of hypertension\| PubMed ID: 24322199	2014
RADIANCE: a randomized controlled study of ranibizumab in patients with choroidal neovascularization secondary to pathologic myopia. Ophthalmology\| PubMed ID: 24326106	2014
The prognostic role of body mass index on mortality amongst the middle-aged and elderly: a competing risk analysis. Diabetes research and clinical practice\| PubMed ID: 24382466	2014
Prevalence and causes of vision loss in East Asia: 1990-2010. The British journal of ophthalmology\| PubMed ID: 24390167	2014
Effects of simvastatin on retinal structure and function of a high-fat atherogenic mouse model of thickened Bruch's membrane. Investigative ophthalmology & visual science\| PubMed ID: 24398101	2014
Assessment of iris surface features and their relationship with iris thickness in Asian eyes. Ophthalmology\| PubMed ID: 24405741	2014
Personalized Medicine in Ophthalmology: From Pharmacogenetic Biomarkers to Therapeutic and Dosage Optimization. Journal of personalized medicine\| PubMed ID: 24624293	2013
Genetic risk, ethnic variations and pharmacogenetic biomarkers in age-related macular degeneration and polypoidal choroidal vasculopathy. Expert review of ophthalmology\| PubMed ID: 24860613	2013
Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium... Circulation. Cardiovascular genetics\| PubMed ID: 24951664	2014
Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology\| PubMed ID: 24974815	2014
Myopic choroidal neovascularisation: current concepts and update on clinical management. The British journal of ophthalmology\| PubMed ID: 24990871	2015
Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study. Investigative ophthalmology & visual science\| PubMed ID: 25205864	2014
Development and reliability of retinal arteriolar central light reflex quantification system: a new approach for severity grading. Investigative ophthalmology & visual science\| PubMed ID: 25358734	2014
Glaucoma and associated visual acuity and field loss significantly affect glaucoma-specific psychosocial functioning. Ophthalmology\| PubMed ID: 25444640	2015
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nature communications\| PubMed ID: 25631608	2015
Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI. Circulation. Cardiovascular genetics\| PubMed ID: 25663218	2015
Aggregate Effects of Intraocular Pressure and Cup-to-Disc Ratio Genetic Variants on Glaucoma in a Multiethnic Asian Population. Ophthalmology\| PubMed ID: 25745874	2015
Lens status influences the association between CFH polymorphisms and age-related macular degeneration: findings from two population-based studies in Singapore. PloS one\| PubMed ID: 25786237	2015
The Impact of Lens Vault on Visual Acuity and Refractive Error: Implications for Management of Primary Angle-closure Glaucoma. Journal of glaucoma\| PubMed ID: 25943738	2016
Prevalence and determinants of undiagnosed diabetic retinopathy and vision-threatening retinopathy in a multiethnic Asian cohort: the Singapore Epidemiology of Eye Diseases (SEED) study. The British journal of ophthalmology\| PubMed ID: 25953847	2015
Determinants of optical coherence tomography-derived minimum neuroretinal rim width in a normal Chinese population. Investigative ophthalmology & visual science\| PubMed ID: 26024117	2015
African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans. Investigative ophthalmology & visual science\| PubMed ID: 26098467	2015
Retinal Vessel Analysis as a Tool to Quantify Risk of Diabetic Retinopathy. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)\| PubMed ID: 26107480	2012
Retinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis. Diabetologia\| PubMed ID: 26232097	2015
Polypoidal Choroidal Vasculopathy in Asians. Journal of clinical medicine\| PubMed ID: 26239448	2015
Visual Impairment in White, Chinese, Black, and Hispanic Participants from the Multi-Ethnic Study of Atherosclerosis Cohort. Ophthalmic epidemiology\| PubMed ID: 26395659	2015
Assessment of the psychometric properties of the Chinese Impact of Vision Impairment questionnaire in a population-based study: findings from the Singapore Chinese Eye Study. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation\| PubMed ID: 26420045	2016
Ocular Fundus Photography as a Tool to Study Stroke and Dementia. Seminars in neurology\| PubMed ID: 26444393	2015
Composite Measures of Individual and Area-Level Socio-Economic Status Are Associated with Visual Impairment in Singapore. PloS one\| PubMed ID: 26555141	2015
Novel Genetic Loci Associated With Retinal Microvascular Diameter. Circulation. Cardiovascular genetics\| PubMed ID: 26567291	2016
Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye and vision (London, England)\| PubMed ID: 26605370	2015
Retinal Vein Occlusion in a Multi-Ethnic Asian Population: The Singapore Epidemiology of Eye Disease Study. Ophthalmic epidemiology\| PubMed ID: 26751637	2016
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nature genetics\| PubMed ID: 26752265	2016
Joint Effects of Intraocular Pressure and Myopia on Risk of Primary Open-Angle Glaucoma: The Singapore Epidemiology of Eye Diseases Study. Scientific reports\| PubMed ID: 26758554	2016
Determinants of pupil diameters and pupil dynamics in an adult Chinese population. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie\| PubMed ID: 26810838	2016
Retinal ganglion cell neuronal damage in diabetes and diabetic retinopathy. Clinical & experimental ophthalmology\| PubMed ID: 26872562	2016
Incidence of Age-Related Macular Degeneration in a Multi-Ethnic United States Population: The Multi-Ethnic Study of Atherosclerosis. Ophthalmology\| PubMed ID: 26896123	2016
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nature genetics\| PubMed ID: 27064256	2016
Increased Burden of Vision Impairment and Eye Diseases in Persons with Chronic Kidney Disease - A Population-Based Study. EBioMedicine\| PubMed ID: 27077127	2016
Diabetic retinopathy. Nature reviews. Disease primers\| PubMed ID: 27159554	2016
Ten Emerging Trends in the Epidemiology of Diabetic Retinopathy. Ophthalmic epidemiology\| PubMed ID: 27355693	2016
Characterization of Fatty Acid Binding Protein 7 (FABP7) in the Murine Retina. Investigative ophthalmology & visual science\| PubMed ID: 27367508	2016
Posterior Eye Shape Measurement With Retinal OCT Compared to MRI. Investigative ophthalmology & visual science\| PubMed ID: 27409473	2016
Inter-Relationships Between Retinal Vascular Caliber, Retinal Nerve Fiber Layer Thickness, and Glaucoma: A Mediation Analysis Approach. Investigative ophthalmology & visual science\| PubMed ID: 27421069	2016
Sex-Specific Association of Obstructive Sleep Apnea With Retinal Microvascular Signs: The Multi-Ethnic Study of Atherosclerosis. Journal of the American Heart Association\| PubMed ID: 27451457	2016
Association of Vision Impairment and Major Eye Diseases With Mobility and Independence in a Chinese Population. JAMA ophthalmology\| PubMed ID: 27467140	2016
The impact of typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy on vision-related quality of life in Asian patients. The British journal of ophthalmology\| PubMed ID: 27485722	2017
Vision impairment and major eye diseases reduce vision-specific emotional well-being in a Chinese population. The British journal of ophthalmology\| PubMed ID: 27565988	2017
The Association Between Retinal Neuronal Layer and Brain Structure is Disrupted in Patients with Cognitive Impairment and Alzheimer's Disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 27567815	2016
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature genetics\| PubMed ID: 27618452	2016
Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature neuroscience\| PubMed ID: 27694991	2016
Association of Changes in Visual Acuity With Vision-Specific Functioning in the Singapore Malay Eye Study. JAMA ophthalmology\| PubMed ID: 27711912	2016
Rationale and Methodology for a Community-Based Study of Diabetic Retinopathy in an Indonesian Population with Type 2 Diabetes Mellitus: The Jogjakarta Eye Diabetic Study in the Community. Ophthalmic epidemiology\| PubMed ID: 28032809	2017
Evidence of Microvascular Changes in the Retina following Kawasaki Disease. Scientific reports\| PubMed ID: 28094311	2017
Novel genetic loci associated with hippocampal volume. Nature communications\| PubMed ID: 28098162	2017
Retinal angiomatous proliferation. Survey of ophthalmology\| PubMed ID: 28189495	2017
A nationwide cohort study of cigarette smoking and risk of neovascular age-related macular degeneration in East Asian men. The British journal of ophthalmology\| PubMed ID: 28292774	2017
Prevalence and Determinants of Suboptimal Vitamin D Levels in a Multiethnic Asian Population. Nutrients\| PubMed ID: 28327512	2017
Ethnic Differences in the Association Between Age-Related Macular Degeneration and Vision-Specific Functioning. JAMA ophthalmology\| PubMed ID: 28358956	2017
Urinary Isoprostane Levels and Age-Related Macular Degeneration. Investigative ophthalmology & visual science\| PubMed ID: 28492872	2017
Six-Year Incidence of Age-Related Macular Degeneration in Asian Malays: The Singapore Malay Eye Study. Ophthalmology\| PubMed ID: 28501376	2017
Diabetic macular oedema: evidence-based treatment recommendations for Asian countries. Clinical & experimental ophthalmology\| PubMed ID: 28558152	2017
Change in vision-related quality of life and influencing factors in Asians receiving treatment for neovascular age-related macular degeneration. The British journal of ophthalmology\| PubMed ID: 28659392	2017
Combined poor diabetes control indicators are associated with higher risks of diabetic retinopathy and macular edema than poor glycemic control alone. PloS one\| PubMed ID: 28662119	2017
Inter-relationship between visual symptoms, activity limitation and psychological functioning in patients with diabetic retinopathy. The British journal of ophthalmology\| PubMed ID: 28928266	2017
Efficacy and Safety of Ranibizumab With or Without Verteporfin Photodynamic Therapy for Polypoidal Choroidal Vasculopathy: A Randomized Clinical Trial. JAMA ophthalmology\| PubMed ID: 28983556	2017