James R. Woodgett

Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Affiliated withMount Sinai Hospital University of Toronto

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 556	2011

Other Publications

Article	Year
DREAM is a critical transcriptional repressor for pain modulation. Cell\| PubMed ID: 11792319	2002
The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease. Acta neuropathologica\| PubMed ID: 11810173	2002
Role of glycogen synthase kinase-3 in cancer: regulation by Wnts and other signaling pathways. Advances in cancer research\| PubMed ID: 11883528	2002
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent... Molecular and cellular biology\| PubMed ID: 11884598	2002
CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. The Journal of experimental medicine\| PubMed ID: 12163562	2002
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Molecular and cellular biology\| PubMed ID: 12167717	2002
A molecular compendium of genes expressed in multiple myeloma. Blood\| PubMed ID: 12200383	2002
Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC. Cellular signalling\| PubMed ID: 12401518	2003
Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. The Journal of biological chemistry\| PubMed ID: 12458207	2003
Open heart surgery of PI-3 kinase signaling. Cell cycle (Georgetown, Tex.)\| PubMed ID: 12548014	2002
GSK-3: tricks of the trade for a multi-tasking kinase. Journal of cell science\| PubMed ID: 12615961	2003
JNK1 activity lowers the cellular production of H2O2 and modulates the growth arrest response to scavenging of H2O2 by catalase. Experimental cell research\| PubMed ID: 12681294	2003
Unravelling the activation mechanisms of protein kinase B/Akt. FEBS letters\| PubMed ID: 12829245	2003
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15044694	2004
Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15282284	2004
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Current biology : CB\| PubMed ID: 15324660	2004
Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase. The Journal of biological chemistry\| PubMed ID: 15466414	2004
Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. Molecular and cellular biology\| PubMed ID: 15743829	2005
Recent advances in the protein kinase B signaling pathway. Current opinion in cell biology\| PubMed ID: 15780591	2005
CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome. Nucleic acids research\| PubMed ID: 15911630	2005
Problems with co-funding in Canada. Science (New York, N.Y.)\| PubMed ID: 15976286	2005
Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesis. BMC cancer\| PubMed ID: 15982419	2005
Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: events associated with tumorigenesis. Oncogene\| PubMed ID: 16007218	2005
GSK3: an in-Toll-erant protein kinase? Nature immunology\| PubMed ID: 16034428	2005
Modulating autoimmunity: pick your PI3 kinase. Nature medicine\| PubMed ID: 16145571	2005
NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16148125	2005
Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis. Human pathology\| PubMed ID: 16426922	2006
Serum and glucocorticoid-regulated protein kinases: variations on a theme. Journal of cellular biochemistry\| PubMed ID: 16619268	2006
IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. Immunity\| PubMed ID: 16713974	2006
Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3. The Journal of biological chemistry\| PubMed ID: 16790420	2006
Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration. Trends in cell biology\| PubMed ID: 16870447	2006
Glycogen synthase kinase-3--an overview of an over-achieving protein kinase. Current drug targets\| PubMed ID: 17100578	2006
Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth. Neuron\| PubMed ID: 17178402	2006
Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium. Journal of circadian rhythms\| PubMed ID: 17295926	2007
CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase B. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17312138	2007
Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. Developmental cell\| PubMed ID: 17543867	2007
Systematic discovery of in vivo phosphorylation networks. Cell\| PubMed ID: 17570479	2007
Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cells, tissues, organs\| PubMed ID: 17587811	2007
Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3. The Journal of biological chemistry\| PubMed ID: 17711861	2007
GSK-3beta controls osteogenesis through regulating Runx2 activity. PloS one\| PubMed ID: 17786208	2007
Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism. Cell metabolism\| PubMed ID: 17908561	2007
Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 18084253	2008
Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. PLoS biology\| PubMed ID: 18288891	2008
Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide. Bioorganic & medicinal chemistry\| PubMed ID: 18346896	2008
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18367674	2008
Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor? Breast cancer research and treatment\| PubMed ID: 18438706	2009
Glycogen synthase kinase-3beta heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results. Behavioural pharmacology\| PubMed ID: 18469539	2008
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes. The Journal of clinical investigation\| PubMed ID: 18551195	2008
Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action. Molecular and cellular biology\| PubMed ID: 18694957	2008
Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes. Expert opinion on therapeutic targets\| PubMed ID: 18781825	2008
GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. The Journal of clinical investigation\| PubMed ID: 18802478	2008
Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. The Journal of clinical investigation\| PubMed ID: 18830417	2008
Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development. The Journal of biological chemistry\| PubMed ID: 19064989	2009
Exploring pluripotency with chemical genetics. Cell stem cell\| PubMed ID: 19200796	2009
IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain. Science signaling\| PubMed ID: 19244213	2009
Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Cancer research\| PubMed ID: 19491266	2009
GSK-3 is a master regulator of neural progenitor homeostasis. Nature neuroscience\| PubMed ID: 19801986	2009
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice. Molecular brain\| PubMed ID: 19925672	2009
Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo. Circulation research\| PubMed ID: 20360256	2010
When pathways collide: collaboration and connivance among signalling proteins in development. Nature reviews. Molecular cell biology\| PubMed ID: 20461097	2010
Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3. Synapse (New York, N.Y.)\| PubMed ID: 20687111	2011
Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility. Hypertension\| PubMed ID: 20696985	2010
Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival. The Journal of biological chemistry\| PubMed ID: 20841359	2010
Tissue-specific analysis of glycogen synthase kinase-3Î± (GSK-3Î±) in glucose metabolism: effect of strain variation. PloS one\| PubMed ID: 21253590	2011
Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling? F1000 biology reports\| PubMed ID: 21283602	2010
Selective loss of glycogen synthase kinase-3Î± in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation. FEBS letters\| PubMed ID: 21419127	2011
Genetic inactivation of GSK3Î± rescues spine deficits in Disc1-L100P mutant mice. Schizophrenia research\| PubMed ID: 21498050	2011
Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation. Bioorganic & medicinal chemistry letters\| PubMed ID: 22321216	2012