K. Sandy Pang

Department of Pharmaceutical Sciences, University of Toronto

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2017

Other Publications

Article	Year
Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2. Hepatology (Baltimore, Md.)\| PubMed ID: 11981753	2002
Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 12642462	2003
Retention of transporter activities in cryopreserved, isolated rat hepatocytes. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 12642471	2003
Moment analysis of metabolic heterogeneity: conjugation of benzoate with glycine in rat liver studied by multiple indicator dilution technique. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 12649380	2003
Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 12842829	2003
Influence of P-glycoprotein, transfer clearances, and drug binding on intestinal metabolism in Caco-2 cell monolayers or membrane preparations: a theoretical analysis. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 12975330	2003
Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the Gillette Review Series). Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 14625347	2003
The roles of transporters and enzymes in hepatic drug processing. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 15466164	2005
Comparative pharmacophore modeling of organic anion transporting polypeptides: a meta-analysis of rat Oatp1a1 and human OATP1B1. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15845861	2005
Binding of acellular, native and cross-linked human hemoglobins to haptoglobin: enhanced distribution and clearance in the rat. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 15890714	2005
Vascular binding, blood flow, transporter, and enzyme interactions on the processing of digoxin in rat liver. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15994370	2005
Transport is not rate-limiting in morphine glucuronidation in the single-pass perfused rat liver preparation. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 16464965	2006
Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor. Molecular pharmacology\| PubMed ID: 16481392	2006
Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 16627748	2006
P-glycoprotein and an unstirred water layer barring digoxin absorption in the vascularly perfused rat small intestine preparation: induction studies with pregnenolone-16alpha-carbonitrile. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 16751264	2006
An integrated approach to model hepatic drug clearance. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 16806855	2006
Increased estrogen sulfation of estradiol 17beta-D-glucuronide in metastatic tumor rat livers. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 16895976	2006
Transporters, enzymes, and enalapril removal in a rat (CC531-induced) liver metastatic model. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 17855765	2007
Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts. The AAPS journal\| PubMed ID: 17907768	2007
Permeability, transport, and metabolism of solutes in Caco-2 cell monolayers: a theoretical study. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 17932224	2008
Role of haptoglobin on the uptake of native and beta-chain [trimesoyl-(Lys82)beta-(Lys82)beta] cross-linked human hemoglobins in isolated perfused rat livers. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 18276837	2008
A catenary model to study transport and conjugation of baicalein, a bioactive flavonoid, in the Caco-2 cell monolayer: demonstration of substrate inhibition. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 18385448	2008
The Caco-2 cell monolayer: usefulness and limitations. Expert opinion on drug metabolism & toxicology\| PubMed ID: 18433344	2008
Formed and preformed metabolites: facts and comparisons. The Journal of pharmacy and pharmacology\| PubMed ID: 18812018	2008
Safety testing of metabolites: Expectations and outcomes. Chemico-biological interactions\| PubMed ID: 18926805	2009
Disparity in intestine disposition between formed and preformed metabolites and implications: a theoretical study. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 18948379	2009
Up-regulation of transporters and enzymes by the vitamin D receptor ligands, 1alpha,25-dihydroxyvitamin D3 and vitamin D analogs, in the Caco-2 cell monolayer. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 19414624	2009
Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 19429418	2009
Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver. Biopharmaceutics & drug disposition\| PubMed ID: 19562681	2009
1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo. Biopharmaceutics & drug disposition\| PubMed ID: 19753549	2009
Interplay of transporters and enzymes in drug and metabolite processing. Molecular pharmaceutics\| PubMed ID: 19891494	2009
Effects of 1alpha,25-dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo. Biopharmaceutics & drug disposition\| PubMed ID: 20013813	2010
Interplay of phase II enzymes and transporters in futile cycling: influence of multidrug resistance-associated protein 2-mediated excretion of estradiol 17beta-D-glucuronide and its 3-sulfat... Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 20124397	2010
Physiological modeling to understand the impact of enzymes and transporters on drug and metabolite data and bioavailability estimates. Pharmaceutical research\| PubMed ID: 20372987	2010
Interplay of transporters and enzymes in the Caco-2 cell monolayer: I. effect of altered apical secretion. Biopharmaceutics & drug disposition\| PubMed ID: 20437461	2010
The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 20888898	2011
Comparative effects of doxercalciferol (1α-hydroxyvitamin D₂) versus calcitriol (1α,25-dihydroxyvitamin D₃) on the expression of transporters and enzymes in the rat in vivo. Journal of pharmaceutical sciences\| PubMed ID: 20967888	2011
Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion. Journal of pharmacokinetics and pharmacodynamics\| PubMed ID: 21153869	2010
PBPK modeling of intestinal and liver enzymes and transporters in drug absorption and sequential metabolism. Current drug metabolism\| PubMed ID: 21189137	2010
1α,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac. Biopharmaceutics & drug disposition\| PubMed ID: 21341280	2011
1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of d... The Journal of pharmacology and experimental therapeutics\| PubMed ID: 21421739	2011
Fraction absorbed (Fabs ): different connotations and confusion for the literature? Biopharmaceutics & drug disposition\| PubMed ID: 21630284	2011
Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation. Journal of clinical pharmacology\| PubMed ID: 22232759	2012
Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review ... Biopharmaceutics & drug disposition\| PubMed ID: 22270945	2012
Physiologically based pharmacokinetic (PBPK) modeling: it is here to stay! Biopharmaceutics & drug disposition\| PubMed ID: 22351594	2012
Effects of 1α,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 22387228	2012
Commentary: theoretical predictions of flow effects on intestinal and systemic availability in physiologically based pharmacokinetic intestine models: the traditional model, segregated flow ... Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 22745334	2012
Why we need proper PBPK models to examine intestine and liver oral drug absorption. Current drug metabolism\| PubMed ID: 22935069	2013
1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endo... Journal of neurochemistry\| PubMed ID: 23035695	2012
Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3 treatment in mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 23482451	2013
Comparative effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(-/-) mice. Biopharmaceutics & drug disposition\| PubMed ID: 23897575	2013
Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol. Gastroenterology\| PubMed ID: 24365583	2014
1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24849345	2014
Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat. Journal of pharmaceutical sciences\| PubMed ID: 25266751	2014
Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats. Pharmaceutical research\| PubMed ID: 25319098	2015
Dealing with the complex drug-drug interactions: towards mechanistic models. Biopharmaceutics & drug disposition\| PubMed ID: 25545151	2015
PBPK modeling to unravel nonlinear pharmacokinetics of verapamil to estimate the fractional clearance for verapamil N-demethylation in the recirculating rat liver preparation. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 25650380	2015
Pharmacokinetic modeling of tranexamic acid for patients undergoing cardiac surgery with normal renal function and model simulations for patients with renal impairment. Biopharmaceutics & drug disposition\| PubMed ID: 25704361	2015
PKPD modelling to predict altered disposition of 1α,25-dihydroxyvitamin D3 in mice due to dose-dependent regulation of CYP27B1 on synthesis and CYP24A1 on degradation. British journal of pharmacology\| PubMed ID: 25829051	2015
Response to letter to the editor on "fractional clearance for verapamil N-demethylation in the isolated rat liver preparation". Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 25964425	2015
Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1α,25-Dihydroxyvitamin D3 in Mice. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 26586377	2016
Polymer-lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin-mitomycin C and enable their spatiotemporal co-delivery and local bioavailability in breast tum... Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 26772427	2016
Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in ... Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 27098743	2016
Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 27342868	2016
Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 27789682	2017
Physiologically based pharmacokinetic modeling revealed minimal codeine intestinal metabolism in first-pass removal in rats. Biopharmaceutics & drug disposition\| PubMed ID: 27925239	2017
Unequivocal evidence supporting the segregated flow intestinal model that discriminates intestine versus liver first-pass removal with PBPK modeling. Biopharmaceutics & drug disposition\| PubMed ID: 27977852	2017
Comparing early liver graft function from heart beating and living-donors: A pilot study aiming to identify new biomarkers of liver injury. Biopharmaceutics & drug disposition\| PubMed ID: 28102538	2017
Revisiting the role of gut wall in the fate of orally administered drugs: Why now and to what effect? Biopharmaceutics & drug disposition\| PubMed ID: 28317174	2017
Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist. Journal of pharmaceutical sciences\| PubMed ID: 28479350	2017