Avijit Chakrabartty

Department of Medical Biophysics, University of Toronto

Research Area

Biography

Avijit Chakrabartty has not added Biography.
If you are Avijit Chakrabartty and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 43	2017

Other Publications

Article	Year
Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis. The Journal of biological chemistry\| PubMed ID: 12356748	2002
The PrP-like protein Doppel binds copper. The Journal of biological chemistry\| PubMed ID: 12482851	2003
Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: Abeta association kinetics at endosomal pH. Journal of molecular biology\| PubMed ID: 12507477	2003
Lipopeptide detergents designed for the structural study of membrane proteins. Nature biotechnology\| PubMed ID: 12524549	2003
Co-incorporation of A beta 40 and A beta 42 to form mixed pre-fibrillar aggregates. European journal of biochemistry\| PubMed ID: 12581205	2003
Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region. Molecular and cellular biology\| PubMed ID: 12697809	2003
Conformational coupling of Mg2+ and Ca2+ on the three-state folding of calexcitin B. Biochemistry\| PubMed ID: 12731896	2003
Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis. The Journal of biological chemistry\| PubMed ID: 14734542	2004
Interactions of Alzheimer amyloid peptides with cultured cells and brain tissue, and their biological consequences. Biopolymers\| PubMed ID: 14997469	2004
Identification of stable helical bundles from a combinatorial library of amphipathic peptides. Biopolymers\| PubMed ID: 15148684	2004
Alzheimer's Abeta40 studied by NMR at low pH reveals that sodium 4,4-dimethyl-4-silapentane-1-sulfonate (DSS) binds and promotes beta-ball oligomerization. The Journal of biological chemistry\| PubMed ID: 15557279	2005
Interaction of human and mouse Abeta peptides. Journal of neurochemistry\| PubMed ID: 15584916	2004
Reversible assembly of helical filaments by de novo designed minimalist peptides. Biopolymers\| PubMed ID: 15612048	2005
Hyperactive antifreeze protein from winter flounder is a very long rod-like dimer of alpha-helices. The Journal of biological chemistry\| PubMed ID: 15716269	2005
Charge substitution shows that repulsive electrostatic interactions impede the oligomerization of Alzheimer amyloid peptides. FEBS letters\| PubMed ID: 15964569	2005
NMR-driven secondary and tertiary structure model of Ca2+-loaded calexcitin. Biochemical and biophysical research communications\| PubMed ID: 16546129	2006
Structure, folding, and misfolding of Cu,Zn superoxide dismutase in amyotrophic lateral sclerosis. Biochimica et biophysica acta\| PubMed ID: 16814528	2006
Variants of DsRed fluorescent protein: Development of a copper sensor. Protein science : a publication of the Protein Society\| PubMed ID: 17008724	2006
Requirement of aggregation propensity of Alzheimer amyloid peptides for neuronal cell surface binding. BMC neuroscience\| PubMed ID: 17475015	2007
An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS. Nature medicine\| PubMed ID: 17486090	2007
Getting specificity from simplicity in putative proteins from the prebiotic earth. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17855563	2007
Metal ion-dependent, reversible, protein filament formation by designed beta-roll polypeptides. BMC structural biology\| PubMed ID: 17908326	2007
Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants. BMC neuroscience\| PubMed ID: 18234110	2008
Denaturational stress induces formation of zinc-deficient monomers of Cu,Zn superoxide dismutase: implications for pathogenesis in amyotrophic lateral sclerosis. Journal of molecular biology\| PubMed ID: 18761352	2008
Two distinct conformations of Abeta aggregates on the surface of living PC12 cells. Biophysical journal\| PubMed ID: 19450496	2009
Probing Alzheimer amyloid peptide aggregation using a cell-free fluorescent protein refolding method. Biochemistry and cell biology = Biochimie et biologie cellulaire\| PubMed ID: 19767826	2009
Conversion of Abeta42 into a folded soluble native-like protein using a semi-random library of amphipathic helices. Journal of molecular biology\| PubMed ID: 20026077	2010
Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form. Acta neuropathologica\| PubMed ID: 20111867	2010
Putative one-pot prebiotic polypeptides with ribonucleolytic activity. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 20232309	2010
Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21041683	2010
Cell surface binding and internalization of aβ modulated by degree of aggregation. International journal of Alzheimer's disease\| PubMed ID: 21331340	2011
Multiphoton ANS fluorescence microscopy as an in vivo sensor for protein misfolding stress. Cell stress & chaperones\| PubMed ID: 21484286	2011
ALS-causing SOD1 mutations promote production of copper-deficient misfolded species. Journal of molecular biology\| PubMed ID: 21549128	2011
CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization. The Journal of biological chemistry\| PubMed ID: 21561863	2011
Aβ behavior on neuronal membranes: aggregation and toxicities. International journal of Alzheimer's disease\| PubMed ID: 21760987	2011
Relative and regional stabilities of the hamster, mouse, rabbit, and bovine prion proteins toward urea unfolding assessed by nuclear magnetic resonance and circular dichroism spectroscopies. Biochemistry\| PubMed ID: 21800884	2011
Conformation specificity and arene binding in a peptide composed only of Lys, Ile, Ala and Gly. European biophysics journal : EBJ\| PubMed ID: 22038076	2012
Analyzing complicated protein folding kinetics rapidly by analytical Laplace inversion using a Tikhonov regularization variant. Analytical biochemistry\| PubMed ID: 22119751	2012
Early steps in oxidation-induced SOD1 misfolding: implications for non-amyloid protein aggregation in familial ALS. Journal of molecular biology\| PubMed ID: 22542526	2012
Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase. Structure (London, England : 1993)\| PubMed ID: 22632832	2012
Targeting of monomer/misfolded SOD1 as a therapeutic strategy for amyotrophic lateral sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22745481	2012
An Arg-rich putative prebiotic protein is as stable as its Lys-rich variant. Archives of biochemistry and biophysics\| PubMed ID: 23022061	2012
Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis. Proteins\| PubMed ID: 23508986	2013
N-terminal helix-cap in α-helix 2 modulates β-state misfolding in rabbit and hamster prion proteins. PloS one\| PubMed ID: 23675452	2013
Structure of a simplified β-hairpin and its ATP complex. Archives of biochemistry and biophysics\| PubMed ID: 23811197	2013
Wild-type Cu/Zn superoxide dismutase stabilizes mutant variants by heterodimerization. Neurobiology of disease\| PubMed ID: 24200866	2014
"Structural characterization of the minimal segment of TDP-43 competent for aggregation". Archives of biochemistry and biophysics\| PubMed ID: 24440310	2014
Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death. Acta neuropathologica\| PubMed ID: 25788357	2015
Determining composition of micron-scale protein deposits in neurodegenerative disease by spatially targeted optical microproteomics. eLife\| PubMed ID: 26418743	2015
Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation. PLoS biology\| PubMed ID: 27096426	2016
Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses. Scientific reports\| PubMed ID: 27122057	2016
Corrigendum: Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloido... Scientific reports\| PubMed ID: 27282221	2016
Phase to Phase with TDP-43. Biochemistry\| PubMed ID: 28112502	2017
Transthyretin amyloidosis: an under-recognized neuropathy and cardiomyopathy. Clinical science (London, England : 1979)\| PubMed ID: 28213611	2017
Quercitrin and quercetin 3-β-d-glucoside as chemical chaperones for the A4V SOD1 ALS-causing mutant. Protein engineering, design & selection : PEDS\| PubMed ID: 28475686	2017