Eric B. Kmiec

Gene Editing Institute, Christiana Care Health Services

Affiliated withChristiana Care Health Services University of Delaware

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2017

Other Publications

Article	Year
Targeted gene repair and its application to neurodegenerative disorders. Neuron\| PubMed ID: 11856524	2002
Strand bias in targeted gene repair is influenced by transcriptional activity. Molecular and cellular biology\| PubMed ID: 11997519	2002
The 'biased' evolution of targeted gene repair. Current opinion in molecular therapeutics\| PubMed ID: 12044039	2002
Rad51p and Rad54p, but not Rad52p, elevate gene repair in Saccharomyces cerevisiae directed by modified single-stranded oligonucleotide vectors. Nucleic acids research\| PubMed ID: 12087156	2002
Targeted nucleotide exchange in Saccharomyces cerevisiae directed by short oligonucleotides containing locked nucleic acids. Chemistry & biology\| PubMed ID: 12401492	2002
Nucleotide replacement at two sites can be directed by modified single-stranded oligonucleotides in vitro and in vivo. Biomolecular engineering\| PubMed ID: 12485680	2003
DNA pairing is an important step in the process of targeted nucleotide exchange. Nucleic acids research\| PubMed ID: 12560486	2003
Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 12597913	2003
The synaptic complex of RecA protein participates in hybridization and inverse strand exchange reactions. Biochemistry\| PubMed ID: 12614159	2003
Targeted nucleotide repair of cyc1 mutations in Saccharomyces cerevisiae directed by modified single-stranded DNA oligonucleotides. Genetics\| PubMed ID: 12618392	2003
The development and regulation of gene repair. Nature reviews. Genetics\| PubMed ID: 12951569	2003
Targeted gene repair -- in the arena. The Journal of clinical investigation\| PubMed ID: 12952907	2003
Targeted nucleotide exchange in the CAG repeat region of the human HD gene. Biochemical and biophysical research communications\| PubMed ID: 14521962	2003
Nuclease activity of Saccharomyces cerevisiae Mre11 functions in targeted nucleotide alteration. Applied and environmental microbiology\| PubMed ID: 14532083	2003
Reduction of Htt inclusion formation in strains of Saccharomyces cerevisiae deficient in certain DNA repair functions: a statistical analysis of phenotype. Experimental cell research\| PubMed ID: 14597407	2003
Fluorescent detection and isolation of DNA variants using stabilized RecA-coated oligonucleotides. Genome research\| PubMed ID: 14672976	2004
The effect of hydroxyurea and trichostatin a on targeted nucleotide exchange in yeast and Mammalian cells. Annals of the New York Academy of Sciences\| PubMed ID: 14751821	2003
Enhancement of in vivo targeted nucleotide exchange by nonspecific carrier DNA. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 14769964	2004
Genetic re-engineering of Saccharomyces cerevisiae RAD51 leads to a significant increase in the frequency of gene repair in vivo. Nucleic acids research\| PubMed ID: 15087488	2004
DNA replication and transcription direct a DNA strand bias in the process of targeted gene repair in mammalian cells. Journal of cell science\| PubMed ID: 15265980	2004
Enhanced oligonucleotide-directed gene targeting in mammalian cells following treatment with DNA damaging agents. Experimental cell research\| PubMed ID: 15383324	2004
Modified single-stranded oligonucleotides inhibit aggregate formation and toxicity induced by expanded polyglutamine. Journal of molecular neuroscience : MN\| PubMed ID: 15456939	2004
Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination. Nucleic acids research\| PubMed ID: 15466591	2004
Double displacement loops (double d-loops) are templates for oligonucleotide-directed mutagenesis and gene repair. Oligonucleotides\| PubMed ID: 15665595	2004
Gene repair in mammalian cells is stimulated by the elongation of S phase and transient stalling of replication forks. DNA repair\| PubMed ID: 15725625	2005
Reaction parameters of targeted gene repair in mammalian cells. Molecular biotechnology\| PubMed ID: 15767697	2005
A tolerance of DNA heterology in the mammalian targeted gene repair reaction. Oligonucleotides\| PubMed ID: 16201904	2005
Targeted gene repair activates Chk1 and Chk2 and stalls replication in corrected cells. DNA repair\| PubMed ID: 16414312	2006
Multiple roles for MSH2 in the repair of a deletion mutation directed by modified single-stranded oligonucleotides. Gene\| PubMed ID: 17113727	2007
Reduction of gene repair by selenomethionine with the use of single-stranded oligonucleotides. BMC molecular biology\| PubMed ID: 17257432	2007
Manipulation of cell cycle progression can counteract the apparent loss of correction frequency following oligonucleotide-directed gene repair. BMC molecular biology\| PubMed ID: 17284323	2007
Recovery of cell cycle delay following targeted gene repair by oligonucleotides. DNA repair\| PubMed ID: 17560837	2007
Genetic conversion of an SMN2 gene to SMN1: a novel approach to the treatment of spinal muscular atrophy. Experimental cell research\| PubMed ID: 18078930	2008
G-rich oligonucleotides alter cell cycle progression and induce apoptosis specifically in OE19 esophageal tumor cells. Oligonucleotides\| PubMed ID: 18321162	2008
DNA replication, cell cycle progression and the targeted gene repair reaction. Cell cycle (Georgetown, Tex.)\| PubMed ID: 18424915	2008
DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates. Journal of neuroscience research\| PubMed ID: 18831068	2009
Regulation of targeted gene repair by intrinsic cellular processes. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 19204988	2009
DNA breakage associated with targeted gene alteration directed by DNA oligonucleotides. Mutation research\| PubMed ID: 19463835	2009
A stable G-quartet binds to a huntingtin protein fragment containing expanded polyglutamine tracks. Journal of neuroscience research\| PubMed ID: 19705452	2010
Fluorescent detection and isolation of DNA variants using stabilized RecA-coated oligonucleotides. Discovery medicine\| PubMed ID: 20705000	2004
Gene editing activity on extrachromosomal arrays in C. elegans transgenics. Gene\| PubMed ID: 21241788	2011
Strand bias influences the mechanism of gene editing directed by single-stranded DNA oligonucleotides. Nucleic acids research\| PubMed ID: 21343181	2011
Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin. Journal of molecular neuroscience : MN\| PubMed ID: 21465263	2011
Oligonucleotide delivery by nucleofection does not rescue the reduced proliferation phenotype of gene-edited cells. Nucleic acid therapeutics\| PubMed ID: 23072627	2012
Proliferation of genetically modified human cells on electrospun nanofiber scaffolds. Molecular therapy. Nucleic acids\| PubMed ID: 23212298	2012
DNA damage response pathway and replication fork stress during oligonucleotide directed gene editing. Molecular therapy. Nucleic acids\| PubMed ID: 23343929	2012
Electrospun fiber membranes enable proliferation of genetically modified cells. International journal of nanomedicine\| PubMed ID: 23467983	2013
Combinatorial gene editing in mammalian cells using ssODNs and TALENs. Scientific reports\| PubMed ID: 24445749	2014
Enrichment of breast cancer stem-like cells by growth on electrospun polycaprolactone-chitosan nanofiber scaffolds. International journal of nanomedicine\| PubMed ID: 24570583	2014
The position of DNA cleavage by TALENs and cell synchronization influences the frequency of gene editing directed by single-stranded oligonucleotides. PloS one\| PubMed ID: 24788536	2014
Is the age of genetic surgery finally upon us? Surgical oncology\| PubMed ID: 25936245	2015
Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems. PloS one\| PubMed ID: 26053390	2015
Genetic spell-checking: gene editing using single-stranded DNA oligonucleotides. Plant biotechnology journal\| PubMed ID: 26402400	2016
Analyses of point mutation repair and allelic heterogeneity generated by CRISPR/Cas9 and single-stranded DNA oligonucleotides. Scientific reports\| PubMed ID: 27609304	2016
Insertional Mutagenesis by CRISPR/Cas9 Ribonucleoprotein Gene Editing in Cells Targeted for Point Mutation Repair Directed by Short Single-Stranded DNA Oligonucleotides. PloS one\| PubMed ID: 28052104	2017
To cleave or not to cleave: therapeutic gene editing with and without programmable nucleases. Nature reviews. Drug discovery\| PubMed ID: 28303022	2017
CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome. Molecular therapy. Nucleic acids\| PubMed ID: 28624204	2017