John P. Lydon

Department of Molecular and Cellular Biology, Baylor College of Medicine

Affiliated withBaylor College of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2017

Other Publications

Article	Year
Reproductive functions of progesterone receptors. Recent progress in hormone research\| PubMed ID: 12017551	2002
Progesterone's role in mammary gland development and tumorigenesis as disclosed by experimental mouse genetics. Breast cancer research : BCR\| PubMed ID: 12223123	2002
A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 12403837	2002
Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro. Cancer letters\| PubMed ID: 12406547	2002
Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 12456789	2002
Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12897242	2003
Progesterone receptors in mammary gland development and tumorigenesis. Journal of mammary gland biology and neoplasia\| PubMed ID: 14635795	2003
Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids\| PubMed ID: 14667967	2003
Progesterone involvement in breast development and tumorigenesis--as revealed by progesterone receptor "knockout" and "knockin" mouse models. Steroids\| PubMed ID: 14667968	2003
Hormonal defect in maspin heterozygous mice reveals a role of progesterone in pubertal ductal development. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 15178746	2004
Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis. Fertility and sterility\| PubMed ID: 15374713	2004
Cre-mediated recombination in cell lineages that express the progesterone receptor. Genesis (New York, N.Y. : 2000)\| PubMed ID: 15682389	2005
Revealing progesterone's role in uterine and mammary gland biology: insights from the mouse. Seminars in reproductive medicine\| PubMed ID: 15714387	2005
Identification of murine uterine genes regulated in a ligand-dependent manner by the progesterone receptor. Endocrinology\| PubMed ID: 15845616	2005
Enhanced sexual behaviors and androgen receptor immunoreactivity in the male progesterone receptor knockout mouse. Endocrinology\| PubMed ID: 16002522	2005
Generation of a mouse for conditional excision of progesterone receptor. Genesis (New York, N.Y. : 2000)\| PubMed ID: 16868919	2006
Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse. Molecular and cellular biology\| PubMed ID: 16914740	2006
Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus. Nature genetics\| PubMed ID: 16951680	2006
Steroid receptor coactivator 2 is essential for progesterone-dependent uterine function and mammary morphogenesis: insights from the mouse--implications for the human. The Journal of steroid biochemistry and molecular biology\| PubMed ID: 17045797	2006
Targeting iCre expression to murine progesterone receptor cell-lineages using bacterial artificial chromosome transgenesis. Genesis (New York, N.Y. : 2000)\| PubMed ID: 17149722	2006
Progesterone-action in the murine uterus and mammary gland requires steroid receptor coactivator 2: relevance to the human. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 17485327	2007
Bmp2 is critical for the murine uterine decidual response. Molecular and cellular biology\| PubMed ID: 17515606	2007
The p160 steroid receptor coactivator 2, SRC-2, regulates murine endometrial function and regulates progesterone-independent and -dependent gene expression. Endocrinology\| PubMed ID: 17556502	2007
Mouse models of implantation. Trends in endocrinology and metabolism: TEM\| PubMed ID: 17588769	2007
COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity. PLoS genetics\| PubMed ID: 17590085	2007
The pattern of beta-catenin responsiveness within the mammary gland is regulated by progesterone receptor. Development (Cambridge, England)\| PubMed ID: 17881490	2007
A repressive role for prohibitin in estrogen signaling. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 17932104	2008
Targeting reverse tetracycline-dependent transactivator to murine mammary epithelial cells that express the progesterone receptor. Genesis (New York, N.Y. : 2000)\| PubMed ID: 17941046	2007
Maternal heparin-binding-EGF deficiency limits pregnancy success in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17986609	2007
Peroxisome proliferator-activated receptor gamma is a target of progesterone regulation in the preovulatory follicles and controls ovulation in mice. Molecular and cellular biology\| PubMed ID: 18172011	2008
Steroid receptor coactivator 2 is required for female fertility and mammary morphogenesis: insights from the mouse, relevance to the human. Nuclear receptor signaling\| PubMed ID: 18174919	2007
Bone growth and turnover in progesterone receptor knockout mice. Endocrinology\| PubMed ID: 18276762	2008
In vivo analysis of progesterone receptor action in the uterus during embryo implantation. Seminars in cell & developmental biology\| PubMed ID: 18280760	2008
Gap junction communication between uterine stromal cells plays a critical role in pregnancy-associated neovascularization and embryo survival. Development (Cambridge, England)\| PubMed ID: 18599509	2008
Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer research\| PubMed ID: 18632614	2008
Transcriptional response of the murine mammary gland to acute progesterone exposure. Endocrinology\| PubMed ID: 18687774	2008
The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse. Developmental biology\| PubMed ID: 19298785	2009
The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression. Endocrinology\| PubMed ID: 19325006	2009
Stromal progesterone receptors mediate induction of Indian Hedgehog (IHH) in uterine epithelium and its downstream targets in uterine stroma. Endocrinology\| PubMed ID: 19372202	2009
Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19439667	2009
Finally! A model for progesterone receptor action in normal human breast. Endocrinology\| PubMed ID: 19549883	2009
Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells. Cancer research\| PubMed ID: 19679546	2009
The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action. Journal of oncology\| PubMed ID: 19884980	2010
ERBB receptor feedback inhibitor 1 regulation of estrogen receptor activity is critical for uterine implantation in mice. Biology of reproduction\| PubMed ID: 20018910	2010
A mouse model to dissect progesterone signaling in the female reproductive tract and mammary gland. Genesis (New York, N.Y. : 2000)\| PubMed ID: 20029965	2010
Ablation of Indian hedgehog in the murine uterus results in decreased cell cycle progression, aberrant epidermal growth factor signaling, and increased estrogen signaling. Biology of reproduction\| PubMed ID: 20056671	2010
Epithelial-stromal interaction and progesterone receptors in the mouse uterus. Seminars in reproductive medicine\| PubMed ID: 20104426	2010
Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse. Biology of reproduction\| PubMed ID: 20130264	2010
Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 20219888	2010
Foxa2 is essential for mouse endometrial gland development and fertility. Biology of reproduction\| PubMed ID: 20484741	2010
Stem cells: Cues from steroid hormones. Nature\| PubMed ID: 20535190	2010
Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20605949	2010
WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development. Biology of reproduction\| PubMed ID: 20962251	2011
Minireview: steroid receptor coactivator-3: a multifarious coregulator in mammary gland metastasis. Endocrinology\| PubMed ID: 21047941	2011
A mouse transgenic approach to induce β-catenin signaling in a temporally controlled manner. Transgenic research\| PubMed ID: 21120693	2011
WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21163860	2011
Estrogen-regulated prohibitin is required for mouse uterine development and adult function. Endocrinology\| PubMed ID: 21209023	2011
The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2. Science (New York, N.Y.)\| PubMed ID: 21330545	2011
Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice. Molecular and cellular endocrinology\| PubMed ID: 21664244	2011
Connective tissue growth factor is required for normal follicle development and ovulation. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 21868453	2011
From the ranks of mammary progesterone mediators, RANKL takes the spotlight. Molecular and cellular endocrinology\| PubMed ID: 21964466	2012
Epithelial progesterone receptor exhibits pleiotropic roles in uterine development and function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22155565	2012
CDH1 is essential for endometrial differentiation, gland development, and adult function in the mouse uterus. Biology of reproduction\| PubMed ID: 22378759	2012
NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy. Biology of reproduction\| PubMed ID: 22378764	2012
GATA2 is expressed at critical times in the mouse uterus during pregnancy. Gene expression patterns : GEP\| PubMed ID: 22476030	2012
Uterine development and fertility are dependent on gene dosage of the nuclear receptor coregulator REA. Endocrinology\| PubMed ID: 22585830	2012
Progesterone receptors: a key for neuroprotection in experimental stroke. Endocrinology\| PubMed ID: 22635678	2012
Research resource: Genome-wide profiling of progesterone receptor binding in the mouse uterus. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 22638070	2012
A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nature medicine\| PubMed ID: 22660634	2012
Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability. European journal of immunology\| PubMed ID: 22740122	2012
Dysregulation of uterine signaling pathways in progesterone receptor-Cre knockout of dicer. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 22798293	2012
Nuclear receptor coactivator-6 attenuates uterine estrogen sensitivity to permit embryo implantation. Developmental cell\| PubMed ID: 23079602	2012
Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression. The Journal of pathology\| PubMed ID: 23288720	2013
Functional role of progestin and the progesterone receptor in the suppression of spermatogenesis in rodents. Andrology\| PubMed ID: 23408752	2013
Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development (Cambridge, England)\| PubMed ID: 23462470	2013
Signal transducer and activator of transcription-3 (Stat3) plays a critical role in implantation via progesterone receptor in uterus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23531596	2013
BMPR2 is required for postimplantation uterine function and pregnancy maintenance. The Journal of clinical investigation\| PubMed ID: 23676498	2013
Loss of CDH1 and Pten accelerates cellular invasiveness and angiogenesis in the mouse uterus. Biology of reproduction\| PubMed ID: 23740945	2013
β-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition. The Journal of pathology\| PubMed ID: 23784889	2013
Critical tumor suppressor function mediated by epithelial Mig-6 in endometrial cancer. Cancer research\| PubMed ID: 23811943	2013
Liver receptor homolog-1 is essential for pregnancy. Nature medicine\| PubMed ID: 23817023	2013
Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 23820898	2013
VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO molecular medicine\| PubMed ID: 23853117	2013
Progesterone signaling inhibits cervical carcinogenesis in mice. The American journal of pathology\| PubMed ID: 24012679	2013
Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 24014651	2013
Integrated chromatin immunoprecipitation sequencing and microarray analysis identifies FOXA2 target genes in the glands of the mouse uterus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 24025729	2014
Paracrine-rescued lobulogenesis in chimeric outgrowths comprising progesterone-receptor-null mammary epithelium and redirected wild-type testicular cells. Journal of cell science\| PubMed ID: 24190884	2014
Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization. PLoS genetics\| PubMed ID: 24204309	2013
Fibroblast growth factor receptor two (FGFR2) regulates uterine epithelial integrity and fertility in mice. Biology of reproduction\| PubMed ID: 24227756	2014
Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. PLoS genetics\| PubMed ID: 24244176	2013
Application of 13C isotope labeling using liquid chromatography mass spectrometry (LC-MS) to determining phosphate-containing metabolic incorporation. Journal of mass spectrometry : JMS\| PubMed ID: 24338880	2013
A mouse model for endometrioid ovarian cancer arising from the distal oviduct. International journal of cancer\| PubMed ID: 24474556	2014
A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells. Biology of reproduction\| PubMed ID: 24571987	2014
Activated AKT pathway promotes establishment of endometriosis. Endocrinology\| PubMed ID: 24605828	2014
Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function. PloS one\| PubMed ID: 24905738	2014
The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS genetics\| PubMed ID: 24945252	2014
Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell research\| PubMed ID: 24971735	2014
Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance. Neoplasia (New York, N.Y.)\| PubMed ID: 25016594	2014
The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction. Biology of reproduction\| PubMed ID: 25297546	2014
A role for site-specific phosphorylation of mouse progesterone receptor at serine 191 in vivo. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 25333515	2014
Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation. Cancer research\| PubMed ID: 25377472	2014
Constitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and function. Biology of reproduction\| PubMed ID: 25505200	2015
Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation. The Journal of clinical investigation\| PubMed ID: 25774501	2015
Maximal Dexamethasone Inhibition of Luminal Epithelial Proliferation Involves Progesterone Receptor (PR)- and Non-PR-Mediated Mechanisms in Neonatal Mouse Uterus. Biology of reproduction\| PubMed ID: 25882702	2015
Aberrant Activation of the RANK Signaling Receptor Induces Murine Salivary Gland Tumors. PloS one\| PubMed ID: 26061636	2015
Steroid receptor coactivators as therapeutic targets in the female reproductive system. The Journal of steroid biochemistry and molecular biology\| PubMed ID: 26151740	2015
Reprint of "Steroid receptor coactivators as therapeutic targets in the female reproductive system". The Journal of steroid biochemistry and molecular biology\| PubMed ID: 26291832	2015
ARID1A Is Essential for Endometrial Function during Early Pregnancy. PLoS genetics\| PubMed ID: 26378916	2015
Correction: Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization. PLoS genetics\| PubMed ID: 26418340	2015
Application of (13) C isotope labeling using liquid chromatography mass spectrometry (LC-MS) to determining phosphate-containing metabolic incorporation. Journal of mass spectrometry : JMS\| PubMed ID: 26456788	2015
GATA4 and GATA6 Knockdown During Luteinization Inhibits Progesterone Production and Gonadotropin Responsiveness in the Corpus Luteum of Female Mice. Biology of reproduction\| PubMed ID: 26510866	2015
Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell\| PubMed ID: 26544941	2015
Correction: Perturbing the Cellular Levels of Steroid Receptor Coactivator-2 Impairs Murine Endometrial Function. PloS one\| PubMed ID: 26580555	2015
Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26598666	2015
Uterine ALK3 is essential during the window of implantation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26721398	2016
Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice. Scientific reports\| PubMed ID: 26833131	2016
Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development. Oncotarget\| PubMed ID: 26910913	2016
Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus. Oncotarget\| PubMed ID: 27007157	2016
Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 27018534	2016
The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization. PLoS genetics\| PubMed ID: 27035670	2016
The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker. The Prostate\| PubMed ID: 27272765	2016
Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts. Endocrinology\| PubMed ID: 27309940	2016
The essential role of GATA transcription factors in adult murine prostate. Oncotarget\| PubMed ID: 27374105	2016
Loss of Fertility in the Absence of Progesterone Receptor Expression in Kisspeptin Neurons of Female Mice. PloS one\| PubMed ID: 27441639	2016
A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function. Cell reports\| PubMed ID: 27783953	2016
Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence. Endocrinology\| PubMed ID: 28005395	2017
Three-Dimensional High-Frequency Ultrasonography for Early Detection and Characterization of Embryo Implantation Site Development in the Mouse. PloS one\| PubMed ID: 28046063	2017
Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment. Biology of reproduction\| PubMed ID: 28203817	2017
A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin. PloS one\| PubMed ID: 28253313	2017
CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy. PLoS genetics\| PubMed ID: 28278176	2017
Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28424251	2017
A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland. Stem cell reports\| PubMed ID: 28447939	2015
Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice. Endocrinology\| PubMed ID: 28498971	2017
Conditional abrogation of transforming growth factor-β receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice. The Journal of pathology\| PubMed ID: 28657664	2017
PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice. Cell death and differentiation\| PubMed ID: 28731465	2017
Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization. Molecular human reproduction\| PubMed ID: 28911214	2017