K. Peter R. Nilsson

IFM-Department of Chemistry, linköping university

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 27	2017

Other Publications

Article	Year
Chip and solution detection of DNA hybridization using a luminescent zwitterionic polythiophene derivative. Nature materials\| PubMed ID: 12754497	2003
Self-assembly of synthetic peptides control conformation and optical properties of a zwitterionic polythiophene derivative. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12928490	2003
Twisting macromolecular chains: self-assembly of a chiral supermolecule from nonchiral polythiophene polyanions and random-coil synthetic peptides. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15280547	2004
Synthesis of a regioregular zwitterionic conjugated oligoelectrolyte, usable as an optical probe for detection of amyloid fibril formation at acidic pH. Journal of the American Chemical Society\| PubMed ID: 15713111	2005
Conjugated polyelectrolytes: conformation-sensitive optical probes for detection of amyloid fibril formation. Biochemistry\| PubMed ID: 15751948	2005
Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter. Biopolymers\| PubMed ID: 15931669	2005
Surface energy modified chips for detection of conformational states and enzymatic activity in biomolecules. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 16489808	2006
Conjugated polyelectrolytes--conformation-sensitive optical probes for staining and characterization of amyloid deposits. Chembiochem : a European journal of chemical biology\| PubMed ID: 16729336	2006
Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes. ACS chemical biology\| PubMed ID: 17672509	2007
Studies of luminescent conjugated polythiophene derivatives: enhanced spectral discrimination of protein conformational states. Bioconjugate chemistry\| PubMed ID: 17939727	2007
Prion strain discrimination using luminescent conjugated polymers. Nature methods\| PubMed ID: 18026110	2007
A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice. Neurobiology of aging\| PubMed ID: 18192084	2009
De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19073920	2009
Small organic probes as amyloid specific ligands--past and recent molecular scaffolds. FEBS letters\| PubMed ID: 19376114	2009
Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science (New York, N.Y.)\| PubMed ID: 19541956	2009
Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS chemical biology\| PubMed ID: 19624097	2009
Fluorescent oligo and poly-thiophenes and their utilization for recording biological events of diverse origin-when organic chemistry meets biology. Journal of chemical biology\| PubMed ID: 19649670	2009
Amyloid fibrils of human prion protein are spun and woven from morphologically disordered aggregates. Prion\| PubMed ID: 19923901	2009
Structural typing of systemic amyloidoses by luminescent-conjugated polymer spectroscopy. The American journal of pathology\| PubMed ID: 20035056	2010
Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses. Nature protocols\| PubMed ID: 20431539	2010
Conjugated polymers for enhanced bioimaging. Biochimica et biophysica acta\| PubMed ID: 20471455	2011
A molecular switch controls interspecies prion disease transmission in mice. The Journal of clinical investigation\| PubMed ID: 20551516	2010
Two amyloid States of the prion protein display significantly different folding patterns. Journal of molecular biology\| PubMed ID: 20553730	2010
A fluorescent pentameric thiophene derivative detects in vitro-formed prefibrillar protein aggregates. Biochemistry\| PubMed ID: 20604540	2010
Spatially controlled amyloid reactions using organic electronics. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 20814927	2010
Prion strain interactions are highly selective. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20826672	2010
Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease. The American journal of pathology\| PubMed ID: 21514441	2011
Tracking protein aggregate interactions. Prion\| PubMed ID: 21597336	2011
Drosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation. PloS one\| PubMed ID: 21695120	2011
Cross β-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusions. Gastroenterology\| PubMed ID: 21699779	2011
Spongiform encephalopathy in transgenic mice expressing a point mutation in the Î²2-Î±2 loop of the prion protein. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21957246	2011
Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates. Organic & biomolecular chemistry\| PubMed ID: 22051883	2011
Cell interaction study of amyloid by using luminescent conjugated polythiophene: implication that amyloid cytotoxicity is correlated with prolonged cellular binding. Chembiochem : a European journal of chemical biology\| PubMed ID: 22262644	2012
Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila. PloS one\| PubMed ID: 22348084	2012
Nanoscopic and photonic ultrastructural characterization of two distinct insulin amyloid states. International journal of molecular sciences\| PubMed ID: 22408402	2012
Identification of distinct physiochemical properties of toxic prefibrillar species formed by Aβ peptide variants. Biochemical and biophysical research communications\| PubMed ID: 22475489	2012
Structure of the β2-α2 loop and interspecies prion transmission. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22490928	2012
Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates. The Journal of biological chemistry\| PubMed ID: 22493452	2012
A pentameric luminescent-conjugated oligothiophene for optical imaging of in vitro-formed amyloid fibrils and protein aggregates in tissue sections. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22528107	2012
Derivatization of a bioorthogonal protected trisaccharide linker-toward multimodal tools for chemical biology. Bioconjugate chemistry\| PubMed ID: 22568531	2012
Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway. The Journal of biological chemistry\| PubMed ID: 22669942	2012
Luminescent conjugated poly- and oligo-thiophenes: optical ligands for spectral assignment of a plethora of protein aggregates. Biochemical Society transactions\| PubMed ID: 22817720	2012
Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imag... Acta neuropathologica\| PubMed ID: 22996963	2013
Spectral discrimination of cerebral amyloid lesions after peripheral application of luminescent conjugated oligothiophenes. The American journal of pathology\| PubMed ID: 23041059	2012
Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies. Chembiochem : a European journal of chemical biology\| PubMed ID: 23450708	2013
Enhanced fluorescent assignment of protein aggregates by an oligothiophene-porphyrin-based amyloid ligand. Macromolecular rapid communications\| PubMed ID: 23468206	2013
Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits. ACS chemical biology\| PubMed ID: 23521783	2013
Superresolution imaging of amyloid fibrils with binding-activated probes. ACS chemical neuroscience\| PubMed ID: 23594172	2013
Defining the conformational features of anchorless, poorly neuroinvasive prions. PLoS pathogens\| PubMed ID: 23637596	2013
The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein ag... Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 23780508	2013
Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice. EMBO reports\| PubMed ID: 23999102	2013
Cell type related differences in staining with pentameric thiophene derivatives. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 24500794	2014
Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nature communications\| PubMed ID: 24691351	2014
An azide functionalized oligothiophene ligand--a versatile tool for multimodal detection of disease associated protein aggregates. Biosensors & bioelectronics\| PubMed ID: 25089818	2015
Pentameric thiophene-based ligands that spectrally discriminate amyloid-β and tau aggregates display distinct solvatochromism and viscosity-induced spectral shifts. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 25111601	2014
Aβ seeds resist inactivation by formaldehyde. Acta neuropathologica\| PubMed ID: 25193240	2014
Toward a molecular understanding of the detection of amyloid proteins with flexible conjugated oligothiophenes. The journal of physical chemistry. A\| PubMed ID: 25247879	2014
Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands. Prion\| PubMed ID: 25495506	2014
Differential vital staining of normal fibroblasts and melanoma cells by an anionic conjugated polyelectrolyte. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 25605326	2015
Sensitive and rapid assessment of amyloid by oligothiophene fluorescence in subcutaneous fat tissue. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 25847117	2015
Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice. Neurobiology of aging\| PubMed ID: 25911278	2015
Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 26013403	2015
The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice. Frontiers in neuroscience\| PubMed ID: 26074756	2015
Structure-based drug design identifies polythiophenes as antiprion compounds. Science translational medicine\| PubMed ID: 26246168	2015
Pathological, biochemical, and biophysical characteristics of the transthyretin variant Y114H (p.Y134H) explain its very mild clinical phenotype. Journal of the peripheral nervous system : JPNS\| PubMed ID: 26306725	2015
A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 26388448	2015
An imidazole functionalized pentameric thiophene displays different staining patterns in normal and malignant cells. Frontiers in chemistry\| PubMed ID: 26501054	2015
Protein aggregation as an antibiotic design strategy. Molecular microbiology\| PubMed ID: 26559925	2016
Establishing the fluorescent amyloid ligand h-FTAA for studying human tissues with systemic and localized amyloid. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 26987044	2016
Labeling nanoparticles: Dye leakage and altered cellular uptake. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 27077940	2017
(11)C and (18)F Radiolabeling of Tetra- and Pentathiophenes as PET-Ligands for Amyloid Protein Aggregates. ACS medicinal chemistry letters\| PubMed ID: 27096043	2016
Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 27147660	2016
Nondestructive, real-time determination and visualization of cellulose, hemicellulose and lignin by luminescent oligothiophenes. Scientific reports\| PubMed ID: 27759105	2016
Anionic Oligothiophenes Compete for Binding of X-34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain-Derived Aβ. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 27767229	2016
De novo design of a biologically active amyloid. Science (New York, N.Y.)\| PubMed ID: 27846578	2016
Nanoscale Structure and Spectroscopic Probing of Aβ1-40 Fibril Bundle Formation. Frontiers in chemistry\| PubMed ID: 27921029	2016
In vivo polymerization and manufacturing of wires and supercapacitors in plants. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28242683	2017
Post-translational modifications in PrP expand the conformational diversity of prions in vivo. Scientific reports\| PubMed ID: 28272426	2017
Specific Imaging of Intracellular Lipid Droplets Using a Benzothiadiazole Derivative with Solvatochromic Properties. Bioconjugate chemistry\| PubMed ID: 28402621	2017
Establishing and validating the fluorescent amyloid ligand h-FTAA (heptamer formyl thiophene acetic acid) to identify transthyretin amyloid deposits in carpal tunnel syndrome. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 28434259	2017
Seed-dependent templating of murine AA amyloidosis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 28434369	2017
Non-fused Phospholes as Fluorescent Probes for Imaging of Lipid Droplets in Living Cells. Frontiers in chemistry\| PubMed ID: 28487854	2017
Real-time optotracing of curli and cellulose in live Salmonella biofilms using luminescent oligothiophenes. NPJ biofilms and microbiomes\| PubMed ID: 28721253	2016
Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets. Endocrine connections\| PubMed ID: 28790139	2017