Jian-Xing Ma

Department of Physiology, University of Oklahoma Health Sciences Center

Affiliated withUniversity of Oklahoma Health Sciences Center

Research Area

Biography

Jian-Xing Ma has not added Biography.
If you are Jian-Xing Ma and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 21	2018

Other Publications

Article	Year
The effect of angiostatin on vascular leakage and VEGF expression in rat retina. FEBS letters\| PubMed ID: 15094037	2004
Suppression of corneal neovascularization by PEDF release from human amniotic membranes. Investigative ophthalmology & visual science\| PubMed ID: 15161837	2004
Decreased expression of pigment epithelium-derived factor is involved in the pathogenesis of diabetic nephropathy. Diabetes\| PubMed ID: 15616035	2005
Targeted expression of Cre recombinase to cone photoreceptors in transgenic mice. Molecular vision\| PubMed ID: 15635292	2004
Systemic and periocular deliveries of plasminogen kringle 5 reduce vascular leakage in rat models of oxygen-induced retinopathy and diabetes. Current eye research\| PubMed ID: 16109649	2005
RPE65 is the isomerohydrolase in the retinoid visual cycle. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16116091	2005
Identification of conserved histidines and glutamic acid as key residues for isomerohydrolase activity of RPE65, an enzyme of the visual cycle in the retinal pigment epithelium. FEBS letters\| PubMed ID: 16198348	2005
RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle. The Journal of biological chemistry\| PubMed ID: 16319067	2006
Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16368716	2006
Therapeutic potential of angiostatin in diabetic nephropathy. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16394111	2006
Deletion of smooth muscle alpha-actin alters blood-retina barrier permeability and retinal function. Investigative ophthalmology & visual science\| PubMed ID: 16723488	2006
Two point mutations of RPE65 from patients with retinal dystrophies decrease the stability of RPE65 protein and abolish its isomerohydrolase activity. The Journal of biological chemistry\| PubMed ID: 16754667	2006
Impacts of two point mutations of RPE65 from Leber's congenital amaurosis on the stability, subcellular localization and isomerohydrolase activity of RPE65. FEBS letters\| PubMed ID: 16828753	2006
Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy. Journal of molecular endocrinology\| PubMed ID: 16901919	2006
Ocular neovascularization: Implication of endogenous angiogenic inhibitors and potential therapy. Progress in retinal and eye research\| PubMed ID: 17074526	2007
The roles of three palmitoylation sites of RPE65 in its membrane association and isomerohydrolase activity. Investigative ophthalmology & visual science\| PubMed ID: 17122102	2006
Light induces programmed cell death by activating multiple independent proteases in a cone photoreceptor cell line. Investigative ophthalmology & visual science\| PubMed ID: 17197514	2007
Conditional gene knockout system in cone photoreceptors. Advances in experimental medicine and biology\| PubMed ID: 17249572	2006
Rat strain-dependent susceptibility to ischemia-induced retinopathy associated with retinal vascular endothelial growth factor regulation. Journal of molecular endocrinology\| PubMed ID: 17446232	2007
RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. Genes & development\| PubMed ID: 17473173	2007
Very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularization. The Journal of biological chemistry\| PubMed ID: 17890782	2007
Retinoid processing in cone and Müller cell lines. Experimental eye research\| PubMed ID: 18163989	2008
RPE65 from cone-dominant chicken is a more efficient isomerohydrolase compared with that from rod-dominant species. The Journal of biological chemistry\| PubMed ID: 18216020	2008
Down-regulation of angiogenic inhibitors: a potential pathogenic mechanism for diabetic complications. Current diabetes reviews\| PubMed ID: 18220594	2005
Anti-inflammatory effects of pigment epithelium-derived factor in diabetic nephropathy. American journal of physiology. Renal physiology\| PubMed ID: 18322021	2008
Salamander blue-sensitive cones lost during metamorphosis. Photochemistry and photobiology\| PubMed ID: 18331398	2008
Intraretinal leakage and oxidation of LDL in diabetic retinopathy. Investigative ophthalmology & visual science\| PubMed ID: 18362112	2008
Pigment epithelium-derived factor mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized low-density lipoprotein. Journal of molecular endocrinology\| PubMed ID: 18586837	2008
Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients. Diabetes research and clinical practice\| PubMed ID: 18715664	2008
Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65. The Journal of biological chemistry\| PubMed ID: 19049981	2009
SERPINA3K prevents oxidative stress induced necrotic cell death by inhibiting calcium overload. PloS one\| PubMed ID: 19115003	2008
Systemic administration of HMG-CoA reductase inhibitor protects the blood-retinal barrier and ameliorates retinal inflammation in type 2 diabetes. Experimental eye research\| PubMed ID: 19254713	2009
Photoreceptor degeneration and retinal inflammation induced by very low-density lipoprotein receptor deficiency. Microvascular research\| PubMed ID: 19281829	2009
Anti-inflammatory and antioxidant effects of SERPINA3K in the retina. Investigative ophthalmology & visual science\| PubMed ID: 19324842	2009
The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. Investigative ophthalmology & visual science\| PubMed ID: 19458327	2009
Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane. The FEBS journal\| PubMed ID: 19490105	2009
Nanoparticle-mediated expression of an angiogenic inhibitor ameliorates ischemia-induced retinal neovascularization and diabetes-induced retinal vascular leakage. Diabetes\| PubMed ID: 19491211	2009
Evidence for two retinoid cycles in the cone-dominated chicken eye. Biochemistry\| PubMed ID: 19492794	2009
Müller cell-derived VEGF is a significant contributor to retinal neovascularization. The Journal of pathology\| PubMed ID: 19768732	2009
Pigment epithelium-derived factor suppresses adipogenesis via inhibition of the MAPK/ERK pathway in 3T3-L1 preadipocytes. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 19808909	2009
The pathogenic role of the canonical Wnt pathway in age-related macular degeneration. Investigative ophthalmology & visual science\| PubMed ID: 19875668	2010
Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models. The American journal of pathology\| PubMed ID: 19893025	2009
Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65. Biochemical and biophysical research communications\| PubMed ID: 20043869	2010
Inhibition of connective tissue growth factor overexpression in diabetic retinopathy by SERPINA3K via blocking the WNT/beta-catenin pathway. Diabetes\| PubMed ID: 20299474	2010
Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20351274	2010
PEDF as a treatment for cervical cancer. Cancer biology & therapy\| PubMed ID: 20424516	2010
Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20876139	2010
The potential of nanomedicine therapies to treat neovascular disease in the retina. Journal of angiogenesis research\| PubMed ID: 20932321	2010
Wnt pathway antagonists and angiogenesis. Protein & cell\| PubMed ID: 21204016	2010
An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain. The FEBS journal\| PubMed ID: 21235714	2011
Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization. The American journal of pathology\| PubMed ID: 21281801	2011
Anti-angiogenic and anti-inflammatory effects of SERPINA3K on corneal injury. PloS one\| PubMed ID: 21304961	2011
Anti-inflammatory and antiangiogenic effects of nanoparticle-mediated delivery of a natural angiogenic inhibitor. Investigative ophthalmology & visual science\| PubMed ID: 21357401	2011
Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity. The Biochemical journal\| PubMed ID: 21446919	2011
Comparison of ocular pathologies in vitamin A-deficient mice and RPE65 gene knockout mice. Investigative ophthalmology & visual science\| PubMed ID: 21551411	2011
Identification of a novel inhibitor of the canonical Wnt pathway. Molecular and cellular biology\| PubMed ID: 21576363	2011
An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species. The FEBS journal\| PubMed ID: 21676174	2011
A PEDF-derived peptide inhibits retinal neovascularization and blocks mobilization of bone marrow-derived endothelial progenitor cells. Experimental diabetes research\| PubMed ID: 21754923	2012
RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis. Developmental biology\| PubMed ID: 21782811	2011
Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity. The Journal of biological chemistry\| PubMed ID: 21785167	2011
RPE65 is present in human green/red cones and promotes photopigment regeneration in an in vitro cone cell model. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22171060	2011
Identification of the key residues determining the product specificity of isomerohydrolase. Biochemistry\| PubMed ID: 22512451	2012
Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium. The Journal of biological chemistry\| PubMed ID: 22645143	2012
Therapeutic potential of a monoclonal antibody blocking the Wnt pathway in diabetic retinopathy. Diabetes\| PubMed ID: 22891217	2012
Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization. Investigative ophthalmology & visual science\| PubMed ID: 22915031	2012
Therapeutic effects of PPARα agonists on diabetic retinopathy in type 1 diabetes models. Diabetes\| PubMed ID: 23043158	2013
Nitrosative stress plays an important role in Wnt pathway activation in diabetic retinopathy. Antioxidants & redox signaling\| PubMed ID: 23066786	2013
Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism. Molecular and cellular biology\| PubMed ID: 23071093	2012
A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis. Investigative ophthalmology & visual science\| PubMed ID: 23211825	2013
Dual inhibition of plasminogen kringle 5 on angiogenesis and chemotaxis suppresses tumor metastasis by targeting HIF-1α pathway. PloS one\| PubMed ID: 23300882	2012
Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy. Biochemical and biophysical research communications\| PubMed ID: 23353086	2013
MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model. Investigative ophthalmology & visual science\| PubMed ID: 23404117	2013
Increased importin 13 activity is associated with the pathogenesis of pterygium. Molecular vision\| PubMed ID: 23559854	2013
Antiangiogenic and antineuroinflammatory effects of kallistatin through interactions with the canonical Wnt pathway. Diabetes\| PubMed ID: 23884893	2013
Pathogenic role of diabetes-induced PPAR-α down-regulation in microvascular dysfunction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24003152	2013
Regulation of endothelial progenitor cell release by Wnt signaling in bone marrow. Investigative ophthalmology & visual science\| PubMed ID: 24130179	2013
Coexpression of three opsins in cone photoreceptors of the salamander Ambystoma tigrinum. The Journal of comparative neurology\| PubMed ID: 24374736	2014
Inhibition of pathological corneal neovascularization by a small peptide derived from human apolipoprotein (a) Kringle V. Cornea\| PubMed ID: 24452210	2014
Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. The Journal of investigative dermatology\| PubMed ID: 24463424	2014
Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients. Journal of diabetes and its complications\| PubMed ID: 24560422	2014
Immune complex formation in human diabetic retina enhances toxicity of oxidized LDL towards retinal capillary pericytes. Journal of lipid research\| PubMed ID: 24616481	2014
Protective and antioxidant effects of PPARα in the ischemic retina. Investigative ophthalmology & visual science\| PubMed ID: 24825105	2014
PPARα regulates mobilization and homing of endothelial progenitor cells through the HIF-1α/SDF-1 pathway. Investigative ophthalmology & visual science\| PubMed ID: 24845641	2014
Serine Proteinase Inhibitor SERPINA3K Suppresses Corneal Neovascularization via Inhibiting Wnt Signaling and VEGF. Investigative ophthalmology & visual science\| PubMed ID: 25028361	2014
Peroxisome proliferator-activated receptor α protects capillary pericytes in the retina. The American journal of pathology\| PubMed ID: 25108226	2014
Identification of key residues determining isomerohydrolase activity of human RPE65. The Journal of biological chemistry\| PubMed ID: 25112876	2014
Nanoparticle-assisted targeted delivery of eye-specific genes to eyes significantly improves the vision of blind mice in vivo. Nano letters\| PubMed ID: 25115433	2014
Receptor heterodimerization as a novel mechanism for the regulation of Wnt/β-catenin signaling. Journal of cell science\| PubMed ID: 25271056	2014
Interruption of Wnt signaling in Müller cells ameliorates ischemia-induced retinal neovascularization. PloS one\| PubMed ID: 25271989	2014
SERPINA3K plays antioxidant roles in cultured pterygial epithelial cells through regulating ROS system. PloS one\| PubMed ID: 25296038	2014
High levels of pigment epithelium-derived factor in diabetes impair wound healing through suppression of Wnt signaling. Diabetes\| PubMed ID: 25368097	2015
Posttranslational modification of Sirt6 activity by peroxynitrite. Free radical biology & medicine\| PubMed ID: 25476852	2015
Nanoparticle-mediated expression of a Wnt pathway inhibitor ameliorates ocular neovascularization. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25657312	2015
Angiogenesis in diabetes and obesity. Reviews in endocrine & metabolic disorders\| PubMed ID: 25663658	2015
Therapeutic Effects of PPAR α on Neuronal Death and Microvascular Impairment. PPAR research\| PubMed ID: 25705219	2015
Identification of active retinaldehyde dehydrogenase isoforms in the postnatal human eye. PloS one\| PubMed ID: 25793304	2015
MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization. FEBS letters\| PubMed ID: 25796186	2015
Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nature communications\| PubMed ID: 25871009	2015
PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases. Clinical science (London, England : 1979)\| PubMed ID: 25881671	2015
The oxidant role of 4-hydroxynonenal in corneal epithelium. Scientific reports\| PubMed ID: 26023743	2015
Wnt signaling in age-related macular degeneration: human macular tissue and mouse model. Journal of translational medicine\| PubMed ID: 26476672	2015
Down-Regulation of MicroRNA-184 Is Associated With Corneal Neovascularization. Investigative ophthalmology & visual science\| PubMed ID: 27018842	2016
The regulatory role of hepatoma-derived growth factor as an angiogenic factor in the eye. Molecular vision\| PubMed ID: 27122967	2016
sFlt Multivalent Conjugates Inhibit Angiogenesis and Improve Half-Life In Vivo. PloS one\| PubMed ID: 27257918	2016
Extravascular modified lipoproteins: a role in the propagation of diabetic retinopathy in a mouse model of type 1 diabetes. Diabetologia\| PubMed ID: 27306616	2016
Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 27473938	2016
Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling. Molecular and cellular biology\| PubMed ID: 27528615	2016
Interaction of PPARα With the Canonic Wnt Pathway in the Regulation of Renal Fibrosis. Diabetes\| PubMed ID: 27543085	2016
Postnatal Chick Choroids Exhibit Increased Retinaldehyde Dehydrogenase Activity During Recovery From Form Deprivation Induced Myopia. Investigative ophthalmology & visual science\| PubMed ID: 27654415	2016
Complete metabolome and lipidome analysis reveals novel biomarkers in the human diabetic corneal stroma. Experimental eye research\| PubMed ID: 27742548	2016
ROS-mediated Different Homeostasis of Murine Corneal Epithelial Progenitor Cell Line under Oxidative Stress. Scientific reports\| PubMed ID: 27805062	2016
Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway. Kidney international\| PubMed ID: 27914705	2017
Establishment of a 3D In Vitro Model to Accelerate the Development of Human Therapies against Corneal Diabetes. PloS one\| PubMed ID: 28005998	2016
A Dominant Mutation in Rpe65, D477G, Delays Dark Adaptation and Disturbs the Visual Cycle in the Mutant Knock-In Mice. The American journal of pathology\| PubMed ID: 28041994	2017
Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARα. Diabetes\| PubMed ID: 28270521	2017
Transgenic expression of a canonical Wnt inhibitor, kallistatin, is associated with decreased circulating CD19+ B lymphocytes in the peripheral blood. International journal of hematology\| PubMed ID: 28299632	2017
Inhibition of Stat3 by a Small Molecule Inhibitor Slows Vision Loss in a Rat Model of Diabetic Retinopathy. Investigative ophthalmology & visual science\| PubMed ID: 28395025	2017
Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration. Scientific reports\| PubMed ID: 28455497	2017
Canonical Wnt signaling in diabetic retinopathy. Vision research\| PubMed ID: 28545982	2017
SERPINA3K Ameliorates the Corneal Oxidative Injury Induced by 4-Hydroxynonenal. Investigative ophthalmology & visual science\| PubMed ID: 28586911	2017
Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy. The American journal of pathology\| PubMed ID: 28734946	2017
Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration. Investigative ophthalmology & visual science\| PubMed ID: 28813718	2017
Unravelling the stromal-nerve interactions in the human diabetic cornea. Experimental eye research\| PubMed ID: 28827027	2017
Therapeutic Effects of a Novel Agonist of Peroxisome Proliferator-Activated Receptor Alpha for the Treatment of Diabetic Retinopathy. Investigative ophthalmology & visual science\| PubMed ID: 28979999	2017
Therapeutic Effects of PPARα Agonist on Ocular Neovascularization in Models Recapitulating Neovascular Age-Related Macular Degeneration. Investigative ophthalmology & visual science\| PubMed ID: 28980001	2017
PPARα is essential for retinal lipid metabolism and neuronal survival. BMC biology\| PubMed ID: 29183319	2017