Pramod Upadhyaya

Masonic Cancer Center, University of Minnesota

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2017

Other Publications

Article	Year
Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in bile duct-cannulated rats: stereoselective metabolism and tiss... Carcinogenesis\| PubMed ID: 11756238	2002
Analysis of N- and O-glucuronides of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine. Chemical research in toxicology\| PubMed ID: 11952341	2002
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Carcinogenesis\| PubMed ID: 12189184	2002
Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination. Carcinogenesis\| PubMed ID: 12189187	2002
Metabolism and pharmacokinetics of N'-nitrosonornicotine in the patas monkey. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 12228188	2002
Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung. Cancer letters\| PubMed ID: 12359355	2002
Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA. Chemical research in toxicology\| PubMed ID: 12588189	2003
Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats. Carcinogenesis\| PubMed ID: 12663513	2003
Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific c... Chemical research in toxicology\| PubMed ID: 12755591	2003
Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chemical research in toxicology\| PubMed ID: 12807363	2003
Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 14709623	2004
Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Biochemistry\| PubMed ID: 14717610	2004
Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine... Carcinogenesis\| PubMed ID: 14988218	2004
Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol w... Chemical research in toxicology\| PubMed ID: 15144215	2004
Identification of adducts formed in the reaction of 5'-acetoxy-N'-nitrosonornicotine with deoxyguanosine and DNA. Chemical research in toxicology\| PubMed ID: 16544948	2006
Quantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-L-cysteine in human urine: comparison with glutathione-S-transferase genotypes in smokers. Chemical research in toxicology\| PubMed ID: 16978029	2006
Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. Chemical research in toxicology\| PubMed ID: 17291014	2007
Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein l... Cancer research\| PubMed ID: 17616712	2007
Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice. Carcinogenesis\| PubMed ID: 18192687	2008
Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyr... Chemical research in toxicology\| PubMed ID: 18205321	2008
Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosa... Chemical research in toxicology\| PubMed ID: 18570389	2008
Extensive metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 18628430	2008
Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-... Carcinogenesis\| PubMed ID: 18780894	2008
Identification of adducts formed in the reactions of 5'-acetoxy-N'-nitrosonornicotine with deoxyadenosine, thymidine, and DNA. Chemical research in toxicology\| PubMed ID: 18821782	2008
Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-inositol inhibit tobacco carcinogen-induced lung adenocarcinoma in mice. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 19138972	2008
Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 19138990	2008
Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 19139007	2008
Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitr... Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 19324941	2009
Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers o... Chemical research in toxicology\| PubMed ID: 19358518	2009
Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice. Carcinogenesis\| PubMed ID: 19625346	2010
Formation and distribution of NNK metabolites in an isolated perfused rat lung. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 20159989	2010
Preferential glutathione conjugation of a reverse diol epoxide compared with a bay region diol epoxide of benzo[a]pyrene in human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 20547966	2010
Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combi... Carcinogenesis\| PubMed ID: 20603442	2010
Immediate consequences of cigarette smoking: rapid formation of polycyclic aromatic hydrocarbon diol epoxides. Chemical research in toxicology\| PubMed ID: 21184614	2011
Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice. Carcinogenesis\| PubMed ID: 21273642	2011
Evolution of research on the DNA adduct chemistry of N-nitrosopyrrolidine and related aldehydes. Chemical research in toxicology\| PubMed ID: 21480629	2011
Metabolism of [D10]phenanthrene to tetraols in smokers for potential lung cancer susceptibility assessment: comparison of oral and inhalation routes of administration. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 21515812	2011
Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice. The American journal of Chinese medicine\| PubMed ID: 21721153	2011
Indole-3-carbinol inhibited tobacco smoke carcinogen-induced lung adenocarcinoma in A/J mice when administered during the post-initiation or progression phase of lung tumorigenesis. Cancer letters\| PubMed ID: 21767909	2011
Phenanthrene metabolism in smokers: use of a two-step diagnostic plot approach to identify subjects with extensive metabolic activation. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 22674470	2012
The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. Biochemical and biophysical research communications\| PubMed ID: 22727907	2012
Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice. Chemical research in toxicology\| PubMed ID: 22928598	2012
Levels of (S)-N'-nitrosonornicotine in U.S. tobacco products. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco\| PubMed ID: 23212437	2013
Chemoprevention of lung tumorigenesis by intranasally administered diindolylmethane in A/J mice. Carcinogenesis\| PubMed ID: 23239747	2013
DNA adducts in aldehyde dehydrogenase-positive lung stem cells of A/J mice treated with the tobacco specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chemical research in toxicology\| PubMed ID: 23477619	2013
(S)-N'-Nitrosonornicotine, a constituent of smokeless tobacco, is a powerful oral cavity carcinogen in rats. Carcinogenesis\| PubMed ID: 23671129	2013
Contamination of deconjugation enzymes derived from Helix pomatia with the plant bioactive compounds 3,3'-diindolylmethane, 5-methoxypsoralen, and 8-methoxypsoralen. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 23994708	2013
Quantitation of pyridyloxobutyl-DNA adducts in tissues of rats treated chronically with (R)- or (S)-N'-nitrosonornicotine (NNN) in a carcinogenicity study. Chemical research in toxicology\| PubMed ID: 24001146	2013
Urinary 3,3'-diindolylmethane: a biomarker of glucobrassicin exposure and indole-3-carbinol uptake in humans. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 24357105	2014
Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 24403291	2014
Application of a high-resolution mass-spectrometry-based DNA adductomics approach for identification of DNA adducts in complex mixtures. Analytical chemistry\| PubMed ID: 24410521	2014
Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice. Carcinogenesis\| PubMed ID: 25053626	2014
Liquid chromatography-electrospray ionization-tandem mass spectrometry quantitation of urinary [pyridine-D4]4-hydroxy-4-(3-pyridyl)butanoic acid, a biomarker of 4-(methylnitrosamino)-1-(3-py... Chemical research in toxicology\| PubMed ID: 25098652	2014
Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats. Carcinogenesis\| PubMed ID: 25269804	2014
Intranasal delivery of liposomal indole-3-carbinol improves its pulmonary bioavailability. International journal of pharmaceutics\| PubMed ID: 25311179	2014
Quantitative analysis of 3'-hydroxynorcotinine in human urine. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco\| PubMed ID: 25324430	2015
RNA-sequencing studies identify genes differentially regulated during inflammation-driven lung tumorigenesis and targeted by chemopreventive agents. Inflammation research : official journal of the European Histamine Research Society ... [et al.]\| PubMed ID: 25795230	2015
Combinations of indole-3-carbinol and silibinin suppress inflammation-driven mouse lung tumorigenesis by modulating critical cell cycle regulators. Carcinogenesis\| PubMed ID: 25896445	2015
Comprehensive High-Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chemical research in toxicology\| PubMed ID: 26398225	2015
Analysis of O(6)-[4-(3-Pyridyl)-4-oxobut-1-yl]-2'-deoxyguanosine and Other DNA Adducts in Rats Treated with Enantiomeric or Racemic N'-Nitrosonornicotine. Chemical research in toxicology\| PubMed ID: 26633576	2016
Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 26744252	2016
Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis. Molecular carcinogenesis\| PubMed ID: 26785143	2016
DNA Adduct Formation from Metabolic 5'-Hydroxylation of the Tobacco-Specific Carcinogen N'-Nitrosonornicotine in Human Enzyme Systems and in Rats. Chemical research in toxicology\| PubMed ID: 26808005	2016
Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg. Molecular nutrition & food research\| PubMed ID: 26840393	2016
Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 26951845	2016
Multiclass Carcinogenic DNA Adduct Quantification in Formalin-Fixed Paraffin-Embedded Tissues by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry. Analytical chemistry\| PubMed ID: 27043225	2016
Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors. Oncotarget\| PubMed ID: 27458163	2016
Harnessing the Power of Cruciferous Vegetables: Developing a Biomarker for Brassica Vegetable Consumption Using Urinary 3,3'-Diindolylmethane. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 27538743	2016
Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O(6)-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (A... Chemical research in toxicology\| PubMed ID: 27728767	2016
Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines. Chemical research in toxicology\| PubMed ID: 27989137	2016
Identification of 4-(3-Pyridyl)-4-oxobutyl-2'-deoxycytidine Adducts Formed in the Reaction of DNA with 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone: A Chemically Activated Form of T... ACS omega\| PubMed ID: 28393135	2017
Investigation of the presence in human urine of mercapturic acids derived from phenanthrene, a representative polycyclic aromatic hydrocarbon. Chemico-biological interactions\| PubMed ID: 28693886	2017
Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O(6)-Methylguanine and Lung Tumor in A/J Mice. Journal of medicinal chemistry\| PubMed ID: 28806079	2017