Augustine M.K. Choi

Department of Medicine, Harvard Medical School

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 67	2011

Other Publications

Article	Year
Carbon monoxide-dependent signaling. Critical care medicine\| PubMed ID: 11782556	2002
The saga of leucine zippers continues: in response to oxidative stress. American journal of respiratory cell and molecular biology\| PubMed ID: 11804863	2002
Carbon monoxide-dependent signaling. Critical care medicine\| PubMed ID: 11839940	2001
Emerging role of carbon monoxide in physiologic and pathophysiologic states. Antioxidants & redox signaling\| PubMed ID: 12006173	2002
Differential modulation by exogenous carbon monoxide of TNF-alpha stimulated mitogen-activated protein kinases in rat pulmonary artery endothelial cells. Antioxidants & redox signaling\| PubMed ID: 12006175	2002
Heme oxygenase-1: the "emerging molecule" has arrived. American journal of respiratory cell and molecular biology\| PubMed ID: 12091240	2002
Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance. Molecular and cellular biochemistry\| PubMed ID: 12162441	2002
Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12225959	2002
Mitogen activated protein kinase (MAPK) pathway regulates heme oxygenase-1 gene expression by hypoxia in vascular cells. Antioxidants & redox signaling\| PubMed ID: 12230870	2002
Heme oxygenase-1: molecular mechanisms of gene expression in oxygen-related stress. Antioxidants & redox signaling\| PubMed ID: 12230874	2002
TGF-beta1 stimulates HO-1 via the p38 mitogen-activated protein kinase in A549 pulmonary epithelial cells. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12376363	2002
规例的 IL 1beta-GM-CSF 生产中人气道平滑肌细胞诱导一氧化碳。 American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12388337	2003
Carbon monoxide inhibits human airway smooth muscle cell proliferation via mitogen-activated protein kinase pathway. American journal of respiratory cell and molecular biology\| PubMed ID: 12397020	2002
Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. The Journal of biological chemistry\| PubMed ID: 12399465	2003
Carbon monoxide modulates endotoxin-induced production of granulocyte macrophage colony-stimulating factor in macrophages. American journal of respiratory cell and molecular biology\| PubMed ID: 12444034	2002
Transcriptional regulation of the HO-1 gene in cultured macrophages exposed to model airborne particulate matter. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12456389	2003
Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nature medicine\| PubMed ID: 12539038	2003
Inhaled carbon monoxide suppresses the development of postoperative ileus in the murine small intestine. Gastroenterology\| PubMed ID: 12557144	2003
Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium. American journal of respiratory cell and molecular biology\| PubMed ID: 12594056	2003
Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12651633	2003
Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway. The Journal of biological chemistry\| PubMed ID: 12754217	2003
Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects. The American journal of pathology\| PubMed ID: 12819027	2003
Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. The Journal of biological chemistry\| PubMed ID: 12857751	2003
Low-dose carbon monoxide reduces airway hyperresponsiveness in mice. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12896878	2003
Pathways of cell signaling in hyperoxia. Free radical biology & medicine\| PubMed ID: 12899937	2003
Protective effect of carbon monoxide inhalation for cold-preserved small intestinal grafts. Surgery\| PubMed ID: 12947331	2003
Heme oxygenase-1 and carbon monoxide in pulmonary medicine. Respiratory research\| PubMed ID: 12964953	2003
Carbon monoxide inhalation protects rat intestinal grafts from ischemia/reperfusion injury. The American journal of pathology\| PubMed ID: 14507665	2003
Hepatocyte growth factor protects against hypoxia/reoxygenation-induced apoptosis in endothelial cells. The Journal of biological chemistry\| PubMed ID: 14625309	2004
Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1. The Journal of experimental medicine\| PubMed ID: 14657222	2003
Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14707100	2004
一氧化碳对内毒素休克的保护涉及到对 iNOS 在肺和肝的相... FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15001560	2004
Carbon monoxide: to boldly go where NO has gone before. Science's STKE : signal transduction knowledge environment\| PubMed ID: 15114002	2004
Inhaled carbon monoxide confers antiinflammatory effects against ventilator-induced lung injury. American journal of respiratory and critical care medicine\| PubMed ID: 15142867	2004
Caveolae compartmentalization of heme oxygenase-1 in endothelial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15226268	2004
Carbon monoxide promotes Fas/CD95-induced apoptosis in Jurkat cells. The Journal of biological chemistry\| PubMed ID: 15280387	2004
Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15469929	2004
Bcl-XL disrupts death-inducing signal complex formation in plasma membrane induced by hypoxia/reoxygenation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15576486	2004
Enhanced nitric oxide production associated with airway hyporesponsiveness in the absence of IL-10. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 15618456	2005
Carbon monoxide suppresses bleomycin-induced lung fibrosis. The American journal of pathology\| PubMed ID: 15631997	2005
Heme oxygenase-1: redox regulation of a stress protein in lung and cell culture models. Antioxidants & redox signaling\| PubMed ID: 15650398	2005
FLIP protects against hypoxia/reoxygenation-induced endothelial cell apoptosis by inhibiting Bax activation. Molecular and cellular biology\| PubMed ID: 15899875	2005
Heme oxygenase-1: from bench to bedside. American journal of respiratory and critical care medicine\| PubMed ID: 15901614	2005
"Therapeutic" carbon monoxide may be a reality soon. American journal of respiratory and critical care medicine\| PubMed ID: 15914570	2005
Brief inhalation of low-dose carbon monoxide protects rodents and swine from postoperative ileus. Critical care medicine\| PubMed ID: 15942350	2005
Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells. American journal of respiratory cell and molecular biology\| PubMed ID: 15961723	2005
Alterations in nitric oxide and cytokine production with airway inflammation in the absence of IL-10. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16002724	2005
Carbon monoxide inhibits IL-17-induced IL-6 production through the MAPK pathway in human pulmonary epithelial cells. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 16003000	2005
Caveolin-1 expression by means of p38beta mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16051704	2005
Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16081837	2005
Low-dose carbon monoxide inhalation prevents development of chronic allograft nephropathy. American journal of physiology. Renal physiology\| PubMed ID: 16131650	2006
Cytoprotection of heme oxygenase-1/carbon monoxide in lung injury. Proceedings of the American Thoracic Society\| PubMed ID: 16222043	2005
Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway. American journal of respiratory cell and molecular biology\| PubMed ID: 16357362	2006
CO as a cellular signaling molecule. Annual review of pharmacology and toxicology\| PubMed ID: 16402911	2006
Heart allograft protection with low-dose carbon monoxide inhalation: effects on inflammatory mediators and alloreactive T-cell responses. Transplantation\| PubMed ID: 16436966	2006
CCAAT/enhancer-binding protein mediates carbon monoxide-induced suppression of cyclooxygenase-2. American journal of respiratory cell and molecular biology\| PubMed ID: 16543610	2006
Gene expression profiling of target genes in ventilator-induced lung injury. Physiological genomics\| PubMed ID: 16569776	2006
Therapeutic applications of carbon monoxide in lung disease. Current opinion in pharmacology\| PubMed ID: 16580257	2006
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiological reviews\| PubMed ID: 16601269	2006
A Peptide with anti-transglutaminase activity decreases lipopolysaccharide-induced lung inflammation in mice. Experimental lung research\| PubMed ID: 16809220	2006
Low-dose carbon monoxide inhalation prevents ischemia/reperfusion injury of transplanted rat lung grafts. Surgery\| PubMed ID: 16904967	2006
Comprehensive analysis of gene expression on GOLD-2 Versus GOLD-0 smokers reveals novel genes important in the pathogenesis of COPD. Proceedings of the American Thoracic Society\| PubMed ID: 16921106	2006
Insulin-like growth factor binding protein 5 induces skin fibrosis: A novel murine model for dermal fibrosis. Arthritis and rheumatism\| PubMed ID: 16947625	2006
Carbon monoxide and bilirubin: potential therapies for pulmonary/vascular injury and disease. American journal of respiratory cell and molecular biology\| PubMed ID: 16980550	2007
Heat-shock proteins: new keys to the development of cytoprotective therapies. Expert opinion on therapeutic targets\| PubMed ID: 16981832	2006
Protective effect of carbon monoxide in transplantation. Journal of cellular and molecular medicine\| PubMed ID: 16989726	2006
Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. The Journal of experimental medicine\| PubMed ID: 17000866	2006
Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration. The American journal of pathology\| PubMed ID: 17071587	2006
Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death. American journal of respiratory cell and molecular biology\| PubMed ID: 17079780	2007
Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts. American journal of respiratory cell and molecular biology\| PubMed ID: 17099140	2007
Mechanisms of cell death in oxidative stress. Antioxidants & redox signaling\| PubMed ID: 17115887	2007
Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation. The Journal of biological chemistry\| PubMed ID: 17135272	2007
Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. The Journal of experimental medicine\| PubMed ID: 17178917	2006
Hemodynamic and molecular response to intermittent hypoxia (IH) versus continuous hypoxia (CH) in normal humans. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 17240318	2007
Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models. Novartis Foundation symposium\| PubMed ID: 17380794	2007
FLIP inhibits endothelial cell apoptosis during hyperoxia by suppressing Bax. Free radical biology & medicine\| PubMed ID: 17448907	2007
MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 17494953	2007
Cellular and humoral autoreactivity in idiopathic pulmonary fibrosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17675522	2007
Carbon monoxide in sepsis. Antioxidants & redox signaling\| PubMed ID: 17822362	2007
Protective functions of heme oxygenase-1 and carbon monoxide in the respiratory system. Antioxidants & redox signaling\| PubMed ID: 17845132	2007
Inverse association of plasma IL-13 and inflammatory chemokines with lung function impairment in stable COPD: a cross-sectional cohort study. Respiratory research\| PubMed ID: 17868461	2007
A new road to induce heme oxygenase-1 expression by carbon monoxide. Circulation research\| PubMed ID: 17967796	2007
Nitric oxide-deficiency regulates hepatic heme oxygenase-1. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society\| PubMed ID: 17999922	2008
Functional significance of apoptosis in chronic obstructive pulmonary disease. COPD\| PubMed ID: 18027162	2007
Gene expression profiling in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine\| PubMed ID: 18250352	2008
Inhaled CO in the treatment of acute lung injury. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 18263669	2008
Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. PloS one\| PubMed ID: 18270588	2008
Caveolin-1: a critical regulator of pulmonary vascular architecture and nitric oxide bioavailability in pulmonary hypertension. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 18296499	2008
Caveolin-1 stops profibrogenic signaling? American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 18296500	2008
Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1. American journal of respiratory cell and molecular biology\| PubMed ID: 18323531	2008
Protein kinase C alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18354190	2008
Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1. American journal of respiratory and critical care medicine\| PubMed ID: 18356564	2008
Non-invasive measurements of exhaled NO and CO associated with methacholine responses in mice. Respiratory research\| PubMed ID: 18505586	2008
Carbon monoxide ameliorates renal cold ischemia-reperfusion injury with an upregulation of vascular endothelial growth factor by activation of hypoxia-inducible factor. Transplantation\| PubMed ID: 18580478	2008
Ex vivo carbon monoxide prevents cytochrome P450 degradation and ischemia/reperfusion injury of kidney grafts. Kidney international\| PubMed ID: 18633343	2008
Inducing hypoxemia in healthy humans: a method for intermittently lowering arterial blood oxygenation during physiological studies. Wilderness & environmental medicine\| PubMed ID: 18715123	2008
Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1. Autophagy\| PubMed ID: 18769149	2008
CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema. The American journal of pathology\| PubMed ID: 18772344	2008
Caveolin-1 regulates the secretion and cytoprotection of Cyr61 in hyperoxic cell death. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 18801924	2009
Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs. Physiological genomics\| PubMed ID: 18826996	2008
Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PloS one\| PubMed ID: 18830406	2008
Identifying targets for COPD treatment through gene expression analyses. International journal of chronic obstructive pulmonary disease\| PubMed ID: 18990963	2008
Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 19010292	2008
Autophagy in chronic obstructive pulmonary disease: homeostatic or pathogenic mechanism? Autophagy\| PubMed ID: 19066468	2009
Carbon monoxide modulates alpha-smooth muscle actin and small proline rich-1a expression in fibrosis. American journal of respiratory cell and molecular biology\| PubMed ID: 19097987	2009
Discovery of the gene signature for acute lung injury in patients with sepsis. Physiological genomics\| PubMed ID: 19174476	2009
Analyzing autophagy in clinical tissues of lung and vascular diseases. Methods in enzymology\| PubMed ID: 19216908	2009
The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19265160	2009
Carbon monoxide prevents ventilator-induced lung injury via caveolin-1. Critical care medicine\| PubMed ID: 19325477	2009
Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease. Free radical biology & medicine\| PubMed ID: 19362144	2009
Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 19411310	2009
Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy. American journal of respiratory cell and molecular biology\| PubMed ID: 19617398	2009
The fibrotic phenotype induced by IGFBP-5 is regulated by MAPK activation and egr-1-dependent and -independent mechanisms. The American journal of pathology\| PubMed ID: 19628764	2009
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. The Journal of biological chemistry\| PubMed ID: 19648648	2009
The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease. PloS one\| PubMed ID: 19718453	2009
NHLBI workshop: respiratory medicine-related research training for adult and pediatric fellows. Lung\| PubMed ID: 19763688	2009
Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. American journal of human genetics\| PubMed ID: 19800047	2009
Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation. Circulation\| PubMed ID: 20026772	2010
Autophagy in the lung. Proceedings of the American Thoracic Society\| PubMed ID: 20160144	2010
Autophagy in vascular disease. Proceedings of the American Thoracic Society\| PubMed ID: 20160147	2010
Inhaled hydrogen sulfide protects against ventilator-induced lung injury. Anesthesiology\| PubMed ID: 20574227	2010
Heme oxygenase-1/carbon monoxide: novel therapeutic strategies in critical care medicine. Current drug targets\| PubMed ID: 20704552	2010
Global gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Discovery medicine\| PubMed ID: 20704930	2005
Evaluation of inhaled carbon monoxide as an anti-inflammatory therapy in a nonhuman primate model of lung inflammation. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 20729385	2010
Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension. American journal of respiratory and critical care medicine\| PubMed ID: 20889906	2011
Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20956295	2010
Caveolin-1: a critical regulator of lung injury. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 21097526	2011
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nature immunology\| PubMed ID: 21151103	2011
Deadly triplex: smoke, autophagy and apoptosis. Autophagy\| PubMed ID: 21200154	2011
Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis. Free radical biology & medicine\| PubMed ID: 21382479	2011
Bronchoprovocation testing in asthma: effect on exhaled monoxides. Journal of breath research\| PubMed ID: 21383491	2010
Carbon monoxide activates autophagy via mitochondrial reactive oxygen species formation. American journal of respiratory cell and molecular biology\| PubMed ID: 21441382	2011
Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy\| PubMed ID: 21460622	2011
Dampening insulin signaling by an NLRP3 'meta-flammasome'. Nature immunology\| PubMed ID: 21502990	2011
Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis. Autophagy\| PubMed ID: 21685724	2011
Autophagy: a core cellular process with emerging links to pulmonary disease. American journal of respiratory and critical care medicine\| PubMed ID: 21836133	2011
Nucleotide-binding oligomerization domain protein 2 deficiency enhances neointimal formation in response to vascular injury. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21903945	2011
Autophagy: cellular defense to excessive inflammation. Microbes and infection / Institut Pasteur\| PubMed ID: 21924374	2012
Autophagy in pulmonary diseases. Annual review of physiology\| PubMed ID: 22035347	2012
Hyperoxia Induced LC3B Interacts with the Fas Apoptotic Pathway in Epithelial Cell Death. American journal of respiratory cell and molecular biology\| PubMed ID: 22095627	2011
Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Human molecular genetics\| PubMed ID: 22140090	2011
Genetically Manipulated Mouse Models of Lung Disease: Potential and Pitfalls. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 22198907	2011
Statins and Pulmonary Fibrosis: The Potential Role of NLRP3 Inflammasome Activation. American journal of respiratory and critical care medicine\| PubMed ID: 22246178	2012
Allele Specific Transactivation of Matrix Metalloproteinase 7 by FOXA2 and Correlation with Plasma Levels in Idiopathic Pulmonary Fibrosis. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 22268124	2012
Autophagic proteins: New facets of the oxygen paradox. Autophagy\| PubMed ID: 22302001	2012