Chunzhang Yang

Neuro-Oncology Branch, National Cancer Institute

Affiliated withNational Cancer Institute

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 127	2017

Other Publications

Article	Year
Cystic fibrosis transmembrane conductance regulator expression in human spinal and sympathetic ganglia. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 19333236	2009
Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21098288	2010
Carbon dioxide influence on nitric oxide production in endothelial cells and astrocytes: cellular mechanisms. Brain research\| PubMed ID: 21362408	2011
Missense mutations in the NF2 gene result in the quantitative loss of merlin protein and minimally affect protein intrinsic function. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21383154	2011
Proteomic identification of glutamine synthetase as a differential marker for oligodendrogliomas and astrocytomas. Journal of neurosurgery\| PubMed ID: 21682567	2011
Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22160715	2011
β-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22505738	2012
Neuronatin in a subset of glioblastoma multiforme tumor progenitor cells is associated with increased cell proliferation and shorter patient survival. PloS one\| PubMed ID: 22624064	2012
An innovative approach to the treatment of Gaucher disease and possibly other metabolic disorders of the brain. Journal of inherited metabolic disease\| PubMed ID: 22814681	2013
Missense mutations in the human SDHB gene increase protein degradation without altering intrinsic enzymatic function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22835832	2012
Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia. The New England journal of medicine\| PubMed ID: 22931260	2012
CNTF receptor subunit α as a marker for glioma tumor-initiating cells and tumor grade: laboratory investigation. Journal of neurosurgery\| PubMed ID: 23061382	2012
A novel EPAS1/HIF2A germline mutation in a congenital polycythemia with paraganglioma. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 23090011	2013
Histone deacetylase inhibitors increase glucocerebrosidase activity in Gaucher disease by modulation of molecular chaperones. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23277556	2013
Proteostasis modulators prolong missense VHL protein activity and halt tumor progression. Cell reports\| PubMed ID: 23318261	2013
Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas. Blood\| PubMed ID: 23361906	2013
Regulation and dysregulation of astrocyte activation and implications in tumor formation. Cellular and molecular life sciences : CMLS\| PubMed ID: 23420481	2013
New syndrome of paraganglioma and somatostatinoma associated with polycythemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 23509317	2013
Novel homozygous VHL mutation in exon 2 is associated with congenital polycythemia but not with cancer. Blood\| PubMed ID: 23538339	2013
First report of bilateral pheochromocytoma in the clinical spectrum of HIF2A-related polycythemia-paraganglioma syndrome. The Journal of clinical endocrinology and metabolism\| PubMed ID: 23539726	2013
Characterization of the blood-brain barrier of metastatic and primary malignant neoplasms. Journal of neurosurgery\| PubMed ID: 23621605	2013
Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23754423	2013
Novel compound VHL heterozygosity (VHL T124A/L188V) associated with congenital polycythaemia. British journal of haematology\| PubMed ID: 23772956	2013
Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction. Journal of the National Cancer Institute\| PubMed ID: 23940289	2013
Overexpression of arginine transporter CAT-1 is associated with accumulation of L-arginine and cell growth in human colorectal cancer tissue. PloS one\| PubMed ID: 24040099	2013
Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24351928	2014
Tumor derived vasculogenesis in von Hippel-Lindau disease-associated tumors. Scientific reports\| PubMed ID: 24531117	2014
De novo VHL germline mutation detected in a patient with mild clinical phenotype of von Hippel-Lindau disease. Journal of neurosurgery\| PubMed ID: 24678776	2014
Maotai ameliorates diethylnitrosamine-initiated hepatocellular carcinoma formation in mice. PloS one\| PubMed ID: 24690765	2014
Von hippel-lindau disease associated pulmonary carcinoid with cranial metastasis. The Journal of clinical endocrinology and metabolism\| PubMed ID: 24878057	2014
Ocular Manifestations of Hypoxia-Inducible Factor-2α Paraganglioma-Somatostatinoma-Polycythemia Syndrome. Ophthalmology\| PubMed ID: 25109928	2014
Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 25263965	2015
A morphologic and semi-quantitative technique to analyze synthesis and release of specific proteins in cells. BMC cell biology\| PubMed ID: 25476158	2014
Fab fragment glycosylated IgG may play a central role in placental immune evasion. Human reproduction (Oxford, England)\| PubMed ID: 25505012	2015
Cell transcriptional state alters genomic patterns of DNA double-strand break repair in human astrocytes. Nature communications\| PubMed ID: 25517576	2014
Mutant glucocerebrosidase in Gaucher disease recruits Hsp27 to the Hsp90 chaperone complex for proteasomal degradation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25583479	2015
New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma. International journal of medical sciences\| PubMed ID: 25678837	2015
LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential. Cancer biology & therapy\| PubMed ID: 25897893	2015
Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma. Molecular cancer therapeutics\| PubMed ID: 25939762	2015
Inhibition of protein phosphatase 2A with the small molecule LB100 overcomes cell cycle arrest in osteosarcoma after cisplatin treatment. Cell cycle (Georgetown, Tex.)\| PubMed ID: 25942376	2015
Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy. Oncotarget\| PubMed ID: 25957416	2015
Potential therapeutic target for malignant paragangliomas: ATP synthase on the surface of paraganglioma cells. American journal of cancer research\| PubMed ID: 26101719	2015
Hypoxia and glioblastoma therapy. Aging\| PubMed ID: 26298282	2015
Somatic IDH1 mutation in a pituitary adenoma of a patient with Maffucci syndrome. Journal of neurosurgery\| PubMed ID: 26473790	2016
Somatic gain-of-function HIF2A mutations in sporadic central nervous system hemangioblastomas. Journal of neuro-oncology\| PubMed ID: 26514359	2016
Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling. Oncotarget\| PubMed ID: 26934654	2016
Somatic mosaicism of EPAS1 mutations in the syndrome of paraganglioma and somatostatinoma associated with polycythemia. Human genome variation\| PubMed ID: 27081557	2015
Application of Peptide Nucleic Acid-based Assays Toward Detection of Somatic Mosaicism. Molecular therapy. Nucleic acids\| PubMed ID: 27115839	2016
HIF2A gain-of-function mutations detected in duodenal gangliocytic paraganglioma. Endocrine-related cancer\| PubMed ID: 27130043	2016
ZEB1 expression is increased in IDH1-mutant lower-grade gliomas. Journal of neuro-oncology\| PubMed ID: 27568035	2016
Novel insights into the polycythemia-paraganglioma-somatostatinoma syndrome. Endocrine-related cancer\| PubMed ID: 27679736	2016
Chemosensitivity of IDH1 mutant gliomas due to an impairment in PARP1-mediated DNA repair. Cancer research\| PubMed ID: 28202508	2017
The p38 signaling pathway mediates quiescence of glioma stem cells by regulating epidermal growth factor receptor trafficking. Oncotarget\| PubMed ID: 28410196	2017
Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway. Oncotarget\| PubMed ID: 28423608	2017
Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha. Oncotarget\| PubMed ID: 28915577	2017