Daniel Metzger

Department of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire

Affiliated withInstitut de Génétique et de Biologie Moléculaire et Cellulaire université de strasbourg

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 7	2017
Publication title Cited by 1	2023

Other Publications

Article	Year
Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells. The Journal of cell biology\| PubMed ID: 9348290	1997
Spatio-temporally controlled site-specific somatic mutagenesis in the mouse. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9405652	1997
Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha. Molecular and cellular biology\| PubMed ID: 10409727	1999
Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11134524	2001
Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11287642	2001
Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse. Development (Cambridge, England)\| PubMed ID: 11973266	2002
Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled. The EMBO journal\| PubMed ID: 12093741	2002
Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis. Biology of reproduction\| PubMed ID: 12533419	2003
TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice. Molecular and cellular biology\| PubMed ID: 12773572	2003
Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes. Methods in enzymology\| PubMed ID: 14631857	2003
Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium. The American journal of pathology\| PubMed ID: 14742273	2004
Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14985441	2004
Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15070754	2004
Targeted somatic mutagenesis in the mouse epidermis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 15502196	2005
Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse. Genesis (New York, N.Y. : 2000)\| PubMed ID: 15789425	2005
Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis ... Development (Cambridge, England)\| PubMed ID: 16192310	2005
Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16199515	2005
Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes. Genes & development\| PubMed ID: 16751185	2006
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16880407	2006
Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes. The Journal of investigative dermatology\| PubMed ID: 17301838	2007
Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17556545	2007
The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis. Development (Cambridge, England)\| PubMed ID: 17626060	2007
LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17670946	2007
Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1. Molecular and cellular biology\| PubMed ID: 17908794	2007
Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nature genetics\| PubMed ID: 18026104	2007
Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18268330	2008
Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18272483	2008
Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation. The Journal of investigative dermatology\| PubMed ID: 19092943	2009
Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19188585	2009
Myocytic androgen receptor controls the strength but not the mass of limb muscles. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20660752	2010
The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles. Cell metabolism\| PubMed ID: 21035760	2010
Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell\| PubMed ID: 21496643	2011
Hypoxia-inducible transcription factor 2Î± promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis. Hepatology (Baltimore, Md.)\| PubMed ID: 21538443	2011
Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection. The Journal of biological chemistry\| PubMed ID: 22027820	2011
Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium. Genesis (New York, N.Y. : 2000)\| PubMed ID: 22730183	2012
Genetically engineered mouse models of prostate cancer. Molecular oncology\| PubMed ID: 23481269	2013
Smoothened is a master regulator of adult liver repair. The Journal of clinical investigation\| PubMed ID: 23563311	2013
Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons. Neuroscience letters\| PubMed ID: 24291696	2014
Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells. Nature communications\| PubMed ID: 24448552	2014
Acute effect of androgens on maximal force-generating capacity and electrically evoked calcium transient in mouse skeletal muscles. Steroids\| PubMed ID: 24844204	2014
Mammary stem cells have myoepithelial cell properties. Nature cell biology\| PubMed ID: 25173976	2014
Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation. Blood\| PubMed ID: 25258343	2014
Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type. Developmental cell\| PubMed ID: 25465495	2014
Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nature medicine\| PubMed ID: 25581517	2015
The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice. Molecular and cellular biology\| PubMed ID: 25605333	2015
A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects. Cell reports\| PubMed ID: 25620699	2015
Generation of Spatio-Temporally Controlled Targeted Somatic Mutations in the Mouse. Current protocols in mouse biology\| PubMed ID: 26068987	2011
VDR and gemini ligands. Oncotarget\| PubMed ID: 26356569	2015
Patrolling monocytes control tumor metastasis to the lung. Science (New York, N.Y.)\| PubMed ID: 26494174	2015
The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defence in skeletal muscles. Nature communications\| PubMed ID: 26674215	2015
SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation. Cancer research\| PubMed ID: 26701805	2016
Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucrose diet-induced insulin resistance. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 27507552	2016
Regeneration of fat cells from myofibroblasts during wound healing. Science (New York, N.Y.)\| PubMed ID: 28059714	2017
Nur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice. PloS one\| PubMed ID: 28170423	2017
Gonad-related factors promote muscle performance gain during postnatal development in male and female mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 28351832	2017
The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28411187	2017
Androgen signaling negatively controls group 2 innate lymphoid cells. The Journal of experimental medicine\| PubMed ID: 28484078	2017
IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis. Acta neuropathologica\| PubMed ID: 28623559	2017
BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease. Nature communications\| PubMed ID: 28737171	2017
Peroxisome proliferator-activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut. EMBO molecular medicine\| PubMed ID: 28947679	2017
LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. The Journal of biological chemistry\| PubMed ID: 18990694	2009
Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics & chromatin\| PubMed ID: 21118511	2010
Chromatin remodelling complex dosage modulates transcription factor function in heart development. Nature communications\| PubMed ID: 21304516	2011
Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 21940754	2011
Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production. Experimental physiology\| PubMed ID: 22903980	2013
Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Molecular and cellular biology\| PubMed ID: 23028044	2012
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice. The Journal of clinical investigation\| PubMed ID: 23093780	2012
Retinoid signaling in progenitors controls specification and regeneration of the urothelium. Developmental cell\| PubMed ID: 23993789	2013
Skeletal myofiber VEGF is essential for the exercise training response in adult mice. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 24523345	2014
LSD1 promotes oxidative metabolism of white adipose tissue. Nature communications\| PubMed ID: 24912735	2014
Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine. PLoS genetics\| PubMed ID: 25010414	2014
Myofiber androgen receptor promotes maximal mechanical overload-induced muscle hypertrophy and fiber type transition in male mice. Endocrinology\| PubMed ID: 25216388	2014
Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling. The Journal of clinical investigation\| PubMed ID: 25574839	2015
Moderate Exercise Allows for shorter Recovery Time in Critical Limb Ischemia. Frontiers in physiology\| PubMed ID: 28790926	2017
The histone code reader Spin1 controls skeletal muscle development. Cell death & disease\| PubMed ID: 29168801	2017
deletion in luminal cells of mature prostate induces replication stress and senescence in vivo. The Journal of experimental medicine\| PubMed ID: 29743291	2018
Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways? Frontiers in physiology\| PubMed ID: 29872405	2018
Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver. Cell metabolism\| PubMed ID: 29909969	2018
PGC-1β modulates statin-associated myotoxicity in mice. Archives of toxicology\| PubMed ID: 30511338	2019
[How to limit the progression of PTEN-deficient prostatic tumors?]. Medecine sciences : M/S\| PubMed ID: 30526823	2018
Senescence controls prostatic neoplasia driven by Pten loss. Molecular & cellular oncology\| PubMed ID: 30788414	2019
Skeletal Muscle-Specific Activation of G Signaling Maintains Glucose Homeostasis. Diabetes\| PubMed ID: 30936140	2019
Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle. Antioxidants (Basel, Switzerland)\| PubMed ID: 31181751	2019
Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia. Nature communications\| PubMed ID: 33288743	2020
Tyrosine hydroxylase conditional KO mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways. The Journal of biological chemistry\| PubMed ID: 33737022	2021
Myod1 and GR coordinate myofiber-specific transcriptional enhancers. Nucleic acids research\| PubMed ID: 33836079	2021
Single-cell analyses unravel cell type-specific responses to a vitamin D analog in prostatic precancerous lesions. Science advances\| PubMed ID: 34330705	2021
TRPC3 shapes the ER-mitochondria Ca transfer characterizing tumour-promoting senescence. Nature communications\| PubMed ID: 35177596	2022
Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression. Science advances\| PubMed ID: 35867798	2022
Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants. International journal of molecular sciences\| PubMed ID: 35955580	2022
Hypoxia-inducible factor 1A inhibition overcomes castration resistance of prostate tumors. EMBO molecular medicine\| PubMed ID: 37070472	2023
Androgen receptor coordinates muscle metabolic and contractile functions. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 37208984	2023