Karine Auclair

Department of Chemistry, McGill University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2011

Other Publications

Article	Year
Revisiting the mechanism of P450 enzymes with the radical clocks norcarane and spiro[2,5]octane. Journal of the American Chemical Society\| PubMed ID: 12022835	2002
Solution NMR characterization of an unusual distal H-bond network in the active site of the cyanide-inhibited, human heme oxygenase complex of the symmetric substrate, 2,4-dimethyldeuterohem... The Journal of biological chemistry\| PubMed ID: 12070167	2002
1H NMR detection of immobilized water molecules within a strong distal hydrogen-bonding network of substrate-bound human heme oxygenase-1. Journal of the American Chemical Society\| PubMed ID: 12452690	2002
Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae. Protein expression and purification\| PubMed ID: 12699699	2003
Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes. Organic & biomolecular chemistry\| PubMed ID: 12929390	2003
Solution 1H, 15N NMR spectroscopic characterization of substrate-bound, cyanide-inhibited human heme oxygenase: water occupation of the distal cavity. Journal of the American Chemical Society\| PubMed ID: 14583035	2003
1H NMR investigation of the solution structure of substrate-free human heme oxygenase: comparison to the cyanide-inhibited, substrate-bound complex. The Journal of biological chemistry\| PubMed ID: 14660632	2004
Inhibition of human P450 enzymes by nicotinic acid and nicotinamide. Biochemical and biophysical research communications\| PubMed ID: 15081432	2004
Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract. Biochemical and biophysical research communications\| PubMed ID: 15147983	2004
Composition and biological activity of traditional and commercial kava extracts. Biochemical and biophysical research communications\| PubMed ID: 15313185	2004
Regio- and chemoselective 6'-N-derivatization of aminoglycosides: bisubstrate inhibitors as probes to study aminoglycoside 6'-N-acetyltransferases. Angewandte Chemie (International ed. in English)\| PubMed ID: 16206301	2005
Replacement of natural cofactors by selected hydrogen peroxide donors or organic peroxides results in improved activity for CYP3A4 and CYP2D6. Chembiochem : a European journal of chemical biology\| PubMed ID: 16671126	2006
Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases. Journal of medicinal chemistry\| PubMed ID: 16913716	2006
Progress towards the easier use of P450 enzymes. Molecular bioSystems\| PubMed ID: 17216026	2006
The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6'-N-acetyltransferase and the role of 6'-NH2 in antibacterial activity. Bioorganic & medicinal chemistry\| PubMed ID: 17317190	2007
Activity of human P450 2D6 in biphasic solvent systems. Biotechnology and bioengineering\| PubMed ID: 17461428	2007
CYP3A4 activity in the presence of organic cosolvents, ionic liquids, or water-immiscible organic solvents. Chembiochem : a European journal of chemical biology\| PubMed ID: 17526062	2007
Sugar-mediated lyoprotection of purified human CYP3A4 and CYP2D6. Journal of biotechnology\| PubMed ID: 17599599	2007
Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6'-N-acetyltransferase. Biochemistry\| PubMed ID: 18095712	2008
Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis. Carcinogenesis\| PubMed ID: 18567620	2008
Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-CoA bisubstrates as mechanistic probes for aminoglycoside N-6'-acetyltransferase. Bioorganic & medicinal chemistry letters\| PubMed ID: 18805003	2008
The activity of human CYP2D6 in low water organic solvents. Biotechnology and bioengineering\| PubMed ID: 18988262	2009
Synthesis of a phosphonate-linked aminoglycoside-coenzyme a bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 19152351	2009
Elucidating protein binding mechanisms by variable-c ITC. Chembiochem : a European journal of chemical biology\| PubMed ID: 19856370	2009
Synthesis of 4'-aminopantetheine and derivatives to probe aminoglycoside N-6'-acetyltransferase. Organic & biomolecular chemistry\| PubMed ID: 21225062	2011
Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme. Nature structural & molecular biology\| PubMed ID: 21278754	2011
Geminal dialkyl derivatives of N-substituted pantothenamides: synthesis and antibacterial activity. Bioorganic & medicinal chemistry\| PubMed ID: 21440446	2011
Predictable stereoselective and chemoselective hydroxylations and epoxidations with P450 3A4. Journal of the American Chemical Society\| PubMed ID: 21528858	2011
Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues. ChemMedChem\| PubMed ID: 21905229	2011
Inhibitors of Aminoglycoside Resistance Activated in Cells. ACS chemical biology\| PubMed ID: 22217014	2012