a-surgical-procedure-for-administration-drugs-to-inner-ear-non-human

A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset (<em>Callithrix jacchus</em>)

Hearing research has long been facilitated by rodent models, although in some diseases, human symptoms cannot be recapitulated. The common marmoset ...

Jikei University School of Medicine

Mesenchymal stem cell therapy in renal failure is rarely used because of low rates of cell engraftment after systemic delivery. Repeated intra-arterial cell administration may improve results; however, no current delivery method permits repeated intra-arterial infusions in a rat model. In this study, we developed an intra-arterial delivery system for repeated stem cell infusion via the aorta, catheterizing the left femoral artery to the suprarenal aorta under fluoroscopic guidance in rats with adenosine-induced renal failure.

Intra-arterial catheter system to repeatedly deliver mesenchymal stem cells in a rat renal failure model.

Rapid advancements have been made in alternative treatments for renal diseases. Our goal for renal regeneration is to establish a kidney graft derived from human embryonic tissues. In this study, we investigated the effects of host renal failure on the structure and activity of transplanted embryonic kidney and bladder, and found that diuretics effectively induced urine production in the transplanted kidney.

Article	Year
Intra-arterial catheter system to repeatedly deliver mesenchymal stem cells in a rat renal failure model. Clinical and experimental nephrology\| PubMed ID: 26338463	2016
Embryonic kidney function in a chronic renal failure model in rodents. Clinical and experimental nephrology\| PubMed ID: 27696238	2017

Sho Kurihara

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