Aihua Gu

State Key Laboratory of Reproductive Medicine, Nanjing Medical University

Affiliated withNanjing Medical University Nanjing Medical University

Research Area

Biography

Research Interests

Reproductive and Developmental Toxicology: a) The hazard of environmental-genetic dangerous factors and their interactions to reproduction and development; b) The study of developmental toxicology and environmental toxicology using zebrafish model system; c) The key roles of DNA damage repair events in important time windows during gametogenesis and embryogenesis;

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2020

Other Publications

Article	Year
[Phospholipase C and reproduction]. Zhonghua nan ke xue = National journal of andrology\| PubMed ID: 15354530	2004
The association of Y chromosome haplogroups with spermatogenic failure in the Han Chinese. Journal of human genetics\| PubMed ID: 17558462	2007
Polymorphisms in CYP1A1 gene are associated with male infertility in a Chinese population. International journal of andrology\| PubMed ID: 17651397	2008
The relation between urinary metabolite of pyrethroid insecticides and semen quality in humans. Fertility and sterility\| PubMed ID: 17765231	2008
DNA repair gene XRCC1 and XPD polymorphisms and the risk of idiopathic azoospermia in a Chinese population. International journal of molecular medicine\| PubMed ID: 17912469	2007
XPC gene polymorphisms and risk of idiopathic azoospermia or oligozoospermia in a Chinese population. International journal of andrology\| PubMed ID: 18067564	2009
ERCC1 and ERCC2 polymorphisms and risk of idiopathic azoospermia in a Chinese population. Reproductive biomedicine online\| PubMed ID: 18616887	2008
The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population. Human molecular genetics\| PubMed ID: 19088127	2009
FAS and FASLG polymorphisms and susceptibility to idiopathic azoospermia or severe oligozoospermia. Reproductive biomedicine online\| PubMed ID: 19146781	2009
Urinary metabolites of polycyclic aromatic hydrocarbons in relation to idiopathic male infertility. Human reproduction (Oxford, England)\| PubMed ID: 19202139	2009
Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality. Human reproduction (Oxford, England)\| PubMed ID: 19542541	2009
Relation between urinary metabolites of polycyclic aromatic hydrocarbons and human semen quality. Environmental science & technology\| PubMed ID: 19603678	2009
Variants in the Eppin gene show association with semen quality in Han-Chinese population. Reproductive biomedicine online\| PubMed ID: 20158997	2010
Lack of association between DAZ gene methylation patterns and spermatogenic failure. Clinical chemistry and laboratory medicine\| PubMed ID: 20170395	2010
Joint effects of XRCC1 polymorphisms and polycyclic aromatic hydrocarbons exposure on sperm DNA damage and male infertility. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 20395310	2010
Nucleotide excision repair polymorphisms, polycyclic aromatic hydrocarbon exposure, and their effects on sperm deoxyribonucleic acid damage and male factor infertility. Fertility and sterility\| PubMed ID: 20557883	2010
Exposure to fenvalerate causes brain impairment during zebrafish development. Toxicology letters\| PubMed ID: 20570613	2010
Polymorphisms of nucleotide-excision repair genes may contribute to sperm DNA fragmentation and male infertility. Reproductive biomedicine online\| PubMed ID: 20864414	2010
Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population. Human reproduction (Oxford, England)\| PubMed ID: 20940137	2010
Effects of non-occupational environmental exposure to pyrethroids on semen quality and sperm DNA integrity in Chinese men. Reproductive toxicology (Elmsford, N.Y.)\| PubMed ID: 20955780	2011
Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm. PloS one\| PubMed ID: 20957144	2010
FSH receptor gene polymorphisms in fertile and infertile Han-Chinese males. Clinica chimica acta; international journal of clinical chemistry\| PubMed ID: 21334319	2011
Distribution of Eppin in mouse and human testis. Molecular medicine reports\| PubMed ID: 21461566	2011
Assessment of an association between an aryl hydrocarbon receptor gene (AHR) polymorphism and risk of male infertility. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 21613234	2011
Latent TGF-β binding protein 3 identifies a second heart field in zebrafish. Nature\| PubMed ID: 21623370	2011
Developmental toxicity of cypermethrin in embryo-larval stages of zebrafish. Chemosphere\| PubMed ID: 21840035	2011
Additional genomic duplications in AZFc underlie the b2/b3 deletion-associated risk of spermatogenic impairment in Han Chinese population. Human molecular genetics\| PubMed ID: 21852246	2011
Genetic variants in antioxidant genes are associated with sperm DNA damage and risk of male infertility in a Chinese population. Free radical biology & medicine\| PubMed ID: 22206979	2012
The TERT rs2736100 polymorphism and cancer risk: a meta-analysis based on 25 case-control studies. BMC cancer\| PubMed ID: 22221621	2012
The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis. PloS one\| PubMed ID: 22276117	2012
Contributions of aryl hydrocarbon receptor genetic variants to the risk of glioma and PAH-DNA adducts. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 22539616	2012
Common variants in mismatch repair genes associated with increased risk of sperm DNA damage and male infertility. BMC medicine\| PubMed ID: 22594646	2012
The aryl hydrocarbon receptor (AhR) 1661G>A polymorphism in human cancer: a meta-analysis. Gene\| PubMed ID: 23022626	2013
Association of the maternal MTHFR C677T polymorphism with susceptibility to neural tube defects in offsprings: evidence from 25 case-control studies. PloS one\| PubMed ID: 23056169	2012
Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population. PloS one\| PubMed ID: 23320086	2013
Neurotoxicity of perfluorooctane sulfonate to hippocampal cells in adult mice. PloS one\| PubMed ID: 23382877	2013
The TERT MNS16A polymorphism contributes to cancer susceptibility: meta-analysis of the current studies. Gene\| PubMed ID: 23462332	2013
Hsa-mir-499 rs3746444 polymorphism and cancer risk: a meta-analysis. Journal of biomedical research\| PubMed ID: 23554757	2012
Low-dose monobutyl phthalate stimulates steroidogenesis through steroidogenic acute regulatory protein regulated by SF-1, GATA-4 and C/EBP-beta in mouse Leydig tumor cells. Reproductive biology and endocrinology : RB&E\| PubMed ID: 23889939	2013
8-Oxoguanine DNA glycosylase 1 (ogg1) maintains the function of cardiac progenitor cells during heart formation in zebrafish. Experimental cell research\| PubMed ID: 23892003	2013
IDH1/IDH2 mutations define the prognosis and molecular profiles of patients with gliomas: a meta-analysis. PloS one\| PubMed ID: 23894344	2013
Bulky DNA adducts in human sperm associated with semen parameters and sperm DNA fragmentation in infertile men: a cross-sectional study. Environmental health : a global access science source\| PubMed ID: 24073787	2013
The 8-oxoguanine DNA glycosylase 1 (ogg1) decreases the vulnerability of the developing brain to DNA damage. DNA repair\| PubMed ID: 24075420	2013
Estrogen receptors are involved in polychlorinated biphenyl-induced apoptosis on mouse spermatocyte GC-2 cell line. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 24216299	2014
Genetic variants in telomerase reverse transcriptase (TERT) and telomerase-associated protein 1 (TEP1) and the risk of male infertility. Gene\| PubMed ID: 24269974	2014
Association between CTLA-4 60G/A and -1661A/G polymorphisms and the risk of cancers: a meta-analysis. PloS one\| PubMed ID: 24376736	2013
Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. Journal of hematology & oncology\| PubMed ID: 24598081	2014
Seminal superoxide dismutase activity and its relationship with semen quality and SOD gene polymorphism. Journal of assisted reproduction and genetics\| PubMed ID: 24658925	2014
Association of interferon regulatory factor 4 gene polymorphisms rs12203592 and rs872071 with skin cancer and haematological malignancies susceptibility: a meta-analysis of 19 case-control s... BMC cancer\| PubMed ID: 24906573	2014
Association between the XRCC1 Arg194Trp polymorphism and glioma risk: an updated meta-analysis. Asian Pacific journal of cancer prevention : APJCP\| PubMed ID: 25227852	2014
Increased incidence of head and neck cancer in liver transplant recipients: a meta-analysis. BMC cancer\| PubMed ID: 25338638	2014
Association between HIF-1α C1772T/G1790A polymorphisms and cancer susceptibility: an updated systematic review and meta-analysis based on 40 case-control studies. BMC cancer\| PubMed ID: 25496056	2014
Genetic variants in nitric oxide synthase genes and the risk of male infertility in a Chinese population: a case-control study. PloS one\| PubMed ID: 25517965	2014
Urinary enterolactone is associated with obesity and metabolic alteration in men in the US National Health and Nutrition Examination Survey 2001-10. The British journal of nutrition\| PubMed ID: 25634494	2015
Altered profile of gut microbiota after subchronic exposure to neochamaejasmin A in rats. Environmental toxicology and pharmacology\| PubMed ID: 25812769	2015
Urinary enterolactone associated with liver enzyme levels in US adults: National Health and Nutrition Examination Survey (NHANES). The British journal of nutrition\| PubMed ID: 25990984	2015
Low Serum Testosterone Levels Are Associated with Elevated Urinary Mandelic Acid, and Strontium Levels in Adult Men According to the US 2011-2012 National Health and Nutrition Examination Su... PloS one\| PubMed ID: 25996772	2015
Effects of urban particulate matter with high glucose on human monocytes U937. Journal of applied toxicology : JAT\| PubMed ID: 26179980	2016
miRNA-200c mediates mono-butyl phthalate-disrupted steroidogenesis by targeting vimentin in Leydig tumor cells and murine adrenocortical tumor cells. Toxicology letters\| PubMed ID: 26581634	2016
Association of polycyclic aromatic hydrocarbons and asthma among children 6-19 years: NHANES 2001-2008 and NHANES 2011-2012. Respiratory medicine\| PubMed ID: 26626452	2016
Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease. Oncotarget\| PubMed ID: 27203212	2016
Sublethal effects of zinc oxide nanoparticles on male reproductive cells. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 27247145	2016
Toxicological assessment of multi-walled carbon nanotubes in vitro: potential mitochondria effects on male reproductive cells. Oncotarget\| PubMed ID: 27248475	2016
Perfluorooctane sulfonate-induced testicular toxicity and differential testicular expression of estrogen receptor in male mice. Environmental toxicology and pharmacology\| PubMed ID: 27310206	2016
Association between level of urinary trace heavy metals and obesity among children aged 6-19 years: NHANES 1999-2011. Environmental science and pollution research international\| PubMed ID: 28321702	2017
Estrogen receptor beta mediates hepatotoxicity induced by perfluorooctane sulfonate in mouse. Environmental science and pollution research international\| PubMed ID: 28386898	2017
Organochloride pesticides modulated gut microbiota and influenced bile acid metabolism in mice. Environmental pollution (Barking, Essex : 1987)\| PubMed ID: 28392238	2017
Organochloride pesticides impaired mitochondrial function in hepatocytes and aggravated disorders of fatty acid metabolism. Scientific reports\| PubMed ID: 28397872	2017
Ibrutinib, a Bruton's tyrosine kinase inhibitor, exhibits antitumoral activity and induces autophagy in glioblastoma. Journal of experimental & clinical cancer research : CR\| PubMed ID: 28716053	2017
NF-κB-vimentin is involved in steroidogenesis stimulated by mono-butyl phthalate in primary cultured ovarian granulosa cells. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 28735033	2017
Involvement of Insulin Signaling Disturbances in Bisphenol A-Induced Alzheimer's Disease-like Neurotoxicity. Scientific reports\| PubMed ID: 28790390	2017
Effect of exposure to ambient PM pollution on the risk of respiratory tract diseases: a meta-analysis of cohort studies. Journal of biomedical research\| PubMed ID: 28808195	2017
, a long-noncoding RNA, promotes malignancy in glioblastoma. OncoTargets and therapy\| PubMed ID: 28894380	2017
Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29078374	2017
Involvement of the delayed rectifier outward potassium channel Kv2.1 in methamphetamine-induced neuronal apoptosis via the p38 mitogen-activated protein kinase signaling pathway. Journal of applied toxicology : JAT\| PubMed ID: 29297590	2018
Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis. Cell death & disease\| PubMed ID: 30068904	2018
NF-κB-vimentin is involved in steroidogenesis stimulated by di--butyl phthalate in prepubertal female rats. Toxicology research\| PubMed ID: 30310660	2018
RhoG-ELMO1-RAC1 is involved in phagocytosis suppressed by mono-butyl phthalate in TM4 cells. Environmental science and pollution research international\| PubMed ID: 30350139	2018
Neurobehavioral effects of bisphenol S exposure in early life stages of zebrafish larvae (Danio rerio). Chemosphere\| PubMed ID: 30447611	2019
Quantification of Mitochondrial Genome Transcription in Male Reproductive Cells by Real-Time PCR. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30547462	2019
Deficiency of X-ray repair cross-complementing group 1 in primordial germ cells contributes to male infertility. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 30998386	2019
FMO3 and its metabolite TMAO contribute to the formation of gallstones. Biochimica et biophysica acta. Molecular basis of disease\| PubMed ID: 31251986	2019
Association of smoking with coronary artery disease in Nepalese populations: a case control study. Toxicology research\| PubMed ID: 31588344	2019
SREBP2-STARD4 is involved in synthesis of cholesteryl ester stimulated by mono-butyl phthalate in MLTC-1 cells. Environmental toxicology\| PubMed ID: 31705742	2020
Oxidative stress in bisphenol AF-induced cardiotoxicity in zebrafish and the protective role of N-acetyl N-cysteine. The Science of the total environment\| PubMed ID: 32408210	2020
Di-n-butyl phthalate promotes lipid accumulation via the miR200c-5p-ABCA1 pathway in THP-1 macrophages. Environmental pollution (Barking, Essex : 1987)\| PubMed ID: 32417575	2020
Increased serum levels of aldehydes are associated with cardiovascular disease and cardiovascular risk factors in adults. Journal of hazardous materials\| PubMed ID: 32569983	2020
In vitro evaluation of the hepatic lipid accumulation of bisphenol analogs: A high-content screening assay. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 32763284	2020