capturing-interaction-kinetics-an-ion-channel-protein-with-small

Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay

The bio-layer interferometry (BLI) assay is a valuable tool for measuring protein-protein and protein-small molecule interactions. Here, we first describe ...

Shanghai Jiao Tong University School of Medicine

                    
1 (Eag1, Kv10.1, KCNH1) Kchannel is a member of the voltage-gated Kchannel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated Kchannels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.

Bo Han

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