Narla Mohandas

Red Cell Physiology Laboratory, New York Blood Center

Affiliated withNew York Blood Center New York Blood Center

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 51	2018

Other Publications

Article	Year
Identification of a functional role for lipid asymmetry in biological membranes: Phosphatidylserine-skeletal protein interactions modulate membrane stability. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11830646	2002
Shear-response of the spectrin dimer-tetramer equilibrium in the red blood cell membrane. The Journal of biological chemistry\| PubMed ID: 12105217	2002
Ribosomal protein S19 expression during erythroid differentiation. Blood\| PubMed ID: 12393682	2003
Phosphatidylserine binding sites in erythroid spectrin: location and implications for membrane stability. Biochemistry\| PubMed ID: 14717584	2004
Red blood cell blood group antigens: structure and function. Seminars in hematology\| PubMed ID: 15071789	2004
Phosphatidylserine binding sites in red cell spectrin. Blood cells, molecules & diseases\| PubMed ID: 15121103	2004
Phospholipid binding by proteins of the spectrin family: a comparative study. Biochemical and biophysical research communications\| PubMed ID: 15649416	2005
Blood group antigens in health and disease. Current opinion in hematology\| PubMed ID: 15725904	2005
The hydration state of human red blood cells and their susceptibility to invasion by Plasmodium falciparum. Blood\| PubMed ID: 15728121	2005
Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis. Blood\| PubMed ID: 15855279	2005
Nuclear substructure reorganization during late-stage erythropoiesis is selective and does not involve caspase cleavage of major nuclear substructural proteins. Blood\| PubMed ID: 15933051	2005
Structural and functional studies of interaction between Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) and erythrocyte spectrin. The Journal of biological chemistry\| PubMed ID: 16006556	2005
Identification and functional characterization of protein 4.1R and actin-binding sites in erythrocyte beta spectrin: regulation of the interactions by phosphatidylinositol-4,5-bisphosphate. Biochemistry\| PubMed ID: 16060676	2005
High frequency of alternative first exons in erythroid genes suggests a critical role in regulating gene function. Blood\| PubMed ID: 16293607	2006
Mammalian alpha I-spectrin is a neofunctionalized polypeptide adapted to small highly deformable erythrocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16407147	2006
Conformational stabilities of the structural repeats of erythroid spectrin and their functional implications. The Journal of biological chemistry\| PubMed ID: 16476728	2006
A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells. The Journal of cell biology\| PubMed ID: 16520384	2006
Phosphatidylinositol-4,5-biphosphate (PIP2) differentially regulates the interaction of human erythrocyte protein 4.1 (4.1R) with membrane proteins. Biochemistry\| PubMed ID: 16669616	2006
Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation. Blood\| PubMed ID: 16690966	2006
Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood\| PubMed ID: 16882712	2006
Tropomyosin modulates erythrocyte membrane stability. Blood\| PubMed ID: 17008534	2007
Thermal stabilities of brain spectrin and the constituent repeats of subunits. Biochemistry\| PubMed ID: 17087521	2006
Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain. Biochimica et biophysica acta\| PubMed ID: 17123648	2006
Erythrocyte G protein as a novel target for malarial chemotherapy. PLoS medicine\| PubMed ID: 17194200	2006
The ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum stabilizes spectrin tetramers and suppresses further invasion. Blood\| PubMed ID: 17468340	2007
Cytoplasmic remodeling of erythrocyte raft lipids during infection by the human malaria parasite Plasmodium falciparum. Blood\| PubMed ID: 17526861	2007
Interactions of Plasmodium falciparum erythrocyte membrane protein 3 with the red blood cell membrane skeleton. Biochimica et biophysica acta\| PubMed ID: 17570341	2007
Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) destabilizes erythrocyte membrane skeleton. The Journal of biological chemistry\| PubMed ID: 17626011	2007
The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3. Blood\| PubMed ID: 17638854	2007
Intrasplicing coordinates alternative first exons with alternative splicing in the protein 4.1R gene. The EMBO journal\| PubMed ID: 18079699	2008
Fluctuations of the red blood cell membrane: relation to mechanical properties and lack of ATP dependence. Biophysical journal\| PubMed ID: 18234829	2008
Disorders of red cell membrane. British journal of haematology\| PubMed ID: 18341630	2008
Morphological and functional platelet abnormalities in Berkeley sickle cell mice. Blood cells, molecules & diseases\| PubMed ID: 18374611	2008
Integral protein linkage and the bilayer-skeletal separation energy in red blood cells. Biophysical journal\| PubMed ID: 18390600	2008
In vivo studies support the role of trafficking and cytoskeletal-binding motifs in the interaction of MESA with the membrane skeleton of Plasmodium falciparum-infected red blood cells. Molecular and biochemical parasitology\| PubMed ID: 18482775	2008
Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18524950	2008
Erythroblastic islands: niches for erythropoiesis. Blood\| PubMed ID: 18650462	2008
Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice. Blood\| PubMed ID: 18698006	2008
Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice. Blood\| PubMed ID: 18723693	2008
Adhesive activity of Lu glycoproteins is regulated by interaction with spectrin. Blood\| PubMed ID: 18815288	2008
Functional alteration of red blood cells by a megadalton protein of Plasmodium falciparum. Blood\| PubMed ID: 18832660	2009
Red cell membrane: past, present, and future. Blood\| PubMed ID: 18988878	2008
Cytoskeletal protein 4.1R negatively regulates T-cell activation by inhibiting the phosphorylation of LAT. Blood\| PubMed ID: 19190245	2009
A Golgi-associated protein 4.1B variant is required for assimilation of proteins in the membrane. Journal of cell science\| PubMed ID: 19299464	2009
Protein 4.1R links E-cadherin/beta-catenin complex to the cytoskeleton through its direct interaction with beta-catenin and modulates adherens junction integrity. Biochimica et biophysica acta\| PubMed ID: 19376086	2009
Targeted deletion of the gamma-adducin gene (Add3) in mice reveals differences in alpha-adducin interactions in erythroid and nonerythroid cells. American journal of hematology\| PubMed ID: 19425068	2009
Adducin forms a bridge between the erythrocyte membrane and its cytoskeleton and regulates membrane cohesion. Blood\| PubMed ID: 19567882	2009
The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume. Blood\| PubMed ID: 19724054	2009
Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19805084	2009
Malaria, erythrocytic infection, and anemia. Hematology. American Society of Hematology. Education Program\| PubMed ID: 20008186	2009
Membrane remodeling during reticulocyte maturation. Blood\| PubMed ID: 20038785	2010
Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species. Blood cells, molecules & diseases\| PubMed ID: 20231105	2010
Hereditary spherocytosis and hereditary elliptocytosis: aberrant protein sorting during erythroblast enucleation. Blood\| PubMed ID: 20339087	2010
Control of erythrocyte membrane-skeletal cohesion by the spectrin-membrane linkage. Biochemistry\| PubMed ID: 20433199	2010
A transgenic mouse model demonstrates a dominant negative effect of a point mutation in the RPS19 gene associated with Diamond-Blackfan anemia. Blood\| PubMed ID: 20606162	2010
The erythroid niche: molecular processes occurring within erythroblastic islands. Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine\| PubMed ID: 20655267	2010
ATP-dependent mechanism protects spectrin against glycation in human erythrocytes. The Journal of biological chemistry\| PubMed ID: 20724481	2010
Similarities and differences in the structure and function of 4.1G and 4.1R135, two protein 4.1 paralogues expressed in erythroid cells. The Biochemical journal\| PubMed ID: 20812914	2010
Comprehensive characterization of expression patterns of protein 4.1 family members in mouse adrenal gland: implications for functions. Histochemistry and cell biology\| PubMed ID: 20890708	2010
"Capping": necessary for graduation. Blood\| PubMed ID: 20930081	2010
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. The Journal of clinical investigation\| PubMed ID: 21099112	2010
Efficient in vivo manipulation of alternative pre-mRNA splicing events using antisense morpholinos in mice. The Journal of biological chemistry\| PubMed ID: 21156798	2011
The sensing of poorly deformable red blood cells by the human spleen can be mimicked in vitro. Blood\| PubMed ID: 21163923	2011
Inter-subunit interactions in erythroid and non-erythroid spectrins. Biochimica et biophysica acta\| PubMed ID: 21215336	2011
Erythroblastic islands, terminal erythroid differentiation and reticulocyte maturation. International journal of hematology\| PubMed ID: 21293952	2011
Congenital erythropoietic porphyria: characterization of murine models of the severe common (C73R/C73R) and later-onset genotypes. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 21365124	2011
Membrane assembly during erythropoiesis. Current opinion in hematology\| PubMed ID: 21372707	2011
Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility. Molecular and cellular biology\| PubMed ID: 21482674	2011
Cysteine shotgun-mass spectrometry (CS-MS) reveals dynamic sequence of protein structure changes within mutant and stressed cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21527722	2011
Phosphorylation-dependent perturbations of the 4.1R-associated multiprotein complex of the erythrocyte membrane. Biochemistry\| PubMed ID: 21542582	2011
The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation. Blood\| PubMed ID: 21566095	2011
Protein 4.1R regulates cell adhesion, spreading, migration and motility of mouse keratinocytes by modulating surface expression of beta1 integrin. Journal of cell science\| PubMed ID: 21693581	2011
Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity. Blood\| PubMed ID: 21951684	2011
"Baby" red cells to the rescue. Blood\| PubMed ID: 21960678	2011
Native ultrastructure of the red cell cytoskeleton by cryo-electron tomography. Biophysical journal\| PubMed ID: 22098732	2011
Exit strategy: one that works. Blood\| PubMed ID: 22282491	2012
Deep intron elements mediate nested splicing events at consecutive AG dinucleotides to regulate alternative 3' splice site choice in vertebrate 4.1 genes. Molecular and cellular biology\| PubMed ID: 22473990	2012
Therapeutic hemoglobin levels after gene transfer in β-thalassemia mice and in hematopoietic cells of β-thalassemia and sickle cells disease patients. PloS one\| PubMed ID: 22479321	2012
Quantitative assessment of sensing and sequestration of spherocytic erythrocytes by the human spleen. Blood\| PubMed ID: 22510876	2012
Novel aspects of Kindlin-3 function in humans based on a new case of leukocyte adhesion deficiency III. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 22564402	2012
Identification of a novel role for dematin in regulating red cell membrane function by modulating spectrin-actin interaction. The Journal of biological chemistry\| PubMed ID: 22927433	2012
Malaria and human red blood cells. Medical microbiology and immunology\| PubMed ID: 22965173	2012
The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons. Glia\| PubMed ID: 23109359	2013
Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis. Blood\| PubMed ID: 23287863	2013
Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease. Blood\| PubMed ID: 23349388	2013
Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo. Blood\| PubMed ID: 23422750	2013
Impaired intestinal calcium absorption in protein 4.1R-deficient mice due to altered expression of plasma membrane calcium ATPase 1b (PMCA1b). The Journal of biological chemistry\| PubMed ID: 23460639	2013
To shrink or not to shrink. Blood\| PubMed ID: 23660856	2013
A bacterial phosphatase-like enzyme of the malaria parasite Plasmodium falciparum possesses tyrosine phosphatase activity and is implicated in the regulation of band 3 dynamics during parasi... Eukaryotic cell\| PubMed ID: 23825180	2013
Membrane peroxidation and methemoglobin formation are both necessary for band 3 clustering: mechanistic insights into human erythrocyte senescence. Biochemistry\| PubMed ID: 23889086	2013
Identification of binding domains on red blood cell glycophorins for Babesia divergens. Transfusion\| PubMed ID: 23944874	2014
Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice. Haematologica\| PubMed ID: 23975182	2014
Interaction of Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) with erythrocyte ankyrin R is required for its attachment to the erythrocyte membrane. Biochimica et biophysica acta\| PubMed ID: 24090929	2014
Significant biochemical, biophysical and metabolic diversity in circulating human cord blood reticulocytes. PloS one\| PubMed ID: 24116088	2013
An open-and-shut case? Blood\| PubMed ID: 24159165	2013
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c. Nature medicine\| PubMed ID: 24216752	2013
A 130-kDa protein 4.1B regulates cell adhesion, spreading, and migration of mouse embryo fibroblasts by influencing actin cytoskeleton organization. The Journal of biological chemistry\| PubMed ID: 24381168	2014
A dynamic alternative splicing program regulates gene expression during terminal erythropoiesis. Nucleic acids research\| PubMed ID: 24442673	2014
Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development. Blood\| PubMed ID: 24497530	2014
Abnormal red cell features associated with hereditary neurodegenerative disorders: the neuroacanthocytosis syndromes. Current opinion in hematology\| PubMed ID: 24626044	2014
Global transcriptome analyses of human and murine terminal erythroid differentiation. Blood\| PubMed ID: 24637361	2014
KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia. Blood\| PubMed ID: 24829204	2014
Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia. Gene\| PubMed ID: 24835311	2014
The iron fist: malaria and hepcidin. Blood\| PubMed ID: 24855192	2014
Inactivation of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation. Molecular and cellular biology\| PubMed ID: 24865965	2014
Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification. Cell stem cell\| PubMed ID: 24953180	2014
Isolation and transcriptome analyses of human erythroid progenitors: BFU-E and CFU-E. Blood\| PubMed ID: 25339359	2014
Abnormal erythroid maturation leads to microcytic anemia in the TSAP6/Steap3 null mouse model. American journal of hematology\| PubMed ID: 25515317	2015
Altered chromatin occupancy of master regulators underlies evolutionary divergence in the transcriptional landscape of erythroid differentiation. PLoS genetics\| PubMed ID: 25521328	2014
Malaria induces anemia through CD8+ T cell-dependent parasite clearance and erythrocyte removal in the spleen. mBio\| PubMed ID: 25604792	2015
Human and murine erythropoiesis. Current opinion in hematology\| PubMed ID: 25719574	2015
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature\| PubMed ID: 25874676	2015
Interactions between Plasmodium falciparum skeleton-binding protein 1 and the membrane skeleton of malaria-infected red blood cells. Biochimica et biophysica acta\| PubMed ID: 25883090	2015
Jekyll and Hyde: the role of heme oxygenase-1 in erythroid biology. Haematologica\| PubMed ID: 25944635	2015
The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis. Antioxidants & redox signaling\| PubMed ID: 26058667	2015
More than one way to shrink. Blood\| PubMed ID: 26359428	2015
The erythroblastic island as an emerging paradigm in the anemia of inflammation. Immunologic research\| PubMed ID: 26376896	2015
The human Kell blood group binds the erythroid 4.1R protein: new insights into the 4.1R-dependent red cell membrane complex. British journal of haematology\| PubMed ID: 26455906	2015
A dynamic intron retention program enriched in RNA processing genes regulates gene expression during terminal erythropoiesis. Nucleic acids research\| PubMed ID: 26531823	2016
Diagnostic tool for red blood cell membrane disorders: Assessment of a new generation ektacytometer. Blood cells, molecules & diseases\| PubMed ID: 26603718	2016
Protein 4.1G Regulates Cell Adhesion, Spreading, and Migration of Mouse Embryonic Fibroblasts through the β1 Integrin Pathway. The Journal of biological chemistry\| PubMed ID: 26644476	2016
Human STEAP3 mutations with no phenotypic red cell changes. Blood\| PubMed ID: 26675350	2016
Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors. Blood\| PubMed ID: 26679864	2016
Long-term follow-up of subtotal splenectomy for hereditary spherocytosis: a single-center study. Blood\| PubMed ID: 26773041	2016
No evidence for cell activation or brain vaso-occlusion with plerixafor mobilization in sickle cell mice. Blood cells, molecules & diseases\| PubMed ID: 26852658	2016
ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia. Haematologica\| PubMed ID: 26944472	2016
A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages. Blood\| PubMed ID: 26962124	2016
Malaria Parasite Proteins and Their Role in Alteration of the Structure and Function of Red Blood Cells. Advances in parasitology\| PubMed ID: 27015947	2016
An Unrecognized Function of Cholesterol: Regulating the Mechanism Controlling Membrane Phospholipid Asymmetry. Biochemistry\| PubMed ID: 27267274	2016
Comprehensive Proteomic Analysis of Human Erythropoiesis. Cell reports\| PubMed ID: 27452463	2016
Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function. British journal of haematology\| PubMed ID: 27507623	2016
The road not taken? Blood\| PubMed ID: 27539995	2016
Exome sequencing results in successful diagnosis and treatment of a severe congenital anemia. Cold Spring Harbor molecular case studies\| PubMed ID: 27551681	2016
Unexpected role for p19INK4d in posttranscriptional regulation of GATA1 and modulation of human terminal erythropoiesis. Blood\| PubMed ID: 27879259	2017
Characterization, regulation, and targeting of erythroid progenitors in normal and disordered human erythropoiesis. Current opinion in hematology\| PubMed ID: 28099275	2017
Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice. Blood\| PubMed ID: 28151426	2017
Distinct roles for TET family proteins in regulating human erythropoiesis. Blood\| PubMed ID: 28167661	2017
Measurements of red cell deformability and hydration reflect HbF and HbA2 in blood from patients with sickle cell anemia. Blood cells, molecules & diseases\| PubMed ID: 28472705	2017
Confounding in ex vivo models of Diamond-Blackfan anemia. Blood\| PubMed ID: 28615220	2017
Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating. Scientific reports\| PubMed ID: 28701737	2017
Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis. Antioxidants & redox signaling\| PubMed ID: 28793778	2018
Enhancing diversity in the hematology biomedical research workforce: A mentoring program to improve the odds of career success for early stage investigators. American journal of hematology\| PubMed ID: 28857249	2017
Unraveling Macrophage Heterogeneity in Erythroblastic Islands. Frontiers in immunology\| PubMed ID: 28979259	2017
Case series supporting heme detoxification via therapeutic plasma exchange in acute multiorgan failure syndrome resistant to red blood cell exchange in sickle cell disease. Transfusion\| PubMed ID: 29193101	2017
Developmental Differences Between Neonatal and Adult Human Erythropoiesis. American journal of hematology\| PubMed ID: 29274096	2017
The severe phenotype of Diamond-Blackfan anemia is modulated by heat shock protein 70. Blood advances\| PubMed ID: 29296843	2017