George K. Michalopoulos

Department of Pathology, University of Pittsburgh School of Medicine

Affiliated withUniversity of Pittsburgh School of Medicine University of Pittsburgh

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 22	2018

Other Publications

Article	Year
Cationic colloidal silica membrane perturbation as a means of examining changes at the sinusoidal surface during liver regeneration. The American journal of pathology\| PubMed ID: 10550305	1999
Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth. Hepatology (Baltimore, Md.)\| PubMed ID: 11283849	2001
The processing and utilization of hepatocyte growth factor/scatter factor following partial hepatectomy in the rat. Hepatology (Baltimore, Md.)\| PubMed ID: 11584364	2001
Histological organization in hepatocyte organoid cultures. The American journal of pathology\| PubMed ID: 11696448	2001
Differential mitogenic effects of single chain hepatocyte growth factor (HGF)/scatter factor and HGF/NK1 following cleavage by factor Xa. The Journal of biological chemistry\| PubMed ID: 11832492	2002
Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures. Hepatology (Baltimore, Md.)\| PubMed ID: 12143035	2002
Beta-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification. Gastroenterology\| PubMed ID: 12512043	2003
Gene expression analysis of human soft tissue leiomyosarcomas. Human pathology\| PubMed ID: 12827608	2003
PPARgamma ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21 pathway. Hepatology (Baltimore, Md.)\| PubMed ID: 12829999	2003
HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures. Gene expression\| PubMed ID: 12837037	2003
Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. Hepatology (Baltimore, Md.)\| PubMed ID: 12939602	2003
Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Hepatology (Baltimore, Md.)\| PubMed ID: 15057910	2004
Liver regeneration, growth factors, and amphiregulin. Gastroenterology\| PubMed ID: 15685562	2005
Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology (Baltimore, Md.)\| PubMed ID: 15726663	2005
Liver regeneration. Advances in biochemical engineering/biotechnology\| PubMed ID: 15791946	2005
Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. Journal of cellular physiology\| PubMed ID: 16331686	2006
Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 action. American journal of physiology. Renal physiology\| PubMed ID: 16332928	2006
Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation. The American journal of pathology\| PubMed ID: 16651617	2006
Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR. Hepatology (Baltimore, Md.)\| PubMed ID: 16799975	2006
Flexible lineage specifications of adult hepatic cells, associated molecular pathways, and their relationship to liver cancer. Cell transplantation\| PubMed ID: 16826797	2006
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. The American journal of pathology\| PubMed ID: 17003483	2006
Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas. Hepatology (Baltimore, Md.)\| PubMed ID: 17006932	2006
Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation. Biochemical and biophysical research communications\| PubMed ID: 17194454	2007
Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis. Hepatology (Baltimore, Md.)\| PubMed ID: 17385211	2007
Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference. Hepatology (Baltimore, Md.)\| PubMed ID: 17427161	2007
Liver regeneration. Journal of cellular physiology\| PubMed ID: 17559071	2007
Promotion of Fas-mediated apoptosis in Type II cells by high doses of hepatocyte growth factor bypasses the mitochondrial requirement. Journal of cellular physiology\| PubMed ID: 17620325	2007
Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes. Journal of cellular physiology\| PubMed ID: 18314882	2008
Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology (Baltimore, Md.)\| PubMed ID: 18393386	2008
Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium. Hepatology (Baltimore, Md.)\| PubMed ID: 18398918	2008
Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. The American journal of pathology\| PubMed ID: 18502824	2008
Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 18574450	2008
Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology (Baltimore, Md.)\| PubMed ID: 18846549	2008
Investigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation. The American journal of pathology\| PubMed ID: 19574424	2009
Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology (Baltimore, Md.)\| PubMed ID: 19575460	2009
Liver regeneration: alternative epithelial pathways. The international journal of biochemistry & cell biology\| PubMed ID: 19788929	2011
Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility. Experimental neurology\| PubMed ID: 19853606	2010
Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. The American journal of pathology\| PubMed ID: 20019184	2010
Interaction of integrin-linked kinase and miniature chromosome maintenance 7-mediating integrin {alpha}7 induced cell growth suppression. Cancer research\| PubMed ID: 20460506	2010
Bid agonist regulates murine hepatocyte proliferation by controlling endoplasmic reticulum calcium homeostasis. Hepatology (Baltimore, Md.)\| PubMed ID: 20578150	2010
Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transfor... Hepatology (Baltimore, Md.)\| PubMed ID: 20683962	2010
Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice. Hepatology (Baltimore, Md.)\| PubMed ID: 20812357	2010
Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation. Comparative hepatology\| PubMed ID: 21126359	2010
Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene. Hepatology (Baltimore, Md.)\| PubMed ID: 21274879	2011
Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice. Hepatology (Baltimore, Md.)\| PubMed ID: 21574168	2011
Genes inducing iPS phenotype play a role in hepatocyte survival and proliferation in vitro and liver regeneration in vivo. Hepatology (Baltimore, Md.)\| PubMed ID: 21739467	2011
A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology (Baltimore, Md.)\| PubMed ID: 21953681	2012
Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice. Comparative hepatology\| PubMed ID: 22104495	2011
Gene deletions and amplifications in human hepatocellular carcinomas: correlation with hepatocyte growth regulation. The American journal of pathology\| PubMed ID: 22326833	2012
Expression of hepatocyte epidermal growth factor receptor, FAS and glypican 3 in EpCAM-positive regenerative clusters of hepatocytes, cholangiocytes, and progenitor cells in human liver fail... Human pathology\| PubMed ID: 23114924	2013
Gliotoxin-induced changes in rat liver regeneration after partial hepatectomy. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 23552057	2013
Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex. The American journal of pathology\| PubMed ID: 23665349	2013
Principles of liver regeneration and growth homeostasis. Comprehensive Physiology\| PubMed ID: 23720294	2013
Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis. PloS one\| PubMed ID: 24058607	2013
The degree of segmental aneuploidy measured by total copy number abnormalities predicts survival and recurrence in superficial gastroesophageal adenocarcinoma. PloS one\| PubMed ID: 24454681	2014
The liver is a peculiar organ when it comes to stem cells. The American journal of pathology\| PubMed ID: 24681248	2014
Signals and cells involved in regulating liver regeneration. Cells\| PubMed ID: 24710554	2012
Development of a chemically defined medium and discovery of new mitogenic growth factors for mouse hepatocytes: mitogenic effects of FGF1/2 and PDGF. PloS one\| PubMed ID: 24743506	2014
Advances in liver regeneration. Expert review of gastroenterology & hepatology\| PubMed ID: 24964729	2014
Novel fusion transcripts associate with progressive prostate cancer. The American journal of pathology\| PubMed ID: 25238935	2014
Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 26237273	2015
Liver-Specific Deletion of Integrin-Linked Kinase in Mice Attenuates Hepatotoxicity and Improves Liver Regeneration After Acetaminophen Overdose. Gene expression\| PubMed ID: 27125733	2016
Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers. PloS one\| PubMed ID: 27196317	2016
Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation. Hepatology (Baltimore, Md.)\| PubMed ID: 27397846	2016
Bile Duct Ligation Induces ATZ Globule Clearance in a Mouse Model of α-1 Antitrypsin Deficiency. Gene expression\| PubMed ID: 27938510	2017
MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice. Gastroenterology\| PubMed ID: 28245430	2017
Immunohistochemical Analysis of the Stem Cell Marker LGR5 in Pediatric Liver Disease. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society\| PubMed ID: 28276299	2017
Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene. Nature biotechnology\| PubMed ID: 28459452	2017
Dose-dependent biphasic effects of phenobarbital on growth and differentiation of primary culture rat hepatocytes. Journal of gastroenterology and hepatology\| PubMed ID: 28976694	1998
Oct4 Is Crucial for Transdifferentiation of Hepatocytes to Biliary Epithelial Cells in an In Vitro Organoid Culture Model. Gene expression\| PubMed ID: 29212575	2018
Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 29486138	2018