methodology-for-establishing-community-wide-life-laboratory-for

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

An end-to-end suite of technologies has been established for the unobtrusive and continuous monitoring of health and activity changes occurring in the ...

Oregon Health & Science University

Pressure beat detection is an integral part of most analysis techniques for arterial blood pressure (ABP), intracranial pressure (ICP), and pulse oximetry (SpO(2)) signals. Beat detection has been used to estimate heart rate in the ABP signal, to classify ICP morphologies, and to estimate blood pressure using pulse oximeter waveforms. This paper describes an algorithm that was developed to detect pressure peak beats in ABP, ICP, and SpO(2) signals. When compared to the expert annotation of several signals consisting of over 42,500 pressure beats, the algorithm detected pressure peaks with an average sensitivity of 99.6% +/- 0.27 and an average positive predictivity of 98.6% +/- 1.1.

Algorithm for automatic beat detection of cardiovascular pressure signals.

Sleep disturbances are prevalent, financially taxing, and have a negative effect on health and quality of life. One of the most common sleep disturbances is obstructive sleep apnea-hypopnea syndrome (OSAHS) which frequently goes undiagnosed. The gold standard for diagnosing OSAHS is polysomnography (PSG)-a procedure that is inconvenient, time-consuming, and interferes with normal sleep patterns. We are investigating an alternative to PSG in which unobtrusive load cells fitted under the bed are used to monitor movement, heart rate, and respiration. In this paper we describe how load cell data can be used to distinguish between clinically relevant disordered breathing (apneas and hypopneas) and normal respiration. The method correctly classified disordered breathing segments with a sensitivity of 0.77 and a specificity of 0.91.

Classification of breathing events using load cells under the bed.

A patient's sleep/wake schedule is an important step underlying clinical evaluation of sleep-related complaints. Aspects related to timing of a person's sleep routine provide important clues regarding diagnosis and treatments. Solutions for sleep complaints may sometimes rely solely on changes in habits and life style, based on what is learned from daily rest-activity patterns. This paper describes an approach for determining two states, in-bed and out-of-bed, using load cells under the bed. These states are important because they can help characterize rest-activity patterns at nighttime or detect bed exits in hospitals or nursing homes. The information derived from the load cells is valuable as an objective and continuous measure of daily patterns, and it is particularly valuable in sleep studies in populations who would not be able to remember specific hours to complete sleep diaries. The approach is evaluated on data collected in a laboratory experiment, in a sleep clinic, and also on data collected from residents of an assisted-living facility.

A subject state detection approach to determine rest-activity patterns using load cells.

Individuals who suffer from acid reflux at night, who snore chronically, or who have sleep apnea are frequently encouraged to sleep in a particular lying position. Side sleeping decreases the frequency and severity of obstructive respiratory events (e.g. apnea and hypopnea) in patients with positional sleep apnea. It has been suggested that individuals with Gastroesophageal Reflux Disease sleep on their left sides in order to help minimize symptoms. In this paper, we present a method of predicting the position of an individual lying on the bed using load cells placed under each of the bed supports. Our results suggest that load cells utilized in this manner could be successfully implemented into a system that tracks or helps train individuals to sleep in a particular lying position.

Classification of lying position using load cells under the bed.

Sleep apnea is a serious condition that afflicts many individuals and is associated with serious health complications. Polysomnography, the gold standard for assessing and diagnosing sleep apnea, uses breathing sensors that are intrusive and can disrupt the patient's sleep during the overnight testing. We investigated the use of breathing signals derived from non-contact force sensors (i.e. load cells) placed under the supports of the bed as an alternative to traditional polysomnography breathing sensors (e.g. nasal pressure, oral-nasal thermistor, chest belt and abdominal belt). The apnea-hypopnea index estimated using the load cells was not different than that estimated using standard polysomnography leads (t44  = 0.37, P = 0.71). Overnight polysomnography sleep studies scored using load cell breathing signals had an intra-class correlation coefficient of 0.97 for the apnea-hypopnea index and an intra-class correlation coefficient of 0.85 for the respiratory disturbance index when compared with scoring using traditional polysomnography breathing sensors following American Academy of Sleep Medicine guidelines. These results demonstrate the feasibility of using unobtrusive load cells installed under the bed to measure the apnea-hypopnea index.

Accurate scoring of the apnea-hypopnea index using a simple non-contact breathing sensor.

Quality of sleep is an important attribute of an individual's health state and its assessment is therefore a useful diagnostic feature. Changes in the patterns of mobility in bed during sleep can be a disease marker or can reflect various abnormal physiological and neurological conditions. This paper describes a method for detection of movement in bed that is evaluated on data collected from patients admitted for regular polysomnography. The system is based on load cells installed at the supports of a bed. Since the load cell signal varies the most during movement, the approach uses a weighted combination of the short-term mean-square differences of each load cell signal to capture the variations in the signal caused by movement. We use a single univariate Gaussian model to represent each class: movement versus non-movement. We assess the performance of the method against manual annotation performed by a sleep clinic technician from seventeen patients. The proposed detection method achieved an overall sensitivity of 97.9% and specificity of 98.7%.

A Gaussian model for movement detection during sleep.

Poor quality of sleep increases the risk of many adverse health outcomes. Some measures of sleep, such as sleep efficiency or sleep duration, are calculated from periods of time when a patient is asleep and awake. The current method for assessing sleep and wakefulness is based on polysomnography, an expensive and inconvenient method of measuring sleep in a clinical setting. In this paper, we suggest an alternative method of detecting periods of sleep and wake that can be obtained unobtrusively in a patient's own home by placing load cells under the supports of their bed. Specifically, we use a support vector machine to classify periods of sleep and wake in a cohort of patients admitted to a sleep lab. The inputs to the classifier are subject demographic information, a statistical characterization of the load cell derived signals, and several sleep parameters estimated from the load cell data that are related to movement and respiration. Our proposed classifier achieves an average sensitivity of 0.808 and specificity of 0.812 with 90% confidence intervals of (0.790, 0.821) and (0.798, 0.826), respectively, when compared to the "gold-standard" sleep/wake annotations during polysomnography. As this performance is over 27 sleep patients with a wide variety of diagnosis levels of sleep disordered breathing, age, body mass index, and other demographics, our method is robust and works well in clinical practice.

Unobtrusive classification of sleep and wakefulness using load cells under the bed.

Sleep apnea is a breathing disorder that affects many individuals and has been associated with serious health conditions such as cardiovascular disease. Clinical diagnosis of sleep apnea requires that a patient spend the night in a sleep clinic while being wired up to numerous obtrusive sensors. We are developing a system that utilizes respiration rate and breathing amplitude inferred from non-contact bed sensors (i.e. load cells placed under bed supports) to detect sleep apnea. Multi-harmonic artifacts generated either biologically or as a result of the impulse response of the bed have made it challenging to track respiration rate and amplitude with high resolution in time. In this paper, we present an algorithm that can accurately track respiration on a second-by-second basis while removing noise harmonics. The algorithm is tested using data collected from 5 patients during overnight sleep studies. Respiration rate is compared with polysomnography estimations of respiration rate estimated by a technician following clinical standards. Results indicate that certain subjects exhibit a large harmonic component of their breathing signal that can be removed by our algorithm. When compared with technician transcribed respiration rates using polysomnography signals, we demonstrate improved accuracy of respiration rate tracking using harmonic artifact rejection (mean error: 0.18 breaths/minute) over tracking not using harmonic artifact rejection (mean error: -2.74 breaths/minute).

Article	Year
Algorithm for automatic beat detection of cardiovascular pressure signals. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference\| PubMed ID: 19163234	2008
Classification of breathing events using load cells under the bed. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference\| PubMed ID: 19964321	2009
A subject state detection approach to determine rest-activity patterns using load cells. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference\| PubMed ID: 21097181	2010
Classification of lying position using load cells under the bed. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference\| PubMed ID: 22254351	2011
Accurate scoring of the apnea-hypopnea index using a simple non-contact breathing sensor. Journal of sleep research\| PubMed ID: 23363404	2013
A Gaussian model for movement detection during sleep. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference\| PubMed ID: 23366374	2012
Unobtrusive classification of sleep and wakefulness using load cells under the bed. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference\| PubMed ID: 23367114	2012
A time-frequency respiration tracking system using non-contact bed sensors with harmonic artifact rejection. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference\| PubMed ID: 26738176	2015

Zachary Beattie

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