James B. Hurley

Department of Biochemistry, University of Washington

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 5	2018
Publication title Cited by 2	2023

Other Publications

Article	Year
The core domain of a new retina specific RGS protein stimulates the GTPase activity of transducin in vitro. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9096326	1997
A new form of inherited red-blindness identified in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 9151740	1997
Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9600905	1998
Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10097103	1999
Biochemical analysis of a dimerization domain mutation in RetGC-1 associated with dominant cone-rod dystrophy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10430891	1999
Folding and subunit assembly of photoreceptor peripherin/rds is mediated by determinants within the extracellular/intradiskal EC2 domain: implications for heterogeneous molecular pathologies... The Journal of biological chemistry\| PubMed ID: 11553636	2001
Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2). Molecular and cellular biology\| PubMed ID: 11713293	2001
Shedding light on adaptation. The Journal of general physiology\| PubMed ID: 11815663	2002
Mass spectrometric analysis of the kinetics of in vivo rhodopsin phosphorylation. Protein science : a publication of the Protein Society\| PubMed ID: 11910029	2002
Analysis of the visual cycle in cellular retinol-binding protein type I (CRBPI) knockout mice. Investigative ophthalmology & visual science\| PubMed ID: 12036972	2002
Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12533607	2003
Acceleration of key reactions as a strategy to elucidate the rate-limiting chemistry underlying phototransduction inactivation. Investigative ophthalmology & visual science\| PubMed ID: 12601023	2003
AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14555765	2003
Visual pigment phosphorylation but not transducin translocation can contribute to light adaptation in zebrafish cones. Neuron\| PubMed ID: 15046724	2004
A zebrafish model for pyruvate dehydrogenase deficiency: rescue of neurological dysfunction and embryonic lethality using a ketogenic diet. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15070761	2004
Functional analyses of mutant recessive GUCY2D alleles identified in Leber congenital amaurosis patients: protein domain comparisons and dominant negative effects. Molecular vision\| PubMed ID: 15123990	2004
Zebrafish rx3 and mab21l2 are required during eye morphogenesis. Developmental biology\| PubMed ID: 15183718	2004
Leber congenital amaurosis linked to AIPL1: a mouse model reveals destabilization of cGMP phosphodiesterase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15365178	2004
The zebrafish nrc mutant reveals a role for the polyphosphoinositide phosphatase synaptojanin 1 in cone photoreceptor ribbon anchoring. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15470129	2004
Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina. Neuron\| PubMed ID: 15882641	2005
Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Neuron\| PubMed ID: 15944125	2005
Scotopic and photopic visual thresholds and spatial and temporal discrimination evaluated by behavior of mice in a water maze. Photochemistry and photobiology\| PubMed ID: 16683905	2006
Biochemical function of the LCA linked protein, aryl hydrocarbon receptor interacting protein like-1 (AIPL1). Role of AIPL1 in retina. Advances in experimental medicine and biology\| PubMed ID: 17249560	2006
Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17507570	2007
Regulation of arrestin binding by rhodopsin phosphorylation level. The Journal of biological chemistry\| PubMed ID: 17848565	2007
Mechanism of light-induced translocation of arrestin and transducin in photoreceptors: interaction-restricted diffusion. IUBMB life\| PubMed ID: 18379987	2008
Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina. PloS one\| PubMed ID: 19381277	2009
AIPL1, a protein associated with childhood blindness, interacts with alpha-subunit of rod phosphodiesterase (PDE6) and is essential for its proper assembly. The Journal of biological chemistry\| PubMed ID: 19758987	2009
Arrestin competition influences the kinetics and variability of the single-photon responses of mammalian rod photoreceptors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19776273	2009
Relationships among visual cycle retinoids, rhodopsin phosphorylation, and phototransduction in mouse eyes during light and dark adaptation. Biochemistry\| PubMed ID: 20155952	2010
Optimal processing of photoreceptor signals is required to maximize behavioural sensitivity. The Journal of physiology\| PubMed ID: 20403975	2010
Flow of energy in the outer retina in darkness and in light. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20445106	2010
PRE-1, a cis element sufficient to enhance cone- and rod- specific expression in differentiating zebrafish photoreceptors. BMC developmental biology\| PubMed ID: 21261954	2011
CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA. Neuron\| PubMed ID: 21689595	2011
Roles of glucose in photoreceptor survival. The Journal of biological chemistry\| PubMed ID: 21840997	2011
Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22223655	2012
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy\| PubMed ID: 22966490	2012
Cytosolic reducing power preserves glutamate in retina. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24127593	2013
Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina. The Journal of biological chemistry\| PubMed ID: 24187136	2013
The retinal pigment epithelium utilizes fatty acids for ketogenesis. The Journal of biological chemistry\| PubMed ID: 24898254	2014
Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25313047	2014
Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis. Cancer cell\| PubMed ID: 25640402	2015
Glucose, lactate, and shuttling of metabolites in vertebrate retinas. Journal of neuroscience research\| PubMed ID: 25801286	2015
It's never too late to save a photoreceptor. The Journal of clinical investigation\| PubMed ID: 26301805	2015
Probing Metabolism in the Intact Retina Using Stable Isotope Tracers. Methods in enzymology\| PubMed ID: 26358904	2015
Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina. The Journal of biological chemistry\| PubMed ID: 26677218	2016
Deficient glucose and glutamine metabolism in knockout mice contributes to altered visual function. Molecular vision\| PubMed ID: 27746674	2016
Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. The Journal of clinical investigation\| PubMed ID: 27841758	2016
Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27911769	2016
Mitochondria Maintain Distinct Ca Pools in Cone Photoreceptors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 28115482	2017
Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side. The Journal of biological chemistry\| PubMed ID: 28615447	2017
Warburg's vision. eLife\| PubMed ID: 28681722	2017
Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye. eLife\| PubMed ID: 28901286	2017
Pyruvate kinase M2 regulates photoreceptor structure, function, and viability. Cell death & disease\| PubMed ID: 29445082	2018
How Excessive cGMP Impacts Metabolic Proteins in Retinas at the Onset of Degeneration. Advances in experimental medicine and biology\| PubMed ID: 29721955	2018
Impact of euthanasia, dissection and postmortem delay on metabolic profile in mouse retina and RPE/choroid. Experimental eye research\| PubMed ID: 29864440	2018
Loss of MPC1 reprograms retinal metabolism to impair visual function. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30808746	2019
Increasing Ca in photoreceptor mitochondria alters metabolites, accelerates photoresponse recovery, and reveals adaptations to mitochondrial stress. Cell death and differentiation\| PubMed ID: 31371786	2020
Retinal disease: How to use proteomics to speed up diagnosis and metabolomics to slow down degeneration. EBioMedicine\| PubMed ID: 32113163	2020
Non-photopic and photopic visual cycles differentially regulate immediate, early, and late phases of cone photoreceptor-mediated vision. The Journal of biological chemistry\| PubMed ID: 32238432	2020
Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O-Rich Pigment Epithelium. Cell reports\| PubMed ID: 32375026	2020
Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca uptake in photoreceptor mitochondria. Scientific reports\| PubMed ID: 32994451	2020
Daily mitochondrial dynamics in cone photoreceptors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33144507	2020
Absence of retbindin blocks glycolytic flux, disrupts metabolic homeostasis, and leads to photoreceptor degeneration. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33526685	2021
Effect of selectively knocking down key metabolic genes in Müller glia on photoreceptor health. Glia\| PubMed ID: 33835598	2021
Mitochondria: The Retina's Achilles' Heel in AMD. Advances in experimental medicine and biology\| PubMed ID: 33848005	2021
Retina Metabolism and Metabolism in the Pigmented Epithelium: A Busy Intersection. Annual review of vision science\| PubMed ID: 34102066	2021
Fluidics system for resolving concentration-dependent effects of dissolved gases on tissue metabolism. eLife\| PubMed ID: 34734803	2021
An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice. Investigative ophthalmology & visual science\| PubMed ID: 34797906	2021
Extracellular matrix dysfunction in Sorsby patient-derived retinal pigment epithelium. Experimental eye research\| PubMed ID: 34929159	2022
Monocarboxylate Transporter 1 (MCT1) Mediates Succinate Export in the Retina. Investigative ophthalmology & visual science\| PubMed ID: 35363247	2022
Succinate metabolism in the retinal pigment epithelium uncouples respiration from ATP synthesis. Cell reports\| PubMed ID: 35675773	2022
Transducin-Deficient Rod Photoreceptors Evaluated With Optical Coherence Tomography and Oxygen Consumption Rate Energy Biomarkers. Investigative ophthalmology & visual science\| PubMed ID: 36576748	2022
The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging. eLife\| PubMed ID: 36799304	2023
Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina. bioRxiv : the preprint server for biology\| PubMed ID: 37131780	2023
Aerobic Glycolysis in Photoreceptors Supports Energy Demand in the Absence of Mitochondrial Coupling. Advances in experimental medicine and biology\| PubMed ID: 37440069	2023