mouse-models-of-helicobacter-infection-and-gastric-pathologies

Mouse Models Of <em>Helicobacter</em> Infection And Gastric Pathologies

Helicobacter pylori is a gastric pathogen that is present in half of the global population and is a significant cause of morbidity and mortality in ...

Hudson institute of Medical Research

Mouse infection studies have shown that interferon-γ (IFN-γ), a T helper 1 (Th1) cytokine, is required for the development of severe pathology induced by chronic  infection. This finding is largely based on studies performed using mice that have polarised Th1 responses i.e. C57BL/6 animals. The current work aims to investigate the role of IFN-γ in -induced inflammation in BALB/c mice which have Th2-polarised immune responses.

Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in -infected BALB/c mice.

Persistent stomach infection with Helicobacter pylori causes chronic mucosal inflammation (gastritis), which is widely recognized as an essential precursor to gastric cancer. The IL-1 interleukin family cytokines IL-1β and IL-18 have emerged as central mediators of mucosal inflammation. Here, we review the regulation and functions of these cytokines in H. pylori-induced inflammation and carcinogenesis.

Article	Year
Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in -infected BALB/c mice. Gut pathogens\| PubMed ID: 27895717	2016
Regulation and functions of inflammasome-mediated cytokines in Helicobacter pylori infection. Microbes and infection\| PubMed ID: 28690082	2017

Michelle Chonwerawong

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