a-recovery-cardiopulmonary-bypass-model-without-transfusion-or

A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats

Cardiopulmonary bypass (CPB) is indispensable in cardiovascular surgery. Despite the dramatic refinement of CPB technique and devices, multi-organ ...

Kyoto University

Intravascular ultrasound observation of an obstruction of the left main coronary artery caused by displaced leaflet calcification and hematoma after transcatheter aortic valve implantation.

Inflammation-mediated elastin destruction in the aortic medial layer is related to progression of abdominal aortic aneurysm (AAA). Epigallocatechin-3-gallate (EGCG), a major component of green tea polyphenols, reportedly increases elastin synthesis in vitro and may possess anti-inflammatory effects. We used a rat model to investigate whether EGCG could prevent AAA progression.

Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model.

Cardiopulmonary bypass (CPB) may induce systemic inflammatory responses causing acute lung injury. Recombinant human soluble thrombomodulin (rTM) is reported to attenuate the secretion of inflammatory cytokines and the high-mobility group box 1 (HMGB1) protein, which is critical in controlling systemic inflammation and apoptosis. We investigated the protective effects of rTM on CPB-induced lung injury in a rat model.

Article	Year
Intravascular ultrasound observation of an obstruction of the left main coronary artery caused by displaced leaflet calcification and hematoma after transcatheter aortic valve implantation. Circulation\| PubMed ID: 25691706	2015
Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model. Journal of vascular surgery\| PubMed ID: 27473778	2017
Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 28645823	2017

Shingo Hirao

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