Ryoichiro Kageyama

Institute for Frontier Life and Medical Sciences, Kyoto University

Affiliated withKyoto University Kyoto University Graduate School of Medicine Kyoto University Graduate School of Biostudies

Research Area

Biography

Ryoichiro Kageyama has not added Biography.
If you are Ryoichiro Kageyama and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 1	2018
Publication title Cited by 2	2019

Other Publications

Article	Year
The bHLH gene Hes1 is essential for expansion of early T cell precursors. Genes & development\| PubMed ID: 10323870	1999
The bHLH gene hes1 as a repressor of the neuronal commitment of CNS stem cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 10627606	2000
Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system. The EMBO journal\| PubMed ID: 11032813	2000
The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11160397	2001
BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11331769	2001
Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11425898	2001
Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. The EMBO journal\| PubMed ID: 11500373	2001
Dynamic expression and essential functions of Hes7 in somite segmentation. Genes & development\| PubMed ID: 11641270	2001
Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development (Cambridge, England)\| PubMed ID: 11861467	2002
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science (New York, N.Y.)\| PubMed ID: 12399594	2002
Retrovirus-mediated gene transfer to retinal explants. Methods (San Diego, Calif.)\| PubMed ID: 12507456	2002
Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine. FEBS letters\| PubMed ID: 12560091	2003
Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. Genes & development\| PubMed ID: 12783854	2003
Oscillations, clocks and segmentation. Current opinion in genetics & development\| PubMed ID: 12888011	2003
The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. The Journal of biological chemistry\| PubMed ID: 12947105	2003
Retroviral vectors for gene delivery to neural precursor cells. International review of neurobiology\| PubMed ID: 12968534	2003
Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Molecular and cellular biology\| PubMed ID: 12972594	2003
Fate of neural stem cells grafted into injured inner ears of mice. Neuroreport\| PubMed ID: 14512836	2003
Roles of the bHLH gene Hes1 in retinal morphogenesis. Brain research\| PubMed ID: 15033430	2004
Retinal cell fate determination and bHLH factors. Seminars in cell & developmental biology\| PubMed ID: 15036211	2004
Identification of a novel basic helix-loop-helix gene, Heslike, and its role in GABAergic neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15071116	2004
Overexpression of RFT induces G1-S arrest and apoptosis via p53/p21(Waf1) pathway in glioma cell. Biochemical and biophysical research communications\| PubMed ID: 15081425	2004
Requirement of multiple basic helix-loop-helix genes for retinal neuronal subtype specification. The Journal of biological chemistry\| PubMed ID: 15105417	2004
Instability of Hes7 protein is crucial for the somite segmentation clock. Nature genetics\| PubMed ID: 15170214	2004
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15353594	2004
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development (Cambridge, England)\| PubMed ID: 15496443	2004
Otx2 homeobox gene induces photoreceptor-specific phenotypes in cells derived from adult iris and ciliary tissue. Investigative ophthalmology & visual science\| PubMed ID: 15557469	2004
The role of notch signaling in the development of intrahepatic bile ducts. Gastroenterology\| PubMed ID: 15578515	2004
Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine. Biochemical and biophysical research communications\| PubMed ID: 15670790	2005
Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. Molecular and cellular biology\| PubMed ID: 15870295	2005
Roles of bHLH genes in neural stem cell differentiation. Experimental cell research\| PubMed ID: 15925590	2005
Mash1 and Math3 are required for development of branchiomotor neurons and maintenance of neural progenitors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15976074	2005
Iris-derived cells from adult rodents and primates adopt photoreceptor-specific phenotypes. Investigative ophthalmology & visual science\| PubMed ID: 16123446	2005
Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors. The EMBO journal\| PubMed ID: 16292344	2005
Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16432209	2006
Hes1 and Hes5 regulate the development of the cranial and spinal nerve systems. Developmental neuroscience\| PubMed ID: 16508307	2006
Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. The Journal of cell biology\| PubMed ID: 16651378	2006
Temporal regulation of Cre recombinase activity in neural stem cells. Genesis (New York, N.Y. : 2000)\| PubMed ID: 16652364	2006
Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. The Journal of clinical investigation\| PubMed ID: 16710472	2006
Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system. Development (Cambridge, England)\| PubMed ID: 16728479	2006
The 20th IUBMB International Congress in Kyoto. IUBMB life\| PubMed ID: 16754309	2006
Notch1 expression is spatiotemporally correlated with neurogenesis and negatively regulated by Notch1-independent Hes genes in the developing nervous system. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 16766699	2006
[Biological clock as a conductor for embryogenesis]. Seikagaku. The Journal of Japanese Biochemical Society\| PubMed ID: 16856559	2006
High levels of Cre expression in neuronal progenitors cause defects in brain development leading to microencephaly and hydrocephaly. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16971543	2006
Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Genes & development\| PubMed ID: 17015435	2006
The Hes gene family: repressors and oscillators that orchestrate embryogenesis. Development (Cambridge, England)\| PubMed ID: 17329370	2007
Oscillator mechanism of Notch pathway in the segmentation clock. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 17366573	2007
Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 17426285	2007
Regulation of retinal cell fate specification by multiple transcription factors. Brain research\| PubMed ID: 17488643	2008
Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17592117	2007
The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Developmental cell\| PubMed ID: 17681139	2007
Mash1 is required for neuroendocrine cell development in the glandular stomach. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 18173746	2008
Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron\| PubMed ID: 18400163	2008
[Transcription factor network that regulates neural development]. Brain and nerve = Shinkei kenkyu no shinpo\| PubMed ID: 18421974	2008
Roles of Hes genes in neural development. Development, growth & differentiation\| PubMed ID: 18430159	2008
Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7. Biochemical and biophysical research communications\| PubMed ID: 18477475	2008
Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development (Cambridge, England)\| PubMed ID: 18579678	2008
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nature neuroscience\| PubMed ID: 18758458	2008
Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition. Nature neuroscience\| PubMed ID: 18956012	2008
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity\| PubMed ID: 18976936	2008
Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. PloS one\| PubMed ID: 19050759	2008
Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. The Journal of cell biology\| PubMed ID: 19124651	2009
Hopf bifurcation in the presomitic mesoderm during the mouse segmentation. Journal of theoretical biology\| PubMed ID: 19236883	2009
Continuous neurogenesis in the adult brain. Development, growth & differentiation\| PubMed ID: 19298551	2009
Rhythmic gene expression in somite formation and neural development. Molecules and cells\| PubMed ID: 19466597	2009
Dynamic advances in NF-kappaB signaling analysis. Science signaling\| PubMed ID: 19638614	2009
The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes & development\| PubMed ID: 19684110	2009
Dynamic regulation of Notch signaling in neural progenitor cells. Current opinion in cell biology\| PubMed ID: 19783418	2009
Spatiotemporal pattern in somitogenesis: a non-Turing scenario with wave propagation. Physical review. E, Statistical, nonlinear, and soft matter physics\| PubMed ID: 19792150	2009
Practical lessons from theoretical models about the somitogenesis. Gene regulation and systems biology\| PubMed ID: 19936076	2007
Maximizing functional photoreceptor differentiation from adult human retinal stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 20014120	2010
Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20203209	2010
Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 20545770	2010
Automatic reconstruction of the mouse segmentation network from an experimental evidence database. Bio Systems\| PubMed ID: 20682331	2010
Ultradian oscillations in Notch signaling regulate dynamic biological events. Current topics in developmental biology\| PubMed ID: 20816400	2010
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. Developmental biology\| PubMed ID: 21300049	2011
Intronic delay is essential for oscillatory expression in the segmentation clock. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21300886	2011
Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells. The Journal of biological chemistry\| PubMed ID: 21349854	2011
Continuous neurogenesis in the adult forebrain is required for innate olfactory responses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21536899	2011
The role of Notch signaling in adult neurogenesis. Molecular neurobiology\| PubMed ID: 21541768	2011
The role of neurogenesis in olfaction-dependent behaviors. Behavioural brain research\| PubMed ID: 21557970	2012
Genetic methods to identify and manipulate newly born neurons in the adult brain. Frontiers in neuroscience\| PubMed ID: 21562606	2011
Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis. Genes & development\| PubMed ID: 21632822	2011
Dynamic expression of notch signaling genes in neural stem/progenitor cells. Frontiers in neuroscience\| PubMed ID: 21716644	2011
Gene expression profiling of neural stem cells and identification of regulators of neural differentiation during cortical development. Stem cells (Dayton, Ohio)\| PubMed ID: 21898698	2011
The role of Hes genes in intestinal development, homeostasis and tumor formation. Development (Cambridge, England)\| PubMed ID: 22318232	2012
A multifunctional teal-fluorescent Rosa26 reporter mouse line for Cre- and Flp-mediated recombination. Neuroscience research\| PubMed ID: 22343123	2012
Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2.0. Neuroscience research\| PubMed ID: 22465523	2013
Mind bomb 1 is required for pancreatic β-cell formation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22529374	2012
In vivo evaluation of ΦC31 recombinase activity in transgenic mice. Neuroscience research\| PubMed ID: 22608021	2012
Genetic visualization of notch signaling in mammalian neurogenesis. Cellular and molecular life sciences : CMLS\| PubMed ID: 22971775	2013
Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development. Development (Cambridge, England)\| PubMed ID: 22991445	2012
MicroRNA9 regulates neural stem cell differentiation by controlling Hes1 expression dynamics in the developing brain. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 23134481	2012
Dclk1 distinguishes between tumor and normal stem cells in the intestine. Nature genetics\| PubMed ID: 23202126	2013
Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene. Cell reports\| PubMed ID: 23219549	2013
Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. The Journal of experimental medicine\| PubMed ID: 23267012	2013
Hes1 in the somatic cells of the murine ovary is necessary for oocyte survival and maturation. Developmental biology\| PubMed ID: 23274689	2013
Hyperpolarisation-activated cyclic nucleotide-gated channels regulate the spontaneous firing rate of olfactory receptor neurons and affect glomerular formation in mice. The Journal of physiology\| PubMed ID: 23318872	2013
Control of Hes7 expression by Tbx6, the Wnt pathway and the chemical Gsk3 inhibitor LiCl in the mouse segmentation clock. PloS one\| PubMed ID: 23326414	2013
Retinoid acid specifies neuronal identity through graded expression of Ascl1. Current biology : CB\| PubMed ID: 23416099	2013
Oscillatory links of Fgf signaling and Hes7 in the segmentation clock. Current opinion in genetics & development\| PubMed ID: 23465881	2013
Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease. Cell stem cell\| PubMed ID: 23746982	2013
Oscillatory gene expression and somitogenesis. Wiley interdisciplinary reviews. Developmental biology\| PubMed ID: 23799565	2012
Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development. Mechanisms of development\| PubMed ID: 23871867	2013
Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea. Development (Cambridge, England)\| PubMed ID: 23946445	2013
Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science (New York, N.Y.)\| PubMed ID: 24179156	2013
bHLH factors in self-renewal, multipotency, and fate choice of neural progenitor cells. Neuron\| PubMed ID: 24698265	2014
Hes1 oscillations contribute to heterogeneous differentiation responses in embryonic stem cells. Genes\| PubMed ID: 24710146	2011
Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24760839	2014
Dynamic expression and roles of Hes factors in neural development. Cell and tissue research\| PubMed ID: 24850276	2015
The roles and mechanism of ultradian oscillatory expression of the mouse Hes genes. Seminars in cell & developmental biology\| PubMed ID: 24865153	2014
The functional significance of newly born neurons integrated into olfactory bulb circuits. Frontiers in neuroscience\| PubMed ID: 24904263	2014
Visualization of Notch signaling oscillation in cells and tissues. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25053489	2014
Oscillatory control of bHLH factors in neural progenitors. Trends in neurosciences\| PubMed ID: 25149265	2014
Expression dynamics and functions of Hes factors in development and diseases. Current topics in developmental biology\| PubMed ID: 25248479	2014
Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions. Development (Cambridge, England)\| PubMed ID: 25249457	2014
Impact of Sox9 dosage and Hes1-mediated Notch signaling in controlling the plasticity of adult pancreatic duct cells in mice. Scientific reports\| PubMed ID: 25687338	2015
Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25733872	2015
Therapeutic targeting of HES1 transcriptional programs in T-ALL. Blood\| PubMed ID: 25784680	2015
Deubiquitinating enzymes regulate Hes1 stability and neuronal differentiation. The FEBS journal\| PubMed ID: 25846153	2015
Disappearance of centroacinar cells in the Notch ligand-deficient pancreas. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 25919081	2015
Hbp1 regulates the timing of neuronal differentiation during cortical development by controlling cell cycle progression. Development (Cambridge, England)\| PubMed ID: 26041766	2015
In vivo overactivation of the Notch signaling pathway in the developing cochlear epithelium. Hearing research\| PubMed ID: 26209882	2015
Real-time imaging of bHLH transcription factors reveals their dynamic control in the multipotency and fate choice of neural stem cells. Frontiers in cellular neuroscience\| PubMed ID: 26300726	2015
Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development. Brain research\| PubMed ID: 26348989	2015
The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS genetics\| PubMed ID: 26355680	2015
Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis. Genes & development\| PubMed ID: 26728556	2016
Oscillatory control of Delta-like1 in somitogenesis and neurogenesis: A unified model for different oscillatory dynamics. Seminars in cell & developmental biology\| PubMed ID: 26818178	2016
Making Waves toward the Shore by Synchronicity. Developmental cell\| PubMed ID: 26906731	2016
Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information. Genes & development\| PubMed ID: 28373207	2017
Topological defects control collective dynamics in neural progenitor cell cultures. Nature\| PubMed ID: 28403137	2017
Hes5 regulates the transition timing of neurogenesis and gliogenesis in mammalian neocortical development. Development (Cambridge, England)\| PubMed ID: 28851724	2017
Segmentation Genes Enter an Excited State. Developmental cell\| PubMed ID: 29065304	2017
Illuminating information transfer in signaling dynamics by optogenetics. Current opinion in cell biology\| PubMed ID: 29175322	2017
ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock. Development (Cambridge, England)\| PubMed ID: 29437832	2018
Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. The Journal of biological chemistry\| PubMed ID: 29523683	2018
Reconstitution of an Ultradian Oscillator in Mammalian Cells by a Synthetic Biology Approach. ACS synthetic biology\| PubMed ID: 29727574	2018
The proneural bHLH genes Mash1, Math3 and NeuroD are required for pituitary development. Journal of molecular endocrinology\| PubMed ID: 29941487	2018
Oscillatory Control of Notch Signaling in Development. Advances in experimental medicine and biology\| PubMed ID: 30030831	2018
Dynamic control of neural stem cells by bHLH factors. Neuroscience research\| PubMed ID: 30227160	2019
The proneural bHLH genes Mash1, Math3 and NeuroD are required for pituitary development Journal of molecular endocrinology\| PubMed ID: 30307165	2018
Multilayered gene control drives timely exit from the stem cell state in uncommitted progenitors during asymmetric neural stem cell division. Genes & development\| PubMed ID: 30463902	2018
Regulation of temporal properties of neural stem cells and transition timing of neurogenesis and gliogenesis during mammalian neocortical development. Seminars in cell & developmental biology\| PubMed ID: 30634047	2019
Timing and shaping mechanisms of neural development. Neuroscience research\| PubMed ID: 30665588	2019
Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis. Oncogene\| PubMed ID: 30705405	2019
Notch-Hes signaling in pituitary development. Expert review of endocrinology & metabolism\| PubMed ID: 30743788	2008
Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells. Genes & development\| PubMed ID: 30862660	2019
High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain. Genes & development\| PubMed ID: 30862661	2019
Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors. Scientific reports\| PubMed ID: 31160641	2019
Bursting the Notch Bubble: New Insights into In Vivo Transcriptional Dynamics. Developmental cell\| PubMed ID: 31430449	2019
Regulation of active and quiescent somatic stem cells by Notch signaling. Development, growth & differentiation\| PubMed ID: 31489617	2019
Generation of a MOR-CreER knock-in mouse line to study cells and neural circuits involved in mu opioid receptor signaling. Genesis (New York, N.Y. : 2000)\| PubMed ID: 31651080	2019
Three-dimensional live imaging of Atoh1 reveals the dynamics of hair cell induction and organization in the developing cochlea. Development (Cambridge, England)\| PubMed ID: 31676552	2019
The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension. Science signaling\| PubMed ID: 31719172	2019
Enhanced lysosomal degradation maintains the quiescent state of neural stem cells. Nature communications\| PubMed ID: 31784517	2019