Robert A. Hegele

Robarts Research Institute, Western University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 41	2018

Other Publications

Article	Year
Clinical equivalence of proprietary and generic atorvastatin in lipid clinic patients. The Canadian journal of cardiology\| PubMed ID: 22840301	2013
Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib. Drug design, development and therapy\| PubMed ID: 23055695	2012
Hypertriglyceridemia. Nutrients\| PubMed ID: 23525082	2013
The 2013 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension. The Canadian journal of cardiology\| PubMed ID: 23541660	2013
Sequencing: the next generation--what is the role of whole-exome sequencing in the diagnosis of familial cardiovascular diseases? The Canadian journal of cardiology\| PubMed ID: 24461915	2014
Exome sequencing identifies NFS1 deficiency in a novel Fe-S cluster disease, infantile mitochondrial complex II/III deficiency. Molecular genetics & genomic medicine\| PubMed ID: 24498631	2014
LipidSeq: a next-generation clinical resequencing panel for monogenic dyslipidemias. Journal of lipid research\| PubMed ID: 24503134	2014
The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. The lancet. Diabetes & endocrinology\| PubMed ID: 24731657	2014
Inducing thyrotoxicosis in the liver to treat raised cholesterol. The lancet. Diabetes & endocrinology\| PubMed ID: 24731675	2014
Simple genetics language as source of miscommunication between genetics researchers and potential research participants in informed consent documents. Public understanding of science (Bristol, England)\| PubMed ID: 24751688	2015
The 2014 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension. The Canadian journal of cardiology\| PubMed ID: 24786438	2014
Exome sequencing: new insights into lipoprotein disorders. Current cardiology reports\| PubMed ID: 24893940	2014
Linkage analysis and exome sequencing identify a novel mutation in KCTD7 in patients with progressive myoclonus epilepsy with ataxia. Epilepsia\| PubMed ID: 25060828	2014
Is plant-based cardioprotection evidence-based? The Canadian journal of cardiology\| PubMed ID: 25138482	2014
G-protein estrogen receptor as a regulator of low-density lipoprotein cholesterol metabolism: cellular and population genetic studies. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25395619	2015
Treatment of severe hypertriglyceridaemia--authors' reply. The lancet. Diabetes & endocrinology\| PubMed ID: 25439460	2014
The effect of infrequent low-dose rosuvastatin on the lipid profile. The Canadian journal of cardiology\| PubMed ID: 25442436	2014
Canadian Cardiovascular Society position statement on familial hypercholesterolemia. The Canadian journal of cardiology\| PubMed ID: 25448461	2014
Congenital sucrase-isomaltase deficiency: identification of a common Inuit founder mutation. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne\| PubMed ID: 25452324	2015
Doctor my eyes: a statin-cataract connection? The Canadian journal of cardiology\| PubMed ID: 25475455	2014
A novel LIPE nonsense mutation found using exome sequencing in siblings with late-onset familial partial lipodystrophy. The Canadian journal of cardiology\| PubMed ID: 25475467	2014
Hypertriglyceridemia in the genomic era: a new paradigm. Endocrine reviews\| PubMed ID: 25554923	2015
A novel MC4R mutation associated with childhood-onset obesity: A case report. Paediatrics & child health\| PubMed ID: 25587224	2014
A homozygous PMS2 founder mutation with an attenuated constitutional mismatch repair deficiency phenotype. Journal of medical genetics\| PubMed ID: 25691505	2015
HDL re-examined. Current opinion in lipidology\| PubMed ID: 25692348	2015
Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. European heart journal\| PubMed ID: 25694464	2015
Chylomicronaemia--current diagnosis and future therapies. Nature reviews. Endocrinology\| PubMed ID: 25732519	2015
The new dyslipidemia guidelines: what is the debate? The Canadian journal of cardiology\| PubMed ID: 25816728	2015
Cardiology patient page. Statin intolerance. Circulation\| PubMed ID: 25825402	2015
The 2015 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension. The Canadian journal of cardiology\| PubMed ID: 25936483	2015
Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease. Digestive diseases and sciences\| PubMed ID: 26160437	2015
Incident Diabetes With Statins: Biology, Artifact, or Both? The Canadian journal of cardiology\| PubMed ID: 26211707	2015
Erratum to: Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease. Digestive diseases and sciences\| PubMed ID: 26233551	2016
Old gene, new phenotype: mutations in heparan sulfate synthesis enzyme, EXT2 leads to seizure and developmental disorder, no exostoses. Journal of medical genetics\| PubMed ID: 26246518	2015
Trial Watch: Antisenses working overtime in lipids. Nature reviews. Endocrinology\| PubMed ID: 26303603	2015
Severe Hypertriglyceridemia due to a novel p.Q240H mutation in the Lipoprotein Lipase gene. Lipids in health and disease\| PubMed ID: 26337181	2015
Nonstatin Low-Density Lipoprotein-Lowering Therapy and Cardiovascular Risk Reduction-Statement From ATVB Council. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 26376908	2015
Finding the Therapeutic Sweet Spot: Using Naturally Occurring Human Variants to Inform Drug Design. Circulation. Cardiovascular genetics\| PubMed ID: 26487725	2015
Combined hyperlipidemia: familial but not (usually) monogenic. Current opinion in lipidology\| PubMed ID: 26709473	2016
Novel therapeutics in hypertriglyceridemia. Current opinion in lipidology\| PubMed ID: 26780002	2015
Integrated Measure for Atherogenic Lipoproteins in the Modern Era: Risk Assessment Based on Apolipoprotein B. Journal of the American College of Cardiology\| PubMed ID: 26791068	2016
Statin Safety in Chinese: A Population-Based Study of Older Adults. PloS one\| PubMed ID: 26954681	2016
Improving the Monitoring and Care of Patients With Familial Hypercholesterolemia. Journal of the American College of Cardiology\| PubMed ID: 26988948	2016
Pharmacogenetics of Lipid-Lowering Agents: Precision or Indecision Medicine? Current atherosclerosis reports\| PubMed ID: 26993470	2016
Applying Atherosclerotic Risk Prevention Guidelines to Elderly Patients: A Bridge Too Far? The Canadian journal of cardiology\| PubMed ID: 27040095	2016
Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension. The Canadian journal of cardiology\| PubMed ID: 27118291	2016
Rare Genetic Variants and High-Density Lipoprotein: Marching to a Different Drum. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 27127203	2016
Proprietary Considerations in the Use of Cardiovascular Genetic Data. The Canadian journal of cardiology\| PubMed ID: 27166076	2016
Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution. Atherosclerosis\| PubMed ID: 27182959	2016
Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholest... The lancet. Diabetes & endocrinology\| PubMed ID: 27246162	2016
Pharmacological Targeting of the Atherogenic Dyslipidemia Complex: The Next Frontier in CVD Prevention Beyond Lowering LDL Cholesterol. Diabetes\| PubMed ID: 27329952	2016
Complying With the National Institutes of Health Guidelines and Principles for Rigor and Reproducibility: Refutations. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 27335467	2016
Whole-genome sequencing in French Canadians from Quebec. Human genetics\| PubMed ID: 27376640	2016
Multidimensional regulation of lipoprotein lipase: impact on biochemical and cardiovascular phenotypes. Journal of lipid research\| PubMed ID: 27412676	2016
PCSK9: Regulation and Target for Drug Development for Dyslipidemia. Annual review of pharmacology and toxicology\| PubMed ID: 27575716	2017
Genetic Confirmation Rate in Clinically Suspected Maturity-Onset Diabetes of the Young. Canadian journal of diabetes\| PubMed ID: 27634015	2016
New oral agents for treating dyslipidemia. Current opinion in lipidology\| PubMed ID: 27676196	2016
Polygenic Versus Monogenic Causes of Hypercholesterolemia Ascertained Clinically. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 27765764	2016
Lomitapide for the treatment of hypertriglyceridemia. Expert opinion on investigational drugs\| PubMed ID: 27785928	2016
Seeking 'meta guidelines' for lipids. European journal of preventive cardiology\| PubMed ID: 27807189	2017
PCSK9 inhibition and diabetes: turning to Mendel for clues. The lancet. Diabetes & endocrinology\| PubMed ID: 27939390	2017
Identification and Characterization of Trimethylamine-N-oxide Uptake and Efflux Transporters. Molecular pharmaceutics\| PubMed ID: 27977217	2017
KMT2D p.Gln3575His segregating in a family with autosomal dominant choanal atresia strengthens the Kabuki/CHARGE connection. American journal of medical genetics. Part A\| PubMed ID: 27991736	2017
The Ontario Neurodegenerative Disease Research Initiative (ONDRI). The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques\| PubMed ID: 28003035	2017
Clinical utility gene card for: Sitosterolaemia. European journal of human genetics : EJHG\| PubMed ID: 28029149	2017
Genetics for the Identification of Lipid Targets Beyond PCSK9. The Canadian journal of cardiology\| PubMed ID: 28109622	2017
Variants in ANGPTL4 and the Risk of Coronary Artery Disease. The New England journal of medicine\| PubMed ID: 28112898	2016
Functional foods and dietary supplements for the management of dyslipidaemia. Nature reviews. Endocrinology\| PubMed ID: 28133369	2017
Complexity of mechanisms among human proprotein convertase subtilisin-kexin type 9 variants. Current opinion in lipidology\| PubMed ID: 28157721	2017
A Novel APOC2 Missense Mutation Causing Apolipoprotein C-II Deficiency With Severe Triglyceridemia and Pancreatitis. The Journal of clinical endocrinology and metabolism\| PubMed ID: 28201738	2017
Barriers to the Implementation of Lipoprotein Apheresis in Canada. The Canadian journal of cardiology\| PubMed ID: 28232020	2017
Genetics of Lipid and Lipoprotein Disorders and Traits. Current genetic medicine reports\| PubMed ID: 28286704	2016
Treatment of Severe Hypercholesterolemia in a Woman With Advanced Primary Sclerosing Cholangitis. JAMA cardiology\| PubMed ID: 28384790	2017
Heterozygous familial hypercholesterolemia presenting as chylomicronemia syndrome. Journal of clinical lipidology\| PubMed ID: 28391899	2017
Insulin affordability. The lancet. Diabetes & endocrinology\| PubMed ID: 28434485	2017
Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults. The Canadian journal of cardiology\| PubMed ID: 28449828	2017
PCSK9 inhibitors: smooth sailing or a little turbulence ahead? The lancet. Diabetes & endocrinology\| PubMed ID: 28483371	2017
Recent advances in genetic testing for familial hypercholesterolemia. Expert review of molecular diagnostics\| PubMed ID: 28524730	2017
Genetics of Triglycerides and the Risk of Atherosclerosis. Current atherosclerosis reports\| PubMed ID: 28534127	2017
Clinical utility gene card for: Tangier disease. European journal of human genetics : EJHG\| PubMed ID: 28537273	2017
Lomitapide for the treatment of hypercholesterolemia. Expert opinion on pharmacotherapy\| PubMed ID: 28598687	2017
Tools for Enhancement and Quality Improvement of Peer Assessment and Clinical Care in Endocrinology and Metabolism. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry\| PubMed ID: 28739080	2017
HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology. Nature reviews. Cardiology\| PubMed ID: 28795686	2018
Clinical Validation of Copy Number Variant Detection from Targeted Next-Generation Sequencing Panels. The Journal of molecular diagnostics : JMD\| PubMed ID: 28818680	2017
Polygenic determinants in extremes of high-density lipoprotein cholesterol. Journal of lipid research\| PubMed ID: 28870971	2017
Use of next-generation sequencing to detectgene copy number variation in familial hypercholesterolemia. Journal of lipid research\| PubMed ID: 28874442	2017
The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation. Journal of lipid research\| PubMed ID: 28887372	2017
Recent Advances in the Genetics of Atherothrombotic Disease and Its Determinants. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28954809	2017
ARHGEF28 p.Lys280Metfs40Ter in an amyotrophic lateral sclerosis family with a C9orf72 expansion. Neurology. Genetics\| PubMed ID: 28971145	2017
Identification of a novel synaptic protein, TMTC3, involved in periventricular nodular heterotopia with intellectual disability and epilepsy. Human molecular genetics\| PubMed ID: 28973161	2017
Imputation of Baseline LDL Cholesterol Concentration in Patients with Familial Hypercholesterolemia on Statins or Ezetimibe. Clinical chemistry\| PubMed ID: 29038147	2018
OPTN p.Met468Arg and ATXN2 intermediate length polyQ extension in families with C9orf72 mediated amyotrophic lateral sclerosis and frontotemporal dementia. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics\| PubMed ID: 29080331	2018
Food Effect on Rosuvastatin Disposition and Low-Density Lipoprotein Cholesterol. Clinical pharmacology and therapeutics\| PubMed ID: 29218707	2017
The ONDRISeq panel: custom-designed next-generation sequencing of genes related to neurodegeneration. NPJ genomic medicine\| PubMed ID: 29263818	2016
A Novel Generalized Lipodystrophy-Associated Progeroid Syndrome Due to Recurrent Heterozygous LMNA p.T10I Mutation. The Journal of clinical endocrinology and metabolism\| PubMed ID: 29267953	2018
Nutraceuticals in 2017: Nutraceuticals in endocrine disorders. Nature reviews. Endocrinology\| PubMed ID: 29286047	2018
Ezetimibe prescriptions in older Canadian adults after an acute myocardial infarction: a population-based cohort study. Lipids in health and disease\| PubMed ID: 29310674	2018
Learning From Patients With Ultrarare Conditions: Cholesterol Hoof Beats. Journal of the American College of Cardiology\| PubMed ID: 29348021	2018
Secondary causes of chylomicronemia: defining the underside of the iceberg. Journal of internal medicine\| PubMed ID: 29392780	2018
Whole genome sequencing in the clinic: empowerment or too much information? CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne\| PubMed ID: 29431109	2018
The Atherogenic Dyslipidemia Complex and Novel Approaches to Cardiovascular Disease Prevention in Diabetes. The Canadian journal of cardiology\| PubMed ID: 29459241	2017
Fatty liver in a non-obese patient. Paediatrics & child health\| PubMed ID: 29479178	2017
Complex genetic architecture in severe hypobetalipoproteinemia. Lipids in health and disease\| PubMed ID: 29540175	2018