Margaret A. Goodell

Stem Cells & Regenerative Medicine Center, Baylor College of Medicine

Affiliated withBaylor College of Medicine Texas Children's Hospital & Houston Methodist Hospital

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 26	2018

Other Publications

Article	Year
Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10588731	1999
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. The Journal of clinical investigation\| PubMed ID: 11390421	2001
Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11830662	2002
Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. Developmental biology\| PubMed ID: 11969254	2002
Stem cells: a minireview. Journal of cellular biochemistry. Supplement\| PubMed ID: 12046843	2002
Use of CD9 expression to enrich for porcine hematopoietic progenitors. Experimental hematology\| PubMed ID: 12135680	2002
The therapeutic potential of stem cells from adults. BMJ (Clinical research ed.)\| PubMed ID: 12183311	2002
Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science (New York, N.Y.)\| PubMed ID: 12193778	2002
Anti-CD45-mediated cytoreduction to facilitate allogeneic stem cell transplantation. Blood\| PubMed ID: 12433683	2003
Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration. The Journal of clinical investigation\| PubMed ID: 12511590	2003
Tracing the origin of non-hematopoietic cells using CD45 PCR restriction fragment length polymorphisms. BioTechniques\| PubMed ID: 12545553	2003
Techniques for the study of adult stem cells: be fruitful and multiply. BioTechniques\| PubMed ID: 12661162	2003
Adenoviral transduction of mouse hematopoietic stem cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 12668129	2003
Stem-cell "plasticity": befuddled by the muddle. Current opinion in hematology\| PubMed ID: 12690288	2003
Complement-fixing CD45 monoclonal antibodies to facilitate stem cell transplantation in mouse and man. Annals of the New York Academy of Sciences\| PubMed ID: 12799286	2003
Phenotype and hematopoietic potential of side population cells throughout embryonic development. Blood\| PubMed ID: 12805065	2003
Transient RNA interference in hematopoietic progenitors with functional consequences. Genesis (New York, N.Y. : 2000)\| PubMed ID: 12929091	2003
Altered phenotype and reduced function of muscle-derived hematopoietic stem cells. Experimental hematology\| PubMed ID: 12962727	2003
Isolation and characterization of functional mammary gland stem cells. Cell proliferation\| PubMed ID: 14521513	2003
Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates. Nature medicine\| PubMed ID: 14625546	2003
Primitive adult hematopoietic stem cells can function as osteoblast precursors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14673088	2003
An in vivo propagated human acute myeloid leukemia expressing ABCA3. Leukemia research\| PubMed ID: 14687625	2004
Skeletal muscle fiber-specific green autofluorescence: potential for stem cell engraftment artifacts. Stem cells (Dayton, Ohio)\| PubMed ID: 14990857	2004
Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage. Biochemistry\| PubMed ID: 15122901	2004
Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. The Journal of clinical investigation\| PubMed ID: 15124017	2004
Circulating hematopoietic stem cells do not efficiently home to bone marrow during homeostasis. Experimental hematology\| PubMed ID: 15345289	2004
Isolation and characterization of side population cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 15361673	2005
Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS biology\| PubMed ID: 15459755	2004
Roles of Sca-1 in hematopoietic stem/progenitor cell function. Experimental hematology\| PubMed ID: 15963860	2005
Hematopoietic stem cells do not engraft with absolute efficiencies. Blood\| PubMed ID: 16204316	2006
Differential mRNA processing in hematopoietic stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 16373690	2006
Evidence for diversity in transcriptional profiles of single hematopoietic stem cells. PLoS genetics\| PubMed ID: 17009876	2006
The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood\| PubMed ID: 17032926	2007
Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways. Blood\| PubMed ID: 17119121	2007
Plasticity and tissue regenerative potential of bone marrow-derived cells. Stem cell reviews\| PubMed ID: 17132877	2005
Purification of hematopoietic stem cells using the side population. Methods in enzymology\| PubMed ID: 17161700	2006
Pluripotentiality and conditional transgene regulation in human embryonic stem cells expressing insulated tetracycline-ON transactivator. Stem cells (Dayton, Ohio)\| PubMed ID: 17628023	2007
Molecular profiling of hematopoietic stem cells. Methods in molecular medicine\| PubMed ID: 17666739	2007
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS biology\| PubMed ID: 17676974	2007
Efficacy of delayed administration of post-chemotherapy granulocyte colony-stimulating factor: evidence from murine studies of bone marrow cell kinetics. Experimental hematology\| PubMed ID: 17949891	2008
CD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells. Blood\| PubMed ID: 18055867	2008
An argument against a role for Oct4 in somatic stem cells. Cell stem cell\| PubMed ID: 18371372	2007
Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell stem cell\| PubMed ID: 18371395	2007
Promiscuous expression of H2B-GFP transgene in hematopoietic stem cells. PloS one\| PubMed ID: 18523660	2008
Stem cell identification and sorting using the Hoechst 33342 side population (SP). Current protocols in cytometry\| PubMed ID: 18770827	2005
Mouse hematopoietic stem cell identification and analysis. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 19023891	2009
Identification and characterization of side population cells in embryonic stem cell cultures. Stem cells and development\| PubMed ID: 19113897	2009
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell stem cell\| PubMed ID: 19200805	2009
Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression. Molecular cancer\| PubMed ID: 19922650	2009
Enhanced generation of myeloid lineages in hematopoietic differentiation from embryonic stem cells by silencing transcriptional repressor Twist-2. Cloning and stem cells\| PubMed ID: 20025523	2009
Mechanisms of hematopoietic stem cell aging. Experimental gerontology\| PubMed ID: 20034552	2010
Chk1 haploinsufficiency results in anemia and defective erythropoiesis. PloS one\| PubMed ID: 20052416	2010
Selective elimination of a chemoresistant side population of B-CLL cells by cytotoxic T lymphocytes in subjects receiving an autologous hCD40L/IL-2 tumor vaccine. Leukemia\| PubMed ID: 20072155	2010
Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells. Experimental hematology\| PubMed ID: 20206228	2010
Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell stem cell\| PubMed ID: 20207229	2010
Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature\| PubMed ID: 20535209	2010
The expansion of T-cells and hematopoietic progenitors as a result of overexpression of the lymphoblastic leukemia gene, Lyl1 can support leukemia formation. Leukemia research\| PubMed ID: 20705338	2011
LYL1 degradation by the proteasome is directed by a N-terminal PEST rich site in a phosphorylation-independent manner. PloS one\| PubMed ID: 20844761	2010
The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells. Nature cell biology\| PubMed ID: 21076412	2010
Inflammatory signals regulate hematopoietic stem cells. Trends in immunology\| PubMed ID: 21233016	2011
Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans. PloS one\| PubMed ID: 21283700	2011
Direct conversion of skin cells into blood: alchemy or science? Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21289635	2011
A new allele of Lyl1 confirms its important role in hematopoietic stem cell function. Genesis (New York, N.Y. : 2000)\| PubMed ID: 21387538	2011
Investigating the role of hematopoietic stem and progenitor cells in regulating the osteogenic differentiation of mesenchymal stem cells in vitro. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 21495066	2011
TIMP-1 deficiency subverts cell-cycle dynamics in murine long-term HSCs. Blood\| PubMed ID: 21521782	2011
CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation. Blood\| PubMed ID: 21576698	2011
Hematopoietic stem cell characterization and isolation. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21618082	2011
Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood\| PubMed ID: 21633090	2011
Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nature reviews. Immunology\| PubMed ID: 21904387	2011
CD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway. PLoS biology\| PubMed ID: 21931533	2011
Bridge over troubled stem cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21964307	2011
Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells. PloS one\| PubMed ID: 22039481	2011
Dnmt3a is essential for hematopoietic stem cell differentiation. Nature genetics\| PubMed ID: 22138693	2012
Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood\| PubMed ID: 22289892	2012
The Hematopoietic Expression Viewer: expanding mobile apps as a scientific tool. Bioinformatics (Oxford, England)\| PubMed ID: 22576171	2012
Genomic hypomethylation in the human germline associates with selective structural mutability in the human genome. PLoS genetics\| PubMed ID: 22615578	2012
Flow cytometry analysis of murine hematopoietic stem cells. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 22736515	2013
The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors. Nature immunology\| PubMed ID: 22772404	2012
Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell stem cell\| PubMed ID: 22958929	2012
Gpr171, a putative P2Y-like receptor, negatively regulates myeloid differentiation in murine hematopoietic progenitors. Experimental hematology\| PubMed ID: 23022127	2013
Isolation and characterization of mouse side population cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23179831	2013
Confounding by repetitive elements and CpG islands does not explain the association between hypomethylation and genomic instability. PLoS genetics\| PubMed ID: 23468659	2013
Ataxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discovery. PLoS genetics\| PubMed ID: 23555280	2013
Perspectives and future directions for epigenetics in hematology. Blood\| PubMed ID: 23692857	2013
Rising from the crypt: decreasing DNA methylation during differentiation of the small intestine. Genome biology\| PubMed ID: 23714004	2013
Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells. The Journal of biological chemistry\| PubMed ID: 23729667	2013
Parental permissions: H19 and keeping the stem cell progeny under control. Cell stem cell\| PubMed ID: 23910078	2013
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells. Blood\| PubMed ID: 24167195	2013
Large conserved domains of low DNA methylation maintained by Dnmt3a. Nature genetics\| PubMed ID: 24270360	2014
Hematopoietic stem cell development: an epigenetic journey. Current topics in developmental biology\| PubMed ID: 24439802	2014
MOABS: model based analysis of bisulfite sequencing data. Genome biology\| PubMed ID: 24565500	2014
Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell stem cell\| PubMed ID: 24792119	2014
mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature\| PubMed ID: 24870234	2014
A gallon of sweat to make a pint of blood. The Journal of experimental medicine\| PubMed ID: 24980745	2014
New answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells. Experimental hematology\| PubMed ID: 24993071	2014
Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell stem cell\| PubMed ID: 25130491	2014
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. Blood\| PubMed ID: 25416277	2015
DNMT3A in haematological malignancies. Nature reviews. Cancer\| PubMed ID: 25693834	2015
Long non-coding RNAs control hematopoietic stem cell function. Cell stem cell\| PubMed ID: 25772072	2015
Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments. Nature reviews. Molecular cell biology\| PubMed ID: 25907613	2015
Comparative long-term effects of interferon α and hydroxyurea on human hematopoietic progenitor cells. Experimental hematology\| PubMed ID: 26072330	2015
Comparison of Cesium-137 and X-ray Irradiators by Using Bone Marrow Transplant Reconstitution in C57BL/6J Mice. Comparative medicine\| PubMed ID: 26141441	2015
Acute loss of TET function results in aggressive myeloid cancer in mice. Nature communications\| PubMed ID: 26607761	2015
Stem cells and healthy aging. Science (New York, N.Y.)\| PubMed ID: 26785478	2015
Noncoding Regulatory RNAs in Hematopoiesis. Current topics in developmental biology\| PubMed ID: 27137659	2016
Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes. Experimental hematology\| PubMed ID: 27208809	2016
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer cell\| PubMed ID: 27300438	2016
DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood\| PubMed ID: 27335278	2016
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells. Nature genetics\| PubMed ID: 27428748	2016
Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27582470	2016
Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. Cell reports\| PubMed ID: 27783956	2016
DNMT3A in Leukemia. Cold Spring Harbor perspectives in medicine\| PubMed ID: 28003281	2017
Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Nature communications\| PubMed ID: 28695892	2017
Genome-Wide Analysis of DNA Methylation in Hematopoietic Cells: DNA Methylation Analysis by WGBS. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28735485	2017
DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A. Genome biology\| PubMed ID: 28923089	2017
Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29382756	2018
Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo. Cell reports\| PubMed ID: 29617651	2018