Phillip D. Zamore

Department of Biochemistry & Molecular Pharmacology and Howard Hughes Medical Institute, University of Massachusetts Medical School

Affiliated withUniversity of Massachusetts Medical School

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 17	2011

Other Publications

Article	Year
Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients. Current biology : CB\| PubMed ID: 19361997	2009
Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell\| PubMed ID: 19395009	2009
MicroRNAs: regulating a change of heart. Circulation\| PubMed ID: 19398677	2009
RNAi: nature abhors a double-strand. Current opinion in genetics & development\| PubMed ID: 11893497	2002
Why do miRNAs live in the miRNP? Genes & development\| PubMed ID: 12000786	2002
Ancient pathways programmed by small RNAs. Science (New York, N.Y.)\| PubMed ID: 12016303	2002
A microRNA in a multiple-turnover RNAi enzyme complex. Science (New York, N.Y.)\| PubMed ID: 12154197	2002
Modular recognition of RNA by a human pumilio-homology domain. Cell\| PubMed ID: 12202039	2002
Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Molecular cell\| PubMed ID: 12408822	2002
A biochemical framework for RNA silencing in plants. Genes & development\| PubMed ID: 12514099	2003
siRNAs knock down hepatitis. Nature medicine\| PubMed ID: 12612573	2003
In vitro analysis of RNA interference in Drosophila melanogaster. Methods (San Diego, Calif.)\| PubMed ID: 12828947	2003
Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis. Aging cell\| PubMed ID: 12934714	2003
Asymmetry in the assembly of the RNAi enzyme complex. Cell\| PubMed ID: 14567917	2003
Biochemical dissection of RNA silencing in plants. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 14770009	2004
Sequence-specific inhibition of small RNA function. PLoS biology\| PubMed ID: 15024405	2004
Plant RNAi: How a viral silencing suppressor inactivates siRNA. Current biology : CB\| PubMed ID: 15028237	2004
RISC assembly defects in the Drosophila RNAi mutant armitage. Cell\| PubMed ID: 15035985	2004
The RNA-induced silencing complex is a Mg2+-dependent endonuclease. Current biology : CB\| PubMed ID: 15120070	2004
Kinetic analysis of the RNAi enzyme complex. Nature structural & molecular biology\| PubMed ID: 15170178	2004
MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region. The EMBO journal\| PubMed ID: 15282547	2004
A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe. Genes & development\| PubMed ID: 15371329	2004
A protein sensor for siRNA asymmetry. Science (New York, N.Y.)\| PubMed ID: 15550672	2004
MicroRNA biogenesis: drosha can't cut it without a partner. Current biology : CB\| PubMed ID: 15668159	2005
Perspective: machines for RNAi. Genes & development\| PubMed ID: 15741316	2005
Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein. PLoS biology\| PubMed ID: 15918770	2005
Ribo-gnome: the big world of small RNAs. Science (New York, N.Y.)\| PubMed ID: 16141061	2005
microPrimer: the biogenesis and function of microRNA. Development (Cambridge, England)\| PubMed ID: 16224044	2005
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell\| PubMed ID: 16271386	2005
Rethinking the microprocessor. Cell\| PubMed ID: 16751089	2006
A distinct small RNA pathway silences selfish genetic elements in the germline. Science (New York, N.Y.)\| PubMed ID: 16809489	2006
Designing siRNA that distinguish between genes that differ by a single nucleotide. PLoS genetics\| PubMed ID: 16965178	2006
RNA interference: big applause for silencing in Stockholm. Cell\| PubMed ID: 17174883	2006
RNA silencing: genomic defence with a slice of pi. Nature\| PubMed ID: 17443172	2007
The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Current biology : CB\| PubMed ID: 17604629	2007
Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell\| PubMed ID: 17662943	2007
Sorting of Drosophila small silencing RNAs. Cell\| PubMed ID: 17662944	2007
Beginning to understand microRNA function. Cell research\| PubMed ID: 17694094	2007
Small silencing RNAs. Current biology : CB\| PubMed ID: 17878043	2007
Argonaute loading improves the 5' precision of both MicroRNAs and their miRNA* strands in flies. Current biology : CB\| PubMed ID: 18207740	2008
Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells. Science (New York, N.Y.)\| PubMed ID: 18403677	2008
Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells. Nature protocols\| PubMed ID: 18802435	2008
Linking SNPs to CAG repeat length in Huntington's disease patients. Nature methods\| PubMed ID: 18931668	2008
Small silencing RNAs: an expanding universe. Nature reviews. Genetics\| PubMed ID: 19148191	2009
Nucleus and gene expression. Current opinion in cell biology\| PubMed ID: 19447016	2009
A role for microRNAs in the Drosophila circadian clock. Genes & development\| PubMed ID: 19696147	2009
The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters. Cell\| PubMed ID: 19732946	2009
Huntington's disease: silencing a brutal killer. Experimental neurology\| PubMed ID: 19786020	2009
SnapShot: Fly piRNAs, PIWI proteins, and the ping-pong cycle. Cell\| PubMed ID: 19879848	2009
SnapShot: mouse piRNAs, PIWI proteins, and the ping-pong cycle. Cell\| PubMed ID: 19914174	2009
Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway. RNA (New York, N.Y.)\| PubMed ID: 19917635	2010
Welcome to silence. Silence\| PubMed ID: 20226068	2010
Target RNA-directed trimming and tailing of small silencing RNAs. Science (New York, N.Y.)\| PubMed ID: 20558712	2010
Somatic piRNA biogenesis. The EMBO journal\| PubMed ID: 20924396	2010
Target RNA-directed tailing and trimming purifies the sorting of endo-siRNAs between the two Drosophila Argonaute proteins. RNA (New York, N.Y.)\| PubMed ID: 21106652	2011
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome research\| PubMed ID: 21177969	2011
MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21179009	2011
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell\| PubMed ID: 21183072	2010
Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease. Molecular cell\| PubMed ID: 21419681	2011
A 5'-uridine amplifies miRNA/miRNA* asymmetry in Drosophila by promoting RNA-induced silencing complex formation. Silence\| PubMed ID: 21649885	2011
Argonaute proteins. Current biology : CB\| PubMed ID: 21683893	2011
Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing. RNA (New York, N.Y.)\| PubMed ID: 21878547	2011
The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Current biology : CB\| PubMed ID: 22055293	2011
Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains. Molecular cell\| PubMed ID: 22099305	2011
Adaptation to P element transposon invasion in Drosophila melanogaster. Cell\| PubMed ID: 22196730	2011
Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22252449	2012