Stephen Lye

Department of Physiology, University of Toronto

Affiliated withUniversity of Toronto Sinai Health System

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 8	2018

Other Publications

Article	Year
Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies. The Journal of clinical investigation\| PubMed ID: 10377170	1999
Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3) The Journal of clinical investigation\| PubMed ID: 10712429	2000
Effect of labor on glucocorticoid receptor (GR(Total), GRalpha, and GRbeta) proteins in ovine intrauterine tissues. Journal of the Society for Gynecologic Investigation\| PubMed ID: 12699875	2003
Fetal signals and parturition. The journal of obstetrics and gynaecology research\| PubMed ID: 16343248	2005
Transcriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb. Molecular and cellular biology\| PubMed ID: 17452459	2007
p54nrb is a transcriptional corepressor of the progesterone receptor that modulates transcription of the labor-associated gene, connexin 43 (Gja1). Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 19423654	2009
Developmental regulation of cardiovascular function is dependent on both genotype and environment. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19783772	2009
Expression and regulation of prostaglandin receptors in the human placenta and fetal membranes at term and preterm. Reproduction, fertility, and development\| PubMed ID: 20450832	2010
Vascular-leukocyte interactions: mechanisms of human decidual spiral artery remodeling in vitro. The American journal of pathology\| PubMed ID: 20558572	2010
LOX family enzymes expression in vaginal tissue of premenopausal women with severe pelvic organ prolapse. International urogynecology journal\| PubMed ID: 20559617	2010
Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term. Journal of perinatal medicine\| PubMed ID: 20629487	2010
All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment. BMC pregnancy and childbirth\| PubMed ID: 21192811	2010
Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia. The American journal of pathology\| PubMed ID: 21356369	2011
Expression of Bone Morphogenetic Protein-1 in vaginal tissue of women with severe pelvic organ prolapse. American journal of obstetrics and gynecology\| PubMed ID: 21397208	2011
Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes\| PubMed ID: 21515849	2011
Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 21566083	2011
An integrated systems biology approach to the study of preterm birth using "-omic" technology--a guideline for research. BMC pregnancy and childbirth\| PubMed ID: 21992798	2011
Expression of genes encoding smooth muscle contractile proteins in vaginal tissue of women with and without pelvic organ prolapse. Neurourology and urodynamics\| PubMed ID: 22038928	2012
Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature genetics\| PubMed ID: 22504419	2012
Expression and function of myometrial PSF suggest a role in progesterone withdrawal and the initiation of labor. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 22669741	2012
DREAM mediated regulation of GCM1 in the human placental trophoblast. PloS one\| PubMed ID: 23300953	2013
The All Our Babies pregnancy cohort: design, methods, and participant characteristics. BMC pregnancy and childbirth\| PubMed ID: 23445747	2013
Development and validation of primary human myometrial cell culture models to study pregnancy and labour. BMC pregnancy and childbirth\| PubMed ID: 23445904	2013
Association of a body mass index genetic risk score with growth throughout childhood and adolescence. PloS one\| PubMed ID: 24244521	2013
Expression of extracellular matrix-remodeling proteins is altered in vaginal tissue of premenopausal women with severe pelvic organ prolapse. Reproductive sciences (Thousand Oaks, Calif.)\| PubMed ID: 24343133	2014
Investigation of genetic variants, birthweight and hypothalamic-pituitary-adrenal axis function suggests a genetic variant in the SERPINA6 gene is associated with corticosteroid binding glob... PloS one\| PubMed ID: 24691024	2014
A new role for monocytes in modulating myometrial inflammation during human labor. Biology of reproduction\| PubMed ID: 24829032	2014
Connexin31.1 (Gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development. Stem cells and development\| PubMed ID: 24866916	2014
Stretch-induced human myometrial cytokines enhance immune cell recruitment via endothelial activation. Cellular & molecular immunology\| PubMed ID: 24882387	2015
Inhibition of infection-mediated preterm birth by administration of broad spectrum chemokine inhibitor in mice. Journal of cellular and molecular medicine\| PubMed ID: 24894878	2014
Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin. PLoS genetics\| PubMed ID: 25010111	2014
Leukocyte driven-decidual angiogenesis in early pregnancy. Cellular & molecular immunology\| PubMed ID: 25066422	2014
Identification of a novel neutrophil population: proangiogenic granulocytes in second-trimester human decidua. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25135830	2014
Impact of bacterial and viral challenge on multidrug resistance in first- and third-trimester human placenta. The American journal of pathology\| PubMed ID: 25963552	2015
Improving customized fetal biometry by longitudinal modelling. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians\| PubMed ID: 26169714	2016
Quantitative large scale gene expression profiling from human stem cell culture micro samples using multiplex pre-amplification. Systems biology in reproductive medicine\| PubMed ID: 26237078	2016
Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy. Cellular & molecular immunology\| PubMed ID: 26277900	2017
In Vivo Evidence of the Androgen Receptor in Association With Myometrial Cell Proliferation and Apoptosis. Reproductive sciences (Thousand Oaks, Calif.)\| PubMed ID: 26342051	2016
HoxA13 Regulates Phenotype Regionalization of Human Pregnant Myometrium. The Journal of clinical endocrinology and metabolism\| PubMed ID: 26485220	2015
To serve and to protect: the role of decidual innate immune cells on human pregnancy. Cell and tissue research\| PubMed ID: 26572540	2016
Changes in vascular extracellular matrix composition during decidual spiral arteriole remodeling in early human pregnancy. Histology and histopathology\| PubMed ID: 26602431	2016
Elevated mRNA expression of PGF2α receptor splice variant 2(FP-V2) in human decidua is associated with incomplete mifepristone-misoprostol-induced early medical abortion by regulation of int... The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians\| PubMed ID: 26744271	2016
Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse. Reproductive sciences (Thousand Oaks, Calif.)\| PubMed ID: 26763525	2016
Hypothalamic-pituitary-adrenal axis activity under resting conditions and cardiovascular risk factors in adolescents. Psychoneuroendocrinology\| PubMed ID: 26802599	2016
Characterization and novel analyses of acute stress response patterns in a population-based cohort of young adults: influence of gender, smoking, and BMI. Stress (Amsterdam, Netherlands)\| PubMed ID: 26809721	2016
Impact of maternal physical activity on fetal breathing and body movement--A review. Early human development\| PubMed ID: 26811196	2016
Static Mechanical Loading Influences the Expression of Extracellular Matrix and Cell Adhesion Proteins in Vaginal Cells Derived From Premenopausal Women With Severe Pelvic Organ Prolapse. Reproductive sciences (Thousand Oaks, Calif.)\| PubMed ID: 26823071	2016
Introductory editorial: Effects of maternal physical activity on the fetus. Early human development\| PubMed ID: 26846466	2016
Summary and synthesis of current knowledge. Early human development\| PubMed ID: 26852165	2016
HoxA13 Stimulates Myometrial Cells to Secrete IL-1β and Enhance the Expression of Contraction-Associated Proteins. Endocrinology\| PubMed ID: 26982635	2016
Molecular evidence of functional progesterone withdrawal in human myometrium. Nature communications\| PubMed ID: 27220952	2016
Matrix Metalloproteinase Expression in the Rat Myometrium During Pregnancy, Term Labor, and Postpartum. Biology of reproduction\| PubMed ID: 27251092	2016
Maternal Whole Blood Gene Expression at 18 and 28 Weeks of Gestation Associated with Spontaneous Preterm Birth in Asymptomatic Women. PloS one\| PubMed ID: 27333071	2016
Preeclampsia is associated with low placental transthyretin levels. Taiwanese journal of obstetrics & gynecology\| PubMed ID: 27343320	2016
Dual Energy X-Ray Absorptiometry Compared with Anthropometry in Relation to Cardio-Metabolic Risk Factors in a Young Adult Population: Is the 'Gold Standard' Tarnished? PloS one\| PubMed ID: 27622523	2016
Early childhood development: the foundation of sustainable development. Lancet (London, England)\| PubMed ID: 27717607	2017
Nurturing care: promoting early childhood development. Lancet (London, England)\| PubMed ID: 27717615	2017
Definitive class I human leukocyte antigen expression in gestational placentation: HLA-F, HLA-E, HLA-C, and HLA-G in extravillous trophoblast invasion on placentation, pregnancy, and parturi... American journal of reproductive immunology (New York, N.Y. : 1989)\| PubMed ID: 28185362	2017
HoxA10 and HoxA11 Regulate the Expression of Contraction-Associated Proteins and Contribute to Regionalized Myometrium Phenotypes in Women. Reproductive sciences (Thousand Oaks, Calif.)\| PubMed ID: 28372536	2018
Immunophenotyping and activation status of maternal peripheral blood leukocytes during pregnancy and labour, both term and preterm. Journal of cellular and molecular medicine\| PubMed ID: 28429508	2017
Analysis of S1P Receptor Expression by Uterine Immune Cells Using Standardized Multi-parametric Flow Cytometry. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28434167	2018
Peripheral maternal leukocytes are activated in response to cytokines secreted by uterine tissues of pregnant women. Cellular & molecular immunology\| PubMed ID: 28603281	2017
Prioritizing research for integrated implementation of early childhood development and maternal, newborn, child and adolescent health and nutrition platforms. Journal of global health\| PubMed ID: 28685048	2017
Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia. Nature communications\| PubMed ID: 28794456	2017
Differential expression of myometrial AP-1 proteins during gestation and labour. Journal of cellular and molecular medicine\| PubMed ID: 28945005	2018
Maternal Vascular Malperfusion and Adverse Perinatal Outcomes in Low-Risk Nulliparous Women. Obstetrics and gynecology\| PubMed ID: 29016509	2017
Progesterone Via its Type-A Receptor Promotes Myometrial Gap Junction Coupling. Scientific reports\| PubMed ID: 29042599	2017
Comparative analysis of gene expression in maternal peripheral blood and monocytes during spontaneous preterm labor. American journal of obstetrics and gynecology\| PubMed ID: 29305255	2018
Chorioamnionitis Induces a Specific Signature of Placental ABC Transporters Associated with an Increase of miR-331-5p in the Human Preterm Placenta. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 29402780	2018
Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour. Journal of cellular and molecular medicine\| PubMed ID: 29516617	2018
Nurturing Care for Young Children under Conditions of Fragility and Conflict. New directions for child and adolescent development\| PubMed ID: 29537179	2018
Reply. American journal of obstetrics and gynecology\| PubMed ID: 29604285	2018
Maternal blood endotoxin activity in pregnancies complicated by preterm premature rupture of membranes. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians\| PubMed ID: 29656690	2018
Glucocorticoids modulate multidrug resistance transporters in the first trimester human placenta. Journal of cellular and molecular medicine\| PubMed ID: 29691980	2018