Frank B. Furnari

Ludwig Institute for Cancer Research

Affiliated withLudwig Institute for Cancer Research University of California, San Diego

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2018

Other Publications

Article	Year
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9356475	1997
In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9689095	1998
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Cancer research\| PubMed ID: 9823298	1998
A novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expression. Journal of neurochemistry\| PubMed ID: 12065666	2002
Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the phosphatidylinositol 3-kinase/Akt pathway in glioblastomas. Cancer research\| PubMed ID: 12438278	2002
Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex. Molecular and cellular biology\| PubMed ID: 15456872	2004
Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15659546	2005
PTEN: a novel anti-oncogenic function independent of phosphatase activity. Cell cycle (Georgetown, Tex.)\| PubMed ID: 15753657	2005
Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16144944	2005
PCAF modulates PTEN activity. The Journal of biological chemistry\| PubMed ID: 16829519	2006
The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17363548	2007
Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes & development\| PubMed ID: 17974913	2007
Report from the fifth National Cancer Institute Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop. Neuro-oncology\| PubMed ID: 21727208	2011
Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism. Journal of cell science\| PubMed ID: 21878501	2011
Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22891331	2012
A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments. Carcinogenesis\| PubMed ID: 23455378	2013
The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 24030701	2013
Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science (New York, N.Y.)\| PubMed ID: 24310612	2014
Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks. Cancer biology & medicine\| PubMed ID: 24349829	2013
Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity. Cancer research\| PubMed ID: 24436148	2014
A unified nomenclature and amino acid numbering for human PTEN. Science signaling\| PubMed ID: 24985344	2014
A urokinase receptor-Bim signaling axis emerges during EGFR inhibitor resistance in mutant EGFR glioblastoma. Cancer research\| PubMed ID: 25432173	2015
Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell\| PubMed ID: 25619690	2015
Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma. Nature reviews. Cancer\| PubMed ID: 25855404	2015
Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition. Oncotarget\| PubMed ID: 26059434	2015
EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling. Molecular cell\| PubMed ID: 26455392	2015
The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-). Cancer research\| PubMed ID: 26980765	2016
An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers. Cancer cell\| PubMed ID: 27746144	2016
Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 27825958	2016
Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28011764	2017
Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature\| PubMed ID: 28178237	2017
PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nature communications\| PubMed ID: 28497778	2017
Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity. Genes & development\| PubMed ID: 28724615	2017