Department of Cell Biology and Molecular Genetics, University of Maryland
Affiliated withUniversity of MarylandUniversity of Sao Paulo
Research Area
Dr. Maria Fernanda Laranjeira-Silva is a Young Researcher in the Department of Physiology at the University of Sao Paulo, Brazil. She received her undergraduate degree in Molecular Sciences and a Ph.D. from the University of Sao Paulo, Brazil.
Throughout her research career, Dr. Laranjeira-Silva developed a keen focus on host-parasite interactions and the Leishmania´s mechanisms of subverting host defense responses. During her postdoctoral training and a subsequent Research Associate position at the University of Maryland-College Park, U.S.A. with Prof. Norma Andrews and Prof. Iqbal Hamza, she began to investigate iron and heme metabolism pathways in both the parasite and mammalian host. She identified and characterized the first iron exporter (LIR1) in a trypanosomatid parasite answering an important question about how Leishmania prevents accumulation of free iron to avoid cytotoxicity.
Moving back to Brazil, Dr. Laranjeira-Silva was given a highly prestigious award from The State of Sao Paulo Research Foundation (FAPESP) and began her independent career as an Early-Stage Investigator at the University of Sao Paulo. Her ultimate research goal is to further understand Leishmania pathogenesis to define better therapeutic targets for leishmaniasis treatment.
Article Total : 2 | Year |
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![]() Publication title Cited by 11 | 2018 |
![]() Publication title Cited by 7 | 2020 |
Article | Year |
|---|---|
Melatonin attenuates Leishmania (L.) amazonensis infection by modulating arginine metabolism. Journal of pineal research| PubMed ID: 26383232 | 2015 |
RNA-seq transcriptional profiling of Leishmania amazonensis reveals an arginase-dependent gene expression regulation. PLoS neglected tropical diseases| PubMed ID: 29077741 | 2017 |
Intracellular iron availability modulates the requirement for Leishmania Iron Regulator 1 (LIR1) during macrophage infections. International journal for parasitology| PubMed ID: 30910463 | 2019 |
Ascorbate-Dependent Peroxidase (APX) from Leishmania amazonensis Is a Reactive Oxygen Species-Induced Essential Enzyme That Regulates Virulence. Infection and immunity| PubMed ID: 31527128 | 2019 |
Iron and Heme Metabolism at the Leishmania-Host Interface. Trends in parasitology| PubMed ID: 32005611 | 2020 |
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