murine-distal-colostomy-novel-model-diversion-colitis-c57bl6

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Diversion colitis (DC) is a frequent clinical condition occurring in patients with bowel segments excluded from the fecal stream as a result of a ...

Universitätsmedizin Greifswald

Development of an innovative method of endoscopic laser-supported diaphanoscopy, for precise demonstration of the location of gastrointestinal stromal tumors (GISTs) at laparoscopy is described. The equipment consists of a light transmission cable with an anchoring system for the gastric mucosa, a connecting system for the light source, and the laser light source itself. During surgery, transillumination by laser is used to show the shape of the tumor. The resection margins are then marked by electric coagulation. Ten patients have been successfully treated using this technique in laparoscopic-endoscopic rendezvous procedures. Average time of surgery was 123 minutes. The time for marking the shape of the tumor averaged 16 minutes. Depending on tumor location and size, 4-7 marks were used, and resection margins were 4-15 mm. This new and effective technique facilitates precise locating of gastric GISTs leading to exact and tissue-sparing transmural laparoscopic resections.

Laser-supported diaphanoscopy: an innovative technique for locating gastric stromal tumors in gastroscopic-laparoscopic rendezvous: a case series.

Sinus urachal persistante ou fistules, sont rares mais peuvent potentiellement causer divers sympt&ocirc;mes et mener &agrave; des op&eacute;rations r&eacute;p&eacute;t&eacute;es. La chirurgie laparoscopique tant ouverte ont &eacute;t&eacute; utilis&eacute;s pour la r&eacute;section de l&#39;ouraque.

Single-incision chirurgie laparoscopique en option pour la r&eacute;section laparoscopique d&#39;une fistule urachal : premi&egrave;re description de la technique chirurgicale.

Persistente Urachal Nebenh&ouml;hlen oder Fisteln k&ouml;nnen sind selten aber potenziell verschiedene Symptome verursachen und dazu f&uuml;hren, dass wiederholte Operationen. Sowohl offene als auch Laparoskopische Chirurgie wurden f&uuml;r die Resektion von der Urachus verwendet.

Einzel-Schnitt Laparoskopische Chirurgie als Option f&uuml;r die laparoskopische Resektion eine Urachal Fistel: erste Beschreibung der chirurgischen Technik.

Seni paranasali dell&#39;uraco persistente o fistole sono rare ma possono potenzialmente causare vari sintomi e portare a ripetute operazioni. Chirurgia laparoscopica e aperto sono stati utilizzati per la resezione dell&#39;uraco.

Mono incisione laparoscopica come un&#39;opzione per la resezione laparoscopica di una fistola dell&#39;uraco: prima descrizione della tecnica chirurgica.

Persistent urachal sinuses or fistulas are rare but may potentially cause various symptoms and lead to repeated operations. Both laparoscopic and open surgery have been used for the resection of the urachus.

Single-incision laparoscopic surgery as an option for the laparoscopic resection of an urachal fistula: first description of the surgical technique.

&#x7AA6;&#x6301;&#x4E45;&#x6027;&#x8110;&#x5C3F;&#x7BA1;&#x6216;&#x7618;&#x5F88;&#x5C11;&#xFF0C;&#x4F46;&#x53EF;&#x80FD;&#x53EF;&#x80FD;&#x5F15;&#x8D77;&#x5404;&#x79CD;&#x75C7;&#x72B6;&#xFF0C;&#x5BFC;&#x81F4;&#x91CD;&#x590D;&#x64CD;&#x4F5C;&#x3002;&#x8179;&#x8154;&#x955C;&#x4E0E;&#x5F00;&#x653E;&#x624B;&#x672F;&#x5DF2;&#x7528;&#x4E8E;&#x5207;&#x9664;&#x672F;&#x8110;&#x5C3F;&#x7BA1;&#x3002;

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&#x6C38;&#x7D9A;&#x7684;&#x306A;&#x5C3F;&#x819C;&#x7BA1;&#x526F;&#x9F3B;&#x8154;&#x3084;&#x763B;&#x5B54;&#x306F;&#x307E;&#x308C;&#x3067;&#x3059;&#x304C;&#x53EF;&#x80FD;&#x6027;&#x304C;&#x3042;&#x308A;&#x307E;&#x3059;&#x6F5C;&#x5728;&#x7684;&#x69D8;&#x3005; &#x306A;&#x75C7;&#x72B6;&#x3092;&#x5F15;&#x304D;&#x8D77;&#x3053;&#x3059;&#x3057;&#x3001;&#x7E70;&#x308A;&#x8FD4;&#x3057;&#x64CD;&#x4F5C;&#x306B; &#x3002;&#x8179;&#x8154;&#x93E1;&#x4E0B;&#x3067;&#x30AA;&#x30FC;&#x30D7;&#x30F3;&#x624B;&#x8853;&#x5C3F;&#x819C;&#x5207;&#x9664;&#x306E;&#x305F;&#x3081;&#x306B;&#x4F7F;&#x7528;&#x3055;&#x308C;&#x3066;&#x3044;&#x307E;&#x3059;&#x3002;

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&#xC601;&#xAD6C; urachal sinuses &#xB610;&#xB294; &#xB204; &#xAD00; &#xD76C;&#xADC0; &#xD558;&#xC9C0;&#xB9CC; &#xC7A0;&#xC7AC;&#xC801;&#xC73C;&#xB85C; &#xB2E4;&#xC591; &#xD55C; &#xC99D;&#xC0C1;&#xC744; &#xC77C;&#xC73C;&#xD0AC; &#xC788;&#xC73C;&#xBA70; &#xBC18;&#xBCF5;&#xB41C; &#xC791;&#xC5C5;&#xC73C;&#xB85C; &#xC774;&#xC5B4;&#xC9C8;. &#xBCF5; &#xAC15;&#xACBD; &#xBC0F; &#xC624;&#xD508; &#xC218;&#xC220;&#xC740; urachus&#xC758; &#xC808;&#xC81C;&#xC5D0; &#xB300; &#xD55C; &#xC0AC;&#xC6A9; &#xB418;&#xC5C8;&#xC2B5;&#xB2C8;&#xB2E4;.

Urachal &#xB204;&#xC758; &#xBCF5; &#xAC15;&#xACBD; &#xC808;&#xC81C;&#xC220;&#xC5D0; &#xB300; &#xD55C; &#xC635;&#xC158;&#xC73C;&#xB85C; &#xB2E8;&#xC77C; &#xC808; &#xAC1C; &#xBCF5; &#xAC15;&#xACBD; &#xC218;&#xC220;: &#xC218;&#xC220; &#xBC29;&#xBC95;&#xC758; &#xCCAB; &#xBC88;&#xC9F8; &#xC124;&#xBA85;.

Sinos Uraco persistente o f&iacute;stulas son raras pero pueden potencialmente causar diversos s&iacute;ntomas y conducir a operaciones repetitivas. Tanto laparosc&oacute;pica y la cirug&iacute;a abierta se han utilizado para la resecci&oacute;n del uraco.

Cirug&iacute;a laparosc&oacute;pica de incisi&oacute;n &uacute;nica como una opci&oacute;n para la resecci&oacute;n laparosc&oacute;pica de una f&iacute;stula uracal: primera descripci&oacute;n de la t&eacute;cnica quir&uacute;rgica.

&#x8BB8;&#x591A;&#x4E2D;&#x5FC3;&#x8179;&#x8154;&#x955C;&#x5168;&#x813E;&#x5207;&#x9664;&#x672F;&#x662F;&#x4E00;&#x79CD;&#x65E2;&#x5B9A;&#x7684;&#x4F8B;&#x884C;&#x7A0B;&#x5E8F;&#x3002;&#x7136;&#x800C;&#xFF0C;&#x5728;&#x6253;&#x51FB;&#x7EC6;&#x83CC;&#x611F;&#x67D3;&#xFF0C;&#x7279;&#x522B;&#x662F;&#x80BA;&#x708E;&#xFF0C;&#x813E;&#x7684;&#x91CD;&#x8981;&#x514D;&#x75AB;&#x4F5C;&#x7528;&#x5BFC;&#x81F4;&#x813E;&#x4FDD;&#x7559;&#x6280;&#x672F;&#x5C3D;&#x53EF;&#x80FD;&#x5BFB;&#x627E;&#x3002;&#x7136;&#x800C;&#xFF0C;&#x8179;&#x8154;&#x955C;&#x90E8;&#x5206; splenectomies &#x4ECD;&#x7136;&#x5F88;&#x5C11;&#x63CF;&#x8FF0;&#x53EF;&#x80FD;&#x56E0;&#x4E3A;&#x63A7;&#x5236;&#x671F;&#x95F4;&#x813E;&#x5207;&#x65AD;&#x672F;&#x4E2D;&#x5B9E;&#x8D28;&#x51FA;&#x8840;&#x65F6;&#x9047;&#x5230;&#x56F0;&#x96BE;&#x3002;

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In many centres, the laparoscopic total splenectomy is a well-established routine procedure. However, the crucial immunological role of the spleen in combating bacterial infections, in particular pneumonias, has led to a search for splenic-preserving techniques whenever possible. Yet, laparoscopic partial splenectomies are still rarely described possibly due to difficulties in controlling intra-operative parenchymal bleeding during splenic transection.

Laparoscopic partial splenectomy using a detachable clamp with and without partial splenic embolisation.

Dans de nombreux centres, la spl&eacute;nectomie laparoscopique totale est une proc&eacute;dure de routine bien &eacute;tablie. Cependant, le r&ocirc;le crucial et immunologique de la rate dans la lutte contre les infections bact&eacute;riennes, en particuliers pneumonies, a conduit &agrave; une recherche de techniques spl&eacute;nique-pr&eacute;server autant que possible. Encore, spl&eacute;nectomies partielles laparoscopiques sont encore rarement d&eacute;crit &eacute;ventuellement en raison de difficult&eacute;s &agrave; contr&ocirc;ler le saignement parenchymateux perop&eacute;ratoire lors de transection spl&eacute;nique.

Spl&eacute;nectomie laparoscopique partielle &agrave; l&#39;aide d&#39;une pince d&eacute;tachable avec et sans l&#39;embolisation spl&eacute;nique partielle.

In vielen Zentren ist die laparoskopische total Splenektomie ein etablierter Routine-Verfahren. Die entscheidende immunologische Rolle der Milz bei der Bek&auml;mpfung von bakterielle Infektionen, insbesondere Pneumonien, f&uuml;hrte allerdings zu einer Suche nach Milz-Erhaltung Techniken m&ouml;glichst. Laparoskopische partielle Splenectomies sind doch immer noch selten m&ouml;glicherweise aufgrund von Schwierigkeiten bei der Kontrolle der intraoperative Lungenparenchym Blutungen w&auml;hrend der Milz Transection genannt.

Laparoskopische partielle Splenektomie Verwendung eine abnehmbare Klemme mit und ohne partielle Milz Embolisation.

In molti centri, la splenectomia totale laparoscopica &egrave; una procedura di routine consolidata. Tuttavia, il ruolo cruciale immunologico della milza nella lotta contro le infezioni batteriche, in particolare polmoniti, ha portato alla ricerca di tecniche splenica conservando ogni qualvolta possibile. Ancora, splenectomies parziale laparoscopica sono ancora raramente descritto forse a causa delle difficolt&agrave; nel controllo delle emorragie parenchimali intra-operatoria durante la transezione splenica.

Splenectomia parziale laparoscopica utilizzando un morsetto staccabile con e senza parziale embolizzazione splenica.

&#x591A;&#x304F;&#x306E;&#x30BB;&#x30F3;&#x30BF;&#x30FC;&#x3067;&#x8179;&#x8154;&#x93E1;&#x4E0B;&#x7DCF;&#x813E;&#x5B9A;&#x8A55;&#x306E;&#x3042;&#x308B;&#x30EB;&#x30FC;&#x30C1;&#x30F3;&#x306E;&#x624B;&#x9806;&#x3067;&#x3059;&#x3002;&#x305F;&#x3060;&#x3057;&#x3001;&#x91CD;&#x8981;&#x306A;&#x514D;&#x75AB;&#x5B66;&#x7684;&#x5F79;&#x5272;&#x3067;&#x7279;&#x5B9A;&#x306E;&#x80BA;&#x708E;&#x306E;&#x7D30;&#x83CC;&#x611F;&#x67D3;&#x75C7;&#x3068;&#x306E;&#x95D8;&#x3044;&#x306B;&#x304A;&#x3051;&#x308B;&#x813E;&#x81D3;&#x306E;&#x813E;&#x4FDD;&#x5B58;&#x6280;&#x8853;&#x3068;&#x53EF;&#x80FD;&#x306A;&#x9650;&#x308A;&#x3092;&#x691C;&#x7D22;&#x3059;&#x308B;&#x306B;&#x3064;&#x306A;&#x304C;&#x3063;&#x3066;&#x3044;&#x307E;&#x3059;&#x3002;&#x307E;&#x3060;&#x3001;&#x8179;&#x8154;&#x93E1;&#x4E0B;&#x90E8;&#x5206;&#x7684;&#x306A; splenectomies &#x306F;&#x305D;&#x306E;&#x305D;&#x308C;&#x3067;&#x3082;&#x3081;&#x3063;&#x305F;&#x306B;&#x53EF;&#x80FD;&#x6027;&#x304C;&#x8853;&#x4E2D;&#x5B9F;&#x8CEA;&#x4E2D;&#x306B;&#x813E;&#x5207;&#x9664;&#x306F;&#x51FA;&#x8840;&#x3092;&#x5236;&#x5FA1;&#x3059;&#x308B;&#x96E3;&#x3057;&#x3055;&#x306E;&#x305F;&#x3081;&#x306B;&#x8A18;&#x8F09;&#x3055;&#x308C;&#x3066;&#x3044;&#x307E;&#x3059;&#x3002;

&#x90E8;&#x5206;&#x7684;&#x813E;&#x9A57;&#x306A;&#x3057;&#x53D6;&#x308A;&#x5916;&#x3057;&#x53EF;&#x80FD;&#x306A;&#x30AF;&#x30E9;&#x30F3;&#x30D7;&#x3092;&#x7528;&#x3044;&#x305F;&#x8179;&#x8154;&#x93E1;&#x4E0B;&#x813E;&#x90E8;&#x5206;&#x3002;

&#xB9CE;&#xC740; &#xC13C;&#xD130;&#xC5D0;&#xC11C; &#xBCF5; &#xAC15;&#xACBD; &#xCD1D; splenectomy &#xC798; &#xC124;&#xB9BD; &#xC77C;&#xC0C1;&#xC801;&#xC778; &#xC808;&#xCC28;&#xC785;&#xB2C8;&#xB2E4;. &#xADF8;&#xB7EC;&#xB098;, &#xD2B9;&#xC815; pneumonias&#xC5D0; &#xC138;&#xADE0; &#xAC10;&#xC5FC;&#xC744; &#xD1F4;&#xCE58; &#xBE44;&#xC7A5;&#xC758; &#xC911;&#xC694; &#xD55C; &#xBA74;&#xC5ED; &#xC5ED;&#xD560; &#xAC00;&#xB2A5; &#xD558;&#xBA74; &#xBE44;&#xC7A5;&#xC744; &#xBCF4;&#xC874; &#xAE30;&#xBC95;&#xC5D0; &#xB300; &#xD55C; &#xAC80;&#xC0C9;&#xC744; &#xC8FC;&#xB3C4;&#xD558; &#xACE0; &#xC788;&#xB2E4;. &#xADF8;&#xB7EC;&#xB098;, &#xBCF5; &#xAC15;&#xACBD; &#xBD80;&#xBD84; splenectomies &#xC544;&#xC9C1;&#xB3C4; &#xAC70;&#xC758; &#xC124;&#xBA85; &#xD558;&#xB294; &#xAC00;&#xB2A5; &#xD558; &#xAC8C; &#xBE44;&#xC7A5; transection &#xB3D9;&#xC548; &#xB0B4;&#xBD80; parenchymal &#xCD9C;&#xD608; &#xD1B5;&#xC81C; &#xC5B4;&#xB824;&#xC6C0; &#xB54C;&#xBB38;.

&#xBCF5; &#xAC15;&#xACBD; &#xBD80;&#xBD84; splenectomy &#xBE44;&#xC7A5; embolisation &#xBD80;&#xBD84; &#xC5C6;&#xC774; &#xBD84;&#xB9AC;&#xD615; &#xD074;&#xB7A8;&#xD504;&#xB97C; &#xC0AC;&#xC6A9; &#xD558; &#xC5EC;.

En muchos centros, la esplenectom&iacute;a total laparosc&oacute;pica es un procedimiento de rutinario bien establecido. Sin embargo, el papel crucial de la inmunol&oacute;gico del bazo en la lucha contra las infecciones bacterianas, en particulares neumon&iacute;as, ha llevado a una b&uacute;squeda de t&eacute;cnicas de preservaci&oacute;n espl&eacute;nica siempre que sea posible. Sin embargo, Esplenectomia parcial laparosc&oacute;pica a&uacute;n raramente se describe posiblemente debido a las dificultades en el control de hemorragia parenquimatosa intraoperatoria durante la transecci&oacute;n espl&eacute;nico.

Esplenectom&iacute;a parcial laparosc&oacute;pica utilizando una abrazadera desmontable con y sin embolizaci&oacute;n espl&eacute;nica parcial.

Locating gastrointestinal stromal tumors (GIST) during laparoscopic surgery continues sometimes to be difficult and inaccurate. In addition, the methods used for tumor mapping often do not lead to precise location of tumors. Also, they are too expensive or too complex for an easy surgical approach. Furthermore, the standard wedge resection often sacrifices too much healthy tissue.

Laser-supported diaphanoscopy: a new technique in laparoscopic-endoscopic rendezvous procedures allowing better and more tissue-sparing tumor resection than wedge resection.

Pancreatic pseudocysts are frequent complications following acute and chronic pancreatitis as well as abdominal trauma. They originate from enzymatic and/or necrotizing processes within the organ involving the surrounding tissues through inflammatory processes following pancreatic ductal lesion(s). Pseudocysts require definitive treatment if they become symptomatic, progressive, larger than 5 cm after a period of more than 6 weeks and/or have complications. Cystic neoplasms must be excluded before treatment. Endoscopic interventions are commonly accepted first line approaches. Should these fail or not be feasible surgical procedures have been well established and show comparable results. In summary, pancreatic pseudocysts require a reliable diagnostic approach with a multidisciplinary professional management involving gastroenterologists and surgeons.

[Therapy of pancreatic pseudocysts: endoscopy versus surgery].

Remaining urachal anomalies are seldom found but can result in long-standing recurrent symptoms and repeated surgery. In this single-centre study, we evaluated the laparoscopic approach of excision of the urachus leaving the umbilicus untouched.

Improved laparoscopic treatment of symptomatic urachal anomalies.

In this study, the standard laparoscopic technique versus the single-port approach was evaluated for the excision of benign gastric tumors using tissue-sparing laser-supported diaphanoscopy for localization. The first group consisted of 10 patients suffering from benign gastric tumors treated by standard laparoscopic resection. The second group included 10 patients treated using the single-port technique. All procedures were successfully completed. Histopathologic examination confirmed 15 cases of gastrointestinal stromal tumor, 3 cases of lipoma, 1 case of leiomyoma, and 1 case of high-grade dysplasia. There was no statistically significant difference for the operation times between both groups. Comparison of the largest and smallest resection margins achieved using the standard laparoscopic technique and single-port techniques showed no statistically significant differences between the groups. During follow-up, all patients were evaluated using the total body image and cosmesis questionnaire. Although scores of all body-image functions were similar, independent of laparoscopic technique, scores of all cosmetic functions in patients operated using the single-port technique showed a statistically significant higher degree of satisfaction with the scar (P<0185). The postoperative pain scores evaluated by the visual analog scale score were not significantly different between 2 groups. The single-port technique was found to be a feasible option for the resection of submucosal or mucosal tumors. However, this method is not intended to replace standard laparoscopic resections. 

Single-port versus standard laparoscopic resection for a gastric benign tumor in gastroscopic-laparoscopic rendezvous procedures using a laser-supported diaphanoscopy.

Copper (Cu) could be suitable to create anti-infective implants based on Titanium (Ti), for example by incorporating Cu into the implant surface using plasma immersion ion implantation (Cu-PIII). The cytotoxicity of Cu might be circumvented by an additional cell-adhesive plasma polymerized allylamine film (PPAAm). Thus, this study aimed to examine in vivo local inflammatory reactions for Ti6Al4V implants treated with Cu-PIII (Ti-Cu), alone or with an additional PPAAm film (Ti-Cu-PPAAm), compared to untreated implants (Ti). Successful Cu-PIII and PPAAm treatment was confirmed with X-ray Photoelectron Spectroscopy. Storage of Ti-Cu and Ti-Cu-PPAAm samples in double-distilled water for five days revealed a reduction of Cu release by PPAAm. Subsequently, Ti, Ti-Cu and Ti-Cu-PPAAm samples were simultaneously implanted into the neck musculature of 24 rats. After 7, 14 and 56 days, peri-implant tissue was retrieved from 8 rats/day for morphometric immunohistochemistry of different inflammatory cells. On day 56, Ti-Cu induced significantly stronger reactions compared to Ti (tissue macrophages, antigen-presenting cells, T lymphocytes) and to Ti-Cu-PPAAm (tissue macrophages, T lymphocytes, mast cells). The response for Ti-Cu-PPAAm was comparable with Ti. In conclusion, PPAAm reduced the inflammatory reactions caused by Cu-PIII. Combining both plasma processes could be useful to create antibacterial and tissue compatible Ti-based implants.

A Cell-Adhesive Plasma Polymerized Allylamine Coating Reduces the In Vivo Inflammatory Response Induced by Ti6Al4V Modified with Plasma Immersion Ion Implantation of Copper.

3D laparoscopy has proven to be superior to the 2D approach in experimental settings. The aim of the present study was to investigate the influence of 3D laparoscopy using a novel head-mounted display on the performance of defined steps within a laparoscopic inguinal hernia repair. This effect was investigated both in laparoscopically advanced surgeons and in beginners.

Randomized study of the influence of two-dimensional versus three-dimensional imaging using a novel 3D head-mounted display (HMS-3000MT) on performance of laparoscopic inguinal hernia repair.

Article	Year
Laser-supported diaphanoscopy: an innovative technique for locating gastric stromal tumors in gastroscopic-laparoscopic rendezvous: a case series. Endoscopy\| PubMed ID: 19904700	2009
Single-incision laparoscopic surgery as an option for the laparoscopic resection of an urachal fistula: first description of the surgical technique. Surgical endoscopy\| PubMed ID: 20174937	2010
Laparoscopic partial splenectomy using a detachable clamp with and without partial splenic embolisation. Langenbeck's archives of surgery / Deutsche Gesellschaft fÃ¼r Chirurgie\| PubMed ID: 20683622	2011
Laser-supported diaphanoscopy: a new technique in laparoscopic-endoscopic rendezvous procedures allowing better and more tissue-sparing tumor resection than wedge resection. Surgical endoscopy\| PubMed ID: 21136112	2011
[Therapy of pancreatic pseudocysts: endoscopy versus surgery]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen\| PubMed ID: 23371027	2013
Improved laparoscopic treatment of symptomatic urachal anomalies. World journal of urology\| PubMed ID: 23408208	2013
Single-port versus standard laparoscopic resection for a gastric benign tumor in gastroscopic-laparoscopic rendezvous procedures using a laser-supported diaphanoscopy. Surgical laparoscopy, endoscopy & percutaneous techniques\| PubMed ID: 23917596	2013
A Cell-Adhesive Plasma Polymerized Allylamine Coating Reduces the In Vivo Inflammatory Response Induced by Ti6Al4V Modified with Plasma Immersion Ion Implantation of Copper. Journal of functional biomaterials\| PubMed ID: 28726761	2017
Randomized study of the influence of two-dimensional versus three-dimensional imaging using a novel 3D head-mounted display (HMS-3000MT) on performance of laparoscopic inguinal hernia repair... Surgical endoscopy\| PubMed ID: 29777354	2018

Maciej Patrzyk

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