a-protocol-to-acquire-the-degenerative-tenocyte-from-humans

A Protocol to Acquire the Degenerative Tenocyte from Humans

Tendinopathy, a painful condition that develops in response to tendon degeneration, is on the rise in the developed world due to increasing physical ...

CHA University School of Medicine

There have been debates about the results of surgical treatment in older children, even though many studies showed excellent results in pediatric trigger thumb. The objective of this study was to identify the possible problems or complications related to the delayed surgery for trigger thumb in children. Authors clinically reexamined the patients who had undergone A1 pulley release above the age of 5 years and analyzed the results of surgical treatment.

Trigger thumb in children: results of surgical treatment in children above 5 years of age.

The purpose of this study is to report the long-term results of transphyseal Kirschner (K) wire fixation through the distal physis of ulna in distal fractures of forearm in pediatrics and to determine the safety of this procedure.

Percutaneous transphyseal pin fixation through the distal physis of the ulna in pediatric distal fractures of the forearm.

Authors chose anterior approach through the antecubital fossa for better exposure in that case of isolated coronoid process fracture. The objective of the study was to report validity of anterior approach for the Regan and Morrey type III, isolated fracture of the coronoid process of the ulna without residual valgus or varus instability. From January 2007 and January 2010, we evaluated eleven consecutive patients (7 men, 4 women; mean age 44 years; range 25-67 years) who underwent surgical fixation through the anterior approach. The mean follow-up period was 21 months (range 15-34 months). Preoperative and follow-up roentgenograms were evaluated for assessment of the fracture configuration and confirmation of fracture union. Clinical evaluation included an analysis of surgical complication, range of motion, Mayo elbow performance score, and DASH (disability of the arm, shoulder, and hand) score. Fractures were mainly fixed with plate and screws in 8 cases, cannulated screws in 3 cases. There was no residual joint instability after fracture fragment fixation. All fractures were united, and the average union time was 15.2 weeks with a range of 11-20 weeks. Mean flexion contracture of the elbow was 3.6° (range 0°-10°), and further flexion was 130.9° (range 125°-140°) at the last follow-up. Mean Mayo elbow performance score was 92.3 (range 80-100 points), and mean DASH score was 5.9 (range 1.6-8.3 points). In conclusion, Primary fixation of the coronoid process fractures through the anterior approach could be particularly useful in the Regan and Morrey type III isolated coronoid process fractures.

Anterior approach for fixation of isolated type III coronoid process fracture.

The repair of annular ligament after open reduction and internal fixation of radial head fracture could produce the irritation or crepitation during range of motion exercise. The purpose of this study is to evaluate the significance of unrepaired annular ligament during fixation of isolated radial head fractures.

Repairing the annular ligament is not necessary in the operation of Mason type 2, 3 isolated radial head fractures if the lateral collateral ligament is intact: Minimum 5 years follow-up.

The advent of locking compression plate (LCP) has provided convenient and secure fixation of distal ulna fractures. This study was performed to evaluate the functional and clinical outcomes following LCP distal ulna plate fixation of irreducible or unstable distal ulna fractures with concomitant distal radius fractures.

LCP distal ulna plate fixation of irreducible or unstable distal ulna fractures associated with distal radius fracture.

Angiofibroblastic changes of a musculotendinous origin at the medial epicondyle characterize medial epicondylitis of the elbow. Although nonsurgical treatment is the primary approach for medial epicondylitis, surgical treatment should be considered when conservative therapy fails. This study reports the results of surgical treatment of medial epicondylitis monitored for more than 5 years.

The result of surgical treatment of medial epicondylitis: analysis with more than a 5-year follow-up.

Intraarticular fracture of the metacarpophalangeal (MP) joint presents complex problems related to the sophisticated functional aspects of the hand. Injury to the metacarpal head may have a severe effect on hand function but few studies have investigated the management of this condition. In this study, we applied open reduction and internal fixation for the displaced fracture of the metacarpal head and report the clinical and radiographic outcomes of our experience. Thirteen patients (12 men, 1 woman; mean age 21 years) were included in this study, and medical records and radiographs were reviewed retrospectively. The average follow-up period was 12.5 months. Range of motion (ROM) and Disabilities of the Arm, Shoulder, and Hand (DASH) scores were analyzed, and functional results and serial radiographs were investigated for the maintenance of articular congruity and fracture union. The injured fingers were 5 long, 4 small, 2 ring, and 2 index. Five cases were fixed with K‑wires, 5 cases with headless screws, and 3 cases with screw and K‑wire. The average range of injured MP joint motion was 89°, total active range of motion (TAM) was 265°, and the average DASH score was 3.8 at the last follow-up. All patients showed fracture union on the radiographs and no patient showed significant articular surface incongruence or degenerative change. Open reduction and internal fixation of the metacarpal head fracture had favorable outcomes in our study. The authors suggest accurate reduction and stable fixation for better functional results in metacarpal head fractures.

Open reduction and internal fixation for intraarticular fracture of metacarpal head.

It was reported that substance P had beneficial effects in the healing of acute tendon injury. However, the relationship between substance P and degenerative tendinopathy development remains unclear. The purpose of this study was to determine the role of substance P in the pathogenesis of tendinopathy. Healthy and tendinopathy tendon were harvested from human and tenocytes were cultured individually. The expression levels of genes associated with tendinopathy were compared. Next, substance P was exogenously administered to the healthy tenocyte and the effect was evaluated. The results showed that tendinopathy tenocytes had higher levels of , , , , , and substance P gene expression compared to healthy tenocytes. Next, substance P treatment on the healthy tenocyte displayed similar changes to that of the tendinopathy tenocytes. These differences between the two groups were also determined by Western blot. Additionally, cells with substance P had the tendinopathy change morphologically although cellular proliferation was significantly higher compared to that of the control group. In conclusion, substance P enhanced cellular proliferation, but concomitantly increased immature collagen (type 3 collagen). Substance P plays a crucial role in tendinopathy development and could be a future therapeutic target for treatment.

The Implication of Substance P in the Development of Tendinopathy: A Case Control Study.

For patients with metacarpophalangeal (MCP) extensor tendon subluxation caused by finger flicking injury, we performed an extensor tendon realignment and direct repair technique. The purpose of this study was to evaluate the clinical outcome after direct repair of the sagittal band in patients with MCP extensor tendon subluxation caused by finger flicking injury and to introduce the repair technique.

Direct repair of the sagittal band for extensor tendon subluxation caused by finger flicking.

The treatment of radial nerve palsy caused by closed humeral shaft fracture is a matter of debate. The purpose of this study is to evaluate the outcome of early surgical management of radial nerve palsy in patients with unstable closed humeral shaft fractures and to determine whether patients with this injury should be surgically explored.

Primary exploration for radial nerve palsy associated with unstable closed humeral shaft fracture.

Authors assessed lean body mass (fat free tissue), upper and lower, and bone mineral density (BMD) in patients of osteoporotic bone distal radius fracture (DRF) and degenerative rotator cuff tear (RCT) patients of shoulder. We predict inferior muscle mass and osteoporosis are more frequent in DRF group than RCT group.

Comparison of Bone Mineral Density and Appendicular Lean Body Mass between Osteoporotic Distal Radius Fracture and Degenerative Rotator Cuff Tear in Women Patients.

We determined the prevalence of sarcopenia according to fracture site and evaluated the associated risk factors in female patients with osteoporotic fractures.

Prevalence and Associated Risk Factors of Sarcopenia in Female Patients with Osteoporotic Fracture.

Although distal radius fractures (DRF) are common fractures, intra-articular comminuted DRF with volar free fragments are uncommon. There is considerable difficulty in the fixation of free fragments beyond the watershed line using the existing volar locking plate. We aimed to examine the efficacy and potential complications associated with the use of juxta-articular volar plates in intra-articular DRF accompanied by free fragments beyond the watershed line.

Article	Year
Trigger thumb in children: results of surgical treatment in children above 5 years of age. Journal of pediatric orthopedics\| PubMed ID: 20864858	2010
Percutaneous transphyseal pin fixation through the distal physis of the ulna in pediatric distal fractures of the forearm. Journal of orthopaedic trauma\| PubMed ID: 23287758	2013
Anterior approach for fixation of isolated type III coronoid process fracture. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie\| PubMed ID: 23412150	2013
Repairing the annular ligament is not necessary in the operation of Mason type 2, 3 isolated radial head fractures if the lateral collateral ligament is intact: Minimum 5 years follow-up. Injury\| PubMed ID: 24016458	2013
LCP distal ulna plate fixation of irreducible or unstable distal ulna fractures associated with distal radius fracture. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie\| PubMed ID: 24566964	2014
The result of surgical treatment of medial epicondylitis: analysis with more than a 5-year follow-up. Journal of shoulder and elbow surgery\| PubMed ID: 27491571	2016
Open reduction and internal fixation for intraarticular fracture of metacarpal head. Der Orthopade\| PubMed ID: 28194508	2017
The Implication of Substance P in the Development of Tendinopathy: A Case Control Study. International journal of molecular sciences\| PubMed ID: 28598390	2017
Direct repair of the sagittal band for extensor tendon subluxation caused by finger flicking. Der Orthopade\| PubMed ID: 28721447	2017
Primary exploration for radial nerve palsy associated with unstable closed humeral shaft fracture. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES\| PubMed ID: 29052827	2017
Comparison of Bone Mineral Density and Appendicular Lean Body Mass between Osteoporotic Distal Radius Fracture and Degenerative Rotator Cuff Tear in Women Patients. Journal of bone metabolism\| PubMed ID: 29259963	2017
Prevalence and Associated Risk Factors of Sarcopenia in Female Patients with Osteoporotic Fracture. Journal of bone metabolism\| PubMed ID: 29564307	2018
Juxta-articular Plate Fixation in Distal Radius Intra-articular Fractures with Accompanying Volar Free Fragments beyond the Watershed Line. Clinics in orthopedic surgery\| PubMed ID: 29854335	2018

Soo-Hong Han

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