J. Paul Taylor

Developmental Neurobiology, St. Jude Children’s Research Hospital

Affiliated withSt. Jude Children’s Research Hospital

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 19	2011

Other Publications

Article	Year
Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference. Human molecular genetics\| PubMed ID: 11809726	2002
Toxic proteins in neurodegenerative disease. Science (New York, N.Y.)\| PubMed ID: 12065827	2002
Altered acetylation in polyglutamine disease: an opportunity for therapeutic intervention? Trends in molecular medicine\| PubMed ID: 12067622	2002
Hemolytic anemia presenting as idiopathic intracranial hypertension. Neurology\| PubMed ID: 12297596	2002
Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein. Human molecular genetics\| PubMed ID: 12651870	2003
Polyglutamines placed into context. Neuron\| PubMed ID: 12797953	2003
Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein. Genes & development\| PubMed ID: 12815067	2003
Valproic acid increases SMN levels in spinal muscular atrophy patient cells. Annals of neurology\| PubMed ID: 14595654	2003
A screen for drugs that protect against the cytotoxicity of polyglutamine-expanded androgen receptor. Human molecular genetics\| PubMed ID: 14709594	2004
Hsp70 dynamics in vivo: effect of heat shock and protein aggregation. Journal of cell science\| PubMed ID: 15367583	2004
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. Journal of neuropathology and experimental neurology\| PubMed ID: 17279000	2007
Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy. Acta neuropathologica\| PubMed ID: 17457594	2007
Safety, tolerability, and pharmacokinetics of high-dose idebenone in patients with Friedreich ataxia. Archives of neurology\| PubMed ID: 17562928	2007
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature\| PubMed ID: 17568747	2007
HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration. Autophagy\| PubMed ID: 17912024	2007
The role of autophagy in age-related neurodegeneration. Neuro-Signals\| PubMed ID: 18097162	2008
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy\| PubMed ID: 18188003	2008
Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. Biochimica et biophysica acta\| PubMed ID: 18930136	2008
Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress. Molecular and cellular biology\| PubMed ID: 19158272	2009
Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19228953	2009
Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis. Muscle & nerve\| PubMed ID: 19533646	2009
FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19553463	2009
Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy. Neuron\| PubMed ID: 19679072	2009
Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. Journal of proteome research\| PubMed ID: 20020773	2010
Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Human molecular genetics\| PubMed ID: 20028791	2010
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. The EMBO journal\| PubMed ID: 20075865	2010
Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080745	2010
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy\| PubMed ID: 20104022	2010
Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone. Human molecular genetics\| PubMed ID: 20147319	2010
Repeat expansion disease: progress and puzzles in disease pathogenesis. Nature reviews. Genetics\| PubMed ID: 20177426	2010
Flightless flies: Drosophila models of neuromuscular disease. Annals of the New York Academy of Sciences\| PubMed ID: 20329357	2010
B2 attenuates polyglutamine-expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy. Journal of neuroscience research\| PubMed ID: 20336775	2010
Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. The Journal of cell biology\| PubMed ID: 20457763	2010
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20519548	2010
Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy. Neuron\| PubMed ID: 20869592	2010
Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron\| PubMed ID: 21145000	2010
Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome. PLoS genetics\| PubMed ID: 21170301	2010
A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. Human molecular genetics\| PubMed ID: 21487023	2011
Mutational analysis of the VCP gene in Parkinson's disease. Neurobiology of aging\| PubMed ID: 21920633	2012
Archetypal and New Families With Alexander Disease and Novel Mutations in GFAP. Archives of neurology\| PubMed ID: 21987397	2012
A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells. PloS one\| PubMed ID: 22174917	2011