Richard Rosenquist

Department of Immunology, Uppsala University

Affiliated withUppsala University Karolinska Institutet

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 14	2018

Other Publications

Article	Year
Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood\| PubMed ID: 11877310	2002
Somatic hypermutation and V(H) gene usage in mantle cell lymphoma. European journal of haematology\| PubMed ID: 12071937	2002
Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia. Lancet (London, England)\| PubMed ID: 12493261	2002
A novel B-cell line (U-2932) established from a patient with diffuse large B-cell lymphoma following Hodgkin lymphoma. Leukemia & lymphoma\| PubMed ID: 12533045	2002
Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope. Blood\| PubMed ID: 12586612	2003
Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma. Blood\| PubMed ID: 12637326	2003
Genetic counselling for cancer and risk perception. Acta oncologica (Stockholm, Sweden)\| PubMed ID: 14690158	2003
V(H)3-21 gene usage in chronic lymphocytic leukemia--characterization of a new subgroup with distinct molecular features and poor survival. Leukemia & lymphoma\| PubMed ID: 15101705	2004
Rheumatoid arthritis and malignant lymphomas. Current opinion in rheumatology\| PubMed ID: 15103253	2004
Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood\| PubMed ID: 15217826	2004
VH gene mutation status and cellular drug resistance in chronic lymphocytic leukaemia. European journal of haematology\| PubMed ID: 15522062	2004
Heterogeneous somatic hypermutation status confounds the cell of origin in hairy cell leukemia. Leukemia research\| PubMed ID: 15607363	2005
Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome. Haematologica\| PubMed ID: 15820941	2005
Immunoglobulin Gene Analysis in Chronic Lymphocytic Leukemia. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30350197	2019
Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 15920553	2005
Lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia derives from an extensively hypermutated B cell that lacks ongoing somatic hypermutation. Leukemia research\| PubMed ID: 15927667	2005
Prognostic usage of V(H) gene mutation status and its surrogate markers and the role of antigen selection in chronic lymphocytic leukemia. Medical oncology (Northwood, London, England)\| PubMed ID: 16110132	2005
Immunoglobulin gene analysis of mature B-cell malignancies: reconsideration of cellular origin and potential antigen involvement in pathogenesis. Medical oncology (Northwood, London, England)\| PubMed ID: 16260850	2005
What is the current evidence for antigen involvement in the development of chronic lymphocytic leukemia? Hematological oncology\| PubMed ID: 16315334	2006
Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status. Blood\| PubMed ID: 16317103	2006
Telomere length and correlation with histopathogenesis in B-cell leukemias/lymphomas. European journal of haematology\| PubMed ID: 17286609	2007
Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell\| PubMed ID: 17540169	2007
Mast cell infiltration is a favourable prognostic factor in diffuse large B-cell lymphoma. British journal of haematology\| PubMed ID: 17555448	2007
Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood\| PubMed ID: 17959859	2008
U-2973, a novel B-cell line established from a patient with a mature B-cell leukemia displaying concurrent t(14;18) and MYC translocation to a non-IG gene partner. European journal of haematology\| PubMed ID: 18510704	2008
TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype. Leukemia research\| PubMed ID: 18706692	2009
Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays. Genome biology\| PubMed ID: 18796136	2008
Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios. BMC bioinformatics\| PubMed ID: 18831757	2008
Analysis of a set of missense, frameshift, and in-frame deletion variants of BRCA1. Mutation research\| PubMed ID: 18992264	2009
Rapamycin shows anticancer activity in primary chronic lymphocytic leukemia cells in vitro, as single agent and in drug combination. Leukemia & lymphoma\| PubMed ID: 19052982	2008
Monitoring minimal residual disease with flow cytometry, antigen-receptor gene rearrangements and fusion transcript quantification in Philadelphia-positive childhood acute lymphoblastic leuk... Leukemia research\| PubMed ID: 19157547	2009
Cancer genetic counselees' self-reported psychological distress, changes in life, and adherence to recommended surveillance programs 3-7 years post counseling. Journal of genetic counseling\| PubMed ID: 19212811	2009
In vitro activity of 20 agents in different prognostic subgroups of chronic lymphocytic leukemia--rolipram and prednisolone active in cells from patients with poor prognosis. European journal of haematology\| PubMed ID: 19245531	2009
Quantification of normal cell fraction and copy number neutral LOH in clinical lung cancer samples using SNP array data. PloS one\| PubMed ID: 19557126	2009
Lack of association between the MDM2 promoter polymorphism SNP309 and clinical outcome in chronic lymphocytic leukemia. Leukemia research\| PubMed ID: 19573916	2010
Does enhanced information at cancer genetic counseling improve counselees' knowledge, risk perception, satisfaction and negotiation of information to at-risk relatives?--a randomized study. Acta oncologica (Stockholm, Sweden)\| PubMed ID: 19636983	2009
Lipoprotein lipase is differentially expressed in prognostic subsets of chronic lymphocytic leukemia but displays invariably low catalytical activity. Leukemia research\| PubMed ID: 19709746	2010
Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen. Blood\| PubMed ID: 19713457	2009
A hypothesis-generating search for new genetic breast cancer syndromes--a national study in 803 Swedish families. Hereditary cancer in clinical practice\| PubMed ID: 19769788	2007
IGHV3-21 gene usage is associated with high TCL1 expression in chronic lymphocytic leukemia. European journal of haematology\| PubMed ID: 19889012	2010
Applicability of IG/TCR gene rearrangements as targets for minimal residual disease assessment in a population-based cohort of Swedish childhood acute lymphoblastic leukaemia diagnosed 2002-... European journal of haematology\| PubMed ID: 19895569	2010
Differential genome-wide array-based methylation profiles in prognostic subsets of chronic lymphocytic leukemia. Blood\| PubMed ID: 19897574	2010
Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. Nature genetics\| PubMed ID: 20062064	2010
High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4-34 B-cell receptors. Haematologica\| PubMed ID: 20421269	2010
Disclosing cancer genetic information within families: perspectives of counselees and their at-risk relatives. Familial cancer\| PubMed ID: 20577820	2010
Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors. Haematologica\| PubMed ID: 20801898	2010
TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia. Leukemia research\| PubMed ID: 20870288	2011
Quantitative evaluation of p16(INK4a) promoter methylation using pyrosequencing in de novo diffuse large B-cell lymphoma. Leukemia research\| PubMed ID: 21035853	2011
High-resolution genomic screening in mantle cell lymphoma--specific changes correlate with genomic complexity, the proliferation signature and survival. Genes, chromosomes & cancer\| PubMed ID: 21117067	2011
Minimal residual disease assessment in childhood acute lymphoblastic leukaemia: a Swedish multi-centre study comparing real-time polymerase chain reaction and multicolour flow cytometry. British journal of haematology\| PubMed ID: 21250970	2011
LPL is the strongest prognostic factor in a comparative analysis of RNA-based markers in early chronic lymphocytic leukemia. Haematologica\| PubMed ID: 21508119	2011
Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia. Haematologica\| PubMed ID: 21546498	2011
What information do cancer genetic counselees prioritize? Journal of genetic counseling\| PubMed ID: 21993709	2012
RNA-based markers as prognostic factors in chronic lymphocytic leukemia. Expert review of hematology\| PubMed ID: 22272707	2012
Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis. The Journal of experimental medicine\| PubMed ID: 22312109	2012
Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast cancer research : BCR\| PubMed ID: 22348646	2012
Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia. American journal of hematology\| PubMed ID: 22374828	2012
Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. Blood\| PubMed ID: 22415752	2012
IGHV3-21 gene frequency in a Swedish cohort of patients with newly diagnosed chronic lymphocytic leukemia. Clinical lymphoma, myeloma & leukemia\| PubMed ID: 22464020	2012
Next generation RNA-sequencing in prognostic subsets of chronic lymphocytic leukemia. American journal of hematology\| PubMed ID: 22674506	2012
Lymphoblastoid cell line with B1 cell characteristics established from a chronic lymphocytic leukemia clone by in vitro EBV infection. Oncoimmunology\| PubMed ID: 22720208	2012
Screening for cytotoxic compounds in poor-prognostic chronic lymphocytic leukemia. Anticancer research\| PubMed ID: 22843883	2012
Distinct transcriptional control in major immunogenetic subsets of chronic lymphocytic leukemia exhibiting subset-biased global DNA methylation profiles. Epigenetics\| PubMed ID: 23154584	2012
Exploring the genetic landscape in chronic lymphocytic leukemia using high-resolution technologies. Leukemia & lymphoma\| PubMed ID: 23167608	2013
Uncovering the DNA methylome in chronic lymphocytic leukemia. Epigenetics\| PubMed ID: 23321535	2013
Prognostic markers and their clinical applicability in chronic lymphocytic leukemia: where do we stand? Leukemia & lymphoma\| PubMed ID: 23480493	2013
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS genetics\| PubMed ID: 23544013	2013
Short telomere length is associated with NOTCH1/SF3B1/TP53 aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients. American journal of hematology\| PubMed ID: 23620080	2013
ANGPT2 promoter methylation is strongly associated with gene expression and prognosis in chronic lymphocytic leukemia. Epigenetics\| PubMed ID: 23803577	2013
Temporal dynamics of clonal evolution in chronic lymphocytic leukemia with stereotyped IGHV4-34/IGKV2-30 antigen receptors: longitudinal immunogenetic evidence. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 23922244	2013
Antigen selection in B-cell lymphomas--tracing the evidence. Seminars in cancer biology\| PubMed ID: 23932942	2013
DNA repair genes are selectively mutated in diffuse large B cell lymphomas. The Journal of experimental medicine\| PubMed ID: 23960188	2013
Antigens in lymphoma development--current knowledge and future directions. Seminars in cancer biology\| PubMed ID: 24080344	2013
A key role for EZH2 in epigenetic silencing of HOX genes in mantle cell lymphoma. Epigenetics\| PubMed ID: 24107828	2013
Integrated epigenomic and transcriptomic analysis reveals TP63 as a novel player in clinically aggressive chronic lymphocytic leukemia. International journal of cancer\| PubMed ID: 30447004	2018
IgG-switched CLL has a distinct immunogenetic signature from the common MD variant: ontogenetic implications. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 24240110	2014
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. Nature genetics\| PubMed ID: 24292274	2014
Lymphoma development in patients with autoimmune and inflammatory disorders--what are the driving forces? Seminars in cancer biology\| PubMed ID: 24333759	2014
The microenvironment in lymphomas--dissecting the complex crosstalk between tumor cells and 'by-stander' cells. Seminars in cancer biology\| PubMed ID: 24365642	2014
microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia. Epigenetics\| PubMed ID: 24686393	2014
Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays. Leukemia research\| PubMed ID: 24754901	2014
Immunogenetic studies of chronic lymphocytic leukemia: revelations and speculations about ontogeny and clinical evolution. Cancer research\| PubMed ID: 25074616	2014
MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis. Haematologica\| PubMed ID: 25082786	2014
Silenced B-cell receptor response to autoantigen in a poor-prognostic subset of chronic lymphocytic leukemia. Haematologica\| PubMed ID: 25085355	2014
A comprehensive evaluation of the role of genetic variation in follicular lymphoma survival. BMC medical genetics\| PubMed ID: 25294155	2014
Clonal evolution in chronic lymphocytic leukemia: impact of subclonality on disease progression. Expert review of hematology\| PubMed ID: 25345442	2015
Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting. Haematologica\| PubMed ID: 25480502	2015
An entity evolving into a community: defining the common ancestor and evolutionary trajectory of chronic lymphocytic leukemia stereotyped subset #4. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 25486132	2015
Deciphering the molecular landscape in chronic lymphocytic leukemia: time frame of disease evolution. Haematologica\| PubMed ID: 25552678	2015
Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations. Blood\| PubMed ID: 25634617	2015
Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25779943	2015
Molecular evidence for antigen drive in the natural history of mantle cell lymphoma. The American journal of pathology\| PubMed ID: 25843681	2015
An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers. Breast cancer research : BCR\| PubMed ID: 25925750	2015
SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts. Blood\| PubMed ID: 25957392	2015
The complex interplay between cell-intrinsic and cell-extrinsic factors driving the evolution of chronic lymphocytic leukemia. Seminars in cancer biology\| PubMed ID: 25963298	2015
Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia. The Journal of experimental medicine\| PubMed ID: 25987724	2015
A new piece to the stereotypy "puzzle" in chronic lymphocytic leukemia. Leukemia & lymphoma\| PubMed ID: 26133940	2015
Prognostic relevance of MYD88 mutations in CLL: the jury is still out. Blood\| PubMed ID: 26294719	2015
Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 26338994	2016
An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 26647217	2016
Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations. Blood\| PubMed ID: 26675346	2016
Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go? Haematologica\| PubMed ID: 26928246	2016
Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 26957556	2016
Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study. The Lancet. Haematology\| PubMed ID: 27030157	2014
Epigenetic silencing of miR-26A1 in chronic lymphocytic leukemia and mantle cell lymphoma: Impact on EZH2 expression. Epigenetics\| PubMed ID: 27052808	2016
Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference. Haematologica\| PubMed ID: 27102498	2016
Not all subclones matter in CLL. Blood\| PubMed ID: 27127300	2016
Prognostic impact of epigenetic classification in chronic lymphocytic leukemia: The case of subset #2. Epigenetics\| PubMed ID: 27128508	2016
The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia. Oncotarget\| PubMed ID: 27191993	2016
Different spectra of recurrent gene mutations in subsets of chronic lymphocytic leukemia harboring stereotyped B-cell receptors. Haematologica\| PubMed ID: 27198719	2016
Genetic heterogeneity in primary and relapsed mantle cell lymphomas: Impact of recurrent CARD11 mutations. Oncotarget\| PubMed ID: 27224912	2016
ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres. Haematologica\| PubMed ID: 27479817	2016
NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions. Seminars in cancer biology\| PubMed ID: 27491692	2016
B-cell malignancies: All roads lead to NF-κB activation. Seminars in cancer biology\| PubMed ID: 27546288	2016
Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond. Haematologica\| PubMed ID: 27582569	2016
Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma. Blood\| PubMed ID: 27670424	2016
Massive and parallel expression profiling using microarrayed single-cell sequencing. Nature communications\| PubMed ID: 27739429	2016
Unraveling the DNA Methylome in Mantle Cell Lymphoma: New Insights into the Cellular Origin. Cancer cell\| PubMed ID: 27846388	2016
T cells in chronic lymphocytic leukemia display dysregulated expression of immune checkpoints and activation markers. Haematologica\| PubMed ID: 27927767	2017
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. Nature communications\| PubMed ID: 28165464	2017
Possible Interaction Between Cigarette Smoking and HLA-DRB1 Variation in the Risk of Follicular Lymphoma. American journal of epidemiology\| PubMed ID: 28369180	2017
Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia. Scientific reports\| PubMed ID: 28377570	2017
Numerous Ontogenetic Roads to Mantle Cell Lymphoma: Immunogenetic and Immunohistochemical Evidence. The American journal of pathology\| PubMed ID: 28457696	2017
Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 28536306	2017
Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification. Haematologica\| PubMed ID: 28566340	2017
U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden. Acta oncologica (Stockholm, Sweden)\| PubMed ID: 28631533	2018
Reproducible diagnosis of chronic lymphocytic leukemia by flow cytometry: An European Research Initiative on CLL (ERIC) & European Society for Clinical Cell Analysis (ESCCA) Harmonisation pr... Cytometry. Part B, Clinical cytometry\| PubMed ID: 29024461	2018
No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy. Haematologica\| PubMed ID: 29269523	2018
Epigenetic deregulation in chronic lymphocytic leukemia: Clinical and biological impact. Seminars in cancer biology\| PubMed ID: 29427646	2018
Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations. Haematologica\| PubMed ID: 29449433	2018
Clinical and functional impact of recurrent mutations in mantle cell lymphoma. Blood advances\| PubMed ID: 29549086	2018
A novel high-throughput assay reveals antiproliferative effects of idelalisib and ibrutinib in chronic lymphocytic leukemia. Oncotarget\| PubMed ID: 29899839	2018
Introduction: Epigenetics in cancer. Seminars in cancer biology\| PubMed ID: 29990621	2018
Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia. Haematologica\| PubMed ID: 30262567	2018
Automated shape-based clustering of 3D immunoglobulin protein structures in chronic lymphocytic leukemia. BMC bioinformatics\| PubMed ID: 30453883	2018