Scott Diamond

Institute for Medicine and Engineering, University of Pennsylvania

Affiliated withUniversity of Pennsylvania

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 171	2008

Other Publications

Article	Year
Adenovirus or HA-2 fusogenic peptide-assisted lipofection increases cytoplasmic levels of plasmid in nondividing endothelium with little enhancement of transgene expression. The journal of gene medicine\| PubMed ID: 11828390	2002
Comparison of PSGL-1 microbead and neutrophil rolling: microvillus elongation stabilizes P-selectin bond clusters. Biophysical journal\| PubMed ID: 11916843	2002
Endovascular microcoil gene delivery using immobilized anti-adenovirus antibody for vector tethering. Stroke; a journal of cerebral circulation\| PubMed ID: 11988618	2002
Selectin-like kinetics and biomechanics promote rapid platelet adhesion in flow: the GPIb(alpha)-vWF tether bond. Biophysical journal\| PubMed ID: 12080112	2002
Adhesion of normal erythrocytes at depressed venous shear rates to activated neutrophils, activated platelets, and fibrin polymerized from plasma. Blood\| PubMed ID: 12393714	2002
Neutrophil cathepsin G promotes prothrombinase and fibrin formation under flow conditions by activating fibrinogen-adherent platelets. The Journal of biological chemistry\| PubMed ID: 12524437	2003
Shear stress causes nuclear localization of endothelial glucocorticoid receptor and expression from the GRE promoter. Circulation research\| PubMed ID: 12595339	2003
Alterations in the intrinsic properties of the GPIbalpha-VWF tether bond define the kinetics of the platelet-type von Willebrand disease mutation, Gly233Val. Blood\| PubMed ID: 12637314	2003
The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression. DNA and cell biology\| PubMed ID: 12713734	2003
Printing chemical libraries on microarrays for fluid phase nanoliter reactions. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12851459	2003
Vascular injuries to the extremities in a suburban trauma center. The American surgeon\| PubMed ID: 14570361	2003
Surfactants attenuate gas embolism-induced thrombin production. Anesthesiology\| PubMed ID: 14695727	2004
Exogenous nitric oxide activates the endothelial glucocorticoid receptor. Biochemical and biophysical research communications\| PubMed ID: 15110772	2004
Mouse embryonic stem cells efficiently lipofected with nuclear localization peptide result in a high yield of chimeric mice and retain germline transmission potency. Methods (San Diego, Calif.)\| PubMed ID: 15121165	2004
Blood coagulation kinetics: high throughput method for real-time reaction monitoring. Thrombosis and haemostasis\| PubMed ID: 15467920	2004
Use of D-dimer to aid in excluding deep venous thrombosis in ambulatory patients. American journal of surgery\| PubMed ID: 15701485	2005
High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays. Molecular & cellular proteomics : MCP\| PubMed ID: 15705970	2005
Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays. Proteomics\| PubMed ID: 15742319	2005
Nanoliter homogenous ultra-high throughput screening microarray for lead discoveries and IC50 profiling. Assay and drug development technologies\| PubMed ID: 15871692	2005
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16081529	2005
Targeting viral-mediated transduction to the lung airway epithelium with the anti-inflammatory cationic lipid dexamethasone-spermine. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16099413	2005
Fibrin affinity of erythrocyte-coupled tissue-type plasminogen activators endures hemodynamic forces and enhances fibrinolysis in vivo. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 16284278	2006
Microarrays for the functional analysis of the chemical-kinase interactome. Journal of biomolecular screening\| PubMed ID: 16314406	2006
Stochastic modeling of blood coagulation initiation. Pathophysiology of haemostasis and thrombosis\| PubMed ID: 16432310	2005
Functional phenotyping of human plasma using a 361-fluorogenic substrate biosensing microarray. Biotechnology and bioengineering\| PubMed ID: 16575920	2006
Photocleavage of o-nitrobenzyl ether derivatives for rapid biomedical release applications. Bioorganic & medicinal chemistry letters\| PubMed ID: 16713258	2006
Matrix protein microarrays for spatially and compositionally controlled microspot thrombosis under laminar flow. Biophysical journal\| PubMed ID: 16905604	2006
Controlled release of DNA/polyamine complex by photoirradiation of a solid phase presenting o-nitrobenzyl ether tethered spermine or polyethyleneimine. Bioorganic & medicinal chemistry letters\| PubMed ID: 16931009	2006
Differential utilization of transcription activation subdomains by distinct coactivators regulates Pit-1 basal and Ras responsiveness. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 17021049	2007
Methods for mapping protease specificity. Current opinion in chemical biology\| PubMed ID: 17157549	2007
Synthesis and structure-activity relationships of a series of increasingly hydrophobic cationic steroid lipofection reagents. The journal of gene medicine\| PubMed ID: 17366520	2007
Biotinylated photocleavable polyethylenimine: capture and triggered release of nucleic acids from solid supports. Bioconjugate chemistry\| PubMed ID: 17432825	2007
Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays. Bioorganic & medicinal chemistry letters\| PubMed ID: 17656088	2007
A Saccharomyces cerevisiae cell-based quantitative beta-galactosidase assay compatible with robotic handling and high-throughput screening. Yeast (Chichester, England)\| PubMed ID: 17957822	2008
Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorganic & medicinal chemistry letters\| PubMed ID: 18060772	2008
Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow. Blood\| PubMed ID: 18203955	2008
Hemodynamic regulation of inflammation at the endothelial-neutrophil interface. Annals of biomedical engineering\| PubMed ID: 18299991	2008
Harry L. Goldsmith, Ph.d. Annals of biomedical engineering\| PubMed ID: 18330702	2008
Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L. Molecular pharmacology\| PubMed ID: 18403718	2008
A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood. Lab on a chip\| PubMed ID: 18432339	2008
Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype. Bioorganic & medicinal chemistry letters\| PubMed ID: 18499453	2008
Proteases' prime targets revealed. Nature biotechnology\| PubMed ID: 18536687	2008
Evaluation of an orthogonal pooling strategy for rapid high-throughput screening of proteases. Assay and drug development technologies\| PubMed ID: 18593377	2008
A molecular signaling model of platelet phosphoinositide and calcium regulation during homeostasis and P2Y1 activation. Blood\| PubMed ID: 18596227	2008
Molecular docking of cathepsin L inhibitors in the binding site of papain. Journal of chemical information and modeling\| PubMed ID: 18598021	2008
RNA interference screen to identify pathways that enhance or reduce nonviral gene transfer during lipofection. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18628755	2008
Ethanol enhances neutrophil membrane tether growth and slows rolling on P-selectin but reduces capture from flow and firm arrest on IL-1-treated endothelium. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18684938	2008
High-throughput screening for modulators of mesenchymal stem cell chondrogenesis. Annals of biomedical engineering\| PubMed ID: 18791827	2008
Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor. Journal of medicinal chemistry\| PubMed ID: 19226137	2009
Steady-state kinetic modeling constrains cellular resting states and dynamic behavior. PLoS computational biology\| PubMed ID: 19266013	2009
Lattice kinetic Monte Carlo simulations of convective-diffusive systems. The Journal of chemical physics\| PubMed ID: 19275421	2009
Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19390055	2009
Cationic lipid formulations alter the in vivo tropism of AAV2/9 vector in lung. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19638960	2009
Membrane cholesterol is a biomechanical regulator of neutrophil adhesion. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19667108	2009
Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast. Assay and drug development technologies\| PubMed ID: 19715453	2009
Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juice. BMC microbiology\| PubMed ID: 19728885	2009
From imide to lactam metallo-pyridocarbazoles: distinct scaffolds for the design of selective protein kinase inhibitors. The Journal of organic chemistry\| PubMed ID: 19886617	2009
Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19940238	2009
Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC). Bioorganic & medicinal chemistry\| PubMed ID: 19969466	2010
Tissue factor activity under flow. Thrombosis research\| PubMed ID: 20149924	2010
Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. Antimicrobial agents and chemotherapy\| PubMed ID: 20308375	2010
Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors. Combinatorial chemistry & high throughput screening\| PubMed ID: 20438448	2010
Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii. Molecular microbiology\| PubMed ID: 20444089	2010
A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells. Molecular pharmacology\| PubMed ID: 20466822	2010
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrobial agents and chemotherapy\| PubMed ID: 20547797	2010
Pairwise agonist scanning predicts cellular signaling responses to combinatorial stimuli. Nature biotechnology\| PubMed ID: 20562863	2010
Novel cationic lipids with enhanced gene delivery and antimicrobial activity. Molecular pharmacology\| PubMed ID: 20573781	2010
Identification of novel inhibitors of dietary lipid absorption using zebrafish. PloS one\| PubMed ID: 20811635	2010
High-throughput screening of a small molecule library for promoters and inhibitors of mesenchymal stem cell osteogenic differentiation. Biotechnology and bioengineering\| PubMed ID: 20824673	2011
RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood\| PubMed ID: 20852125	2010
Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D. Blood\| PubMed ID: 20855865	2010
Nanodroplet chemical microarrays and label-free assays. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20857358	2010
Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood. PLoS computational biology\| PubMed ID: 20941387	2010
The kinetics of Î±IIbÎ²3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy. Blood\| PubMed ID: 20971951	2011
A high-throughput multiplexed screening assay for optimizing serum-free differentiation protocols of human embryonic stem cells. Stem cell research\| PubMed ID: 21169079	2011
Simulation of aggregating particles in complex flows by the lattice kinetic Monte Carlo method. The Journal of chemical physics\| PubMed ID: 21261389	2011
Enhancers of adeno-associated virus AAV2 transduction via high throughput siRNA screening. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21304495	2011
Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms. The Journal of antimicrobial chemotherapy\| PubMed ID: 21393183	2011
Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening. ACS chemical biology\| PubMed ID: 21428443	2011
Relipidated tissue factor linked to collagen surfaces potentiates platelet adhesion and fibrin formation in a microfluidic model of vessel injury. Bioconjugate chemistry\| PubMed ID: 21902184	2011
Small Molecule Inhibition of RISC Loading. ACS chemical biology\| PubMed ID: 22026461	2011
Drug discovery for Duchenne muscular dystrophy via utrophin promoter activation screening. PloS one\| PubMed ID: 22028826	2011