Jun Yang

Jun Yang

Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Affiliated withShanghai Jiao Tong University Affiliated Sixth People's HospitalZhejiang University School of MedicineChinese Academy of Medical Sciences and Peking Union Medical College

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Research Area

Biography

Dr. Jun YANG is a principal investigator at Department of Physiology, Zhejiang University School of Medicine. She was recruited from University of Cambridge in 2014 by “The National Recruitment Program of Global Experts”to be Professor of Department of Cell Biology, Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences. Then she moved to Zhejiang University and funded by the 'Hundred Talents Program' in 2019.

She had undergraduate education in Zhejiang University, and received her Ph.D. degree from Chinese Academy of Medical Sciences & Peking Union Medical College. She devoted on the medical research of cardiopulmonary disease for more than 8 years in university of Cambridge with Professor Nick Morrell. Combined with her expertise on the drug discovery she applied stem cell technology to drug screening for small molecular intervention on BMPR2 signaling for the treatment of pulmonary arterial hypertension. The Yang lab sets up the human inducible pluoripotent stem cell reprogramming and differentiation syestem to study the pathogenesis of related diseases. Also her group professionally generates mutaions in human embroynic stem cells for understanding the vascular development as well as performs mutation correction for potential cell therapy.

She has published more than 30 research papers in the national and internationally recognized journals, including European Respiratory Journal, Circulation Research and Am J Respir Crit Care Med, and applied more than 5 national and international patents. She was awarded British Associate of Lung Research young investigator first prize in British Thoracic Society meeting and Pfizer European pulmonary vascular disease research. Her current project is aim to study the cellular and molecular pathogenesis of cardiopulmonary disease.

JoVE Journal Publications

ArticleTotal : 5
Year
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Publication title
2019
Whole-Mount In Situ Hybridization in Zebrafish Embryos and Tube Formation Assay in iPSC-ECs to Study the Role of Endoglin in Vascular Development
Publication title

Cited by 1

2020
2023
2025
2026

Other Publications

Article
Year
Protein kinases and their involvement in the cellular responses to genotoxic stress.

Mutation research| PubMed ID: 12510016

2003
2003
2003
2003
2003
2004
Cytokines in Mycoplasma pneumoniae infections.

Cytokine & growth factor reviews| PubMed ID: 15110799

2004
2004
2004
2004
Study of a novel antiosteoporosis screening model targeted on cathepsin K.

Biomedical and environmental sciences : BES| PubMed ID: 15602824

2004
2005
2005
2005
2006
A comparative study of using comet assay and gammaH2AX foci formation in the detection of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage.

Toxicology in vitro : an international journal published in association with BIBRA| PubMed ID: 16473493

2006
2006
Evaluation of sphingolipids changes in brain tissues of rats with pentylenetetrazol-induced kindled seizures using MALDI-TOF-MS.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences| PubMed ID: 17931985

2007
2008
2009
2009
2010
2011
Association between occult hepatitis B infection and the risk of hepatocellular carcinoma: a meta-analysis.

Liver international : official journal of the International Association for the Study of the Liver| PubMed ID: 21745272

2012
Role of benzalkonium chloride in DNA strand breaks in human corneal epithelial cells.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie| PubMed ID: 21842132

2011
2012
2012
2012
2013
2013
2014
2014
2014
2014
2014
2014
2014
2015
Diagnostic and prognostic value of microRNA-21 in colorectal cancer: an original study and individual participant data meta-analysis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology| PubMed ID: 25178983

2014
2015
2014
2015
2015
2016
2015
2015
2015
2016
2016
2016
2016
2016
2016
2017
2017
2017
2017
2017
Effects of a Long-Acting Formulation of Octreotide on Patients with Portal Hypertension.

Gastroenterology research and practice| PubMed ID: 28855918

2017
MicroRNA-542-3p functions as a tumor suppressor via directly targeting survivin in hepatocellular carcinoma.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie| PubMed ID: 29710480

2018
2019
2019
2020
2020
2020
2020
Evaluation of the cytotoxic and genotoxic effects by melamine and cyanuric acid co-exposure in human embryonic kidney 293 cells.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas| PubMed ID: 32348426

2020
2017
2017
2018
2019
Reference Values of Carotid Ultrafast Pulse-Wave Velocity: A Prospective, Multicenter, Population-Based Study.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography| PubMed ID: 33422666

2021
2021
2021
2022
2022
2022
2023
2023
2023
2023
2023
The characteristics and molecular targets of antiarrhythmic natural products.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie| PubMed ID: 37897974

2023
2008
2007
2007
2008
2009
2010
2010
2010
2010
2011
2011
2013
2013
2013
Identification of a miRNA signature in neutrophils after traumatic injury.

Acta biochimica et biophysica Sinica| PubMed ID: 24108763

2013
[Facial nerve function and hearing preservation experience in middle fossa approach removal of small acoustic tumor surgery].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery| PubMed ID: 24406173

2013
2014
2014
2014
2015
2014
Fabrication of three-dimensional porous scaffold based on collagen fiber and bioglass for bone tissue engineering.

Journal of biomedical materials research. Part B, Applied biomaterials| PubMed ID: 25430707

2015
2015
Specific miRNA and its target in neutrophils after traumatic injury.

Acta biochimica et biophysica Sinica| PubMed ID: 26232986

2015
2015
2016
2016
2016
2017
2017
2018
2018
2018
2018
2018
2019
2018
2019
Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 30487223

2018
2018
Preoperative 3-Dimensional Reconstruction of Dermatofibrosarcoma Protuberans.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]| PubMed ID: 30640785

2019
2019
2019
Transthoracic Pulmonary Artery Denervation for Pulmonary Arterial Hypertension.

Arteriosclerosis, thrombosis, and vascular biology| PubMed ID: 30816802

2019
2019
2020
2020
Three Dimensional Printing Bilayer Membrane Scaffold Promotes Wound Healing.

Frontiers in bioengineering and biotechnology| PubMed ID: 31803738

2019
Evaluation of PLGA microspheres with triple regimen on long-term survival of vascularized composite allograft - an experimental study.

Transplant international : official journal of the European Society for Organ Transplantation| PubMed ID: 31930539

2020
2020
Diabetes mortality burden attributable to short-term effect of PM in China.

Environmental science and pollution research international| PubMed ID: 32207004

2020
2020
2020
2020
Geng et al. reply.

Cell research| PubMed ID: 32661309

2020
2020
2020
2020
2021
2021
2021
2021
2021
2021
2021
2021
2021
2021
2022
2022
2022
2022
Preoperative 3D Reconstruction Model in Slow Mohs Surgery for Dermatofibrosarcoma Protuberans.

Computational intelligence and neuroscience| PubMed ID: 35432518

2022
2022
2022
2022
2022
2022
2022
2022
2022
2022
2022
2023
2023
2022
2022
2023
2023
2022
2023
2023
2023
2023
2023
2023
2023
2023
2023
2023
2023
2023
2023
2024
2023
2023
2023
2023
2024
2023
2024
2024
Identifying Potential Drug Targets for Keloid: A Mendelian Randomization Study.

The Journal of investigative dermatology| PubMed ID: 38797322

2025
2024
2024
2024
2024
2024
2024
2024
2024
2025
2025
2025
2025
2025
2025
2025
2025
2025
A high-radial strength, flex-resistant PLLA cuff tube for microvascular anastomosis.

International journal of biological macromolecules| PubMed ID: 40348229

2025
2025
2025
2025
2025
2025
2025
2025
2025
2025
2025
2025
ATM and ATR: sensing DNA damage.

World journal of gastroenterology| PubMed ID: 14716813

2004
2010
2010
2014
2014
Tumor markers CA19-9, CA242 and CEA in the diagnosis of pancreatic cancer: a meta-analysis.

International journal of clinical and experimental medicine| PubMed ID: 26380005

2015
2015
2016
2016
2017
2017
2017
2017
2017
2018
2018
2018
2019
2019
2019
2019
2021
2020
2020
MicroRNA-191 modulates cisplatin-induced DNA damage response by targeting RCC2.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology| PubMed ID: 32803782

2020
2020
2020
2020
2020
2020
2020
2020
2020
2021
2021
Metastatic microcalcification in the lungs and stomach due to hyperparathyroidism: A case report.

The Journal of international medical research| PubMed ID: 33641498

2021
2021
2021
2021
2021
2021
2021
2021
2021
2021
2021
2021
2021
2021
2022
The LPS induced pyroptosis exacerbates BMPR2 signaling deficiency to potentiate SLE-PAH.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology| PubMed ID: 34818449

2021
2022
2021
2021
2021
2022
2021
2022
2022
2022
2022
2022
2022
2022
2022
2022
2022
2022
2022
2022
2022
Toripalimab Plus Chemotherapy for Patients With Treatment-Naive Advanced Non-Small-Cell Lung Cancer: A Multicenter Randomized Phase III Trial (CHOICE-01).

Journal of clinical oncology : official journal of the American Society of Clinical Oncology| PubMed ID: 36206498

2023
2023
2022
2022
A Cohort Study on Deficiency of ADA2 from China.

Journal of clinical immunology| PubMed ID: 36807221

2023
2023
Malic Enzyme 1 as a Novel Anti-Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)| PubMed ID: 36840630

2023
2023
2023
2023
2023
2023
2023
2023
2023
2023
Mesenchymal stem cell-derived exosomes attenuate DNA damage response induced by cisplatin and bleomycin.

Mutation research. Genetic toxicology and environmental mutagenesis| PubMed ID: 37491116

2023
2023
2024
2023
Host CD34 cells are replacing donor endothelium of transplanted heart.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation| PubMed ID: 37634574

2023
2024
2023
2023
2023
2024
2023
Pyopneumothorax caused by and : a case report.

World journal of emergency medicine| PubMed ID: 37969220

2023
2023
2024
2024
2024
2024
2024
2024
Minor hepatectomy combined with cholangioplasty and cholangiojejunostomy for Bismuth II hilar cholangiocarcinoma: A propensity score matching analysis.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology| PubMed ID: 38640604

2024
A 5-Hydroxymethylcytosine-Based Noninvasive Model for Early Detection of Colorectal Carcinomas and Advanced Adenomas: The METHOD-2 Study.

Clinical cancer research : an official journal of the American Association for Cancer Research| PubMed ID: 38814264

2024
2024
2024
2024
2024
2024
2024
2024
2024
2024
2025
The main and added effects of heat on mortality in 33 Chinese cities from 2007 to 2013.

Frontiers of environmental science & engineering| PubMed ID: 39450420

2023
2024
STAP2 promotes the progression of renal fibrosis via HSP27.

Journal of translational medicine| PubMed ID: 39533293

2024
2025
2025
2024
2024
The functional regulation between extracellular vesicles and the DNA damage responses.

Mutation research. Reviews in mutation research| PubMed ID: 39828141

2025
2025
2025
2025
2025
2025
2025
2025
Comparison of four-dimensional CT and Sestamibi SPECTCT in the localization management of primary hyperparathyroidism.

Cancer imaging : the official publication of the International Cancer Imaging Society| PubMed ID: 40646585

2025
2025
Polystyrene Nanoparticles Induce Transcriptional Repression in TM4 Sertoli Cells.

Journal of applied toxicology : JAT| PubMed ID: 40926514

2026
Mechanistic roles of long non-coding RNAs in DNA damage response and genome stability.

Mutation research. Reviews in mutation research| PubMed ID: 40929751

2025
2025
2026
2025
2025
2025
2025
Development of a novel circulating miRNA panel for early detection of esophageal cancer.

American journal of translational research| PubMed ID: 41268270

2025
Clinical consensus on vestibular infant screening.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery| PubMed ID: 41276659

2025
2025
2025
2026
2026
2026
2026
2026
2026
2026
2026
2026
2026
2026
2026
2026
2026