evaluation-feasibility-safety-accuracy-an-intraoperative-high

Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases

Today, the only potentially curative option in patients with colorectal liver metastases is surgery. However, liver resection is feasible in less than 20% ...

Centre Léon Bérard

HER2-negative metastatic breast cancer (MBC) is a common setting in which chemotherapy could be effective even in later lines of treatment. Oral etoposide has demonstrated clinical activity in this setting in small-scale studies, but its efficacy has not been compared to that of other chemotherapy regimens.

Oral etoposide in heavily pre-treated metastatic breast cancer: results from the ESME cohort and comparison with other chemotherapy regimens.

 Nucleolin (NCL) is a multifunctional protein with oncogenic properties. Anti-NCL drugs show strong cytotoxic effects, including in triple-negative breast cancer (TNBC) models, and are currently being evaluated in phase II clinical trials. However, few studies have investigated the clinical value of  and whether  stratified cancer patients. Here, we have investigated for the first time the association of  with clinical characteristics in breast cancers independently of the different subtypes.  Using two independent series ( = 216;  = 661), we evaluated the prognostic value of  in non-metastatic breast cancers using univariate and/or multivariate Cox-regression analyses.  We reported that  mRNA expression levels are markers of poor survivals independently of tumour size and lymph node invasion status ( = 216). In addition, an association of  expression levels with poor survival was observed in TNBC ( = 40, overall survival (OS)  = 0.0287, disease-free survival (DFS)  = 0.0194). Transcriptomic analyses issued from The Cancer Genome Atlas (TCGA) database ( = 661) revealed that breast tumours expressing either low or high  mRNA expression levels exhibit different gene expression profiles. These data suggest that tumours expressing high  mRNA levels are different from those expressing low  mRNA levels.  is an independent marker of prognosis in breast cancers. We anticipated that anti-NCL is a promising therapeutic strategy that could rapidly be evaluated in high -expressing tumours to improve breast cancer management.

Druggable  Identifies Breast Tumours Associated with Poor Prognosis That Exhibit Different Biological Processes.

Continuous wound infiltration (CWI) with local anesthetics to reduce morphine consumption in postoperative pain management after open liver resection in patients with cancer.

A 96-hour continuous wound infiltration with ropivacaine reduces analgesic consumption after liver resection: A randomized, double-blind, controlled trial.

Article	Year
Oral etoposide in heavily pre-treated metastatic breast cancer: results from the ESME cohort and comparison with other chemotherapy regimens. Breast cancer research and treatment\| PubMed ID: 30357526	2018
Druggable Identifies Breast Tumours Associated with Poor Prognosis That Exhibit Different Biological Processes. Cancers\| PubMed ID: 30360377	2018
A 96-hour continuous wound infiltration with ropivacaine reduces analgesic consumption after liver resection: A randomized, double-blind, controlled trial. Journal of surgical oncology\| PubMed ID: 30481374	2019

David Perol

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