subtype-specific-optical-action-potential-recordings-human-induced

Subtype-specific Optical Action Potential Recordings in Human Induced Pluripotent Stem Cell-derived Ventricular Cardiomyocytes

Cardiomyocytes generated from human induced pluripotent stem cells (iPSC-CMs) are an emerging tool in cardiovascular research. Rather than being a ...

Technical University of Munich

German Centre for Cardiovascular Research (DZHK), Munich Heart Alliance

Long-QT syndromes are heritable diseases associated with prolongation of the QT interval on an electrocardiogram and a high risk of sudden cardiac death due to ventricular tachyarrhythmia. In long-QT syndrome type 1, mutations occur in the KCNQ1 gene, which encodes the repolarizing potassium channel mediating the delayed rectifier I(Ks) current.

Patient-specific induced pluripotent stem-cell models for long-QT syndrome.

B-lymphoblastic lymphoma: a heartening diagnosis.

The promises of human-induced pluripotent stem cells (hiPSCs) for modeling arrhythmogenic disease, but also for drug discovery and toxicity tests, are straightforward and exciting. However, the full potential of this new technology has not been fully realized yet. The purpose of this review is to provide an overview of the state-of-the-art research in arrhythmogenic disease modeling and drug discovery and an outlook of what can be expected from the second decade of hiPSC-based arrhythmia research.

Article	Year
Patient-specific induced pluripotent stem-cell models for long-QT syndrome. The New England journal of medicine\| PubMed ID: 20660394	2010
B-lymphoblastic lymphoma: a heartening diagnosis. European heart journal cardiovascular Imaging\| PubMed ID: 25227266	2015
Perspectives and Challenges of Pluripotent Stem Cells in Cardiac Arrhythmia Research. Current cardiology reports\| PubMed ID: 28220464	2017

Alexander Goedel

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