Christian Siebold

Division of Structural Biology, University of Oxford

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2018

Other Publications

Article	Year
Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14769912	2004
Multiple sclerosis: MHC associations and therapeutic implications. Expert reviews in molecular medicine\| PubMed ID: 15710050	2005
High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16275925	2005
Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion. The EMBO journal\| PubMed ID: 16456543	2006
MHC class II proteins and disease: a structural perspective. Nature reviews. Immunology\| PubMed ID: 16557259	2006
Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. Cell\| PubMed ID: 17218254	2007
Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function. Protein science : a publication of the Protein Society\| PubMed ID: 17473009	2007
Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism. Science (New York, N.Y.)\| PubMed ID: 17761881	2007
Structure and functional analysis of the IGF-II/IGF2R interaction. The EMBO journal\| PubMed ID: 18046459	2008
Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73. Structure (London, England : 1993)\| PubMed ID: 18275817	2008
Receptor protein tyrosine phosphatase micro: measuring where to stick. Biochemical Society transactions\| PubMed ID: 18363557	2008
Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP. Nature structural & molecular biology\| PubMed ID: 19561611	2009
Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors. Journal of molecular biology\| PubMed ID: 19651138	2009
Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling. Structure (London, England : 1993)\| PubMed ID: 19836338	2009
Interactions between Hedgehog proteins and their binding partners come into view. Genes & development\| PubMed ID: 20844013	2010
Structural basis of semaphorin-plexin signalling. Nature\| PubMed ID: 20877282	2010
Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension. Science (New York, N.Y.)\| PubMed ID: 21454754	2011
Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 21543847	2011
Automation of large scale transient protein expression in mammalian cells. Journal of structural biology\| PubMed ID: 21571074	2011
Recording information on protein complexes in an information management system. Journal of structural biology\| PubMed ID: 21605682	2011
Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1. Nature structural & molecular biology\| PubMed ID: 21743455	2011
A dual binding mode for RhoGTPases in plexin signalling. PLoS biology\| PubMed ID: 21912513	2011
Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling. Developmental cell\| PubMed ID: 22000855	2011
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Nature structural & molecular biology\| PubMed ID: 23104057	2012
Structural insights into semaphorins and their receptors. Seminars in cell & developmental biology\| PubMed ID: 23253452	2013
Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP. Cancer cell\| PubMed ID: 23623661	2013
Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub. Science (New York, N.Y.)\| PubMed ID: 23744777	2013
Structural insights into proteoglycan-shaped Hedgehog signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24062467	2013
Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. eLife\| PubMed ID: 24171105	2013
Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein. Nature structural & molecular biology\| PubMed ID: 25938661	2015
Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function. The Journal of cell biology\| PubMed ID: 26056142	2015
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases. Developmental cell\| PubMed ID: 26651291	2015
Initiation of T cell signaling by CD45 segregation at 'close contacts'. Nature immunology\| PubMed ID: 26998761	2016
Structural basis for integration of GluD receptors within synaptic organizer complexes. Science (New York, N.Y.)\| PubMed ID: 27418511	2016
Structural basis of Smoothened regulation by its extracellular domains. Nature\| PubMed ID: 27437577	2016
Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling. eLife\| PubMed ID: 27705744	2016
RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling. Trends in cell biology\| PubMed ID: 28007423	2017
Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates. Current opinion in cell biology\| PubMed ID: 29268141	2018
A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling. Science signaling\| PubMed ID: 29463778	2018