Jian Jin

Chemical Biology and Drug Discovery, Icahn School of Medicine at Mount Sinai

Affiliated withIcahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2018

Other Publications

Article	Year
Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase. Scientific reports\| PubMed ID: 28487506	2017
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood\| PubMed ID: 25395428	2015
Selective inhibitors of protein methyltransferases. Journal of medicinal chemistry\| PubMed ID: 25406853	2015
Chemical probes of histone lysine methyltransferases. ACS chemical biology\| PubMed ID: 25423077	2015
A chromatin activity-based chemoproteomic approach reveals a transcriptional repressome for gene-specific silencing. Nature communications\| PubMed ID: 25502336	2014
EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon cancer cells. Cancer biology & therapy\| PubMed ID: 25535899	2014
Structure-activity relationship studies of SETD8 inhibitors. MedChemComm\| PubMed ID: 25554733	2014
The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS chemical neuroscience\| PubMed ID: 25587888	2015
A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angewandte Chemie (International ed. in English)\| PubMed ID: 25728001	2015
Targeting EZH2 and PRC2 dependence as novel anticancer therapy. Experimental hematology\| PubMed ID: 26027790	2015
Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX. Chemistry & biology\| PubMed ID: 26119999	2015
Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 26129680	2016
The promise and peril of chemical probes. Nature chemical biology\| PubMed ID: 26196764	2015
A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin. The Journal of biological chemistry\| PubMed ID: 26338712	2015
A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS chemical biology\| PubMed ID: 26598975	2016
Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic... Oncotarget\| PubMed ID: 26755663	2016
Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform. Nucleic acids research\| PubMed ID: 26893353	2016
Novel Therapeutics Targeting Epigenetics: New Molecules, New Methods. ACS medicinal chemistry letters\| PubMed ID: 26985299	2016
Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science (New York, N.Y.)\| PubMed ID: 27127234	2016
Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors. Journal of medicinal chemistry\| PubMed ID: 27468126	2016
Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase. MedChemComm\| PubMed ID: 27547295	2016
Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. Journal of medicinal chemistry\| PubMed ID: 27584694	2016
Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. Journal of medicinal chemistry\| PubMed ID: 27804297	2016
Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists. Journal of medicinal chemistry\| PubMed ID: 27805392	2016
Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27911814	2016
Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome. Nature medicine\| PubMed ID: 28024084	2017
EZH2 inhibition in multiple myeloma downregulates myeloma associated oncogenes and upregulates microRNAs with potential tumor suppressor functions. Oncotarget\| PubMed ID: 28052011	2017
Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma. Cancer cell\| PubMed ID: 28073004	2017
Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. Journal of medicinal chemistry\| PubMed ID: 28135087	2017
Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice. Blood\| PubMed ID: 28246193	2017
An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity. JACC. Basic to translational science\| PubMed ID: 28286875	2017
In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nature chemical biology\| PubMed ID: 28288109	2017
Inhibitors of Protein Methyltransferases and Demethylases. Chemical reviews\| PubMed ID: 28338320	2018
Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 28490465	2017
Recent progress in developing selective inhibitors of protein methyltransferases. Current opinion in chemical biology\| PubMed ID: 28662389	2017
Structure-activity relationship studies of G9a-like protein (GLP) inhibitors. Bioorganic & medicinal chemistry\| PubMed ID: 28662962	2017
Report and Application of a Tool Compound Data Set. Journal of chemical information and modeling\| PubMed ID: 29035535	2017
Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity. ACS synthetic biology\| PubMed ID: 29073761	2018
Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs. Nature chemical biology\| PubMed ID: 29227473	2018
VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression. Circulation research\| PubMed ID: 29233846	2018
Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). Journal of medicinal chemistry\| PubMed ID: 29244490	2018
The polycomb group protein BMI-1 inhibitor PTC-209 is a potent anti-myeloma agent alone or in combination with epigenetic inhibitors targeting EZH2 and the BET bromodomains. Oncotarget\| PubMed ID: 29262596	2017
Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT). Journal of medicinal chemistry\| PubMed ID: 29320176	2018
Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice. Acta pharmacologica Sinica\| PubMed ID: 29417943	2018
Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK). European journal of medicinal chemistry\| PubMed ID: 29627725	2018
Structural determinants of 5-HT receptor activation and biased agonism. Nature structural & molecular biology\| PubMed ID: 30127358	2018
Influenza virus infection causes global RNAPII termination defects. Nature structural & molecular biology\| PubMed ID: 30177761	2018