achieving-moderate-pressures-sealed-vessels-using-dry-ice-as-solid

Achieving Moderate Pressures in Sealed Vessels Using Dry Ice As a Solid CO<sub>2</sub> Source

Herein is presented a general strategy to perform reactions under mild to moderate CO2 pressures with dry ice. This technique obviates the need for ...

University of Toledo

Elaborating amines via C-H functionalization has been an important area of research over the past decade but has generally relied on an added directing group or sterically hindered amine approach. Since free-amine-directed C(sp)-H activation is still primarily limited to cyclization reactions and to improve the sustainability and reaction scope of amine-based C-H activation, we present a strategy using CO in the form of dry ice that facilitates intermolecular C-H arylation. This methodology has been used to enable an operationally simple procedure whereby 1° and 2° aliphatic amines can be arylated selectively at their γ-C-H positions. In addition to potentially serving as a directing group, CO has also been demonstrated to curtail the oxidation of sensitive amine substrates.

Michael C. Young

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