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An Automated Method to Determine the Performance of <em>Drosophila</em> in Response to Temperature Changes in Space and Time

Temperature is a ubiquitous environmental factor that affects how species distribute and behave. Different species of Drosophila fruit flies have specific ...

University of Groningen

In cost-minimization studies, it is important to establish noninferiority in the clinical effect of the treatments under investigation. The relationship between the proportion of patients reaching the end point in a study, equivalence limit (delta), and power is investigated in the context of cost-minimization studies with dichotomous clinical end points. Two formulations of the null-hypothesis, absolute and relative formulations of delta, will be explored.

Noninferiority testing in cost-minimization studies: Practical issues concerning power analysis.

To study the safe and unsafe duration of fasting in children with medium chain acyl-Coenzyme A dehydrogenase (MCAD) deficiency, the literature and the database on Dutch MCAD-deficient patients were searched for data on fasting studies in patients with MCAD deficiency.

Safe and unsafe duration of fasting for children with MCAD deficiency.

Non-professional treatment programmes are presumed to relieve the extensive need for care of anxiety and depression disorders. This study investigates the effectiveness of cognitive self- therapy (CST) in the treatment of depression or generalized anxiety disorder.

Cognitive self-therapy for chronic depression and anxiety: a multi-centre randomized controlled study.

The purpose of the present study is to examine the effects of mental fatigue and motivation on neural network dynamics activated during task switching. Mental fatigue was induced by 2 h of continuous performance; after which subjects were motivated by using social comparison and monetary reward as motivating factors to perform well for an additional 20 min. EEG coherence was used as a measure of synchronization of brain activity. Electrodes of interest were identified using a data-driven pre-processing method (ten Caat, M., Lorist, M.M., Bezdan, E., Roerdink, J.B.T.M., Maurits, N.M., 2008a. High-density EEG coherence analysis using functional units applied to mental fatigue. J. Neurosci. Meth. 171, 271-278; ten Caat, M., Maurits, N.M. and Roerdink, J.B.T.M., 2008b. Data-driven visualization and group analysis of multichannel EEG coherence with functional units. IEEE T. Vis. Comp. Gr. 14, 756-771). Performance on repetition trials was faster and more accurate than on switch trials. EEG data revealed more pronounced, frequency specific fronto-parietal network activation in switch trials, while power density was higher in repetition trials. The effects of mental fatigue on power and coherence were widespread, and not limited to specific frequency bands. Moreover, these effects were independent of specific task manipulations. This increase in neuronal activity and stronger synchronization between neural networks did not result in more efficient performance; response speed decreased and the number of errors increased in fatigued subjects. A modulation of the dopamine system is proposed as a common mechanism underlying the observed the fatigue effects.

Article	Year
Noninferiority testing in cost-minimization studies: Practical issues concerning power analysis. International journal of technology assessment in health care\| PubMed ID: 16571203	2006
Safe and unsafe duration of fasting for children with MCAD deficiency. European journal of pediatrics\| PubMed ID: 16788829	2007
Cognitive self-therapy for chronic depression and anxiety: a multi-centre randomized controlled study. Psychological medicine\| PubMed ID: 17076917	2007
The influence of mental fatigue and motivation on neural network dynamics; an EEG coherence study. Brain research\| PubMed ID: 19306850	2009

Mark Span

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