induction-endothelial-differentiation-cardiac-progenitor-cells-under

Induction of Endothelial Differentiation in Cardiac Progenitor Cells Under Low Serum Conditions

Cardiac progenitor cells (CPCs) may have therapeutic potential for cardiac regeneration after injury. In the adult mammalian heart, intrinsic CPCs are ...

University Hospital and University of Basel

university hospital basel

University Hospital Basel

Antioxidative drugs continue to be developed for the treatment of atherosclerosis. Apocynin is an nicotinamide adenine dinucleotide phosphate oxidase inhibitor with anti-inflammatory properties. We used contrast-enhanced ultrasound molecular imaging to assess whether short-term apocynin therapy in atherosclerosis reduces vascular oxidative stress and endothelial activation

Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties.

To define the role of fms-like tyrosine kinase 3 (Flt3) in the heart.

Flt3 activation improves post-myocardial infarction remodeling involving a cytoprotective effect on cardiomyocytes.

Recent studies suggest that adult cardiac progenitor cells (CPCs) can produce new cardiac cells. Such cell formation requires an intricate coordination of progenitor cell proliferation and commitment, but the molecular cues responsible for this regulation in CPCs are ill defined.

Polo-Like Kinase 2 is Dynamically Regulated to Coordinate Proliferation and Early Lineage Specification Downstream of Yes-Associated Protein 1 in Cardiac Progenitor Cells.

Article	Year
Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative properties. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23908248	2013
Flt3 activation improves post-myocardial infarction remodeling involving a cytoprotective effect on cardiomyocytes. Journal of the American College of Cardiology\| PubMed ID: 24184252	2013
Polo-Like Kinase 2 is Dynamically Regulated to Coordinate Proliferation and Early Lineage Specification Downstream of Yes-Associated Protein 1 in Cardiac Progenitor Cells. Journal of the American Heart Association\| PubMed ID: 29066438	2017

Gabriela M. Kuster

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