proton-therapy-delivery-its-clinical-application-select-solid-tumor

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Radiation therapy is a frequently used modality for the treatment of solid cancers. Although the mechanisms of cell kill are similar for all forms of ...

University of Maryland School of Medicine

Evaluation of combined anti-PD-1 immunotherapy and radiation therapy in a preclinical mouse model of pneumonitis and fibrosis.

Non-ablative or mild hyperthermia (HT) has been shown in preclinical (and clinical) studies as a localized radiosensitizer that enhances the tumoricidal effects of radiation. Most pre-clinical in vivo HT studies use subcutaneous tumor models which do not adequately represent clinical conditions (e.g. proximity of normal/critical organs) or replicate the tumor microenvironment - both of which are important factors for eventual clinical translation. The purpose of this work is to demonstrate proof-of-concept of locoregional radiosensitization with superficially applied, radiofrequency (RF)-induced HT in an orthotopic mouse model of prostate cancer.

Article	Year
Evaluation of combined anti-PD-1 immunotherapy and radiation therapy in a preclinical mouse model of pneumonitis and fibrosis. Journal of thoracic disease\| PubMed ID: 30622798	2018
Mild hyperthermia as a localized radiosensitizer for deep-seated tumors: Investigation in an orthotopic prostate cancer model in mice. The British journal of radiology\| PubMed ID: 30673305	2019
Hyperthermia and Hyper-fractionated Radiation for a Cutaneous Squamous Cell Carcinoma Progressing on Standard Therapy: A Case Report. Advances in radiation oncology\| PubMed ID: 30706002	2019

Zeljko Vujaskovic

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