Sriram Subramaniam

Laboratory of Cell Biology, National Institutes of Health

Affiliated withNational Institutes of Health

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 16	2011

Other Publications

Article	Year
Compositional mapping of the surface and interior of mammalian cells at submicrometer resolution. Analytical chemistry\| PubMed ID: 21268648	2011
Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis. PloS one\| PubMed ID: 21346816	2011
Increased severity of experimental allergic encephalomyelitis in lyn-/- mice in the absence of elevated proinflammatory cytokine response in the central nervous system. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11884485	2002
Three-dimensional structure of a bacterial oxalate transporter. Nature structural biology\| PubMed ID: 12118242	2002
Molecular architecture and mechanism of an icosahedral pyruvate dehydrogenase complex: a multifunctional catalytic machine. The EMBO journal\| PubMed ID: 12411477	2002
Comparative study of the presence of Chlamydia pneumoniae in cerebrospinal fluid of Patients with clinically definite and monosymptomatic multiple sclerosis. Clinical and diagnostic laboratory immunology\| PubMed ID: 12414770	2002
Chlamydia pneumoniae infection of the central nervous system worsens experimental allergic encephalitis. The Journal of experimental medicine\| PubMed ID: 12486106	2002
A core-weighted fitting method for docking atomic structures into low-resolution maps: application to cryo-electron microscopy. Journal of structural biology\| PubMed ID: 12576021	2003
Structural model for 12-helix transporters belonging to the major facilitator superfamily. Journal of bacteriology\| PubMed ID: 12591890	2003
Electron microscopic analysis of membrane assemblies formed by the bacterial chemotaxis receptor Tsr. Journal of bacteriology\| PubMed ID: 12775701	2003
Structural insights into the mechanism of proton pumping by bacteriorhodopsin. FEBS letters\| PubMed ID: 12788485	2003
From structure to mechanism: electron crystallographic studies of bacteriorhodopsin. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences\| PubMed ID: 12804283	2002
Automated image acquisition and processing using a new generation of 4K x 4K CCD cameras for cryo electron microscopic studies of macromolecular assemblies. Journal of structural biology\| PubMed ID: 12972350	2003
CNS infection with C. pneumoniae complicated by multiple strokes. Journal of neurology\| PubMed ID: 14504982	2003
Association of Chlamydia pneumoniae with central nervous system disease. Microbes and infection / Institut Pasteur\| PubMed ID: 14623021	2003
Projection structure of the bacterial oxalate transporter OxlT at 3.4A resolution. Journal of structural biology\| PubMed ID: 14643200	2003
Signaling through JAK2-STAT5 pathway is essential for IL-3-induced activation of microglia. Glia\| PubMed ID: 14730712	2004
Three-dimensional electron microscopy at molecular resolution. Annual review of biophysics and biomolecular structure\| PubMed ID: 15139808	2004
Three-dimensional electron microscopic imaging of membrane invaginations in Escherichia coli overproducing the chemotaxis receptor Tsr. Journal of bacteriology\| PubMed ID: 15262942	2004
Structure and transport mechanism of the bacterial oxalate transporter OxlT. Biophysical journal\| PubMed ID: 15339805	2004
Role of microglia in multiple sclerosis. Current neurology and neuroscience reports\| PubMed ID: 15865890	2005
Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism. Journal of structural biology\| PubMed ID: 15866737	2005
Bridging the imaging gap: visualizing subcellular architecture with electron tomography. Current opinion in microbiology\| PubMed ID: 15939356	2005
Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis. The Journal of infectious diseases\| PubMed ID: 16136465	2005
Defective ATM-p53-mediated apoptotic pathway in multiple sclerosis. Annals of neurology\| PubMed ID: 16178012	2005
An energy-based three-dimensional segmentation approach for the quantitative interpretation of electron tomograms. IEEE transactions on image processing : a publication of the IEEE Signal Processing Society\| PubMed ID: 16190467	2005
Molecular structure of a 9-MDa icosahedral pyruvate dehydrogenase subcomplex containing the E2 and E3 enzymes using cryoelectron microscopy. The Journal of biological chemistry\| PubMed ID: 16308322	2006
Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis. Annals of neurology\| PubMed ID: 16315280	2005
Site-specific 3D imaging of cells and tissues with a dual beam microscope. Journal of structural biology\| PubMed ID: 16713294	2006
The SIV surface spike imaged by electron tomography: one leg or three? PLoS pathogens\| PubMed ID: 16933994	2006
Infectious causes of multiple sclerosis. Lancet neurology\| PubMed ID: 16987736	2006
Automated 100-position specimen loader and image acquisition system for transmission electron microscopy. Journal of structural biology\| PubMed ID: 17240161	2007
Gray matter involvement in multiple sclerosis. Neurology\| PubMed ID: 17325269	2007
Electron tomography of bacterial chemotaxis receptor assemblies. Methods in cell biology\| PubMed ID: 17327165	2007
Direct visualization of Escherichia coli chemotaxis receptor arrays using cryo-electron microscopy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17360429	2007
Identification of molecular biomarkers for multiple sclerosis. The Journal of molecular diagnostics : JMD\| PubMed ID: 17384211	2007
Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry. PLoS pathogens\| PubMed ID: 17480119	2007
In regard to Miller et al.: Multiple sclerosis, brain radiotherapy and risk of neurotoxicity: the Mayo Clinic experience (Int J Radiat Oncol Biol Phys 2006;66:1178-1186). International journal of radiation oncology, biology, physics\| PubMed ID: 17544007	2007
Cryoelectron tomographic analysis of an HIV-neutralizing protein and its complex with native viral gp120. The Journal of biological chemistry\| PubMed ID: 17599917	2007
Cell surface filaments of the gliding bacterium Flavobacterium johnsoniae revealed by cryo-electron tomography. Journal of bacteriology\| PubMed ID: 17693495	2007
Electron tomography of viruses. Current opinion in structural biology\| PubMed ID: 17964134	2007
Stoichiometry and absolute quantification of proteins with mass spectrometry using fluorescent and isotope-labeled concatenated peptide standards. Molecular & cellular proteomics : MCP\| PubMed ID: 18029347	2008
Extended polypeptide linkers establish the spatial architecture of a pyruvate dehydrogenase multienzyme complex. Structure (London, England : 1993)\| PubMed ID: 18184587	2008
Three-dimensional imaging of the highly bent architecture of Bdellovibrio bacteriovorus by using cryo-electron tomography. Journal of bacteriology\| PubMed ID: 18203829	2008
TRAPS and MS: two diseases or an MS mimic? Neurology\| PubMed ID: 18362272	2008
Electron tomography in nanoparticle imaging and analysis. Nanomedicine (London, England)\| PubMed ID: 18393671	2008
Preconditioning with cobalt chloride or desferrioxamine protects oligodendrocyte cell line (MO3.13) from tumor necrosis factor-alpha-mediated cell death. Journal of neuroscience research\| PubMed ID: 18438939	2008
Evaluation of denoising algorithms for biological electron tomography. Journal of structural biology\| PubMed ID: 18585059	2008
Tolerability and safety profile of 12- to 28-week treatment with interferon beta-1b 250 and 500 microg QOD in patients with relapsing-remitting multiple sclerosis: a multicenter, randomized,... Clinical therapeutics\| PubMed ID: 18640466	2008
Molecular architecture of native HIV-1 gp120 trimers. Nature\| PubMed ID: 18668044	2008
Chemoreceptors in Caulobacter crescentus: trimers of receptor dimers in a partially ordered hexagonally packed array. Journal of bacteriology\| PubMed ID: 18689468	2008
Bacterial cell wall products increases stabilization of HIF-1 alpha in an oligodendrocyte cell line preconditioned by cobalt chloride or desferrioxamine. Journal of neuroimmunology\| PubMed ID: 18715655	2008
Aphasic or amnesic status epilepticus detected on PET but not EEG. Epilepsia\| PubMed ID: 18801038	2009
Role of HAMP domains in chemotaxis signaling by bacterial chemoreceptors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18940922	2008
3D imaging of mammalian cells with ion-abrasion scanning electron microscopy. Journal of structural biology\| PubMed ID: 19116171	2009
The spectrum of Susac's syndrome. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology\| PubMed ID: 19145401	2009
3D imaging of diatoms with ion-abrasion scanning electron microscopy. Journal of structural biology\| PubMed ID: 19269330	2009
Qualitative and quantitative detection of Chlamydophila pneumoniae DNA in cerebrospinal fluid from multiple sclerosis patients and controls. PloS one\| PubMed ID: 19357786	2009
Protein conformational changes in the bacteriorhodopsin photocycle: comparison of findings from electron and X-ray crystallographic analyses. PloS one\| PubMed ID: 19488399	2009
Staphylococcal enterotoxin A induces small clusters of HLA-DR1 on B cells. PloS one\| PubMed ID: 19587800	2009
Structural snapshots of conformational changes in a seven-helix membrane protein: lessons from bacteriorhodopsin. Current opinion in structural biology\| PubMed ID: 19643594	2009
Membrane protein structure determination using cryo-electron tomography and 3D image averaging. Current opinion in structural biology\| PubMed ID: 19646859	2009
Cryo-electron tomography of bacteria: progress, challenges and future prospects. Nature reviews. Microbiology\| PubMed ID: 19668224	2009
Identification and characterization of the interferon-beta-mediated p53 signal pathway in human peripheral blood mononuclear cells. Immunology\| PubMed ID: 19740351	2009
Ion-abrasion scanning electron microscopy reveals surface-connected tubular conduits in HIV-infected macrophages. PLoS pathogens\| PubMed ID: 19779568	2009
Ion-abrasion scanning electron microscopy reveals distorted liver mitochondrial morphology in murine methylmalonic acidemia. Journal of structural biology\| PubMed ID: 20399866	2010
3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20624966	2010
The role of infections in the pathogenesis and course of multiple sclerosis. Annals of Indian Academy of Neurology\| PubMed ID: 20814489	2010
A coiled-coil-repeat protein 'Ccrp' in Bdellovibrio bacteriovorus prevents cellular indentation, but is not essential for vibroid cell morphology. FEMS microbiology letters\| PubMed ID: 20977494	2010
Spiral architecture of the nucleoid in Bdellovibrio bacteriovorus. Journal of bacteriology\| PubMed ID: 21148724	2011
Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure. PLoS pathogens\| PubMed ID: 21203482	2010
Chemotaxis kinase CheA is activated by three neighbouring chemoreceptor dimers as effectively as by receptor clusters. Molecular microbiology\| PubMed ID: 21255111	2011
Development of chemical exchange saturation transfer at 7 T. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 21432902	2011
Lateral density of receptor arrays in the membrane plane influences sensitivity of the E. coli chemotaxis response. The EMBO journal\| PubMed ID: 21441899	2011
HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation. Blood\| PubMed ID: 21562048	2011
Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21628584	2011
Analysis of T2 Intensity by Magnetic Resonance Imaging of Deep Gray Matter Nuclei in Multiple Sclerosis Patients: Effect of Immunomodulatory Therapies. Journal of neuroimaging : official journal of the American Society of Neuroimaging\| PubMed ID: 21707826	2011
Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21709254	2011
Role of glial cells in innate immunity and their role in CNS demyelination. Journal of neuroimmunology\| PubMed ID: 21907419	2011
Correlative 3D imaging of whole mammalian cells with light and electron microscopy. Journal of structural biology\| PubMed ID: 21907806	2011
Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography. Journal of virology\| PubMed ID: 21937655	2011
Chemical mapping of mammalian cells by atom probe tomography. Journal of structural biology\| PubMed ID: 22245777	2012
Computational separation of conformational heterogeneity using cryo-electron tomography and 3D sub-volume averaging. Journal of structural biology\| PubMed ID: 22248450	2012