Sidney W. Whiteheart

Department of Molecular and Cellular Biochemistry, University of Kentucky

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 22	2019
Publication title Cited by 5	2023

Other Publications

Article	Year
How Does Protein Disulfide Isomerase Get Into a Thrombus? Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 27225788	2016
Fueling Platelets: Where Does the Glucose Come From? Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 28835484	2017
Dynamic cycling of t-SNARE acylation regulates platelet exocytosis. The Journal of biological chemistry\| PubMed ID: 29352103	2018
The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells. The Journal of cell biology\| PubMed ID: 9647644	1998
Uncoupling the ATPase activity of the N-ethylmaleimide sensitive factor (NSF) from 20S complex disassembly. Biochemistry\| PubMed ID: 11781091	2002
Application of a Saccharomyces cerevisiae model to study requirements for trafficking of Yersinia pestis YopM in eucaryotic cells. Infection and immunity\| PubMed ID: 12540576	2003
Granule stores from cellubrevin/VAMP-3 null mouse platelets exhibit normal stimulus-induced release. Blood\| PubMed ID: 12738662	2003
A role for Sec1/Munc18 proteins in platelet exocytosis. The Biochemical journal\| PubMed ID: 12773094	2003
Multiple binding proteins suggest diverse functions for the N-ethylmaleimide sensitive factor. Journal of structural biology\| PubMed ID: 15037235	2004
Studies of secretion using permeabilized platelets. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 15226539	2004
Platelets from Munc18c heterozygous mice exhibit normal stimulus-induced release. Thrombosis and haemostasis\| PubMed ID: 15467915	2004
Arf6 plays an early role in platelet activation by collagen and convulxin. Blood\| PubMed ID: 16352809	2006
Endobrevin/VAMP-8 is the primary v-SNARE for the platelet release reaction. Molecular biology of the cell\| PubMed ID: 17065550	2007
Asymmetric accumulation of hippocampal 7S SNARE complexes occurs regardless of kindling paradigm. Epilepsy research\| PubMed ID: 17174072	2007
Cellular functions of NSF: not just SNAPs and SNAREs. FEBS letters\| PubMed ID: 17397838	2007
Platelet activation and its patient-specific consequences. Thrombosis research\| PubMed ID: 17949794	2008
Primary platelet signaling cascades and integrin-mediated signaling control ADP-ribosylation factor (Arf) 6-GTP levels during platelet activation and aggregation. The Journal of biological chemistry\| PubMed ID: 18326492	2008
Murine platelets are not regulated by O-linked beta-N-acetylglucosamine. Archives of biochemistry and biophysics\| PubMed ID: 18387355	2008
Levetiracetam prevents kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes. Epilepsia\| PubMed ID: 18513349	2008
The platelet release reaction: just when you thought platelet secretion was simple. Current opinion in hematology\| PubMed ID: 18695380	2008
PKCalpha regulates platelet granule secretion and thrombus formation in mice. The Journal of clinical investigation\| PubMed ID: 19147982	2009
Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo. Blood\| PubMed ID: 19395672	2009
Dissecting the N-ethylmaleimide-sensitive factor: required elements of the N and D1 domains. The Journal of biological chemistry\| PubMed ID: 19887446	2010
Hexahistidine-tag-specific optical probes for analyses of proteins and their interactions. Analytical biochemistry\| PubMed ID: 20036207	2010
Protein expression in platelets from six species that differ in their open canalicular system. Platelets\| PubMed ID: 20196629	2010
Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis. Blood\| PubMed ID: 20435885	2010
Histidine-tag-directed chromophores for tracer analyses in the analytical ultracentrifuge. Methods (San Diego, Calif.)\| PubMed ID: 21187151	2011
A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing. Blood\| PubMed ID: 21224474	2011
Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF). Biochimica et biophysica acta\| PubMed ID: 21689688	2012
Platelet granules: surprise packages. Blood\| PubMed ID: 21816838	2011
Distinct roles for Rap1b protein in platelet secretion and integrin Î±IIbÎ²3 outside-in signaling. The Journal of biological chemistry\| PubMed ID: 21940635	2011
Kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes correlates with enhanced glutamate release. Epilepsia\| PubMed ID: 22150629	2012
Reduction of vesicle-associated membrane protein 2 expression leads to a kindling-resistant phenotype in a murine model of epilepsy. Neuroscience\| PubMed ID: 22183055	2012
Nucleotide-dependent conformational changes in the N-Ethylmaleimide Sensitive Factor (NSF) and their potential role in SNARE complex disassembly. Journal of structural biology\| PubMed ID: 22245547	2012
Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion. Blood\| PubMed ID: 22767500	2012
Munc18b/STXBP2 is required for platelet secretion. Blood\| PubMed ID: 22791290	2012
The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation. The Journal of biological chemistry\| PubMed ID: 23066026	2012
Platelet secretion is kinetically heterogeneous in an agonist-responsive manner. Blood\| PubMed ID: 23086755	2012
IκB kinase phosphorylation of SNAP-23 controls platelet secretion. Blood\| PubMed ID: 23613522	2013
Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway. Nature communications\| PubMed ID: 24150174	2013
α-Granules at the BEACH. Blood\| PubMed ID: 24203928	2013
TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation. Cell\| PubMed ID: 25083866	2014
Granule-mediated release of sphingosine-1-phosphate by activated platelets. Biochimica et biophysica acta\| PubMed ID: 25158625	2014
Platelet secretion and hemostasis require syntaxin-binding protein STXBP5. The Journal of clinical investigation\| PubMed ID: 25244094	2014
Platelet secretion paves the way. Blood\| PubMed ID: 26206945	2015
Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis. Blood\| PubMed ID: 26209658	2015
Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis. Circulation\| PubMed ID: 26399659	2015
Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion. The Biochemical journal\| PubMed ID: 26637270	2016
Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking. Blood\| PubMed ID: 26738539	2016
B-cell-independent sialylation of IgG. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27303031	2016
Respective contributions of single and compound granule fusion to secretion by activated platelets. Blood\| PubMed ID: 27625359	2016
The nuts and bolts of the platelet release reaction. Platelets\| PubMed ID: 27848265	2017
Editorial: Platelet Secretion. Platelets\| PubMed ID: 28281920	2017
The ins and outs of endocytic trafficking in platelet functions. Current opinion in hematology\| PubMed ID: 28650849	2017
Cellubrevin/vesicle-associated membrane protein-3-mediated endocytosis and trafficking regulate platelet functions. Blood\| PubMed ID: 28931526	2017
Linking kindling to increased glutamate release in the dentate gyrus of the hippocampus through the STXBP5/tomosyn-1 gene. Brain and behavior\| PubMed ID: 28948088	2017
In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi. Platelets\| PubMed ID: 29286871	2019
BEACHcombing for α-granules. Blood\| PubMed ID: 29496701	2018
Alterations in platelet secretion differentially affect thrombosis and hemostasis. Blood advances\| PubMed ID: 30185436	2018
SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets. Blood advances\| PubMed ID: 30401752	2018
Autophagy in Platelets. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30610718	2019
Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics. Epilepsy research\| PubMed ID: 31816591	2020
Canalicular system reorganization during mouse platelet activation as revealed by 3D ultrastructural analysis. Platelets\| PubMed ID: 32000578	2021
Platelets Endocytose Viral Particles and Are Activated via TLR (Toll-Like Receptor) Signaling. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 32434410	2020
Structural analysis of resting mouse platelets by 3D-EM reveals an unexpected variation in α-granule shape. Platelets\| PubMed ID: 32815431	2021
Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32929010	2020
Calcium Ion Chelation Preserves Platelet Function During Cold Storage. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 33176450	2021
Does GEC1 Enhance Expression and Forward Trafficking of the Kappa Opioid Receptor (KOR) via Its Ability to Interact with NSF Directly? Handbook of experimental pharmacology\| PubMed ID: 33404775	2022
Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 33448622	2021
Differential Leukocyte and Platelet Profiles in Distinct Models of Traumatic Brain Injury. Cells\| PubMed ID: 33652745	2021
Platelet-HIV: interactions and their implications. Platelets\| PubMed ID: 35086429	2022
VAMP3 and VAMP8 Regulate the Development and Functionality of Parasitophorous Vacuoles Housing Leishmania amazonensis. Infection and immunity\| PubMed ID: 35130453	2022
COMManding platelet α-granule cargo. Blood\| PubMed ID: 35142851	2022
Total Plasma Protein S Is a Prothrombotic Marker in People Living With HIV. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 35616596	2022
A sensitive and adaptable method to measure platelet-fibrin clot contraction kinetics. Research and practice in thrombosis and haemostasis\| PubMed ID: 35873218	2022
In memory of Dr. Susan S. Smyth, MD/Ph.D. Platelets\| PubMed ID: 36813743	2023