a-zebrafish-embryo-model-for-vivo-visualization-intravital-analysis

A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated <em>Staphylococcus aureus</em> Infection

Biomaterial-associated infection (BAI) is a major cause of the failure of biomaterials/medical devices. Staphylococcus aureus is one of the major ...

immunomagnetic-isolation-vascular-wall-resident-cd34-stem-cells-from

Immunomagnetic Isolation of the Vascular Wall-Resident CD34<sup>+</sup> Stem Cells from Mice

Resident CD34+ vascular wall-resident stem and progenitor cells (VW-SCs) are increasingly recognized for their crucial role in regulating vascular injury ...

Amsterdam UMC

University of Twente

southwest medical university

Tumor-induced osteomalacia (TIO) is often misdiagnosed as hypophosphatemia that is not valued. The aim of this study was to analyze the diagnostic value of 68Ga-DOTA-TATE PET/CT imaging for TIO.

Diagnostic value of 68Ga-DOTA-TATE PET/CT imaging for tumor- induced osteomalacia.

The incidence rate of colorectal cancer (CRC) has been increasing significantly in recent years, and it is urgent to develop novel drugs that have more effects for its treatment. It has been reported that many molecules extracted from the root bark of  L. (also known as Cortex Mori) have antitumor activities. In our study, we identified morusinol as a promising anticancer agent by selecting from 30 molecules extracted from  L. We found that morusinol treatment suppressed cell proliferation and promoted apoptosis of CRC cells . Besides this, we observed that morusinol induced cytoprotective autophagy. The GO analysis of differentially expressed genes from RNA-seq data showed that morusinol affected cholesterol metabolism. Then we found that key enzyme genes in the cholesterol biosynthesis pathway as well as the sterol regulatory element binding transcription factor 2 (SREBF2) were significantly downregulated. Furthermore, additional cholesterol treatment reversed the anti-CRC effect of morusinol. Interestingly, we also found that morusinol treatment could promote forkhead box O3 (FOXO3a) nuclear accumulation, which subsequently suppressed SREBF2 transcription. Then SREBF2-controlled cholesterol biosynthesis was blocked, resulting in the suppression of cell proliferation, promotion of apoptosis, and production of autophagy. The experiments in animal models also showed that morusinol significantly impeded tumor growth in mice models. Our results suggested that morusinol may be used as a candidate anticancer drug for the treatment of CRC.

Morusinol Extracted from  Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.

ArticleTotal : 2	Year
Publication title Cited by 6	2019
Publication title Cited by 1	2023

Article	Year
Diagnostic value of 68Ga-DOTA-TATE PET/CT imaging for tumor- induced osteomalacia. Annals of palliative medicine\| PubMed ID: 32921125	2020
Morusinol Extracted from Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer. Journal of agricultural and food chemistry\| PubMed ID: 37870273	2023

Xiaolin Zhang

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