Jens J. Holst

Department of Biomedical Sciences and NNF Centre for Basic Metabolic Research, University of Copenhagen

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 13	2019

Other Publications

Article	Year
Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9192619	1997
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12145326	2002
Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls. World journal of gastroenterology\| PubMed ID: 16609993	2006
Small-molecule agonists for the glucagon-like peptide 1 receptor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17213325	2007
Cecal infusion of butyrate increases intestinal cell proliferation in piglets. The Journal of nutrition\| PubMed ID: 17374654	2007
Exogenous glucagon-like peptide-2 (GLP-2) augments GLP-2 receptor mRNA and maintains proglucagon mRNA levels in resected rats. JPEN. Journal of parenteral and enteral nutrition\| PubMed ID: 18443137	2008
Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 18832087	2008
Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects. The American journal of clinical nutrition\| PubMed ID: 19056578	2009
Natural history of insulin sensitivity and insulin secretion in the progression from normal glucose tolerance to impaired fasting glycemia and impaired glucose tolerance: the Inter99 study. Diabetes care\| PubMed ID: 19056613	2009
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. Endocrinology\| PubMed ID: 19213833	2009
Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring, Md.)\| PubMed ID: 19360006	2009
Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion. Diabetes\| PubMed ID: 19366866	2009
Colonic GLP-2 is not sufficient to promote jejunal adaptation in a PN-dependent rat model of human short bowel syndrome. JPEN. Journal of parenteral and enteral nutrition\| PubMed ID: 19644131	2009
Whey protein potentiates the intestinotrophic action of glucagon-like peptide-2 in parenterally fed rats. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 19776251	2009
Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report. Diabetes care\| PubMed ID: 19918005	2010
The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest. Diabetes\| PubMed ID: 20107109	2010
The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action. Diabetes\| PubMed ID: 20150286	2010
Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men. Diabetes care\| PubMed ID: 20484128	2010
Sustained glucagon-like peptide-2 infusion is required for intestinal adaptation, and cessation reverses increased cellularity in rats with intestinal failure. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 20864657	2010
Delayed β-cell response and glucose intolerance in young women with Turner syndrome. BMC endocrine disorders\| PubMed ID: 21406078	2011
Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans. Diabetes\| PubMed ID: 21430088	2011
Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual β-cell function. Diabetes\| PubMed ID: 21441444	2011
Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes. Diabetes care\| PubMed ID: 21525464	2011
Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes. Diabetes\| PubMed ID: 21677283	2011
Administration of a dipeptidyl peptidase IV inhibitor enhances the intestinal adaptation in a mouse model of short bowel syndrome. Surgery\| PubMed ID: 21719060	2011
Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test. Journal of pharmacokinetics and pharmacodynamics\| PubMed ID: 21922329	2011
The effect of PCSK1 variants on waist, waist-hip ratio and glucose metabolism is modified by sex and glucose tolerance status. PloS one\| PubMed ID: 21935364	2011
Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans. Diabetes\| PubMed ID: 21984584	2011
Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 22094603	2012
The effect of glucagon-like peptide 1 on cardiovascular risk. Nature reviews. Cardiology\| PubMed ID: 22290234	2012
Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects. The Journal of clinical endocrinology and metabolism\| PubMed ID: 22319034	2012
GPR119 as a fat sensor. Trends in pharmacological sciences\| PubMed ID: 22560300	2012
The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells. Nutrition & metabolism\| PubMed ID: 22647249	2012
Improvements in glucose metabolism early after gastric bypass surgery are not explained by increases in total bile acids and fibroblast growth factor 19 concentrations. The Journal of clinical endocrinology and metabolism\| PubMed ID: 25536209	2015
Enteral nutrients potentiate glucagon-like peptide-2 action and reduce dependence on parenteral nutrition in a rat model of human intestinal failure. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 22744334	2012
Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus. Diabetes therapy : research, treatment and education of diabetes and related disorders\| PubMed ID: 22986920	2012
Effects of pre-meal drinks with protein and amino acids on glycemic and metabolic responses at a subsequent composite meal. PloS one\| PubMed ID: 23028596	2012
The glycemic, insulinemic and plasma amino acid responses to equi-carbohydrate milk meals, a pilot- study of bovine and human milk. Nutrition journal\| PubMed ID: 23057765	2012
A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin. Endocrinology\| PubMed ID: 23064014	2012
Postprandial gut hormone responses and glucose metabolism in cholecystectomized patients. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 23275610	2013
Gastrointestinal factors contribute to glucometabolic disturbances in nondiabetic patients with end-stage renal disease. Kidney international\| PubMed ID: 23325073	2013
GLP-2 delays but does not prevent the onset of necrotizing enterocolitis in preterm pigs. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 23343934	2013
Removal of duodenum elicits GLP-1 secretion. Diabetes care\| PubMed ID: 23393218	2013
Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety. The American journal of clinical nutrition\| PubMed ID: 23466396	2013
The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 23599045	2013
Safety and efficacy of liraglutide in patients with type 2 diabetes and end-stage renal disease: protocol for an investigator-initiated prospective, randomised, placebo-controlled, double-bl... BMJ open\| PubMed ID: 23624993	2013
Exaggerated glucagon-like peptide 1 response is important for improved β-cell function and glucose tolerance after Roux-en-Y gastric bypass in patients with type 2 diabetes. Diabetes\| PubMed ID: 23649520	2013
The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway. Diabetes\| PubMed ID: 23674605	2013
Characterisation of oral and i.v. glucose handling in truncally vagotomised subjects with pyloroplasty. European journal of endocrinology\| PubMed ID: 23704713	2013
Long-term effects of bariatric surgery on meal disposal and β-cell function in diabetic and nondiabetic patients. Diabetes\| PubMed ID: 23835342	2013
Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety. Expert opinion on pharmacotherapy\| PubMed ID: 23919507	2013
Effect of dietary advanced glycation end products on postprandial appetite, inflammation, and endothelial activation in healthy overweight individuals. European journal of nutrition\| PubMed ID: 23929260	2014
Mechanisms of the incretin effect in subjects with normal glucose tolerance and patients with type 2 diabetes. PloS one\| PubMed ID: 24019903	2013
Secretion of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes: systematic review and meta-analysis of clinical studies. Diabetes care\| PubMed ID: 24065842	2013
Postprandial responses of incretin and pancreatic hormones in non-diabetic patients with end-stage renal disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 24078334	2014
A pilot study examining the relationship among Crohn disease activity, glucagon-like peptide-2 signalling and intestinal function in pediatric patients. Canadian journal of gastroenterology = Journal canadien de gastroenterologie\| PubMed ID: 24106731	2013
The effect of a glucagon-like peptide-1 receptor agonist on glucose tolerance in women with previous gestational diabetes mellitus: protocol for an investigator-initiated, randomised, placeb... BMJ open\| PubMed ID: 24176797	2013
Insulin resistance alters islet morphology in nondiabetic humans. Diabetes\| PubMed ID: 24215793	2014
GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 24302010	2014
Reduction in cardiovascular risk factors and insulin dose, but no beta-cell regeneration 1 year after Roux-en-Y gastric bypass in an obese patient with type 1 diabetes: a case report. Obesity research & clinical practice\| PubMed ID: 24306154	2013
KCNQ1 long QT syndrome patients have hyperinsulinemia and symptomatic hypoglycemia. Diabetes\| PubMed ID: 24357532	2014
Effects of chronic glucagon-like peptide-2 therapy during weaning in neonatal pigs. Regulatory peptides\| PubMed ID: 24368164	2014
The authors reply. Kidney international\| PubMed ID: 24380909	2014
Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 24497581	2014
Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 24525020	2014
Mechanisms of changes in glucose metabolism and bodyweight after bariatric surgery. The lancet. Diabetes & endocrinology\| PubMed ID: 24622719	2014
Incretin effect and glucagon responses to oral and intravenous glucose in patients with maturity-onset diabetes of the young--type 2 and type 3. Diabetes\| PubMed ID: 24677712	2014
Elimination and degradation of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with end-stage renal disease. The Journal of clinical endocrinology and metabolism\| PubMed ID: 24712563	2014
Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls. Journal of diabetes investigation\| PubMed ID: 24843409	2010
Glucagon responses to increasing oral loads of glucose and corresponding isoglycaemic intravenous glucose infusions in patients with type 2 diabetes and healthy individuals. Diabetologia\| PubMed ID: 24879388	2014
Unprecedented high insulin secretion in a healthy human subject after intravenous glucagon-like peptide-1: a case report. BMC research notes\| PubMed ID: 24885055	2014
Hyperglucagonaemia analysed by glucagon sandwich ELISA: nonspecific interference or truly elevated levels? Diabetologia\| PubMed ID: 24891019	2014
Glucose-lowering effects and low risk of hypoglycemia in patients with maturity-onset diabetes of the young when treated with a GLP-1 receptor agonist: a double-blind, randomized, crossover ... Diabetes care\| PubMed ID: 24929431	2014
Postprandial gallbladder emptying in patients with type 2 diabetes: potential implications for bile-induced secretion of glucagon-like peptide 1. European journal of endocrinology\| PubMed ID: 24986531	2014
Glucose-dependent insulinotropic polypeptide augments glucagon responses to hypoglycemia in type 1 diabetes. Diabetes\| PubMed ID: 25053587	2015
Mechanisms behind the superior effects of interval vs continuous training on glycaemic control in individuals with type 2 diabetes: a randomised controlled trial. Diabetologia\| PubMed ID: 25099941	2014
Glucose-dependent insulinotropic polypeptide inhibits bone resorption in humans. The Journal of clinical endocrinology and metabolism\| PubMed ID: 25144635	2014
Molecular mechanisms of glucose-stimulated GLP-1 secretion from perfused rat small intestine. Diabetes\| PubMed ID: 25157092	2015
A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36 % wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes controlled by d... Journal of nutritional science\| PubMed ID: 25191571	2013
Effects of hydrolysed casein, intact casein and intact whey protein on energy expenditure and appetite regulation: a randomised, controlled, cross-over study. The British journal of nutrition\| PubMed ID: 25191896	2014
GLP-1 as a mediator in the remission of type 2 diabetes after gastric bypass and sleeve gastrectomy surgery. Diabetes\| PubMed ID: 25249642	2014
Therapies for inter-relating diabetes and obesity - GLP-1 and obesity. Expert opinion on pharmacotherapy\| PubMed ID: 25260877	2014
On the role of gallbladder emptying and incretin hormones for nutrient-mediated TSH suppression in patients with type 2 diabetes. Endocrine connections\| PubMed ID: 25277744	2014
Clearance of glucoregulatory peptide hormones during haemodialysis and haemodiafiltration in non-diabetic end-stage renal disease patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 25319937	2015
Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study. PloS one\| PubMed ID: 25412338	2014
The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. Cell metabolism\| PubMed ID: 25453189	2014
Hypoglycemia-associated changes in the electroencephalogram in patients with type 1 diabetes and normal hypoglycemia awareness or unawareness. Diabetes\| PubMed ID: 25488900	2015
Incretin effect after oral amino acid ingestion in humans. The Journal of clinical endocrinology and metabolism\| PubMed ID: 25490278	2015
Stability of glucagon-like peptide 1 and glucagon in human plasma. Endocrine connections\| PubMed ID: 25596009	2015
Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients. Journal of diabetes and its complications\| PubMed ID: 25613093	2015
Immediate enhancement of first-phase insulin secretion and unchanged glucose effectiveness in patients with type 2 diabetes after Roux-en-Y gastric bypass. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 25628424	2015
Patients with psoriasis are insulin resistant. Journal of the American Academy of Dermatology\| PubMed ID: 25653028	2015
Activation of GLP-1 receptors on vascular smooth muscle cells reduces the autoregulatory response in afferent arterioles and increases renal blood flow. American journal of physiology. Renal physiology\| PubMed ID: 25656368	2015
Renal extraction and acute effects of glucagon-like peptide-1 on central and renal hemodynamics in healthy men. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 25670826	2015
The effects of TNF-α on GLP-1-stimulated plasma glucose kinetics. The Journal of clinical endocrinology and metabolism\| PubMed ID: 25675385	2015
Differential effects of glucagon-like peptide-1 on microvascular recruitment and glucose metabolism in short- and long-term insulin resistance. The Journal of physiology\| PubMed ID: 25688993	2015
The glucagon-like peptide 2 receptor is expressed in enteric neurons and not in the epithelium of the intestine. Peptides\| PubMed ID: 25748021	2015
Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy. The Journal of clinical endocrinology and metabolism\| PubMed ID: 25781355	2015
L-glutamine and whole protein restore first-phase insulin response and increase glucagon-like peptide-1 in type 2 diabetes patients. Nutrients\| PubMed ID: 25811109	2015
Dairy proteins, dairy lipids, and postprandial lipemia in persons with abdominal obesity (DairyHealth): a 12-wk, randomized, parallel-controlled, double-blinded, diet intervention study. The American journal of clinical nutrition\| PubMed ID: 25833983	2015
Influence of gastrointestinal factors on glucose metabolism in patients with cirrhosis. Journal of gastroenterology and hepatology\| PubMed ID: 25867498	2015
Bile acid mediated effects on gut integrity and performance of early-weaned piglets. BMC veterinary research\| PubMed ID: 25972097	2015
GLP-1 Receptor Agonist Treatment Increases Bone Formation and Prevents Bone Loss in Weight-Reduced Obese Women. The Journal of clinical endocrinology and metabolism\| PubMed ID: 26043228	2015
Important species differences regarding lymph contribution to gut hormone responses. Peptides\| PubMed ID: 26048091	2015
Intake of Lactobacillus reuteri improves incretin and insulin secretion in glucose-tolerant humans: a proof of concept. Diabetes care\| PubMed ID: 26084343	2015
The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 26136531	2015
Early gradual feeding with bovine colostrum improves gut function and NEC resistance relative to infant formula in preterm pigs. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 26138468	2015
The 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humans. The American journal of clinical nutrition\| PubMed ID: 26178726	2015
Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells. Endocrinology\| PubMed ID: 26181106	2015
Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes. Diabetologia\| PubMed ID: 26186884	2015
Pancreatic polypeptide responses to isoglycemic oral and intravenous glucose in humans with and without intact vagal innervation. Peptides\| PubMed ID: 26218807	2015
Accelerated protein digestion and amino acid absorption after Roux-en-Y gastric bypass. The American journal of clinical nutrition\| PubMed ID: 26245808	2015
Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors. Endocrinology\| PubMed ID: 26280129	2015
Safety and Efficacy of Liraglutide in Patients With Type 2 Diabetes and End-Stage Renal Disease: An Investigator-Initiated, Placebo-Controlled, Double-Blind, Parallel-Group, Randomized Trial... Diabetes care\| PubMed ID: 26283739	2016
Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes. Diabetologia\| PubMed ID: 26385462	2015
IDegLira Improves Both Fasting and Postprandial Glucose Control as Demonstrated Using Continuous Glucose Monitoring and a Standardized Meal Test. Journal of diabetes science and technology\| PubMed ID: 26443290	2015
Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism. Endocrinology\| PubMed ID: 26469136	2016
GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness. The Journal of endocrinology\| PubMed ID: 26483393	2016
Twelve-Week Treatment With Liraglutide as Add-on to Insulin in Normal-Weight Patients With Poorly Controlled Type 1 Diabetes: A Randomized, Placebo-Controlled, Double-Blind Parallel Study. Diabetes care\| PubMed ID: 26486191	2015
Cephalic phase secretion of insulin and other enteropancreatic hormones in humans. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 26492921	2016
Acute disruption of glucagon secretion or action does not improve glucose tolerance in an insulin-deficient mouse model of diabetes. Diabetologia\| PubMed ID: 26537124	2016
Effect of Antibiotics on Gut Microbiota, Gut Hormones and Glucose Metabolism. PloS one\| PubMed ID: 26562532	2015
Effects of Gastric Bypass and Gastric Banding on Bone Remodeling in Obese Patients With Type 2 Diabetes. The Journal of clinical endocrinology and metabolism\| PubMed ID: 26600045	2016
Effects of glucagon-like peptide-1 on glucagon secretion in patients with non-alcoholic fatty liver disease. Journal of hepatology\| PubMed ID: 26626496	2016
The regulation of function, growth and survival of GLP-1-producing L-cells. Clinical science (London, England : 1979)\| PubMed ID: 26637406	2016
Evidence of Extrapancreatic Glucagon Secretion in Man. Diabetes\| PubMed ID: 26672094	2016
Heterogeneity of glucagonomas due to differential processing of proglucagon-derived peptides. Endocrinology, diabetes & metabolism case reports\| PubMed ID: 26693280	2015
Jejunal feeding is followed by a greater rise in plasma cholecystokinin, peptide YY, glucagon-like peptide 1, and glucagon-like peptide 2 concentrations compared with gastric feeding in vivo... The American journal of clinical nutrition\| PubMed ID: 26762368	2016
Effects of endogenous GLP-1 and GIP on glucose tolerance after Roux-en-Y gastric bypass surgery. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 26786780	2016
The intestinal distribution pattern of appetite- and glucose regulatory peptides in mice, rats and pigs. BMC research notes\| PubMed ID: 26830025	2016
Inability of Some Commercial Assays to Measure Suppression of Glucagon Secretion. Journal of diabetes research\| PubMed ID: 26839899	2016
Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men. European journal of nutrition\| PubMed ID: 26857762	2017
GLP-1 Restores Altered Insulin and Glucagon Secretion in Posttransplantation Diabetes. Diabetes care\| PubMed ID: 26908914	2016
Glucagon-like peptide-1 does not have acute effects on central or renal hemodynamics in patients with type 2 diabetes without nephropathy. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 26956188	2016
Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3-36. European journal of endocrinology\| PubMed ID: 26976129	2016
A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats. PloS one\| PubMed ID: 27136422	2016
No Islet Cell Hyperfunction, but Altered Gut-Islet Regulation and Postprandial Hypoglycemia in Glucose-Tolerant Patients 3 Years After Gastric Bypass Surgery. Obesity surgery\| PubMed ID: 27138601	2016
Quantification of the Contribution of GLP-1 to Mediating Insulinotropic Effects of DPP-4 Inhibition With Vildagliptin in Healthy Subjects and Patients With Type 2 Diabetes Using Exendin [9-3... Diabetes\| PubMed ID: 27207543	2016
Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 27245336	2016
Use of anesthesia dramatically alters the oral glucose tolerance and insulin secretion in C57Bl/6 mice. Physiological reports\| PubMed ID: 27255361	2016
Feedback suppression of meal-induced glucagon-like peptide-1 (GLP-1) secretion mediated through elevations in intact GLP-1 caused by dipeptidyl peptidase-4 inhibition: a randomized, prospect... Diabetes, obesity & metabolism\| PubMed ID: 27300579	2016
Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota. Genome medicine\| PubMed ID: 27306058	2016
Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma. EBioMedicine\| PubMed ID: 27322465	2016
Guidelines: Surgical or medical therapy for patients with obesity and T2DM? Nature reviews. Endocrinology\| PubMed ID: 27388983	2016
Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. Diabetologia\| PubMed ID: 27390011	2016
Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial. Cell metabolism\| PubMed ID: 27411009	2016
Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men. Clinical science (London, England : 1979)\| PubMed ID: 27439969	2016
Higher Endogenous Glucose Production During OGTT vs Isoglycemic Intravenous Glucose Infusion. The Journal of clinical endocrinology and metabolism\| PubMed ID: 27533305	2016
Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery. Endocrinology\| PubMed ID: 27580810	2016
The biology of glucagon and the consequences of hyperglucagonemia. Biomarkers in medicine\| PubMed ID: 27611762	2016
Serum lipase activity and concentration during intravenous infusions of GLP-1 and PYY3-36 and after ad libitum meal ingestion in overweight men. Physiological reports\| PubMed ID: 27670407	2016
The impact of EndoBarrier gastrointestinal liner in obese patients with normal glucose tolerance and in patients with type 2 diabetes. Diabetes, obesity & metabolism\| PubMed ID: 27696668	2017
Addition of a dipeptidyl peptidase-4 inhibitor, sitagliptin, to ongoing therapy with the glucagon-like peptide-1 receptor agonist liraglutide: A randomized controlled trial in patients with ... Diabetes, obesity & metabolism\| PubMed ID: 27709794	2017
Effect of GLP-1 receptor agonist treatment on body weight in obese antipsychotic-treated patients with schizophrenia: a randomized, placebo-controlled trial. Diabetes, obesity & metabolism\| PubMed ID: 27717222	2017
Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference. Diabetes care\| PubMed ID: 27810989	2017
Liraglutide as adjunct to insulin treatment in type 1 diabetes does not interfere with glycaemic recovery or gastric emptying rate during hypoglycaemia: A randomized, placebo-controlled, dou... Diabetes, obesity & metabolism\| PubMed ID: 27868372	2017
Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes. Trends in endocrinology and metabolism: TEM\| PubMed ID: 27871675	2017
Gut: A key player in the pathogenesis of type 2 diabetes? Critical reviews in food science and nutrition\| PubMed ID: 27892685	2018
Pancreatic α-cell hyperplasia and hyperglucagonemia due to a glucagon receptor splice mutation. Endocrinology, diabetes & metabolism case reports\| PubMed ID: 27933176	2016
Glucagon-like Peptide 1 Receptor Signaling in Acinar Cells Causes Growth-Dependent Release of Pancreatic Enzymes. Cell reports\| PubMed ID: 27974199	2016
Critical role for GLP-1 in symptomatic post-bariatric hypoglycaemia. Diabetologia\| PubMed ID: 27975209	2017
Proteomics reveals the effects of sustained weight loss on the human plasma proteome. Molecular systems biology\| PubMed ID: 28007936	2016
Glucose-dependent insulinotropic polypeptide promotes lipid deposition in subcutaneous adipocytes in obese type 2 diabetes patients: a maladaptive response. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 28073779	2017
Glucagon and Amino Acids Are Linked in a Mutual Feedback Cycle: The Liver-α-Cell Axis. Diabetes\| PubMed ID: 28108603	2017
Glucagon-like peptide-1 elicits vasodilation in adipose tissue and skeletal muscle in healthy men. Physiological reports\| PubMed ID: 28174344	2017
Variable reliability of surrogate measures of insulin sensitivity after Roux-en-Y gastric bypass. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 28202439	2017
Chenodeoxycholic acid stimulates glucagon-like peptide-1 secretion in patients after Roux-en-Y gastric bypass. Physiological reports\| PubMed ID: 28202805	2017
A safety and pharmacokinetic dosing study of glucagon-like peptide 2 in infants with intestinal failure. Journal of pediatric surgery\| PubMed ID: 28209419	2017
Patients With Long-QT Syndrome Caused by Impaired -Encoded K11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia. Circulation\| PubMed ID: 28235848	2017
Acute effects of glucagon-like peptide-1, GLP-1, and exenatide on mesenteric blood flow, cardiovascular parameters, and biomarkers in healthy volunteers. Physiological reports\| PubMed ID: 28235974	2017
Women with prior gestational diabetes mellitus and prediabetes are characterised by a decreased incretin effect. Diabetologia\| PubMed ID: 28364253	2017
Mathematical Modelling of Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide-1 following Ingestion of Glucose. Basic & clinical pharmacology & toxicology\| PubMed ID: 28374974	2017
The Effect of a Subcutaneous Infusion of GLP-1, OXM, and PYY on Energy Intake and Expenditure in Obese Volunteers. The Journal of clinical endocrinology and metabolism\| PubMed ID: 28379519	2017
Glycaemic control and weight loss with semaglutide in type 2 diabetes. The lancet. Diabetes & endocrinology\| PubMed ID: 28385658	2017
Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals. Gastroenterology\| PubMed ID: 28396144	2017
Glucose ingestion causes cardiac repolarization disturbances in type 1 long QT syndrome patients and healthy subjects. Heart rhythm\| PubMed ID: 28400316	2017
A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 28420649	2017
Sweet Taste Receptor Activation in the Gut Is of Limited Importance for Glucose-Stimulated GLP-1 and GIP Secretion. Nutrients\| PubMed ID: 28441725	2017
Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 28462383	2017
Role of Glucagon in Catabolism and Muscle Wasting of Critical Illness and Modulation by Nutrition. American journal of respiratory and critical care medicine\| PubMed ID: 28475354	2017
Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial. Scientific reports\| PubMed ID: 28539646	2017
The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice. Diabetologia\| PubMed ID: 28551699	2017
Health care professionals from developing countries report educational benefits after an online diabetes course. BMC medical education\| PubMed ID: 28566091	2017
Effect of Liraglutide Treatment on Prediabetes and Overweight or Obesity in Clozapine- or Olanzapine-Treated Patients With Schizophrenia Spectrum Disorder: A Randomized Clinical Trial. JAMA psychiatry\| PubMed ID: 28601891	2017
Why is it so difficult to measure glucagon-like peptide-1 in a mouse? Diabetologia\| PubMed ID: 28669086	2017
Effects of exogenous glucagon-like peptide-2 and distal bowel resection on intestinal and systemic adaptive responses in rats. PloS one\| PubMed ID: 28738080	2017
Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals. Diabetes care\| PubMed ID: 28751547	2017
The bile acid-sequestering resin sevelamer eliminates the acute GLP-1 stimulatory effect of endogenously released bile acids in patients with type 2 diabetes. Diabetes, obesity & metabolism\| PubMed ID: 28786523	2018
Addition of Rye Bran and Pea Fiber to Pork Meatballs Enhances Subjective Satiety in Healthy Men, but Does Not Change Glycemic or Hormonal Responses: A Randomized Crossover Meal Test Study. The Journal of nutrition\| PubMed ID: 28794212	2017
Roles of increased glycaemic variability, GLP-1 and glucagon in hypoglycaemia after Roux-en-Y gastric bypass. European journal of endocrinology\| PubMed ID: 28855269	2017
Pancreatic Polypeptide in Parkinson's Disease: A Potential Marker of Parasympathetic Denervation. Journal of Parkinson's disease\| PubMed ID: 28922171	2017
Relationship between Optimum Mini-doses of Glucagon and Insulin Levels when Treating Mild Hypoglycaemia in Patients with Type 1 Diabetes - A Simulation Study. Basic & clinical pharmacology & toxicology\| PubMed ID: 28922582	2018
Single-Dose Metformin Enhances Bile Acid-Induced Glucagon-Like Peptide-1 Secretion in Patients With Type 2 Diabetes. The Journal of clinical endocrinology and metabolism\| PubMed ID: 28938439	2017
GIP(3-30)NH is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study. Diabetologia\| PubMed ID: 28948296	2018
Enteroendocrine K and L cells in healthy and type 2 diabetic individuals. Diabetologia\| PubMed ID: 28956082	2018
Hyperglucagonemia correlates with plasma levels of non-branched-chain amino acids in patients with liver disease independent of type 2 diabetes. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 28971838	2018
Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition. Cell metabolism\| PubMed ID: 28978426	2017
Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 28978545	2018
Elevated Postoperative Endogenous GLP-1 Levels Mediate Effects of Roux-en-Y Gastric Bypass on Neural Responsivity to Food Cues. Diabetes care\| PubMed ID: 29025878	2017
Glucose-Dependent Insulinotropic Polypeptide (GIP) Inhibits Bone Resorption Independently of Insulin and Glycemia. The Journal of clinical endocrinology and metabolism\| PubMed ID: 29099978	2018
Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production. Cell reports\| PubMed ID: 29117552	2017
TRPV1: A Potential Therapeutic Target in Type 2 Diabetes and Comorbidities? Trends in molecular medicine\| PubMed ID: 29137713	2017
On the relationship between glucose absorption and glucose-stimulated secretion of GLP-1, neurotensin, and PYY from different intestinal segments in the rat. Physiological reports\| PubMed ID: 29199179	2017
Evidence of a liver-alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino acids. Diabetologia\| PubMed ID: 29305624	2018
Erratum: Effect of GLP-1 receptor agonist treatment on body weight in obese antipsychotic-treated patients with schizophrenia: A randomized, placebo-controlled trial. Diabetes, obesity & metabolism\| PubMed ID: 29316175	2018
Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight ... Nutrition & diabetes\| PubMed ID: 29330461	2018
Pre-Meal Effect of Whey Proteins on Metabolic Parameters in Subjects with and without Type 2 Diabetes: A Randomized, Crossover Trial. Nutrients\| PubMed ID: 29370144	2018
Oxyntomodulin: Actions and role in diabetes. Peptides\| PubMed ID: 29412831	2018
Systems Signatures Reveal Unique Remission-path of Type 2 Diabetes Following Roux-en-Y Gastric Bypass Surgery. EBioMedicine\| PubMed ID: 29422288	2018
Glucose-lowering effects and mechanisms of the bile acid-sequestering resin sevelamer. Diabetes, obesity & metabolism\| PubMed ID: 29493868	2018
The glucagon like peptide-2 'axis': Capacity for production and response following intestinal resection or repair of gastroschisis in infants. Journal of pediatric surgery\| PubMed ID: 29523359	2018
Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses. BMC genetics\| PubMed ID: 29548277	2018
Effects of Smoking Versus Nonsmoking on Postprandial Glucose Metabolism in Heavy Smokers Compared With Nonsmokers. Diabetes care\| PubMed ID: 29602793	2018
Is glucagon-like peptide-1 fully protected by the dipeptidyl peptidase 4 inhibitor sitagliptin when administered to patients with type 2 diabetes? Diabetes, obesity & metabolism\| PubMed ID: 29654643	2018
Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. Molecular metabolism\| PubMed ID: 29656109	2018
Older Subjects With β-Cell Dysfunction Have an Accentuated Incretin Release. The Journal of clinical endocrinology and metabolism\| PubMed ID: 29672742	2018
The effect of casein, hydrolyzed casein, and whey proteins on urinary and postprandial plasma metabolites in overweight and moderately obese human subjects. Journal of the science of food and agriculture\| PubMed ID: 29696654	2018
Restoration of enteroendocrine and pancreatic function after internal hernia and short bowel syndrome in a young woman with gastric bypass - a 2-year follow-up. Physiological reports\| PubMed ID: 29732709	2018
Mechanisms in bariatric surgery: Gut hormones, diabetes resolution, and weight loss. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery\| PubMed ID: 29776493	2018
Gut hormone release after gastric bypass depends on the length of the biliopancreatic limb. International journal of obesity (2005)\| PubMed ID: 29795464	2018
Patients with Obesity Caused by Melanocortin-4 Receptor Mutations Can Be Treated with a Glucagon-like Peptide-1 Receptor Agonist. Cell metabolism\| PubMed ID: 29861388	2018
Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine. Gastroenterology\| PubMed ID: 29935151	2018
The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men. Metabolism: clinical and experimental\| PubMed ID: 29953876	2018
Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice. Physiological reports\| PubMed ID: 29981198	2018
Hyperosmolar Duodenal Saline Infusion Lowers Circulating Ghrelin and Stimulates Intestinal Hormone Release in Young Men. The Journal of clinical endocrinology and metabolism\| PubMed ID: 30053031	2018
Glucose Tolerance Tests and Osteocalcin Responses in Healthy People. Frontiers in endocrinology\| PubMed ID: 30057568	2018
Renoprotective effects of dulaglutide in patients with T2DM and CKD. Nature reviews. Nephrology\| PubMed ID: 30171207	2018
No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course. BMC endocrine disorders\| PubMed ID: 30180841	2018
Acute Effects of Dietary Carbohydrate Restriction on Glycemia, Lipemia and Appetite Regulating Hormones in Normal-Weight to Obese Subjects. Nutrients\| PubMed ID: 30213037	2018
Reduced GLP-1 Secretion at 30 Minutes After a 75-g Oral Glucose Load Is Observed in Gestational Diabetes Mellitus: A Prospective Cohort Study. Diabetes\| PubMed ID: 30232211	2018
Gastrointestinal motility, gut hormone secretion, and energy intake after oral loads of free fatty acid or triglyceride in older and middle-aged men. Appetite\| PubMed ID: 30266581	2019
Mechanisms Preserving Insulin Action during High Dietary Fat Intake. Cell metabolism\| PubMed ID: 30269983	2019
Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects. Metabolic syndrome and related disorders\| PubMed ID: 30325692	2018
Cholecystokinin secretion is suppressed by glucagon-like peptide-1: clue to the mechanism of the adverse gallbladder events of GLP-1-derived drugs. Scandinavian journal of gastroenterology\| PubMed ID: 30449207	2018
Neuromedin U Does Not Act as a Decretin in Rats. Cell metabolism\| PubMed ID: 30449683	2018
Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine. Diabetes/metabolism research and reviews\| PubMed ID: 30468287	2019
The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones. Molecular metabolism\| PubMed ID: 30472415	2019
Glucose homeostasis in statin users-The LIFESTAT study. Diabetes/metabolism research and reviews\| PubMed ID: 30517978	2018
Metformin-induced glucagon-like peptide-1 secretion contributes to the actions of metformin in type 2 diabetes. JCI insight\| PubMed ID: 30518693	2018
Energy intake, gastrointestinal transit, and gut hormone release in response to oral triglycerides and fatty acids in men with and without severe obesity. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 30520691	2019
Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery. Cell systems\| PubMed ID: 30528273	2018
Biliopancreatic diversion with duodenal switch (BPD-DS) and single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) result in distinct post-prandial hormone profiles. International journal of obesity (2005)\| PubMed ID: 30538284	2018
The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial. Lipids in health and disease\| PubMed ID: 30591062	2018
Effects of active commuting and leisure-time exercise on appetite in individuals with overweight and obesity. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 30605397	2019
Mechanisms of action of a carbohydrate-reduced, high-protein diet in reducing the risk of postprandial hypoglycemia after Roux-en-Y gastric bypass surgery. The American journal of clinical nutrition\| PubMed ID: 30624666	2019
Separate and Combined Gluco-Metabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 in Healthy Individuals. Diabetes\| PubMed ID: 30626611	2019
Preserved glucose response to low-dose glucagon after exercise in insulin-pump-treated individuals with type 1 diabetes: a randomised crossover study. Diabetologia\| PubMed ID: 30643924	2019
Gastrointestinal motility in patients with end-stage renal disease on chronic hemodialysis. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society\| PubMed ID: 30667131	2019
Effects of combined GIP and GLP-1 infusion on energy intake, appetite and energy expenditure in overweight/obese individuals: a randomised, crossover study. Diabetologia\| PubMed ID: 30683945	2019
Postprandial Nutrient Handling and Gastrointestinal Secretion of Hormones After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy. Gastroenterology\| PubMed ID: 30742833	2019
Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 30767682	2019